Protective role of N-acetylcysteine (NAC) on human sperm exposed to etoposide

ConclusionsThe results indicate that NAC has the ability to counteract etoposide-induced toxicity rather than preventing the etoposide cytotoxic effects over sperm DNA, suggesting that the administration of NAC to cells formerly exposed to etoposide is preferable to its prophylactic use. As the results evidenced that NAC seems to be more efficient in attenuating sperm etoposide cytotoxic effects instead of being used as a chemoprophylactic agent, this reinforces the idea that there might be a new NAC mechanism over DNA.
Source: Basic and Clinical Andrology - Category: Urology & Nephrology Source Type: research