A link between plasma microbial translocation, microbiome, and autoantibody development in first ‐degree relatives of systemic lupus erythematosus patients
ConclusionsThese results indicate a possible role for plasma microbial translocation and microbiome composition in influencing autoantibody development in SLE.This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - May 20, 2019 Category: Rheumatology Authors: Elizabeth Ogunrinde, Zejun Zhou, Zhenwu Luo, Alexander Alekseyenko, Quan ‐Zhen Li, Danielle Macedo, Diane L. Kamen, Jim C. Oates, Gary S. Gilkeson, Wei Jiang Tags: Full Length Source Type: research

Rituximab as maintenance treatment for systemic Lupus Erythematosus: a multicentre observational study of 147 patients
ConclusionsRMT is a potential treatment option in difficult to treat patients. Relapses occur during RMT and are more likely in those with active articular disease at the time of the first RTX. Relapse risk after RMT remains high and apparently comparable to the one seen after a single ‐RTX course.This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - May 18, 2019 Category: Rheumatology Authors: Matthias A. Cassia, Federico Alberici, Rachel B. Jones, Rona M. Smith, Giovanni Casazza, Maria L. Urban, Giacomo Emmi, Gabriella Moroni, Renato A. Sinico, Piergiorgio Messa, Frances Hall, Augusto Vaglio, Maurizio Gallieni, David R. Jayne Tags: Full Length Source Type: research

Rituximab as maintenance treatment for systemic Lupus ErythematosusA multicentre observational study of 147 patients
ConclusionsRMT is a potential treatment option in difficult to treat patients. Relapses occur during RMT and are more likely in those with active articular disease at the time of the first RTX. Relapse risk after RMT remains high and apparently comparable to the one seen after a single ‐RTX course.This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - May 18, 2019 Category: Rheumatology Authors: Matthias A. Cassia, Federico Alberici, Rachel B. Jones, Rona M. Smith, Giovanni Casazza, Maria L. Urban, Giacomo Emmi, Gabriella Moroni, Renato A. Sinico, Piergiorgio Messa, Frances Hall, Augusto Vaglio, Maurizio Gallieni, David R. Jayne Tags: Full Length Source Type: research

Cognitive Dysfunction in SLE: a case for initiating trials
This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - May 18, 2019 Category: Rheumatology Authors: Nina Kello, Erik Anderson, Betty Diamond Tags: Review Article Source Type: research

Noninvasive Mechanical Joint Loading as an Alternative Model for Osteoarthritic Pain
This study was undertaken to characterize and pharmacologically test the pain phenotype of a noninvasive mechanical joint loading model of OA, thus providing an alternative murine model for OA pain.MethodsThe right knees of 12 ‐week‐old male C57BL/6 mice were loaded at 9N or 11N (40 cycles, 3 times per week for 2 weeks). Behavioral measurements of limb disuse and mechanical and thermal hypersensitivity were acquired before mechanical joint loading and monitored for 6 weeks postloading. The severity of articular cartil age lesions was determined postmortem with the Osteoarthritis Research Society International scoring s...
Source: Arthritis and Rheumatology - May 17, 2019 Category: Rheumatology Authors: Freija Heegde, Ana P. Luiz, Sonia Santana ‐Varela, Iain P. Chessell, Fraser Welsh, John N. Wood, Chantal Chenu Tags: Original Article Source Type: research

Causal factors for knee, hip and hand osteoarthritis: a Mendelian randomization study in the UK Biobank
ConclusionsBMI exerts a major causal effect on risk of OA at the weight ‐bearing joints but not at the hand. Evidence of causality was observed for high BMD and low SBP on all, knee and hip OA, whereas no evidence of causality was demonstrated for other metabolic factors or CRP.This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - May 16, 2019 Category: Rheumatology Authors: Thomas Funck ‐Brentano, Maria Nethander, Sofia Movérare‐Skrtic, Pascal Richette, Claes Ohlsson Tags: Full Length Source Type: research

