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Cancer reduction in mice with Prakasine nanomedicine immunotherapy
In this study, non-toxic mercury nanoparticle Prakasine (PRK-NP) was synthesized as per 'Prakash theory of metal drugs' and nanoparticle's non toxicity has been demonstrated by employing in vitro MTT (dose = 320ug/ml), SBR (dose = 80ug/ml) and apoptosis assays (dose = 320ug/ml), and in vivo acute and chronic toxicity studies in mice (n = 12, dose = 900 mg/kg body weight oral), rat (n = 14, dose = 500 mg/kg body weight oral for 18 months), rabbit (n = 14, dose = 500 mg/kg body weight oral for 18 months) and dogs (n = 14, dose = 500 mg/kg body weight oral for 18 months). The MTT, SBR and apoptosis assays established no cytot...
Source: Artificial Cells, Nanomedicine and Biotechnology - October 26, 2023 Category: Biotechnology Authors: Prakash S K Source Type: research

Statement of retraction: Mirt2 functions in synergy with miR-377 to participate in inflammatory pathophysiology of Sj ögren's syndrome
Artif Cells Nanomed Biotechnol. 2023 Dec;51(1):547. doi: 10.1080/21691401.2023.2271700. Epub 2023 Oct 23.NO ABSTRACTPMID:37870520 | DOI:10.1080/21691401.2023.2271700 (Source: Artificial Cells, Nanomedicine and Biotechnology)
Source: Artificial Cells, Nanomedicine and Biotechnology - October 23, 2023 Category: Biotechnology Source Type: research

Statement of retraction: Anti-gastric cancer effect of Salidroside through elevating miR-99a expression
Artif Cells Nanomed Biotechnol. 2023 Dec;51(1):548. doi: 10.1080/21691401.2023.2271702. Epub 2023 Oct 23.NO ABSTRACTPMID:37870523 | DOI:10.1080/21691401.2023.2271702 (Source: Artificial Cells, Nanomedicine and Biotechnology)
Source: Artificial Cells, Nanomedicine and Biotechnology - October 23, 2023 Category: Biotechnology Source Type: research

Ultrasound-triggered release of miR-199a-3p from liposome nanobubbles for enhanced hepatocellular carcinoma treatment
This study was aimed to develop an efficient tumour-targeted liposome nanobubbles (LNBs) system using ultrasound-targeted nanobubble destruction for enhanced release and transfection of miRNA-199a-3p in hepatocellular carcinoma (HCC) therapy. The prepared LNBs comprised a polyethylene glycol-modified liposome shell and a perfluoropentane (PFP) core. MiRNA-199a-3p was attached to the nanocomposite surface via electrostatic adsorption, while RGD peptide functionalized the LNBs surface for enhanced HCC cell targeting, namely PFP@miR-RGD-LNBs. The LNBs were spherical with a narrow size distribution. The gene-loaded LNBs effect...
Source: Artificial Cells, Nanomedicine and Biotechnology - October 18, 2023 Category: Biotechnology Authors: Xinmin Guo Jianru Lin Liwen Pan Kun He Zhihui Huang Jialin Chen Cuiyan Lin Baohui Zeng Sijia Luo Mengdie Wang Source Type: research