Semen and male genital tract characteristics of patients with Fabry disease: the FERTIFABRY multicentre observational study
ConclusionsThese results suggest that, while FD might have a detrimental effect on the semen characteristics, the reproductive function diminished only slightly. Further studies are warranted to assess the impact of the disease and of sperm abnormalities in the fertility of male patients with FD. (Source: Basic and Clinical Andrology)
Source: Basic and Clinical Andrology - May 14, 2019 Category: Urology & Nephrology Source Type: research
Obesity related metabolic endotoxemia is associated with oxidative stress and impaired sperm DNA integrity
ConclusionThis study confirms a link between obesity, increasing intestinal permeability and endotoxin exposure, and oxidative mediated sperm DNA damage. This warrants further investigation to fully understand the effect of metabolic endotoxemia on male reproductive function which could result in the new therapies to improve male fertility potential. (Source: Basic and Clinical Andrology)
Source: Basic and Clinical Andrology - May 12, 2019 Category: Urology & Nephrology Source Type: research
Genetic defects in human azoospermia
AbstractAs with many other diseases, genetic testing in human azoospermia was initially restricted to karyotype analyses (leading to diagnostic chromosome rearrangement tests for Klinefelter and other syndromes). With the advent of molecular biology in the 1980s, genetic screening was broadened to analyses of Y chromosome microdeletions and the gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR). Decades later, the emergence of whole-genome techniques has led to the identification of other genetic defects associated with human azoospermia. AlthoughTEX11 andADGRG2 defects are frequently described ...
Source: Basic and Clinical Andrology - April 22, 2019 Category: Urology & Nephrology Source Type: research
Testosterone replacement therapy and the risk of adverse cardiovascular outcomes and mortality
ConclusionIn hypogonadal men with a modest prevalence of established CVD, TRT was not observed to confer a protective or adverse effect on the risk of MI, CVA or all-cause mortality. (Source: Basic and Clinical Andrology)
Source: Basic and Clinical Andrology - March 28, 2019 Category: Urology & Nephrology Source Type: research
Two cases of male patients followed for a classical form of congenital adrenal hyperplasia (CAH), presenting an azoospermia: analysis and review of the literature
ConclusionCongenital hyperplasia of the adrenal glands is a rare pathology in the context of male infertility. A semen analysis could be performed after puberty and a semen preservation may be proposed. (Source: Basic and Clinical Andrology)
Source: Basic and Clinical Andrology - March 11, 2019 Category: Urology & Nephrology Source Type: research
Genetic causes of male infertility: snapshot on morphological abnormalities of the sperm flagellum
AbstractMale infertility due to Multiple Morphological Abnormalities of the sperm Flagella (MMAF), is characterized by nearly total asthenozoospermia due to the presence of a mosaic of sperm flagellar anomalies, which corresponds to short, angulated, absent flagella and flagella of irregular calibre. In the last four years, 7 novel genes whose mutations account for 45% of a cohort of 78 MMAF individuals were identified:DNAH1,CFAP43,CFAP44,CFAP69,FSIP2,WDR66 (CFAP251), AK7. This successful outcome results from the efficient combination of high-throughput sequencing technologies together with robust and complementary approac...