Clinical Images: Bone lesions in Erdheim ‐Chester disease
Arthritis&Rheumatology, EarlyView. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - May 16, 2019 Category: Rheumatology Authors: Jean W. Liew, Gordon Starkebaum Tags: Clinical Image Source Type: research

Usefulness of 18F ‐labeled Fluorodeoxyglucose–Positron Emission Tomography for the Diagnosis of Lymphoma in Primary Sjögren's Syndrome
ConclusionSome systemic manifestations of primary SS (lymphadenopathy, pulmonary involvement, and salivary gland involvement) can be visualized by PET ‐CT. Involvement of the lymph nodes and parotid glands is commonly observed with a similar frequency in SS patients with and those without lymphoma. An SUVmax in the parotid glands of ≥4.7 and/or the presence of focal lung lesions are associated with the diagnosis of lymphoma. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - May 14, 2019 Category: Rheumatology Authors: J érémy Keraen, Estelle Blanc, Florent L. Besson, Véronique Leguern, Céline Meyer, Julien Henry, Rakiba Belkhir, Gaétane Nocturne, Xavier Mariette, Raphaèle Seror Tags: Original Article Source Type: research

Reply
Arthritis&Rheumatology, EarlyView. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - May 13, 2019 Category: Rheumatology Authors: Muriel Elhai, Anna Maria Hoffmann ‐Vold, Yannick Allanore Tags: Letters Source Type: research

Effects of allopurinol dose escalation on bone erosion and urate volume in gout: a dual energy CT imaging study of a randomized controlled trial
AbstractObjectiveTo examine whether dose escalation of allopurinol to achieve serum urate target can influence bone erosion or monosodium urate (MSU) crystal deposition as measured by DECT in people with gout.MethodsWe conducted an imaging study of a two ‐year randomized clinical trial of immediate allopurinol dose escalation to serum urate (SU) target vs. conventional dosing for one year followed by dose escalation to target (control) in people with gout on allopurinol with SU ≥0.36mmol/L. DECT scans of the feet, and radiographs (XR, hand and f oot) were obtained at the baseline, Year 1 and Year 2 visits. DECT scans ...
Source: Arthritis and Rheumatology - May 13, 2019 Category: Rheumatology Authors: Nicola Dalbeth, Karen Billington, Anthony Doyle, Christopher Frampton, Paul Tan, Opetaia Aati, Jordyn Allan, Jill Drake, Anne Horne, Lisa K Stamp Tags: Full Length Source Type: research

Association of autoantibody quantification with SLE disease activity: Comment on the Article by Kim et al
This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - May 10, 2019 Category: Rheumatology Authors: Xiaojun Tang, Mingzhe Ning, Yantong Zhu, Yun Zhu, Yang Xu, Si Wu, Xuebing Feng Tags: Letter to the Editor Source Type: research

Reply
This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - May 10, 2019 Category: Rheumatology Authors: Alfred H.J. Kim, Vibeke Strand, John P. Atkinson Tags: Reply to Letter to the Editor Source Type: research

Tracheobronchial cobblestone in relapsing polychondritis
This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - May 9, 2019 Category: Rheumatology Authors: Eun Bong Lee, Jin Kyun Park Tags: Clinical Image Source Type: research

Serum CRP, IL ‐17A, and IL‐17F levels are responsive to ustekinumab in psoriatic arthritis: lessons from the PSUMMIT study programme
AbstractObjectivesTo evaluate the associations of CRP and circulating Th17 ‐associated cytokines with psoriatic arthritis (PsA) disease activity and therapeutic response to ustekinumab.MethodsMeasurement of IL ‐17A, IL‐17F, IL‐23 and CRP concentrations was performed on serum samples collected as part of the two PSUMMIT phase 3 studies of ustekinumab in PsA (n=927). In post hoc analyses, relationships of IL‐17A, IL‐17F, and CRP levels at baseline, weeks 4 and 24 with baseline skin and joint disea se activity and response to therapy were evaluated using General Linear Models and Pearson's product‐moment correla...
Source: Arthritis and Rheumatology - May 9, 2019 Category: Rheumatology Authors: Stefan Siebert, Kristen Sweet, Bidisha Dasgupta, Kim Campbell, Iain B. McInnes, Matthew J. Loza Tags: Full Length Source Type: research

