Testicular expression of long non –coding RNAs is affected by curative GnRHa treatment of cryptorchidism

ConclusionGiven that lncRNAs can cooperate with chromatin-modifying enzymes to promote epigenetic regulation of genes, GnRHa treatment may act as a surrogate for mini-puberty by triggering the differentiation of Ad spermatogonia via lncRNA-mediated epigenetic effects. Our work provides additional molecular evidence that infertility and azoospermia in cryptorchidism, resulting from defective mini-puberty cannot be cured with successful orchidopexy alone.
Source: Basic and Clinical Andrology - Category: Urology & Nephrology Source Type: research