Curative GnRHa treatment has an unexpected repressive effect on Sertoli cell specific genes
ConclusionsImpaired-minipuberty with decreased LH and testosterone levels affected Ad and Sertoli cell development through positive and negative regulation of morphoregulatory and apoptotic genes. GnRHa treatment had a repressive effect on most Sertoli cell specific genes, which suggested that Sertoli cells underwent a cellular rearrangement. We propose that gonadotropin-dependent increases inFASLG andGDNF expression drove Sertoli cell proliferation and germ cell self-renewal and supported the transition of gonocytes to Ad spermatogonia, independent of inhibins. (Source: Basic and Clinical Andrology)
Source: Basic and Clinical Andrology - February 9, 2018 Category: Urology & Nephrology Source Type: research
Onco-testicular sperm extraction (Onco-TESE) from a single testis with metachronous bilateral testicular cancer: a case report
ConclusionThis case demonstrates the effectiveness of onco-TESE for challenging cases such as bilateral and nonseminmatous testicular cancer. (Source: Basic and Clinical Andrology)
Source: Basic and Clinical Andrology - January 25, 2018 Category: Urology & Nephrology Source Type: research
On the descent of the epididymo-testicular unit, cryptorchidism, and prevention of infertility
AbstractThis comprehensive review provides in-depth coverage of progress made in understanding the molecular mechanisms underlying cryptorchidism, a frequent pathology first described in about 1786 by John Hunter. The first part focuses on the physiology, embryology, and histology of epididymo-testicular descent. In the last 20 years epididymo-testicular descent has become the victim of schematic drawings with an unjustified rejection of valid histological data. This part also includes discussion on the roles of gonadotropin-releasing hormone, fibroblast growth factors, Müllerian inhibiting substance, androgens, inhibin...
Source: Basic and Clinical Andrology - November 14, 2017 Category: Urology & Nephrology Source Type: research
Paternal obesity: how bad is it for sperm quality and progeny health?
AbstractThere is substantial evidence that paternal obesity is associated not only with an increased incidence of infertility, but also with an increased risk of metabolic disturbance in adult offspring. Apparently, several mechanisms may contribute to the sperm quality alterations associated with paternal obesity, such as physiological/hormonal alterations, oxidative stress, and epigenetic alterations. Along these lines, modifications of hormonal profiles namely reduced androgen levels and elevated estrogen levels, were found associated with lower sperm concentration and seminal volume. Additionally, oxidative stress in t...
Source: Basic and Clinical Andrology - October 26, 2017 Category: Urology & Nephrology Source Type: research
Occurrence and reproductive roles of hormones in seminal plasma
AbstractOnly 2 –5% of seminal fluid is composed of spermatozoa, while the rest is seminal plasma. The seminal plasma is a rich cocktail of organic and inorganic compounds including hormones, serving as a source of nutrients for sperm development and maturation, protecting them from infection and enabling them to overcome the immunological and chemical environment of the female reproductive tract. In this review, a survey of the hormones found in human seminal plasma, with particular emphasis on reproductive hormones is provided. Their participation in fertilization is discussed including their indispensabl e role in ovum...
Source: Basic and Clinical Andrology - October 13, 2017 Category: Urology & Nephrology Source Type: research
ICSI diagnostic: a way to prevent total fertilization failure after 4 unsuccessful IUI
ConclusionsSplitting the oocytes between classical IVF and ICSI increases the chance of embryo transfer on a first IVF cycle after 4 unsuccessful IUI cycles. This half-and-half policy reduces the risk, for the infertile couple, of facing total failure of fertilization and also can provide useful information for the next attempts. (Source: Basic and Clinical Andrology)
Source: Basic and Clinical Andrology - September 21, 2017 Category: Urology & Nephrology Source Type: research
Patterns of residual HIV-1 RNA shedding in the seminal plasma of patients on effective antiretroviral therapy
ConclusionsThe seminal HIV load was used to monitor risk for infertile HIV-infected patients on an assisted reproductive technology program. This can still be recommended for patients who recently (6 months) started ART, or those with a poor history of adherence to ART but may also be usefull for some patients during counselling. Residual HIV seminal shedding is probably linked to breaks in adherence to antiretroviral treatment but local genital factors cannot be ruled out. (Source: Basic and Clinical Andrology)
Source: Basic and Clinical Andrology - September 8, 2017 Category: Urology & Nephrology Source Type: research
Occurrence and reproductive roles of hormones in seminal plasma
AbstractOnly 2 –5% of seminal fluid is composed of spermatozoa, while the rest is seminal plasma. The seminal plasma is a rich cocktail of organic and inorganic compounds including hormones, serving as a source of nutrients for sperm development and maturation, protecting them from infection and enabling them to overcome the immunological and chemical environment of the female reproductive tract. In this review, a survey of the hormones found in human seminal plasma, with particular emphasis on reproductive hormones is provided. Their participation in fertilization is discussed including their indispensabl e role in ovum...
Source: Basic and Clinical Andrology - September 8, 2017 Category: Urology & Nephrology Source Type: research
Patterns of residual HIV-1 RNA shedding in the seminal plasma of patients on effective antiretroviral therapy
ConclusionsThe seminal HIV load was used to monitor risk for infertile HIV-infected patients on an assisted reproductive technology program. This can still be recommended for patients who recently (6 months) started ART, or those with a poor history of adherence to ART but may also be usefull for some patients during counselling. Residual HIV seminal shedding is probably linked to breaks in adherence to antiretroviral treatment but local genital factors cannot be ruled out. (Source: Basic and Clinical Andrology)
Source: Basic and Clinical Andrology - September 8, 2017 Category: Urology & Nephrology Source Type: research
Sleep disturbances and semen quality in an Italian cross sectional study
ConclusionFurther studies are necessary to elucidate the relationship between sleep quality and semen parameters, which may have important public health implication. (Source: Basic and Clinical Andrology)
Source: Basic and Clinical Andrology - August 21, 2017 Category: Urology & Nephrology Source Type: research