Call for caution in using the PainDETECT Questionnaire for patient stratification without additional clinical assessments: comment on the article by Soni et al
Arthritis&Rheumatology, EarlyView. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - May 8, 2019 Category: Rheumatology Authors: Eivind Hasvik, Anne Julsrud Haugen, Lars Gr øvle Tags: Letters Source Type: research

Safety and Tolerability of Omalizumab: A Randomized Clinical Trial of Humanized Anti ‐IgE Monoclonal Antibody in Systemic Lupus Erythematosus
ConclusionOur findings indicate that omalizumab is well tolerated in SLE and is associated with improvement in disease activity. Larger randomized clinical trials will be needed to assess the efficacy of omalizumab in patients with SLE. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - May 8, 2019 Category: Rheumatology Authors: Sarfaraz Hasni, Sarthak Gupta, Michael Davis, Elaine Poncio, Yenealem Temesgen ‐Oyelakin, Elizabeth Joyal, Alice Fike, Zerai Manna, Sungyoung Auh, Yinghui Shi, Diana Chan, Philip Carlucci, Ann Biehl, Barbara Dema, Nicolas Charles, James E Tags: Brief Report Source Type: research

Validation of the REVEAL Prognostic Equation and Risk Score Calculator in Incident Systemic Sclerosis ‐Associated Pulmonary Arterial Hypertension
ConclusionIn predicting one ‐year survival in newly diagnosed SSc‐PAH, the REVEAL prognostic equation and risk score provide very good discrimination but poor calibration. REVEAL prediction scores should be interpreted with caution in newly diagnosed SSc‐PAH patients, particularly those with higher predicted risk resulti ng from a low 6MWD or a high BNP.This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - May 8, 2019 Category: Rheumatology Authors: Christopher J. Mullin, Rubina M. Khair, Rachel L. Damico, Todd M. Kolb, Laura K. Hummers, Paul M. Hassoun, Virginia D. Steen, Stephen C. Mathai, The PHAROS Investigators Tags: Full Length Source Type: research

N ‐linked glycans in the variable domain of ACPA‐IgG predict the development of rheumatoid arthritis
AbstractObjectiveAnti ‐citrullinated protein antibodies (ACPA) are disease‐specific biomarkers in rheumatoid arthritis (RA). More than 90% of ACPA‐IgGs harbourN‐linked glycans in the antibody variable (V) domain. The correspondingN‐glycosylation sites in ACPA V‐region sequences result from somatic hypermutation, a T cell‐dependent process. As ample evidence indicates that T‐cells drive the maturation of the ACPA‐response before arthritis onset, we studied whether the presence of glycans in ACPA‐IgG V‐domains pre dicts the transition from pre‐disease autoimmunity to overt RA.MethodsWe analysed two in...
Source: Arthritis and Rheumatology - May 8, 2019 Category: Rheumatology Authors: Lise Hafkenscheid, Emma de Moel, Irene Smolik, Stacey Tanner, Xiaobo Meng, Bas C. Jansen, Albert Bondt, Manfred Wuhrer, Tom W. J. Huizinga, Rene E. M. Toes, Hani El ‐Gabalawy, Hans U. Scherer Tags: Full length Source Type: research

Reply
Arthritis&Rheumatology, EarlyView. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - May 7, 2019 Category: Rheumatology Authors: Anushka Soni, Irene Tracey Tags: Letters Source Type: research

Gastroesophageal reflux and serum biomarkers in systemic sclerosis –associated interstitial lung disease: comment on the article by Elhai et al
Arthritis&Rheumatology, EarlyView. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - May 6, 2019 Category: Rheumatology Authors: Sergey Moiseev, Antonina Sosnovskaya, Fatima Chotchaeva, Elena Shchegoleva, Pavel Novikov Tags: Letters Source Type: research