Source: Basic and Clinical Andrology - March 3, 2019 Category: Urology & Nephrology Source Type: research
Protective role of N-acetylcysteine (NAC) on human sperm exposed to etoposide
ConclusionsThe results indicate that NAC has the ability to counteract etoposide-induced toxicity rather than preventing the etoposide cytotoxic effects over sperm DNA, suggesting that the administration of NAC to cells formerly exposed to etoposide is preferable to its prophylactic use. As the results evidenced that NAC seems to be more efficient in attenuating sperm etoposide cytotoxic effects instead of being used as a chemoprophylactic agent, this reinforces the idea that there might be a new NAC mechanism over DNA. (Source: Basic and Clinical Andrology)
Source: Basic and Clinical Andrology - February 7, 2019 Category: Urology & Nephrology Source Type: research
Penile Lymphangioma: review of the literature with a case presentation
ConclusionIn this article, we elucidate the causes, symptoms, treatments, and outcomes associated with penile lymphangiomas found in the literature while also presenting the case of a 30-year-old African-American man diagnosed with acquired penile lymphangioma. (Source: Basic and Clinical Andrology)
Source: Basic and Clinical Andrology - January 28, 2019 Category: Urology & Nephrology Source Type: research
The 100 most influential manuscripts in andrology: a bibliometric analysis
ConclusionErectile dysfunction should be considered the most widely researched, published and cited field within andrological practice. This study provides a list of the most influential manuscripts in andrology and serves as a reference of what comprises a ‘highly citable’ paper for both researchers and clinicians. (Source: Basic and Clinical Andrology)
Source: Basic and Clinical Andrology - December 12, 2018 Category: Urology & Nephrology Source Type: research
Effects of lipopolysaccharide-induced inflammation on hypoxia and inflammatory gene expression pathways of the rat testis
ConclusionsTesticular HIF-1 α is up-regulated following LPS-induced inflammation. In contrast to other tissues, in which HIF-1α is up-regulated through transcriptional activation via NF-κB, we conclude that HIF-1α in the testis is not up-regulated through an increase inHif-1 α mRNA or through NF- κB-dependent mechanisms. Hypoxia pathway genes and genes involved in Toll-like receptor (TLR) and cytokine-mediated signaling comprise major functional categories of up-regulated genes, demonstrating that both hypoxia and classic inflammatory pathways are involved in inflammatory responses of the t estis. (Source: Basic and Clinical Andrology)
Source: Basic and Clinical Andrology - November 16, 2018 Category: Urology & Nephrology Source Type: research
Epididymal approaches to male contraception
AbstractToday, a vast arsenal of contraceptive methods interfering at different levels of the female reproductive axis is available. This is not the case for men for whom, until now, there is no reliable male reversible method and for whom vasectomy, condom and withdrawal are the only options available. Despite this limited supply, more than one third of all contraceptive methods used worldwide rely on the cooperation of the male partner. Besides developing hormonal approaches to stop sperm production, there may be attractive approaches that will interfere with sperm functions rather than production. Sperm functions are pr...
Source: Basic and Clinical Andrology - November 6, 2018 Category: Urology & Nephrology Source Type: research
Male reproductive health statement (XIIIth international symposium on Spermatology, may 9th –12th 2018, Stockholm, Sweden
AbstractOn the occasion of theXIIIth International Symposium on Spermatology held from 9 to 13 May 2018 in Stockholm (Sweden), participants (guest speakers and audience) collectively felt the need to make a public statement on the general issue of male reproductive health. Our intention is to raise awareness of what we believe is a neglected area of research despite alarming situations around the world. The disclosure strategy desired by the co-authors is to bring it to the attention of the greatest number partly by considering co-publication in the various periodicals dealing with Reproductive Biology and Andrology. BaCA ...
Source: Basic and Clinical Andrology - October 29, 2018 Category: Urology & Nephrology Source Type: research
Gel electrophoresis of human sperm: a simple method for evaluating sperm protein quality
ConclusionOne-dimensional PAGE constitutes a simple, rapid, reliable, inexpensive method for analyzing proteins associated with sperm motility in individual human ejaculates. (Source: Basic and Clinical Andrology)
Source: Basic and Clinical Andrology - September 3, 2018 Category: Urology & Nephrology Source Type: research
Sperm cryopreservation incidence in men with testicular cancer: towards a stabilization in testicular cancer incidence? Results from the CECOS network
ConclusionsLimitations include the impossibility of analyzing age-standardized incidence. Based on the Verhulst model, results suggest that it is still relevant to follow up TC incidence and sperm cryopreservation in order to confirm or refute the potential decrease already observed in this disease. (Source: Basic and Clinical Andrology)
Source: Basic and Clinical Andrology - August 3, 2018 Category: Urology & Nephrology Source Type: research
