Viruses, bacteria and parasites: infection of the male genital tract and fertility
AbstractBackgroundInfertility affects one couple out of six worldwide. Male infertilty can result from congenital or acquired factors, of which pathogens that reach the genital tract through sexual contact or blood dissemination. The impact of major viral, bacterial and parasitic infections on the male genital tract and fertility has been summarized.Results and conclusionsA systematic review of articles published in the Google Scholar and PubMed databases was conducted. It turns out that viruses, as well as bacteria and parasites are major inducers of male genital tract infections and ensuing infertility through damage to ...
Source: Basic and Clinical Andrology - July 20, 2023 Category: Urology & Nephrology Source Type: research
Causal association between JAK2 and erectile dysfunction: a Mendelian randomization study
ConclusionsThese findings highlighted JAK2 as a risk factor for erectile dysfunction and proved the causal relationship between JAK2 and erectile dysfunction, suggesting that targeting JAK2 signaling might be a novel and promising therapeutic candidate in the treatment of erectile dysfunction. (Source: Basic and Clinical Andrology)
Source: Basic and Clinical Andrology - July 6, 2023 Category: Urology & Nephrology Source Type: research
Long-term effect of sleeve gastrectomy surgery on Hormonal Profile, Semen Parameters and sexual functions of obese infertile men; a prospective observational study
ConclusionWeight loss through sleeve gastrectomy surgery significantly improves testosterone deficiency, sexual performance, and Sperm count in obese infertile men. (Source: Basic and Clinical Andrology)
Source: Basic and Clinical Andrology - June 22, 2023 Category: Urology & Nephrology Source Type: research
Mild COVID-19 has no detrimental effect on semen quality
ConclusionMild COVID-19 seems to have no detrimental effect on semen parameter values. (Source: Basic and Clinical Andrology)
Source: Basic and Clinical Andrology - June 15, 2023 Category: Urology & Nephrology Source Type: research
Effects of alcohol use on sperm chromatin structure, a retrospective analysis
ConclusionsThere was not a significant association between the level of alcohol use and the High DNA Stainability or DNA Fragmentation Index of sperm. Increasing age was associated with semen parameters as expected, heat exposure was associated with lower semen volume, and tobacco use was associated with lower sperm motility and density. Further studies could investigate alcohol use and reactive oxidative species in sperm. (Source: Basic and Clinical Andrology)
Source: Basic and Clinical Andrology - June 8, 2023 Category: Urology & Nephrology Source Type: research
Male obesity is associated with sperm telomere shortening and aberrant mRNA expression of autophagy-related genes
ConclusionAccording to our findings, obesity is associated with sperm telomere shortening and aberrant autophagy-related mRNA expression. It should be emphasized that telomere shortening in sperm may be an indirect consequence of obesity due to the oxidative stress associated with the condition. Nevertheless, further investigation is required for a more comprehensive understanding. (Source: Basic and Clinical Andrology)
Source: Basic and Clinical Andrology - May 25, 2023 Category: Urology & Nephrology Source Type: research
Implantation of skin-derived precursor Schwann cells improves erectile function in a bilateral cavernous nerve injury rat model
ConclusionsImplantation of skin-derived precursor Schwann cells is an effective therapeutic strategy for treating erectile dysfunction induced by bilateral cavernous nerve injury. (Source: Basic and Clinical Andrology)
Source: Basic and Clinical Andrology - May 18, 2023 Category: Urology & Nephrology Source Type: research
Study on clinical outcomes between non-transecting urethroplasty and lingual mucosal urethroplasty for iatrogenic bulbar urethral stricture treatment
ConclusionBoth surgical methods can achieve the clinical goal of treating iatrogenic bulbar urethral stricture. Non-transecting urethroplasty has the characteristics of short operation time, relative technical simplicity, and retention of the original erectile function of most patients, and the surgical outcomes of non-transecting urethroplasty are not inferior to those of lingual mucosal urethroplasty, and it is a promising technique for widespread use to treat bulbar urethral strictures. (Source: Basic and Clinical Andrology)
