Clinical characteristics of cryopyrin ‐associated periodic syndrome and long‐term real‐world efficacy and tolerability of canakinumab in Japan: results of a nationwide survey
ConclusionsThis study provides one of the largest epidemiologic datasets for CAPS. While early initiation of anti-IL-1 treatment with canakinumab is beneficial for improving disease prognosis, some patients do not achieve remission despite a high serum concentration of canakinumab. Moreover, IBD may develop in CAPS following canakinumab treatment. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - January 25, 2024 Category: Rheumatology Authors: Takayuki Miyamoto,
Kazushi Izawa,
Sho Masui,
Atsue Yamazaki,
Yuichi Yamasaki,
Tadashi Matsubayashi,
Mayuka Shiraki,
Hidenori Ohnishi,
Junko Yasumura,
Kawabe Tomohiro,
Takako Miyamae,
Tomoyo Matsubara,
Naoya Arakawa,
Takashi Ishige,
Takumi Ta Tags: Full Length Source Type: research
The effect of recent antirheumatic drug on features of rheumatoid arthritis ‐associated lymphoproliferative disorders
ConclusionAntirheumatic drugs administered before LPD onset may influence the clinicopathological features of RA-LPD, with patterns changing over time. Furthermore, TCZ-only regimens are recommended after LPD onset. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - January 25, 2024 Category: Rheumatology Authors: Yoshihiko Hoshida,
Atsuko Tsujii,
Shiro Ohshima,
Yukihiko Saeki,
Masato Yagita,
Tomoya Miyamura,
Masao Katayama,
Tomonori Kawasaki,
Yasushi Hiramatsu,
Hisaji Oshima,
Toshihiko Murayama,
Shinji Higa,
Kazuya Kuraoka,
Fuminori Hirano,
Kenji Ich Tags: Full Length Source Type: research
Clinical Images: Crowned dens syndrome detected on 18F ‐fludeoxyglucose–positron emission tomography/computed tomography during investigation for giant cell arteritis
(Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - January 25, 2024 Category: Rheumatology Authors: Miao Yunn Lim,
Ivan Ho Shon,
Anthony M. Sammel Tags: Clinical Image Source Type: research
Antiinflammatory Effect of High ‐Density Lipoprotein Blunted by Delivery of Altered MicroRNA Cargo in Patients With Rheumatoid Arthritis
ConclusionHDL-miR-1246 was increased in RA versus control participants and delivery of miR-1246 to macrophages increased IL-6 expression by targetingDUSP3. The altered HDL-miRNA cargo in RA blunted HDL's anti-inflammatory effect. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - January 25, 2024 Category: Rheumatology Authors: Qiong Wu,
Quanhu Sheng,
Danielle Michell,
Marisol Ramirez ‐Solano,
Olivia Posey,
Anastasiia Phothisane,
Shahensha Shaik,
Kasey C. Vickers,
Michelle J. Ormseth Tags: Full Length Source Type: research
Difficult ‐to‐Treat Psoriatic Arthritis: A Conceptual Approach
(Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - January 24, 2024 Category: Rheumatology Authors: Filippo Fagni,
Francesca Motta,
Georg Schett,
Carlo Selmi Tags: Notes from the Field Source Type: research
Modulation of IL ‐23 Signaling With Guselkumab in Biologic‐Naïve Patients Versus TNF Inhibitor‐Inadequate Responders With Active Psoriatic Arthritis
ConclusionGuselkumab modulates IL-23 signaling and provides consistent pharmacodynamic effects in both biologic-na ïve and TNFi-IR PsA patients. Significantly elevated baseline IL-22, TNFα, and BD-2 levels and associations between baseline IL-22, IL-17A, and BD-2 levels and skin responses with guselkumab suggest greater dysregulation of IL-23/Th17 signaling in TNFi-IR patients. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - January 23, 2024 Category: Rheumatology Authors: Stefan Siebert,
Laura C. Coates,
Georg Schett,
Siba P. Raychaudhuri,
Warner Chen,
Sheng Gao,
Loqmane Seridi,
Soumya D. Chakravarty,
May Shawi,
Frederic Lavie,
Mohamed Sharaf,
Miriam Zimmermann,
Alexa P. Kollmeier,
Xie L. Xu,
Proton Rahman,
Tags: Full Length Source Type: research
Physician and Patient Assessment of Extended Language Model Answers to Rheumatology Patient Inquiries: Doctor versus AI. Comment on the article by Ye et al
(Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - January 22, 2024 Category: Rheumatology Authors: Hinpetch Daungsupawong,
Viroj Wiwanitkit Tags: Letters Source Type: research
Modulation of IL ‐23 Signaling With Guselkumab in Biologic‐Naïve Patients Versus TNF Inhibitor‐Inadequate Responders With Active Psoriatic Arthritis
ConclusionGuselkumab modulates IL-23 signaling and provides consistent pharmacodynamic effects in both biologic-na ïve and TNFi-IR PsA patients. Significantly elevated baseline IL-22, TNFα, and BD-2 levels and associations between baseline IL-22, IL-17A, and BD-2 levels and skin responses with guselkumab suggest greater dysregulation of IL-23/Th17 signaling in TNFi-IR patients. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - January 22, 2024 Category: Rheumatology Authors: Stefan Siebert,
Laura C. Coates,
Georg Schett,
Siba P. Raychaudhuri,
Warner Chen,
Sheng Gao,
Loqmane Seridi,
Soumya D. Chakravarty,
May Shawi,
Frederic Lavie,
Mohamed Sharaf,
Miriam Zimmermann,
Alexa P. Kollmeier,
Xie L. Xu,
Proton Rahman,
Tags: Full Length Source Type: research
Physician and Patient Assessment of Extended Language Model Answers to Rheumatology Patient Inquiries: Doctor versus AI. Comment on the article by Ye et al
(Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - January 22, 2024 Category: Rheumatology Authors: Hinpetch Daungsupawong,
Viroj Wiwanitkit Tags: Letters Source Type: research
Associations Between Rheumatoid Arthritis Clinical Factors and Synovial Cell Types and States
ConclusionIn this comprehensive screen of clinical factors, we observed differential associations between DMARDs and cell phenotypes, suggesting that RA therapies, more than other clinical factors, may impact cell type/state in the synovium and ultimately influence response to subsequent therapies. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - January 20, 2024 Category: Rheumatology Authors: Dana Weisenfeld,
Fan Zhang,
Laura Donlin,
Anna Helena Jonsson,
William Apruzzese,
Debbie Campbell,
Accelerating Medicines Partnership Program: RA/SLE Network,
Jennifer Albrecht,
Jennifer L. Barnas,
Joan M. Bathon,
Ami Ben ‐Artzi,
Brendan F. B Tags: Brief Report Source Type: research
