Predictive value of sperm deoxyribonucleic acid (DNA) fragmentation index in male infertility
ConclusionThere was significant difference between the median value of sperm DFI of infertile men and fertile men. Compared to semen analysis, sperm DFI at cut-off point of 26.1% has a higher diagnostic value (AUC). (Source: Basic and Clinical Andrology)
Source: Basic and Clinical Andrology - February 20, 2017 Category: Urology & Nephrology Source Type: research
The contraceptive efficacy of intravas injection of Vasalgel ™ for adult male rhesus monkeys
ConclusionsIntravas injection of Vasalgel in sexually mature adult male rhesus monkeys was effective in preventing conception in a free-living, group environment. Complications were few and similar to those associated with traditional vasectomy. (Source: Basic and Clinical Andrology)
Source: Basic and Clinical Andrology - February 6, 2017 Category: Urology & Nephrology Source Type: research
Sperm quality and paternal age: effect on blastocyst formation and pregnancy rates
ConclusionsThese results allow adjusting our strategies of fertilization technique and embryo transfer. In the case of severe oligospermia, transfer should be carried out at the cleaved embryo stage (day 2 –3) due to the very low blastulation rate. When the man is older than 51 years, couples should be aware of the reduced success rate, especially if the woman is older than 37 years. Finally, promising research avenues should be explored, such as the quantification of free sperm DNA, to optimize t he selection of male gametes. (Source: Basic and Clinical Andrology)
Source: Basic and Clinical Andrology - January 20, 2017 Category: Urology & Nephrology Source Type: research
Hormonal, chemical and thermal inhibition of spermatogenesis: contribution of French teams to international data with the aim of developing male contraception in France
AbstractSince the 1970s, international research on male contraception has been actively pursued. Hormonal and non-hormonal methods (thermal, chemical) have been tested, leading to clinical trials of interest to thousands of men and couples.The results showed that it was possible to develop methods of male contraception that inhibited spermatogenesis with good contraceptive efficacy. However, their side effects (mainly loss of libido), poorly accepted modes of administration, and the high frequency of poor responders prevented their widespread use.Based on earlier initiatives, new avenues were explored and significant progr...
Source: Basic and Clinical Andrology - January 12, 2017 Category: Urology & Nephrology Source Type: research
Mammalian sperm nuclear organization: resiliencies and vulnerabilities
AbstractSperm cells are remarkably complex and highly specialized compared to somatic cells. Their function is to deliver to the oocyte the paternal genomic blueprint along with a pool of proteins and RNAs so a new generation can begin. Reproductive success, including optimal embryonic development and healthy offspring, greatly depends on the integrity of the sperm chromatin structure. It is now well documented that DNA damage in sperm is linked to reproductive failures both in natural and assisted conception (Assisted Reproductive Technologies [ART]). This manuscript reviews recent important findings concerning - the unus...
Source: Basic and Clinical Andrology - December 20, 2016 Category: Urology & Nephrology Source Type: research
Sperm DNA damage and its role in IVF and ICSI
AbstractWhile the semen analysis has traditionally been relied upon to differentiate fertile and infertile men, its utility has been questioned in the current era of assisted reproductive technologies. The desire for more sophisticated diagnostic and predictive tools has led to increased use of sperm DNA damage in the management of male infertility. Despite the availability of numerous assays to measure sperm DNA damage, our understanding of the etiology, measurement, and clinical implications of sperm DNA damage remains incomplete. While the current evidence is fraught with heterogeneity that complicates attempts at compa...
