Is there a relationship between serum vitamin D and semen parameters? A cross-sectional sample of the Iranian infertile men
ConclusionsThe present findings suggest that higher serum vitamin D levels are positively associated with higher semen volume, sperm count, sperm total motility, and normal morphology rate. These findings, however, do not specify a cause-and-effect relationship, and there is a need for further research in this area to understand whether vitamin D supplementation can improve semen parameters. (Source: Basic and Clinical Andrology)
Source: Basic and Clinical Andrology - December 2, 2021 Category: Urology & Nephrology Source Type: research
d-Chiro-Inositol improves testosterone levels in older hypogonadal men with low-normal testosterone: a pilot study
ConclusionsIn this pilot study, DCI treatment improved the levels of testosterone and androstenedione at the expense of oestrogens in elder men with low basal levels of these hormones without adverse effects.Trial registrationClinicaltrials.gov: D-chiroinositol Administration in Hypogonadal Males,NCT04708249 (Source: Basic and Clinical Andrology)
Source: Basic and Clinical Andrology - November 12, 2021 Category: Urology & Nephrology Source Type: research
Azoospermia and reciprocal translocations: should whole-exome sequencing be recommended?
ConclusionsFirstly,TMPRSS9 gene defects might impact spermatogenesis. Secondly, as a function of the chromosome breakpoints for azoospermic patients with chromosome rearrangements, provision of the best possible genetic counselling means that genetic testing should not be limited to karyotyping. Given the risks associated with TESE, it is essential to perform WES - especially for consanguineous patients. (Source: Basic and Clinical Andrology)
Source: Basic and Clinical Andrology - November 11, 2021 Category: Urology & Nephrology Source Type: research
Beneficial effects of hypotaurine supplementation in preparation and freezing media on human sperm cryo-capacitation and DNA quality
ConclusionOur study is the first to demonstrate beneficial effects of hypotaurine supplementation in preparation and freezing procedures on human spermatozoa sperm fertilization capacity and nucleus quality. Hypotaurine supplementation limited cryo-capacitation, increased the proportion of live and progressively motile spermatozoa and reduces the percentage of spermatozoa showing chromatin decondensation, DNA fragmentation and nuclear vacuolation.Trial registrationClinical Trial,NCT04011813. Registered 19 May 2019 - Retrospectively registered. (Source: Basic and Clinical Andrology)
Source: Basic and Clinical Andrology - November 4, 2021 Category: Urology & Nephrology Source Type: research
Apoptotic M540 bodies present in human semen interfere with flow cytometry-assisted assessment of sperm DNA fragmentation and oxidation
ConclusionsWe conclude that M540 bodies interfere with both FC-conducted assays designed to evaluate sperm nuclear/DNA integrity. Exclusion of these contaminants in unprepared semen samples should be performed in order to correctly appreciate the true level of sperm DNA/nuclear damage which is known to be a critical male factor for reproductive success. (Source: Basic and Clinical Andrology)
Source: Basic and Clinical Andrology - October 21, 2021 Category: Urology & Nephrology Source Type: research
Extra-cellular vesicles of the male genital tract: new actors in male fertility?
AbstractExtracellular Vesicles (EVs) are membrane-limited particles containing proteins, lipids, metabolites and nucleic acids that are secreted by healthy and cancerous cells. These vesicles are very heterogeneous in size and content and mediate a variety of biological functions. Three subtypes of EV have been described in the male genital tract: microvesicles, myelinosomes and exosomes. Each type of EVs depends on the location of secretion such as the testis, prostate or epididymis. It has been shown that EVs can fuse together and deliver information to recipient cells, for example spermatozoa in the male genital tract. ...