Use of Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) inhibitors in statin ‐associated immune mediated necrotizing myopathy: a case‐series
ConclusionsPCSK9 inhibitors are safe to our experience for long term use in statin ‐associated IMNM patients as a cholesterol‐lowering agent.This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - May 6, 2019 Category: Rheumatology Authors: Eleni Tiniakou, Erika Rivera, Andrew L. Mammen, Lisa Christopher ‐Stine Tags: Brief Report Source Type: research

Juvenile Idiopathic Arthritis and the Gut Microbiome: More Clues, More Questions
Arthritis&Rheumatology, EarlyView. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - May 6, 2019 Category: Rheumatology Authors: Daniel B. Horton Tags: Editorial Source Type: research

Associations of Symptomatic Knee Osteoarthritis With Histopathologic Features in Subchondral Bone
ObjectiveSubchondral bone and the osteochondral junction are thought to contribute to osteoarthritis (OA) knee pain. We undertook this study to identify osteochondral pathologies specifically associated with symptomatic human knee OA.MethodsMedial tibial plateau samples from 2 groups of subjects (n = 31 per group) were matched for macroscopic chondropathy scores. The symptomatic chondropathy group had undergone total knee replacement for OA knee pain, at which time specimens of the medial tibial plateau were obtained. The asymptomatic chondropathy group included subjects who died of unrelated illness (specimens were obtain...
Source: Arthritis and Rheumatology - May 2, 2019 Category: Rheumatology Authors: Koji Aso, S. Mohsen Shahtaheri, Roger Hill, Deborah Wilson, Daniel F. McWilliams, David A. Walsh Tags: Original Article Source Type: research

No Association of Discontinuing Tumor Necrosis Factor Inhibitors Before Gestational Week Twenty in Well ‐Controlled Rheumatoid Arthritis and Juvenile Idiopathic Arthritis With a Disease Worsening in Late Pregnancy
ConclusionDiscontinuing TNFi before gestational week 20 seems feasible in women with RA and JIA who enter pregnancy with well ‐controlled disease. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - May 2, 2019 Category: Rheumatology Authors: Frauke F örger, Gretchen Bandoli, Yunjun Luo, Loan Robinson, Diana L. Johnson, Christina D. Chambers Tags: Original Article Source Type: research

HLA alleles associated with risk of ankylosing spondylitis and rheumatoid arthritis influence the gut microbiome
ConclusionsThis study shows that the changes in intestinal microbiome composition seen in AS and RA are at least partially due to effects ofHLA ‐B27 and –DRB1 on the gut microbiome. These findings support the hypothesis that HLA alleles operate to cause or increase the risk of these diseases through interaction with the intestinal microbiome, and suggest that therapies targeting the microbiome may be effective in their prevention and/or treatment.This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - April 30, 2019 Category: Rheumatology Authors: Mark Asquith, Peter R. Sternes, Mary ‐Ellen Costello, Lisa Karstens, Sarah Diamond, Tammy M. Martin, Zhixiu Li, Mhairi S. Marshall, Timothy D. Spector, Kim‐Anh le Cao, James T. Rosenbaum, Matthew A. Brown Tags: Full Length Source Type: research

Comparative Risk of Venous Thromboembolism in Rheumatoid Arthritis Patients Receiving Tofacitinib Versus Those Receiving Tumor Necrosis Factor Inhibitors: An  Observational Cohort Study
ConclusionOccurrence of VTE in a total of 50,865 RA patients initiating treatment with tofacitinib or a TNF inhibitor was infrequent (
Source: Arthritis and Rheumatology - April 29, 2019 Category: Rheumatology Authors: Rishi J. Desai, Ajinkya Pawar, Michael E. Weinblatt, Seoyoung C. Kim Tags: Brief Report Source Type: research

