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Molecular docking and physicochemical studies of 1,3-benzodioxole tagged Dacarbazine derivatives as an anticancer agent
Artif Cells Nanomed Biotechnol. 2023 Dec;51(1):520-530. doi: 10.1080/21691401.2023.2253470.ABSTRACTCancer, the biggest cause of death globally, remains a tough illness despite enormous advances in therapy. In the present study, 1,3-benzodioxole-tagged dacarbazine derivates were investigated as microtubule inhibitors in order to control cancer as microtubules are involved in cell proliferation. The tubulin protein was analyzed and its structure was validated by various protein validation tools. The binding potential of 1,3-benzodioxole-based dacarbazine-tagged derivatives with tubulin was checked using molecular docking sof...
Source: Artificial Cells, Nanomedicine and Biotechnology - September 12, 2023 Category: Biotechnology Authors: Sonaxi Kharb Sangeeta Yadav Anshul Singh Anjana Sarkar Ravi Tomar Source Type: research

Molecular complexity of mammary glands development: a review of lactogenic differentiation in epithelial cells
Artif Cells Nanomed Biotechnol. 2023 Dec;51(1):491-508. doi: 10.1080/21691401.2023.2252872.ABSTRACTThe mammary gland is a dynamic organ with various physiological processes like cellular proliferation, differentiation, and apoptosis during the pregnancy-lactation-involution cycle. It is essential to understand the molecular changes during the lactogenic differentiation of mammary epithelial cells (MECs, the milk-synthesizing cells). The MECs are organized as luminal milk-secreting cells and basal myoepithelial cells (responsible for milk ejection by contraction) that form the alveoli. The branching morphogenesis and lactog...
Source: Artificial Cells, Nanomedicine and Biotechnology - September 11, 2023 Category: Biotechnology Authors: Manoj Kumar Jena Farheen Badrealam Khan Syed Azmal Ali Abdullah Abdullah Amarish Kumar Sharma Vikas Yadav Sudhakar Kancharla Prachetha Kolli Gowtham Mandadapu Anjan Kumar Sahoo Prasana Kumar Rath Jalal Taneera Sudarshan Kumar Ashok Kumar Mohanty Khang Wen Source Type: research

Identification and characterization of shark VNARs targeting the < em > Helicobacter pylori < /em > adhesin HpaA
This study isolated VNARs against HpaA from an immune shark VNAR phage display library. The VNARs can bind both recombinant and native HpaA proteins. The VNARs, 2A2 and 3D6, showed high binding affinities to HpaA with different epitopes. Furthermore, homodimeric bivalent VNARs, biNb-2A2 and biNb-3D6, were constructed to enhance the binding affinity. The biNb-2A2 and biNb-3D6 had excellent stability at gastrointestinal pH conditions. Finally, a sandwich ELISA assay was developed to quantify the HpaA protein using BiNb-2A2 as the capture antibody and BiNb-3D6 as the detection antibody. This study provides a potential foundat...
Source: Artificial Cells, Nanomedicine and Biotechnology - September 11, 2023 Category: Biotechnology Authors: Yanchun Gao Ruihong Wang Lin Liu Shitao Feng Xiaozhi Xi Wengong Yu Yuchao Gu Ye Wang Source Type: research

Dissecting the tumour immune microenvironment in merkel cell carcinoma based on a machine learning framework
Artif Cells Nanomed Biotechnol. 2023 Dec;51(1):397-407. doi: 10.1080/21691401.2023.2244998.ABSTRACTMerkel cell carcinoma (MCC) is a primary cutaneous neoplasm of neuroendocrine carcinoma of the skin, which is characterized by molecular heterogeneity with diverse tumour microenvironment (TME). However, we are still lack knowledge of the cellular states and ecosystems in MCC. Here, we systematically identified and characterized the landscape of cellular states and ecotypes in MCC based on a machine learning framework. We obtained 30 distinct cellular states from 9 immune cell types and investigated the B cell, CD8 T cell, fi...
Source: Artificial Cells, Nanomedicine and Biotechnology - September 7, 2023 Category: Biotechnology Authors: Shaowen Cheng Si Li Ping Yang Rong Wang Ping Zhou Jingquan Li Source Type: research