Source: Basic and Clinical Andrology - December 4, 2016 Category: Urology & Nephrology Source Type: research
Literature review of vaccine-related adverse events reported from HPV vaccination in randomized controlled trials
ConclusionBecause the statistically significantly higher incidence of AE in the HPV vaccine group was primarily limited to injection-site reactions, the vaccinations are safe preventative measures in both males and females. (Source: Basic and Clinical Andrology)
Source: Basic and Clinical Andrology - November 20, 2016 Category: Urology & Nephrology Source Type: research
Leydig cell tumor of the testis with azoospermia and elevated delta4 androstenedione: case report
ConclusionsIn this case, the diagnosis of testicular Leydig cell tumor secreting delta4 androstenedione was made in a context of azoospermia. (Source: Basic and Clinical Andrology)
Source: Basic and Clinical Andrology - November 7, 2016 Category: Urology & Nephrology Source Type: research
Gonadal response after a single-dose stimulation test with recombinant human chorionic gonadotropin (rhCG) in patients with isolated prepubertal cryptorchidism
ConclusionsIn this cohort, hormonal responses can be elicited after the rhCG stimulation test, suggesting that rhCG is a promising stimulation test to replace the urinary hCG test during the evaluation of gonadal Leydig cells function. The clinical applicability and adequate performance of rhCG testing must be investigated in future studies. (Source: Basic and Clinical Andrology)
Source: Basic and Clinical Andrology - October 27, 2016 Category: Urology & Nephrology Source Type: research
To be or not to be [fertile], that is the question
ConclusionsThese preliminary results should help us to improve (i) the way that male infertility is announced (it is easier to find the right words if one understands the possible importance of having a high sperm count) and (ii) the psychological, marital and sexual counselling provided to men with a diagnosis of infertility. (Source: Basic and Clinical Andrology)
Source: Basic and Clinical Andrology - October 11, 2016 Category: Urology & Nephrology Source Type: research
Sperm DNA damage and assisted reproductive technologies: reasons to be cautious!
(Source: Basic and Clinical Andrology)
Source: Basic and Clinical Andrology - September 26, 2016 Category: Urology & Nephrology Source Type: research
Zinner ’s syndrome: report of two cases and review of the literature
ConclusionsSeminal vesicle cysts combined with ipsilateral renal agenesis are rare urological anomalies. Usual symptoms that are caused by the seminal vesicle cysts are bladder irritation and obstruction as well as pain in the perineum and scrotum. Epididymitis is frequently found. Treatment consists to removing the seminal vesicle cyst. (Source: Basic and Clinical Andrology)
Source: Basic and Clinical Andrology - September 19, 2016 Category: Urology & Nephrology Source Type: research
A pilot study about infertile men ’s awareness of their reprotoxic exposures and the intervention of occupational medicine to assess them
ConclusionsThe data suggest that patients ’ knowledge about reprotoxic exposures can be improved, particularly knowledge related to physical exposure. The vast majority of patients were satisfied with the introduction of this new collaboration between reproductive and occupational medicine. (Source: Basic and Clinical Andrology)
Source: Basic and Clinical Andrology - August 9, 2016 Category: Urology & Nephrology Source Type: research
Is intracouple assisted reproductive technology an option for men with large-headed spermatozoa? A literature review and a decision guide proposal
Abstract
Although the presence of spermatozoa with an abnormally large head is rare, it is associated with low fertility or even total infertility. We reviewed the literature on assisted reproductive technology (ART) strategies and outcomes for men with large-headed spermatozoa. We also discuss additional analyses that can usefully characterize sperm defects and help with the choice between intra-couple ART and insemination with donor sperm. Lastly, we propose a classification for cases of large-headed spermatozoa. (Source: Basic and Clinical Andrology)
Source: Basic and Clinical Andrology - July 7, 2016 Category: Urology & Nephrology Source Type: research
Gut Endotoxin Leading to a Decline IN Gonadal function (GELDING) - a novel theory for the development of late onset hypogonadism in obese men
Abstract
Obesity is an increasing public health problem, with two-thirds of the adult population in many Western countries now being either overweight or obese. Male obesity is associated with late onset hypogonadism, a condition characterised by decreased serum testosterone, sperm quality plus diminished fertility and quality of life. In this paper we propose a novel theory underlying the development of obesity related hypogonadism- the GELDING theory (Gut Endotoxin Leading to a Decline IN Gonadal function).
Several observational studies have previously reported an association betwe...
Source: Basic and Clinical Andrology - June 21, 2016 Category: Urology & Nephrology Source Type: research
