HBOC alleviated tumour hypoxia during radiotherapy more intensely in large solid tumours than regular ones

In this study, we administered fractionated RT combined with HBOC to treat Miapaca-2 cell and Hela cell xenografts on nude mice. The study found that HBOC relieved hypoxic environment and down-regulate expression of hypoxia-inducible factor-1α (Hif-1α) both in regular (100 mm3) and large (360/400 mm3) tumours. The proliferation and metastasis of tumour tissue also decreased after HBOC application. Nevertheless, in vivo RT combined with HBOC performed more effectively to suppress tumour growth in large tumours than in regular tumours. This is due to more severe hypoxic regions exist in the large solid tumours compared to the regular counterparts, and HBOC administration may be more effective in alleviating hypoxia in large tumours. Thus, HBOC sensitization therapy is more suitable for large solid tumours.PMID:37994792 | DOI:10.1080/21691401.2023.2276768

Source: Artificial Cells, Nanomedicine and Biotechnology - November 23, 2023 Category: Biotechnology Authors: Yingcan Xu Kehui Zhu Jiakang Wu Shifan Zheng Rui Zhong Wentao Zhou Ye Cao Jiaxin Liu Hong Wang Source Type: research