Management of Fournier ’s gangrene during the Covid-19 pandemic era: make a virtue out of necessity
ConclusionsFG is burdened by a high mortality rate, up to 30%. In the literature, HBOT could improve wound restoration and disease-specific survival. Unfortunately, in our center, we do not have HBOT. Moreover, one of the pandemic period problems was the patient ’s displacement and outpatient hospital management. For all these reasons we decided for a conservative inpatient management. Daily cleaning of the surgical wound allowed to obtain its complete restoration avoiding surgical graft and hyperbaric oxygen chamber therapy, without foregoing optimal out comes. (Source: Basic and Clinical Andrology)
Source: Basic and Clinical Andrology - July 19, 2022 Category: Urology & Nephrology Source Type: research
Subfertile patients underestimate their risk factors of reprotoxic exposure
ConclusionWe identified risk factors of reprotoxic exposures in the majority of subfertile patients, more frequently in men than in women, and half of patients were not aware of their exposures. Patients ’ main sources of information were extra medical. Efforts should be made to inform patients, especially men, about potential reprotoxic exposure and to enhance medical training about reprotoxic agents, as recommended by international guidelines. The detection and correction of environmental exposu res in subfertile men could improve their fecundity, but also their general health, which has been shown to be poorer than he...
Source: Basic and Clinical Andrology - July 5, 2022 Category: Urology & Nephrology Source Type: research
A novel role for CFTR interaction with LH and FGF in azoospermia and epididymal maldevelopment caused by cryptorchidism
AbstractCryptorchidism occurs frequently in children with cystic fibrosis. Among boys with cryptorchidism and abrogated mini-puberty, the development of the epididymis and the vas deferens is frequently impaired. This finding suggests that a common cause underlies the abnormal development of Ad spermatogonia and the epididymis. The cystic fibrosis transmembrane conductance regulator (CFTR) is an ATP-binding cassette transporter protein that acts as a chloride channel. TheCFTR gene has been associated with spermatogenesis and male fertility. In boys with cryptorchidism, prepubertal hypogonadotropic hypogonadism induces subo...
Source: Basic and Clinical Andrology - June 21, 2022 Category: Urology & Nephrology Source Type: research
Association between metabolic disorders and seminal plasma miRNA levels: a pilot study
ConclusionFew metabolic and anthropometric disorders are correlated with the level of specific miRNAs in seminal plasma. Further studies will be required to decipher if other small non-coding RNAs may also be correlated with metabolic and anthropometric disorders and to assess their potential implication in the alteration of reproductive functions in men with obesity or metabolic disorders.Clinical studyMetabolic Syndrome and Male Infertility (Metasperme): Trial registration: NCT01974947. Registered 18 July 2013. (Source: Basic and Clinical Andrology)
Source: Basic and Clinical Andrology - June 7, 2022 Category: Urology & Nephrology Source Type: research
The NLRP3 inflammasome: molecular activation and regulation in spermatogenesis and male infertility; a systematic review
AbstractBackgroundInfertility related to varicocele, infections, metabolic dysfunctions, oxidative stress and environmental toxicants is also associated with inflammatory processes that ultimately lead to the activation of the inflammasome pathway (IP). IP is classically activated by DAMPs, MAMPs or LAMPs, which stand for Damage-, Microbe- or Lifestyle-Associated Molecular Patterns, respectively. The most important player in IP activation is the NLRP3 (NOD[Nuclear oligomerization domain]-, LRR[Leucine rich repeat]- and pyrin domain-containing protein 3) which functions as an intracellular sensor of D/M/L-AMPs resulting in ...