Source: Basic and Clinical Andrology - October 14, 2021 Category: Urology & Nephrology Source Type: research
Impact of metabolic syndrome on the viability of human spermatozoa: a cross-sectional descriptive study in men from infertile couples
ConclusionSperm viability was lower in men with MetS. We also observed that age and BMI were independent factors associated with abnormal SST. (Source: Basic and Clinical Andrology)
Source: Basic and Clinical Andrology - October 7, 2021 Category: Urology & Nephrology Source Type: research
Male cancer patient sperm cryopreservation for fertility preservation: 10-year monocentric experience
ConclusionsThe present data confirm the deleterious impact of various cancers on semen quality. Leukaemia was associated with the worst semen quality and the highest number of semen samples that could not be frozen. We suggest that sperm quality may have decreased even before anti-neoplastic treatment and that sperm banking before treatment should be strongly recommended for cancer patients. A sperm banking programme before gonadotoxic therapy requires close cooperation between assisted reproduction centres and cancer clinics. (Source: Basic and Clinical Andrology)
Source: Basic and Clinical Andrology - September 16, 2021 Category: Urology & Nephrology Source Type: research
Is BRD7 associated with spermatogenesis impairment and male infertility in humans? A case-control study in a Han Chinese population
ConclusionsThe lack of an association ofBRD7-linked rare and common variants with spermatogenic failure implied a limited contribution of theBRD7 gene to spermatogenic efficiency and susceptibility to male infertility in humans. (Source: Basic and Clinical Andrology)
Source: Basic and Clinical Andrology - September 2, 2021 Category: Urology & Nephrology Source Type: research
Will whole-genome sequencing become the first-line genetic analysis for male infertility in the near future?
AbstractWhereas the initially strategy for the genetic analysis of male infertility was based on a candidate gene approach, the development of next-generation sequencing technologies (such as whole-exome sequencing (WES)) provides an opportunity to analyze many genes in a single procedure. In order to recommend WES or whole-genome sequencing (WGS) after genetic counselling, an objective evaluation of the current genetic screening strategy for male infertility is required, even if, at present, we have to take into consideration the complexity of such a procedure, not discussed in this commentary. (Source: Basic and Clinical Andrology)
Source: Basic and Clinical Andrology - August 19, 2021 Category: Urology & Nephrology Source Type: research
Effects of vitamin D supplementation in extender on sperm kinematics and apoptosis following the freeze-thaw process in normozoospermic and asthenozoospermic Holstein bulls
ConclusionsThe present study revealed that a high dose (50 ng/mL) of vitamin D protected normozoospermic bulls ’ sperms from the freezing procedure and lead to higher quality of frozen-thawed bull sperm. (Source: Basic and Clinical Andrology)
Source: Basic and Clinical Andrology - August 5, 2021 Category: Urology & Nephrology Source Type: research
Morphometric analysis and redox state of the testicles in nandrolone decanoate and swimming treated adult male rats
ConclusionsNandrolone alone or combined with swimming decreased morphometric parameters and amount of AR in testicle tissue. Changes in the redox state indicate reproductive dysfunction. (Source: Basic and Clinical Andrology)
Source: Basic and Clinical Andrology - July 15, 2021 Category: Urology & Nephrology Source Type: research
Viral infections that alter estrogen levels during pregnancy may contribute to the etiology of cryptorchidism
AbstractCryptorchidism is as common as type 2 diabetes or celiac disease. Boys with congenital cryptorchidism are at increased risk of infertility and testicular cancer. Zika syndrome, which affects pregnant women, is associated with a high incidence of undescended testes in the infant, accompanied by epididymal anomalies. Zika and influenza virus infections during pregnancy trigger a strong anti-inflammatory immune response and elevated estradiol levels. Elevated estradiol and α-fetoprotein in syncytiotrophoblasts from women who have given birth to cryptorchid boys are indicative of increased estradiol levels in the fetu...
Source: Basic and Clinical Andrology - July 7, 2021 Category: Urology & Nephrology Source Type: research
Correction to: Are serum levels of 25-hydroxy vitamin D reduced following orchiectomy in testicular cancer patients?
(Source: Basic and Clinical Andrology)
Source: Basic and Clinical Andrology - June 28, 2021 Category: Urology & Nephrology Source Type: research
Contribution of serum anti-M üllerian hormone in the management of azoospermia and the prediction of testicular sperm retrieval outcomes: a study of 155 adult men
ConclusionsSerum AMH levels, but not AMH/T values, are a good marker for Sertoli and germ cell population dysfunction in adult Caucasian men with non-mosaic Klinefelter syndrome and could help us to predict negative outcomes of SR at TESE with 100 % sensitivity when serum levels of AMH are below 2.5 pmol/l. (Source: Basic and Clinical Andrology)
Source: Basic and Clinical Andrology - June 17, 2021 Category: Urology & Nephrology Source Type: research