Microbiome Analytics of the Gut Microbiota in Patients With Juvenile Idiopathic Arthritis: A Longitudinal Observational Cohort Study
ObjectiveTo assess the composition of gut microbiota in Italian and Dutch patients with juvenile idiopathic arthritis (JIA) at baseline, with inactive disease, and with persistent activity compared to healthy controls.MethodsIn a multicenter, prospective, observational cohort study, fecal samples were collected at baseline from 78 Italian and 21 Dutch treatment ‐naive JIA patients with
Source: Arthritis and Rheumatology - April 29, 2019 Category: Rheumatology Authors: E. H. Pieter Dijkhuizen, Federica Del Chierico, Clara Malattia, Alessandra Russo, Denise Pires Marafon, Nienke M. Haar, Silvia Magni ‐Manzoni, Sebastiaan J. Vastert, Bruno Dallapiccola, Berent Prakken, Alberto Martini, Fabrizio Benedetti, Lo Tags: Original Article Source Type: research

Performance of Candidate Serum Biomarkers for Systemic Sclerosis –Associated Interstitial Lung Disease
ObjectiveInterstitial lung disease (ILD) in systemic sclerosis (SSc) runs a highly variable course, and prediction tools are highly desired. The aim of this study was to assess the diagnostic and prognostic performance of 4 candidate serum biomarkers for SSc ‐associated ILD.MethodsSerum samples from a combined cohort of SSc patients (from Paris, France and Oslo, Norway; n = 427) were analyzed by enzyme ‐linked immunosorbent assay for concentrations of lung epithelial–derived surfactant protein D (SP‐D), Krebs von den Lungen 6 glycoprotein (KL‐6), CCL18, and OX40 ligand (OX40L). Lung fibrosis was measured by h...
Source: Arthritis and Rheumatology - April 26, 2019 Category: Rheumatology Authors: Muriel Elhai, Anna Maria Hoffmann ‐Vold, Jérôme Avouac, Sonia Pezet, Anne Cauvet, Agathe Leblond, Håvard Fretheim, Torhild Garen, Masataka Kuwana, Øyvind Molberg, Yannick Allanore Tags: Original Article Source Type: research

Issue Information
Arthritis&Rheumatology, Volume 71, Issue 5, May 2019. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - April 25, 2019 Category: Rheumatology Tags: Issue Information Source Type: research

Clinical Connections
Arthritis&Rheumatology, Volume 71, Issue 5, May 2019. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - April 25, 2019 Category: Rheumatology Tags: Clinical Connections Source Type: research

In This Issue
Arthritis&Rheumatology, Volume 71, Issue 5, May 2019. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - April 25, 2019 Category: Rheumatology Tags: In This Issue Source Type: research

ACR Announcements
Arthritis&Rheumatology, Volume 71, Issue 5, May 2019. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - April 25, 2019 Category: Rheumatology Tags: ACR Announcements Source Type: research

Galectin 9: Friend or Foe of Systemic Lupus Erythematosus? Comment on the Article by Zeggar et al
Arthritis&Rheumatology, Volume 71, Issue 5, Page 832-832, May 2019. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - April 25, 2019 Category: Rheumatology Authors: Wang ‐Dong Xu, Lin‐Chong Su, An‐Fang Huang Tags: Letters Source Type: research

Monitoring Disease Activity in Systemic Lupus Erythematosus With Single ‐Molecule Array Digital Enzyme‐Linked Immunosorbent Assay Quantification of Serum Interferon‐α
ConclusionDirect serum IFN α determination with a highly sensitive assay might improve monitoring of clinical SLE activity and selection of the best candidates for anti‐IFNα treatment. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - April 25, 2019 Category: Rheumatology Authors: Alexis Mathian, Suzanne Mouries ‐Martin, Karim Dorgham, Hervé Devilliers, Laura Barnabei, Elyès Ben Salah, Fleur Cohen‐Aubart, Laura Garrido Castillo, Julien Haroche, Miguel Hie, Marc Pineton de Chambrun, Makoto Miyara, Delphine Sterlin, Tags: Original Article Source Type: research

Heel Pain in a Young Patient —Calcaneal Involvement in Juvenile Spondyloarthritis
Arthritis&Rheumatology, Volume 71, Issue 5, Page 831-831, May 2019. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - April 25, 2019 Category: Rheumatology Authors: Stacey Lallemand, Jean ‐Denis Laredo Tags: Clinical Image Source Type: research

