Relationship between Semenogelins bound to human sperm and other semen parameters and pregnancy outcomes
ConclusionsThe total SEMG-unbound sperm count would be a relevant parameter for in vivo fertilization. This result suggests that SEMGs inhibit ectopic capacitation before sperm reach the fertilization site and that the number of total SEMG-unbound sperm is a parameter directly linked to the possibility of in vivo fertilization. (Source: Basic and Clinical Andrology)
Source: Basic and Clinical Andrology - August 8, 2017 Category: Urology & Nephrology Source Type: research
Association of admission testosterone level with ST-segment resolution in male patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention
ConclusionThis study suggests that in men with STEMI undergoing PPCI, higher serum levels of testosterone are associated with a better reperfusion response, fewer complications and a better left ventricular function. (Source: Basic and Clinical Andrology)
Source: Basic and Clinical Andrology - July 28, 2017 Category: Urology & Nephrology Source Type: research
Hypogonadotropic hypogonadism in men with hereditary hemochromatosis
AbstractHereditary hemochromatosis is a genetic disease that progresses silently. This disease is often diagnosed late when complications appear. Hypogonadotropic hypogonadism (HH) is one of the classical complications of hemochromatosis. Its frequency is declining probably because of earlier diagnosis and better informed physicians. Certain symptoms linked to HH can have an impact on a patient ’s sexuality, such as decreased libido, erectile dysfunction, and impairment of ejaculation, as well as on his reproductive capacities.This review is based on an online search in English, French and German language publications fo...
Source: Basic and Clinical Andrology - July 8, 2017 Category: Urology & Nephrology Source Type: research
Does sperm quality and DNA integrity differ in cryopreserved semen samples from young, adult, and aged Nellore bulls?
ConclusionThese results indicate that young bulls spermatozoa best survived the freezing procedure, followed by adult and aged bulls. However, young and aged bulls were found to be more susceptible to DNA damage, respectively caused by protamine deficiency and oxidation. Therefore, although young bulls have correct semen parameters according to classical evaluation, our results indicate that they may show some structural nuclear immaturity. (Source: Basic and Clinical Andrology)
Source: Basic and Clinical Andrology - June 21, 2017 Category: Urology & Nephrology Source Type: research
Subinguinal microsurgical varicocelectomy vs. percutaneous embolization in infertile men: Prospective comparison of reproductive and functional outcomes
ConclusionOur study shows that percutaneous embolization seems to be an equivalent alternative to sub-inguinal microscopic ligation in term of sperm quality improvement, pregnancy rate, and overall satisfaction with a slight advantage on post-operative morbidity. (Source: Basic and Clinical Andrology)
Source: Basic and Clinical Andrology - June 8, 2017 Category: Urology & Nephrology Source Type: research
“This is where it all started” – the pivotal role of PLCζ within the sophisticated process of mammalian reproduction: a systemic review
AbstractMammalian reproduction is one of the most complex and fascinating biological phenomenon, which aims to transfer maternal and paternal genetic material to the next generation. At the end of oogenesis and spermatogenesis, both haploid gametes contain a single set of chromosomes ready to form the zygote, the first cell of the newly developing individual. The mature oocyte and spermatozoa remain in a quiescent state, during which the oocyte is characterized by nuclear and cytoplasmic arrest, while the spermatozoa necessitates further maturation within the epididymis and female reproductive track prior to egg fertilizat...
Source: Basic and Clinical Andrology - May 21, 2017 Category: Urology & Nephrology Source Type: research
Interactions between oestrogen and 1 α,25(OH) 2 -vitamin D 3 signalling and their roles in spermatogenesis and spermatozoa functions
AbstractOestrogens and 1 α,25(OH)2-vitamin D3 (1,25-D3) are steroids that can provide effects by binding to their receptors localised in the cytoplasm and in the nucleus or the plasma membrane respectively inducing genomic and non-genomic effects. As confirmed notably by invalidation of the genes, coding for their receptors as tested with mice with in vivo and in vitro treatments, oestrogens and 1,25-D3 are regulators of spermatogenesis. Moreover, some functions of ejaculated spermatozoa as viability, DNA integrity, motility, capacitation, acrosome reaction and fertilizing ability are targets for these hormones. The studi...
Source: Basic and Clinical Andrology - May 8, 2017 Category: Urology & Nephrology Source Type: research
Cell-free and intracellular nucleic acids: new non-invasive biomarkers to explore male infertility
AbstractMale infertility is a devastating problem that affects many couples worldwide. However, the molecular mechanisms and causes of idiopathic male infertility remain unclear. Circulating cell-free nucleic acids have an important role in human physiology and emerging evidence suggests that they play a role in male infertility. This review summarizes recent results on cell-free and intracellular nucleic acids in male infertility and discusses their potential use as biomarkers of male infertility in the clinical practice. (Source: Basic and Clinical Andrology)
Source: Basic and Clinical Andrology - April 21, 2017 Category: Urology & Nephrology Source Type: research
Reversibility of Vasalgel ™ male contraceptive in a rabbit model
ConclusionsVasalgel ’s prevention of sperm transport for 14 months was reversed through an intravasal injection of sodium bicarbonate. Post-reversal sperm concentrations and motility returned to baseline levels during the six-month follow up. Residual material in the vas lumen or compromised epididymal and vas defere ns function may be resulting in reduced forward progression and loss of acrosomes during transit through the vas. Reduced forward progression and the lack of normal acrosomes strongly suggest impaired sperm function. (Source: Basic and Clinical Andrology)
Source: Basic and Clinical Andrology - April 5, 2017 Category: Urology & Nephrology Source Type: research
Processing and selection of surgically-retrieved sperm for ICSI: a review
AbstractAlthough the technique of intracytoplasmic sperm injection (ICSI) has been a revolution in the alleviation of male infertility, the use of testicular sperm for ICSI was a formerly unseen breakthrough in the treatment of the azoospermic man with primary testicular failure. At the clinical level, different procedures of testicular sperm retrieval (conventional TESE, micro-TESE, FNA/TESA, MESA, PESA) are being performed, the choice is mainly based on the cause of azoospermia (obstructive versus non-obstructive) and the surgeon ’s skills. At the level of the IVF laboratory, mechanical procedures to harvest the sperm ...
Source: Basic and Clinical Andrology - March 20, 2017 Category: Urology & Nephrology Source Type: research
Metabolic endotoxaemia related inflammation is associated with hypogonadism in overweight men
ConclusionsObesity and its associated metabolic endotoxaemia helps initiate a pro-inflammatory state characterised by raised serum IL-6 levels, which in turn is correlated with impairment of both Leydig (testosterone) and Sertoli cell function (AMH). These results open up the potential for new treatments of obesity related male hypogonadism that focus on preventing the endotoxaemia associated chronic inflammatory state. (Source: Basic and Clinical Andrology)
Source: Basic and Clinical Andrology - March 7, 2017 Category: Urology & Nephrology Source Type: research
