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Oxygenation through oral Ox66 in a two-hit rodent model of respiratory distress
Artif Cells Nanomed Biotechnol. 2024 Dec;52(1):114-121. doi: 10.1080/21691401.2024.2307462. Epub 2024 Feb 29.ABSTRACTAcute respiratory distress syndrome (ARDS) is a complication of pulmonary disease that produces life-threatening hypoxaemia. Despite ventilation and hyperoxic therapies, undetected hypoxia can manifest in capillary beds leading to multi-organ failure. Ox66™ is an ingestible, solid-state form of oxygen designed to supplement oxygen deficits. Twenty-four anaesthetized rats underwent a two-hit model of respiratory distress (ARDS), where a single dose (5 mg/kg) of lipopolysaccharide (LPS) was given intratrache...
Source: Artificial Cells, Nanomedicine and Biotechnology - February 29, 2024 Category: Biotechnology Authors: Bjorn K Song Danuel A Carr Erica D Bruce William H Nugent Source Type: research

Harvesting decellularized liver extracellular matrix from rodents for 3D scaffold fabrication
This study also compares the efficiency of the proposed protocol in the two animal models viz rat and mice. This method harvests rat and mice liver dECM using ethylenediamine tetra acetic acid (EDTA) and sodium dodecyl sulphate (SDS) within 08 h and 02 h respectively and preserved significant amount of ECM proteins. We reported that the harvested mice decellularized extracellular matrix (mdECM) and rat decellularized extracellular matrix (rdECM) had significant reduction in their DNA content (∼97%) and retained structural architecture resembling their native tissue counterparts. The total protein content retained in mdEC...
Source: Artificial Cells, Nanomedicine and Biotechnology - February 29, 2024 Category: Biotechnology Authors: Meghana Kasturi Kirthanashri S Vasanthan Source Type: research

Comprehensive analysis of anoikis-related genes in diagnosis osteoarthritis: based on machine learning and single-cell RNA sequencing data
The objective of this work was to discover novel transcriptome-based anoikis-related biomarkers and pathways for OA progression.The microarray datasets GSE114007 and GSE89408 were downloaded using the Gene Expression Omnibus (GEO) database. A collection of genes linked to anoikis has been collected from the GeneCards database. The intersection genes of the differential anoikis-related genes (DEARGs) were identified using a Venn diagram. Infiltration analyses were used to identify and study the differentially expressed genes (DEGs). Anoikis clustering was used to identify the DEGs. By using gene clustering, two OA subgroups...
Source: Artificial Cells, Nanomedicine and Biotechnology - February 29, 2024 Category: Biotechnology Authors: Jun-Song Zhang Run-Sang Pan Guo-Lu Li Jian-Xiang Teng Hong-Bo Zhao Chang-Hua Zhou Ji-Sheng Zhu Hao Zheng Xiao-Bin Tian Source Type: research

Nitrogen-doped carbon quantum dots as a novel treatment for black fungal bone infections (Mucormycosis): < em > in vitro < /em > and < em > in vivo < /em > study
In conclusion, the present investigation demonstrates that functional N/CQDs and N/MC are effective antifungal agents against a range of microbial pathogenic bone disorders in immunocompromised individuals, with stronger and superior fungicidal activity for N/CQDs than N/MC in vitro and in vivo studies.PMID:38423087 | DOI:10.1080/21691401.2024.2318212 (Source: Artificial Cells, Nanomedicine and Biotechnology)
Source: Artificial Cells, Nanomedicine and Biotechnology - February 29, 2024 Category: Biotechnology Authors: Amany Belal Atiah H Almalki Ahmed A Farghali Rehab Mahmoud R R Atta Abeer Enaiet Allah Walid Hamdy Hassan Sangmin Lee Amna A Kotp Doaa Essam Ahmed H E Hassan Mohammed M Ghoneim Fatma I Abo El-Ela Abdalla Abdelwahab Source Type: research