ACR Presidential Address: Building on the Strengths of Our Unique Specialty
Arthritis&Rheumatology, Volume 71, Issue 5, Page 664-669, May 2019. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - April 25, 2019 Category: Rheumatology Authors: David I. Daikh Tags: ACR Presidential Address Source Type: research

2019 American College of Rheumatology/Arthritis Foundation Guideline for the Treatment of Juvenile Idiopathic Arthritis: Therapeutic Approaches for Non ‐Systemic Polyarthritis, Sacroiliitis, and Enthesitis
ConclusionThis guideline provides direction for clinicians, caregivers, and patients making treatment decisions. Clinicians, caregivers, and patients should use a shared decision ‐making process that accounts for patients’ values, preferences, and comorbidities. These recommendations should not be used to limit or deny access to therapies. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - April 25, 2019 Category: Rheumatology Authors: Sarah Ringold, Sheila T. Angeles ‐Han, Timothy Beukelman, Daniel Lovell, Carlos A. Cuello, Mara L. Becker, Robert A. Colbert, Brian M. Feldman, Polly J. Ferguson, Harry Gewanter, Jaime Guzman, Jennifer Horonjeff, Peter A. Nigrovic, Michael Tags: Special Article Source Type: research

2019 American College of Rheumatology/Arthritis Foundation Guideline for the Screening, Monitoring, and Treatment of Juvenile Idiopathic Arthritis –Associated Uveitis
ConclusionThis guideline provides direction for clinicians and patients/parents making decisions on the screening, monitoring, and management of children with JIA and uveitis, using GRADE methodology and informed by a consensus process with input from rheumatology and ophthalmology experts, current literature, and patient/parent preferences and values. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - April 25, 2019 Category: Rheumatology Authors: Sheila T. Angeles ‐Han, Sarah Ringold, Timothy Beukelman, Daniel Lovell, Carlos A. Cuello, Mara L. Becker, Robert A. Colbert, Brian M. Feldman, Gary N. Holland, Polly J. Ferguson, Harry Gewanter, Jaime Guzman, Jennifer Horonjeff, Peter A. N Tags: Special Article Source Type: research

Excess Deaths upon Cessation of Xanthine Oxidase Inhibitors: the CARES Data
This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - April 25, 2019 Category: Rheumatology Authors: Michael R. Bubb Tags: Letter to the Editor Source Type: research

Semaphorin4A coordinately induces inflammation and fibrosis in systemic sclerosis
AbstractObjectiveTo analyze the potential role of Sema4A in inflammatory and fibrotic processes involved in the pathology of systemic sclerosis (SSc).MethodsSema4A levels in the plasma of healthy controls (HC, n=10) and systemic sclerosis patients (n=21) were determined by ELISA. The expression of Sema4A and its receptors in monocytes and CD4+ T cells from HC and SSc patients (n=6 ‐7, for both) was determined by ELISA and flow cytometry. Th17 cytokine production by CD4+ T cells (n=5 ‐7) was analyzed by ELISA and flow cytometry. The production of inflammatory mediators and extracellular matrix (ECM) components by dermal...
Source: Arthritis and Rheumatology - April 23, 2019 Category: Rheumatology Authors: Tiago Carvalheiro, Alsya J. Affandi, Beatriz Malvar ‐Fernández, Ilse Dullemond, Marta Cossu, Andrea Ottria, Jorre S. Mertens, Barbara Giovannone, Femke Bonte‐Mineur, Marc R. Kok, Wioleta Marut, Kris A. Reedquist, Timothy R. Radstake, Sam Tags: Full Length Source Type: research