Source: Basic and Clinical Andrology - May 30, 2022 Category: Urology & Nephrology Source Type: research
Sarcoidosis of the spermatic cord – case report and literature review
ConclusionSarcoidosis is a multi-system disease, which should not be omitted in the differential diagnosis. Selective excision of the lesion with intraoperative examination plays a significant role while establishing a diagnosis. However, in the primary site in the genitourinary system, the diagnosis is challenging. (Source: Basic and Clinical Andrology)
Source: Basic and Clinical Andrology - May 19, 2022 Category: Urology & Nephrology Source Type: research
ICSI outcomes for infertile men with severe or complete asthenozoospermia
ConclusionsIn couples with complete asthenozoospermia, testicular spermatozoa should be preferred to ejaculated spermatozoa for obtaining a better ICSI outcome. With the appropriate selection of testicular spermatozoa, the extent of severe or complete asthenozoospermia may not affect the ICSI outcomes. Future studies with a larger sample size are warranted to validate these findings. (Source: Basic and Clinical Andrology)
Source: Basic and Clinical Andrology - April 5, 2022 Category: Urology & Nephrology Source Type: research
Lipopolysaccharide-preconditioned allogeneic adipose-derived stem cells improve erectile function in a rat model of bilateral cavernous nerve injury
ConclusionsL-ADSC treatment may be a promising approach for restoring erectile function after CNI. (Source: Basic and Clinical Andrology)
Source: Basic and Clinical Andrology - March 25, 2022 Category: Urology & Nephrology Source Type: research
A rare case of penile schwannomatosis presenting with painful nocturnal penile tumescence
ConclusionOur hypothesis is that the schwannoma lies along the axis of the dorsal penile nerve, and compression of this nerve occurs during his erection causing pain. However, there are limited presentations of painful erections in penile schwannomas, and we hope that future studies can help confirm this theory. (Source: Basic and Clinical Andrology)
Source: Basic and Clinical Andrology - March 21, 2022 Category: Urology & Nephrology Source Type: research
For patients with non-obstructive azoospermia, the outcome of testicular sperm extraction correlates with self-esteem, sexual health and the quality of the couple ’s relationship
ConclusionFor men with non-obstructive azoospermia (NOA), negative TESE outcomes may have a negative impact on self-esteem and the quality of the couple ’s sex life and overall relationship. This should be borne in mind when counselling men with NOA and their partners to (ideally) help them to cope with and decrease the harmful impacts of azoospermia and negative TESE. (Source: Basic and Clinical Andrology)
Source: Basic and Clinical Andrology - February 16, 2022 Category: Urology & Nephrology Source Type: research
Temperature is not a major factor in the differentiation of gonocytes into ad spermatogonia and fertility outcome in congenitally cryptorchid boys
AbstractSpermatogenesis in mammals is a heat-sensitive developmental pathway incompatible with the typical mammalian body temperature of 37 °C. It is thought that this is the reason why the testicles of most mammalian males are outside of the body cavity, in the scrotum, where they function at approximately 33 °C. It has been suggested that the abnormally high temperature environment of cryptorchid testes may lead to impaired tes ticular development and adult infertility. Here, I summarize the clinical, genetic, and histological evidence that argues against temperature stress and in favor of hypogonadotropic hypogon...
Source: Basic and Clinical Andrology - January 10, 2022 Category: Urology & Nephrology Source Type: research
Effects of unilateral/bilateral amputation of the ischiocavernosus muscle in male rats on erectile function and conception
ConclusionsMale rats undergoing Bi-ICM amputation may develop permanent ED, which affects their fertility. In contrast, rats undergoing Uni-ICM amputation may experience transient ED. (Source: Basic and Clinical Andrology)
Source: Basic and Clinical Andrology - January 5, 2022 Category: Urology & Nephrology Source Type: research
Hormonal response after masturbation in young healthy men – a randomized controlled cross-over pilot study
ConclusionsIt can be assumed that masturbation may have a potential effect on free testosterone concentrations but not on hormonal ratios. However, additional studies with larger sample sizes are needed to validate these findings. (Source: Basic and Clinical Andrology)
Source: Basic and Clinical Andrology - December 23, 2021 Category: Urology & Nephrology Source Type: research
Effect of androgens on Sertoli cell maturation in human testis from birth to puberty
ConclusionsAndrogen action on Sertoli cells is required for onset of spermatogenesis and premature androgen secretion by LCT can induce spermatogenesis in the vicinity of the tumor. AR ir appeared earlier than onset of spermatogenesis, with large interindividual variability. The timing and mechanisms of Sertoli cell responsiveness to androgens are important issues for understanding the induction of spermatogenesis at puberty. (Source: Basic and Clinical Andrology)
Source: Basic and Clinical Andrology - December 14, 2021 Category: Urology & Nephrology Source Type: research
Non-obstructive idiopathic azoospermia vs azoospermia with antecedents of cryptorchidism: ways and probabilities of becoming parents
ConclusionsIn our centre, before considering TESE for a patient with NOA, we explain systematically TESE-ICSI alternatives (sperm donation, embryo donation or adoption). As a result, the couple can consider each solution to become parents. (Source: Basic and Clinical Andrology)
Source: Basic and Clinical Andrology - December 9, 2021 Category: Urology & Nephrology Source Type: research
