Synovial 5 ‐LOX‐derived oxylipins define a lympho‐myeloid‐enriched synovium
ConclusionThe lack of correlation between ST and plasma oxylipins suggests that synovial tissue lipid profiling better characterizes active pathways in treated joints. Synovial 5-LOX-derived oxylipins were highly expressed in lympho-myeloid-enriched synovium. Combination therapy with 5-LOX inhibitors to improve refractory inflammation may be needed in patients with this histological group. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - March 21, 2024 Category: Rheumatology Authors: Jessica D. Murillo ‐Saich,
Roxana Coras,
Julio Ramirez,
Estefania Quesada‐Masachs,
Marta Sala‐Climent,
Katharina Eschelbach,
Christopher B Mahony,
Raquel Celis,
Aaron Armando,
Oswald Quehenberger,
Adam P Croft,
Arthur Kavanaugh,
Eric Cha Tags: Full Length Source Type: research
Association of Muscle Quality and Pain in Adults With Symptomatic Knee Osteoarthritis, Independent of Muscle Strength: Findings From a Cross ‐Sectional Study
ConclusionThese preliminary findings suggest that EI and SWV may impact knee OA pain and could serve as malleable treatment targets. Findings also demonstrate that muscle quality is a unique construct, distinct from muscle strength, which may impact pain and treatment outcomes. More research is needed to fully understand the role of muscle quality in knee OA. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - March 20, 2024 Category: Rheumatology Authors: Alisa J. Johnson,
Sarah M. Barron,
Jennifer A. Nichols,
Yenisel Cruz ‐Almeida Tags: Full Length Source Type: research
Synovial 5 ‐LOX‐derived oxylipins define a lympho‐myeloid‐enriched synovium
ConclusionThe lack of correlation between ST and plasma oxylipins suggests that synovial tissue lipid profiling better characterizes active pathways in treated joints. Synovial 5-LOX-derived oxylipins were highly expressed in lympho-myeloid-enriched synovium. Combination therapy with 5-LOX inhibitors to improve refractory inflammation may be needed in patients with this histological group. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - March 20, 2024 Category: Rheumatology Authors: Jessica D. Murillo ‐Saich,
Roxana Coras,
Julio Ramirez,
Estefania Quesada‐Masachs,
Marta Sala‐Climent,
Katharina Eschelbach,
Christopher B Mahony,
Raquel Celis,
Aaron Armando,
Oswald Quehenberger,
Adam P Croft,
Arthur Kavanaugh,
Eric Cha Tags: Full Length Source Type: research
Association of Muscle Quality and Pain in Adults With Symptomatic Knee Osteoarthritis, Independent of Muscle Strength: Findings From a Cross ‐Sectional Study
ConclusionThese preliminary findings suggest that EI and SWV may impact knee OA pain and could serve as malleable treatment targets. Findings also demonstrate that muscle quality is a unique construct, distinct from muscle strength, which may impact pain and treatment outcomes. More research is needed to fully understand the role of muscle quality in knee OA. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - March 19, 2024 Category: Rheumatology Authors: Alisa J. Johnson,
Sarah M. Barron,
Jennifer A. Nichols,
Yenisel Cruz ‐Almeida Tags: Full Length Source Type: research
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(Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - March 19, 2024 Category: Rheumatology Authors: Medha Barbhaiya,
Stephane Zuily,
Guilherme de Jesus,
D. Ware Branch,
Doruk Erkan Tags: Letters Source Type: research
Standing on Shoulders: Interferon Research, from Viral Interference to Lupus Pathogenesis and Treatment
The discovery of interferon in the 1950s represents much more than the identification of the first cytokine and the key mediator of anti-viral host defense. Defining the molecular nature and complexity of the type I interferon family, as well as its inducers and molecular mechanisms of action, was the work of investigators working at the highest level and producing insights of great consequence. Current knowledge of receptor-ligand interactions, cell signaling, and transcriptional regulation derive from studies of type I interferon. It is on the shoulders of the giants who produced that knowledge that others stand and have...
Source: Arthritis and Rheumatology - March 19, 2024 Category: Rheumatology Authors: Mary K. Crow,
Mikhail Olferiev,
Kyriakos A. Kirou Tags: Review Source Type: research
The systemic score may identify life ‐threatening evolution in Still's disease: data from the GIRRCS AOSD‐study group and the AIDA Network Still's Disease Registry
ConclusionThe clinical utility of the systemic score was shown in identifying Still's disease at higher risk of life-threatening evolution in a large cohort. Furthermore, the clinical relevance of liver involvement and lung disease was highlighted. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - March 19, 2024 Category: Rheumatology Authors: Piero Ruscitti,
Francesco Masedu,
Antonio Vitale,
Valeria Caggiano,
Ilenia Di Cola,
Paola Cipriani,
Marco Valenti,
Henrique A Mayrink Giardini,
Isabele Parente de Brito Antonelli,
Marilia Ambiel Dagostin,
Giuseppe Lopalco,
Florenzo Iannone,
Mo Tags: Full Length Source Type: research
Myeloablation followed by hematopoietic stem cell transplantation leads to long ‐term normalization of systemic sclerosis molecular signatures
ConclusionParalleling the observed clinical benefit, HSCT leads to durable long-term normalization of the molecular signature in SSc with completion of immune resetting to 54 months post-HSCT. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - March 18, 2024 Category: Rheumatology Authors: Nancy Wareing,
Xuan Wang,
Lynette Keyes ‐Elstein,
Ellen A. Goldmuntz,
Marka A. Lyons,
Peter McSweeney,
Daniel E. Furst,
Richard A. Nash,
Leslie J. Crofford,
Beverly Welch,
Ashley Pinckney,
Maureen D. Mayes,
Keith M. Sullivan,
Shervin Assass Tags: Brief Report Source Type: research
A diagnostic performance study of the 2023 American College of Rheumatology/European Alliance of Associations for Rheumatology classification criteria for patients with antiphospholipid syndrome from the Antiphospholipid Syndrome Chinese Collaborative cohort presenting with suspected antiphospholipid syndrome
(Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - March 18, 2024 Category: Rheumatology Authors: Qingyi Lu,
Yuzhou Gan,
Zhongqiang Yao,
Chun Li Tags: Letters Source Type: research
