Artificial Cells, Nanomedicine and Biotechnology 
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In this study, we administered fractionated RT combined with HBOC to treat Miapaca-2 cell and Hela cell xenografts on nude mice. The study found that HBOC relieved hypoxic environment and down-regulate expression of hypoxia-inducible factor-1α (Hif-1α) both in regular (100 mm3) and large (360/400 mm3) tumours. The proliferation and metastasis of tumour tissue also decreased after HBOC application. Nevertheless, in vivo RT combined with HBOC performed more effectively to suppress tumour growth in large tumours than in regular tumours. This is due to more severe hypoxic regions exist in the large solid tumours compared to ...
Source: Artificial Cells, Nanomedicine and Biotechnology - November 23, 2023 Category: Biotechnology Authors: Yingcan Xu Kehui Zhu Jiakang Wu Shifan Zheng Rui Zhong Wentao Zhou Ye Cao Jiaxin Liu Hong Wang Source Type: research
< em > Zingiberis rhizoma < /em > -based carbon dots alter serum oestradiol and follicle-stimulating hormone levels in female mice
Artif Cells Nanomed Biotechnol. 2024 Dec;52(1):12-22. doi: 10.1080/21691401.2023.2276770. Epub 2023 Nov 23.ABSTRACTChinese herbs contain substances that regulate female hormones. Our study confirmed that Zingiberis rhizoma carbonisata contains Zingiberis rhizoma-based carbon dots (ZR-CDs), which exert regulatory effects on serum oestradiol and FSH in mice and show impacts on endometrial growth and follicular development that potentially affect the ability of female fertility. ZR-CDs were characterized to clarify the microstructure, optical features, and functional group characteristics. It shows that ZR-CDs are spherical c...
Source: Artificial Cells, Nanomedicine and Biotechnology - November 23, 2023 Category: Biotechnology Authors: Yumin Chen Xue Bai Ying Zhang Yafang Zhao Huagen Ma Yunbo Yang Meijun Wang Yinghui Guo Xiaopeng Li Tong Wu Yue Zhang Hui Kong Yan Zhao Huaihua Qu Source Type: research
HBOC alleviated tumour hypoxia during radiotherapy more intensely in large solid tumours than regular ones
In this study, we administered fractionated RT combined with HBOC to treat Miapaca-2 cell and Hela cell xenografts on nude mice. The study found that HBOC relieved hypoxic environment and down-regulate expression of hypoxia-inducible factor-1α (Hif-1α) both in regular (100 mm3) and large (360/400 mm3) tumours. The proliferation and metastasis of tumour tissue also decreased after HBOC application. Nevertheless, in vivo RT combined with HBOC performed more effectively to suppress tumour growth in large tumours than in regular tumours. This is due to more severe hypoxic regions exist in the large solid tumours compared to ...
Source: Artificial Cells, Nanomedicine and Biotechnology - November 23, 2023 Category: Biotechnology Authors: Yingcan Xu Kehui Zhu Jiakang Wu Shifan Zheng Rui Zhong Wentao Zhou Ye Cao Jiaxin Liu Hong Wang Source Type: research
< em > Zingiberis rhizoma < /em > -based carbon dots alter serum oestradiol and follicle-stimulating hormone levels in female mice
Artif Cells Nanomed Biotechnol. 2024 Dec;52(1):12-22. doi: 10.1080/21691401.2023.2276770. Epub 2023 Nov 23.ABSTRACTChinese herbs contain substances that regulate female hormones. Our study confirmed that Zingiberis rhizoma carbonisata contains Zingiberis rhizoma-based carbon dots (ZR-CDs), which exert regulatory effects on serum oestradiol and FSH in mice and show impacts on endometrial growth and follicular development that potentially affect the ability of female fertility. ZR-CDs were characterized to clarify the microstructure, optical features, and functional group characteristics. It shows that ZR-CDs are spherical c...
Source: Artificial Cells, Nanomedicine and Biotechnology - November 23, 2023 Category: Biotechnology Authors: Yumin Chen Xue Bai Ying Zhang Yafang Zhao Huagen Ma Yunbo Yang Meijun Wang Yinghui Guo Xiaopeng Li Tong Wu Yue Zhang Hui Kong Yan Zhao Huaihua Qu Source Type: research
HBOC alleviated tumour hypoxia during radiotherapy more intensely in large solid tumours than regular ones
In this study, we administered fractionated RT combined with HBOC to treat Miapaca-2 cell and Hela cell xenografts on nude mice. The study found that HBOC relieved hypoxic environment and down-regulate expression of hypoxia-inducible factor-1α (Hif-1α) both in regular (100 mm3) and large (360/400 mm3) tumours. The proliferation and metastasis of tumour tissue also decreased after HBOC application. Nevertheless, in vivo RT combined with HBOC performed more effectively to suppress tumour growth in large tumours than in regular tumours. This is due to more severe hypoxic regions exist in the large solid tumours compared to ...
Source: Artificial Cells, Nanomedicine and Biotechnology - November 23, 2023 Category: Biotechnology Authors: Yingcan Xu Kehui Zhu Jiakang Wu Shifan Zheng Rui Zhong Wentao Zhou Ye Cao Jiaxin Liu Hong Wang Source Type: research
< em > Zingiberis rhizoma < /em > -based carbon dots alter serum oestradiol and follicle-stimulating hormone levels in female mice
Artif Cells Nanomed Biotechnol. 2024 Dec;52(1):12-22. doi: 10.1080/21691401.2023.2276770. Epub 2023 Nov 23.ABSTRACTChinese herbs contain substances that regulate female hormones. Our study confirmed that Zingiberis rhizoma carbonisata contains Zingiberis rhizoma-based carbon dots (ZR-CDs), which exert regulatory effects on serum oestradiol and FSH in mice and show impacts on endometrial growth and follicular development that potentially affect the ability of female fertility. ZR-CDs were characterized to clarify the microstructure, optical features, and functional group characteristics. It shows that ZR-CDs are spherical c...
Source: Artificial Cells, Nanomedicine and Biotechnology - November 23, 2023 Category: Biotechnology Authors: Yumin Chen Xue Bai Ying Zhang Yafang Zhao Huagen Ma Yunbo Yang Meijun Wang Yinghui Guo Xiaopeng Li Tong Wu Yue Zhang Hui Kong Yan Zhao Huaihua Qu Source Type: research
Study on tumour cell-derived hybrid exosomes as dasatinib nanocarriers for pancreatic cancer therapy
Artif Cells Nanomed Biotechnol. 2023 Dec;51(1):532-546. doi: 10.1080/21691401.2023.2264358. Epub 2023 Oct 5.ABSTRACTPancreatic ductal adenocarcinoma (PDAC) is one of the leading causes of cancer-related death. Therefore, we intend to explore novel strategies against PDAC. The exosomes-based biomimetic nanoparticle is an appealing candidate served as a drug carrier in cancer treatment, due to its inherit abilities. In the present study, we designed dasatinib-loaded hybrid exosomes by fusing human pancreatic cancer cells derived exosomes with dasatinib-loaded liposomes, followed by characterization for particle size (119.9 Â...
Source: Artificial Cells, Nanomedicine and Biotechnology - November 10, 2023 Category: Biotechnology Authors: Xiaofei Zhou Yuetang Zhuang Xiaohong Liu Yaowen Gu Junting Wang Yuchen Shi Li Zhang Rui Li Yelin Zhao Hebing Chen Jiao Li Hongjuan Yao Liang Li Source Type: research
