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Process-structure-biofunctional paradigm in cellular structured implants: an overview and perspective on the synergy between additive manufacturing, bio-mechanical behaviour and biological functions
Artif Cells Nanomed Biotechnol. 2023 Dec;51(1):630-640. doi: 10.1080/21691401.2023.2278156. Epub 2023 Nov 7.ABSTRACTThe overview describes the synergy between biological sciences and cellular structures processed by additive manufacturing to elucidate the significance of cellular structured implants in eliminating stress shielding and in meeting the bio-mechanical property requirements of elastic modulus, impact resistance, and fatigue strength in conjunction with the biological functionality. The convergence of additive manufacturing, computer-aided design, and structure-property relationships is envisaged to provide the ...
Source: Artificial Cells, Nanomedicine and Biotechnology - November 7, 2023 Category: Biotechnology Authors: R D K Misra K P Misra Source Type: research

Advances in screening and diagnostic lab-on-chip tools for gynaecological cancers - a review
Artif Cells Nanomed Biotechnol. 2023 Dec;51(1):618-629. doi: 10.1080/21691401.2023.2274047. Epub 2023 Nov 7.ABSTRACTGynaecological cancers are a major global health concern due to the lack of effective screening programmes for ovarian and endometrial cancer, for example, and variable access to vaccination and screening tests for cervical cancer in many countries. Recent research on portable and cost-effective lab-on-a-chip (LoC) technologies show promise for mass screening and diagnostic procedures for gynaecological cancers. However, most LoCs for gynaecological cancer are still in development, with a need to establish an...
Source: Artificial Cells, Nanomedicine and Biotechnology - November 7, 2023 Category: Biotechnology Authors: Sadeka Nujhat Hannah S Leese Mirella Di Lorenzo Rebecca Bowen Sandhya Moise Source Type: research

Niosomes gel of apigenin to improve the topical delivery: development, optimization, < em > ex vivo < /em > permeation, antioxidant study, and < em > in vivo < /em > evaluation
Artif Cells Nanomed Biotechnol. 2023 Dec;51(1):604-617. doi: 10.1080/21691401.2023.2274526. Epub 2023 Nov 1.ABSTRACTNiosomes (NS) are the promising and novel carrier of the drug for effective transdermal delivery. Apigenin (AN) is a natural bioactive compound and has various pharmacological activities. AN is poorly water soluble which directly affects therapeutic efficacy. The aim of this research work was to develop the AN-NS gel to improve transdermal delivery. The thin-film hydration method was used for the development of AN-NS. The optimized AN-NS (AN-NS2) has a vesicle size of 272.56 ± 12.49 nm, PDI is 0.249, zeta po...
Source: Artificial Cells, Nanomedicine and Biotechnology - November 1, 2023 Category: Biotechnology Authors: Omar Awad Alsaidan Ameeduzzafar Zafar Rayan Hamood Al-Ruwaili Mohd Yasir Sami I Alzarea Aseel Awad Alsaidan Lubhan Singh Mohammad Khalid Source Type: research

A study on the therapeutic potential of graphene titanate nanocomposite for treating chemically induced arthritis in rats
Artif Cells Nanomed Biotechnol. 2023 Dec;51(1):590-603. doi: 10.1080/21691401.2023.2268653. Epub 2023 Oct 30.ABSTRACTNanotechnology holds substantial promise in the innovative therapies for rheumatoid arthritis (RA). The current study was designed to synthesize and characterize a new graphene titanate nanocomposite (GTNc) and explore its anti-arthritic, anti-inflammatory, and antioxidant potencies against Complete Freund's adjuvant (CFA)-induced arthritis in rats, as well as investigate the underlying molecular mechanisms. Our characterization methods included XRD, FT-IR, SEM, EDX, zeta potential, practical size, and XRF t...
Source: Artificial Cells, Nanomedicine and Biotechnology - October 30, 2023 Category: Biotechnology Authors: Amany Belal Mohamed Y Zaky Doaa S Mohamed Eman E Mohamed Rehab Mahmoud Doaa Essam R R Atta Fatma I Abo El-Ela Fatma Mohamed Halfaya Kyung-Tae Lee Ahmed H E Hassan Mohammed M Ghoneim Ahmed Farghali Source Type: research

Cancer reduction in mice with Prakasine nanomedicine immunotherapy
In this study, non-toxic mercury nanoparticle Prakasine (PRK-NP) was synthesized as per 'Prakash theory of metal drugs' and nanoparticle's non toxicity has been demonstrated by employing in vitro MTT (dose = 320ug/ml), SBR (dose = 80ug/ml) and apoptosis assays (dose = 320ug/ml), and in vivo acute and chronic toxicity studies in mice (n = 12, dose = 900 mg/kg body weight oral), rat (n = 14, dose = 500 mg/kg body weight oral for 18 months), rabbit (n = 14, dose = 500 mg/kg body weight oral for 18 months) and dogs (n = 14, dose = 500 mg/kg body weight oral for 18 months). The MTT, SBR and apoptosis assays established no cytot...
Source: Artificial Cells, Nanomedicine and Biotechnology - October 26, 2023 Category: Biotechnology Authors: Prakash S K Source Type: research