< em > Zingiberis rhizoma < /em > -based carbon dots alter serum oestradiol and follicle-stimulating hormone levels in female mice

Artif Cells Nanomed Biotechnol. 2024 Dec;52(1):12-22. doi: 10.1080/21691401.2023.2276770. Epub 2023 Nov 23.ABSTRACTChinese herbs contain substances that regulate female hormones. Our study confirmed that Zingiberis rhizoma carbonisata contains Zingiberis rhizoma-based carbon dots (ZR-CDs), which exert regulatory effects on serum oestradiol and FSH in mice and show impacts on endometrial growth and follicular development that potentially affect the ability of female fertility. ZR-CDs were characterized to clarify the microstructure, optical features, and functional group characteristics. It shows that ZR-CDs are spherical carbon nanostructures ranging from 0.97 to 2.3 nm in diameter, with fluorescent properties and a surface rich in functional groups. We further investigated the impact of ZR-CDs on oestradiol and FSH in serum, growth, and the development of ovarian and uterine using normal female mice and exogenous oestradiol intervention model. It was observed that ZR-CDs accelerated oestrogen metabolism and attenuated oestradiol-induced endometrial hyperplasia. Simultaneously, ZR-CDs triggered an increase in FSH, even in the presence of high-serum oestradiol that inhibits FSH secretion. Our findings suggest that ZR-CDs could be a potential therapeutic treatment for anovulatory menstruation.PMID:37994799 | DOI:10.1080/21691401.2023.2276770
Source: Artificial Cells, Nanomedicine and Biotechnology - Category: Biotechnology Authors: Source Type: research