Source: Basic and Clinical Andrology - May 4, 2023 Category: Urology & Nephrology Source Type: research
Seminal plasma biomarkers for predicting successful sperm retrieval in patients with nonobstructive azoospermia: a narrative review of human studies
ConclusionThe evidence does not conclusively indicate that AMH and INHB in seminal plasma are valuable to predict the SSR. It is worth noting that RNAs, metabolites and other biomarkers in seminal plasma have shown great potential in predicting SSR. However, existing evidence is insufficient to provide clinicians with adequate decision support, and more prospective, large sample size, and multicenter trials are urgently needed. (Source: Basic and Clinical Andrology)
Source: Basic and Clinical Andrology - April 20, 2023 Category: Urology & Nephrology Source Type: research
The relationship between four types of premature ejaculation patients and the quality of residential environment
ConclusionsWe discovered that PE patients more likely resided in high-density areas with little green space and subpar commercial services, which might have an adverse effect on their mental health. This study offered a new viewpoint about the influence of residential environment on PE. (Source: Basic and Clinical Andrology)
Source: Basic and Clinical Andrology - April 13, 2023 Category: Urology & Nephrology Source Type: research
The role of male hypogonadism, aging, and chronic diseases in characterizing adult and elderly men with erectile dysfunction: a cross-sectional study
ConclusionSerum FT, SHBG, and CCI are the leading determinants of ED severity. Besides overt hypogonadism, a relevant burden of severe NTCDs in middle-aged or older adults features the patient ’s characteristics who will suffer from severe ED. Appropriate clinical approaches and, when necessary, treatments are required in these clusters of patients. (Source: Basic and Clinical Andrology)
Source: Basic and Clinical Andrology - April 6, 2023 Category: Urology & Nephrology Source Type: research
The effectiveness of penile curvature treatment by cavernous body rotation and plication of the tunica albuginea
ConclusionThus, the effectiveness of both treatment methods is comparable. However, TAP surgery is not recommended for patients with an initial curvature of more than 60 degrees. (Source: Basic and Clinical Andrology)
Source: Basic and Clinical Andrology - March 30, 2023 Category: Urology & Nephrology Source Type: research
Homocysteine levels correlate with AVSS-RigiScan test parameters in men with erectile dysfunction
ConclusionOur data showed that homocysteine inhibits penile erection. At the same time, homocysteine levels were negatively correlated with the parameters of the AVSS-RigiScan test. (Source: Basic and Clinical Andrology)
Source: Basic and Clinical Andrology - March 23, 2023 Category: Urology & Nephrology Source Type: research
Testicular impairment in Primary Adrenal Insufficiency caused by Nicotinamide Nucleotide Transhydrogenase (NNT) deficiency - a case report: implication of oxidative stress and importance of fertility preservation
ConclusionThis case report provides, for the first time, direct evidence of complete germ line loss in an azoospermic man with NNT deficiency. Additional data further support the hypothesis of a determinant role of oxidative cellular damage due to reactive oxygen species (ROS) imbalance in the severe gonadal impairment observed in this NNT-deficient patient. Early and regular evaluation of gonadal function should be performed in patients with PAI, especially with NNT deficiency, as soon as the patients reach puberty. Fertility preservation options should then be provided in early adulthood for these patients. (Source: Basi...
Source: Basic and Clinical Andrology - March 14, 2023 Category: Urology & Nephrology Source Type: research
The impact of the COVID-19 pandemic on semen quality of uninfected men
ConclusionAlthough the sociodemographic characteristics of sperm donors changed after the COVID-19 pandemic, no decline in semen quality was found. There is no concern about the quality of cryopreserved semen in human sperm banks after the COVID-19 pandemic. (Source: Basic and Clinical Andrology)
Source: Basic and Clinical Andrology - March 9, 2023 Category: Urology & Nephrology Source Type: research
