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Inhibitory effects of < em > Curcumae Radix carbonisata < /em > -based carbon dots against liver fibrosis induced by carbon tetrachloride in mice
In this study, novel carbon dots (CDs) extending from 1.0 to 4.5 nm were separated from fluid extricates of CRC. Meanwhile, a liver fibrosis model induced by carbon tetrachloride (CCl4) was utilized to determine the inhibitory effects of CRC-CDs against liver fibrosis. The results exhibited the CRC-CDs with a quantum yield of 1.34% have a significant inhibitory effect on CCl4-induced liver fibrosis, as demonstrated by improving hepatocyte degeneration and necrosis, inflammatory cell infiltration and fibrotic tissue hyperplasia, downregulating the levels of alanine transaminase (ALT), aspartate aminotransferase (AST), total...
Source: Artificial Cells, Nanomedicine and Biotechnology - November 30, 2023 Category: Biotechnology Authors: Yusheng Zhao Hui Kong Yuru Li Yafang Zhao Yue Zhang Yan Zhao Huihua Qu Source Type: research