A change from gonadotropin releasing hormone antagonist to gonadotropin releasing hormone agonist therapy does not affect the oncological outcomes in hormone sensitive prostate cancer
ConclusionsDegarelix is effective in the treatment of prostate cancer. Degarelix therapy can also be safely changed to a gonadotropin releasing hormone agonist without any adverse clinical or oncological effects. (Source: Basic and Clinical Andrology)
Source: Basic and Clinical Andrology - July 18, 2018 Category: Urology & Nephrology Source Type: research
Testicular microlithiasis and testicular tumor: a review of the literature
ConclusionIn cases of TML incidental finding by US with the presence of risk factors (personal history of testicular cancer, testicular atrophy, infertility, cryptorchidism) a consultation with a specialist should be considered. In the absence of risk factors, the occurrence of testicular cancer in patients with TML is similar to the risk of the general population. (Source: Basic and Clinical Andrology)
Source: Basic and Clinical Andrology - July 9, 2018 Category: Urology & Nephrology Source Type: research
The involvement of the nuclear lamina in human and rodent spermiogenesis: a systematic review
AbstractThe nuclear lamina (NL) is a filamentous protein meshwork, composed essentially of lamins, situated between the inner nuclear membrane and the chromatin. The NL is a component of the nuclear envelope, interacts with a wide range of proteins and is required for normal nuclear structure and physiological development. During spermiogenesis the spermatid nucleus is elongated, and dramatically reduced in size with protamines replacing histones to produce a highly compacted chromatin. There is mounting evidence from studies in human and rodent, that the NL plays an important role in mammalian spermatid differentiation du...
Source: Basic and Clinical Andrology - June 20, 2018 Category: Urology & Nephrology Source Type: research
Understanding the seminal plasma proteome and its role in male fertility
In conclusion, there are a number of studies focused on the proteomic composition of human seminal plasma; downstream confirmatory studies will help to understand specific pathways of infertility in different biological conditions. (Source: Basic and Clinical Andrology)
Source: Basic and Clinical Andrology - June 4, 2018 Category: Urology & Nephrology Source Type: research
Is sperm FISH analysis still useful for Robertsonian translocations? Meiotic analysis for 23 patients and review of the literature
ConclusionsAccording to the discrepancies observed between der(13;15) and all the other Rob T carriers, the differences observed among patients presenting normal and abnormal sperm parameters and the input in genetical counselling, sperm FISH does not seem obsolete for these patients. Moreover, it seems important to collect more data for rare RobT. (Source: Basic and Clinical Andrology)
Source: Basic and Clinical Andrology - May 7, 2018 Category: Urology & Nephrology Source Type: research
Sperm aneuploidy and DNA fragmentation in unexplained recurrent pregnancy loss: a multicenter case-control study
ConclusionsThis prospective case-control study is one of the largest to examine environmental factors, sperm characteristics, sperm DNA fragmentation and chromatin, and chromosome anomalies in spermatozoa in relation to unexplained recurrent pregnancy loss. The originality of our study lies in the comprehensive andrological examination and search for risk factors and fertility history. Further studies are needed to confirm the links between unexplained RPL and a male family history of infertility or miscarriages. The increased sperm aneuploidy observed in unexplained RPL supports a male etiology. These data pave the way fo...
Source: Basic and Clinical Andrology - April 2, 2018 Category: Urology & Nephrology Source Type: research
Longer trinucleotide repeats of androgen receptor are associated with higher testosterone and low oxytocin levels in diabetic premature ejaculatory dysfunction patients
ConclusionThis study indicates that androgen receptor polymorphism modulates the endocrine effect on ejaculatory reflex and depends strongly on its “cofactors”. Moreover, our results also confirmed an association between long tri-nucleotide repeats of androgen receptor, sex steroids, pituitary, and thyroid hormones in relation to acquired premature ejaculatory dysfunction in diabetic patients. However, endocrine regulation of PE reflex is a complex phenomenon that requires further investigation. (Source: Basic and Clinical Andrology)
Source: Basic and Clinical Andrology - March 6, 2018 Category: Urology & Nephrology Source Type: research