Long term outcome of ustekinumab therapy for Beh çet's disease
We report here the long term safety and efficacy of ustekinumab therapy for BD related OU resistant to colchicine.Patients and methodMulticenter prospective open label study including 30 patients fulfilling criteria of the International Study Group for BD and with active OU resistant to colchicine. Patients were treated with ustekinumab 90 mg subcutaneously at inclusion, at week 4, and every 12 weeks. The primary efficacy endpoint was the proportion of patients with complete response (CR) at week 12, defined as patients who had no oral ulcer.ResultsThe median number of OU per patient was significantly lower at week 12 of u...
Source: Arthritis and Rheumatology - April 22, 2019 Category: Rheumatology Authors: Adrien Mirouse, St éphane Barete, Anne‐Claire Desbois, Cloé Comarmond, Damien Sène, Fanny Domont, Bahram Bodaghi, Yasmina Ferfar, Patrice Cacoub, David Saadoun, The French Behçet's network Tags: Full Length Source Type: research

Identification of novel Adenosine Deaminase 2 gene variants and varied clinical phenotype in pediatric vasculitis
AbstractObjectivesIndividuals with deficiency of adenosine deaminase 2 (DADA2), a recently recognized autosomal recessive disease, present with various systemic vascular and inflammatory manifestations, often with early ‐onset age, or recurrent strokes. Their clinical features and histological findings overlap with those of childhood onset polyarteritis nodosa (PAN), a primary “idiopathic” systemic vasculitis. Despite similar clinical presentation, individuals with DADA2 may respond better to biologic therapy than traditional immunosuppression. We aimed to screen an international registry of children with sys...
Source: Arthritis and Rheumatology - April 22, 2019 Category: Rheumatology Authors: Kristen M Gibson, Kimberly A Morishita, Paul Dancey, Paul Moorehead, Britt Dr ögemöller, Xiaohua Han, Jinko Graham, Robert EW Hancock, Dirk Foell, Susanne Benseler, Rashid Luqmani, Rae S M Yeung, Susan Shenoi, Marek Bohm, Alan M Rosenberg, Tags: Full Length Source Type: research

Heberden's Nodes and Knee Osteoarthritis –Related Osseous Structural Damage: Exploratory Study From the Osteoarthritis Initiative
ObjectiveTo explore whether Heberden's nodes (HNs) could predict magnetic resonance imaging (MRI) –based knee osteoarthritis (OA)–related osseous structural progression.MethodsFive hundred seventy ‐five subjects from the Foundation for the National Institutes of Health project underwent clinical examination to evaluate HNs at baseline and knee MRI at baseline and 24 months. The MRI was read according to the semiquantitative MRI OA Knee Score and quantitative periarticular bone morphology me asures. Adjusted linear/logistic regression models were implemented to assess the association between the presence of HN...
Source: Arthritis and Rheumatology - April 22, 2019 Category: Rheumatology Authors: Arya Haj ‐Mirzaian, Bahram Mohajer, Ali Guermazi, Delaram Shakoor, Ida K. Haugen, Frank W. Roemer, Shadpour Demehri Tags: Brief Report Source Type: research

Cardiometabolic Polygenic Risk Scores and Osteoarthritis Outcomes: A Mendelian Randomization Study Using Data From the Malm ö Diet and Cancer Study and the UK Biobank
ConclusionOur MR study provides evidence of a causal role of lower LDL cholesterol level and higher BMI in OA. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - April 17, 2019 Category: Rheumatology Authors: George Hindy, Kristina E. Åkesson, Olle Melander, Krishna G. Aragam, Mary E. Haas, Peter M. Nilsson, Umesh T. Kadam, Marju Orho‐Melander Tags: Original Article Source Type: research

Gastroesophageal reflux and serum biomarkers in systemic sclerosis ‐related interstitial lung disease. Reply
This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - April 17, 2019 Category: Rheumatology Authors: Muriel Elhai, Anna Maria Hoffmann ‐Vold, Yannick Allanore Tags: Reply to Letter to the Editor Source Type: research

Variability in Antinuclear Antibody Testing to Assess Patient Eligibility for Clinical Trials of New Treatments for Systemic Lupus Erythematosus
ConclusionThese findings indicate that, when used for screening, IFA assays can vary because of performance characteristics of kits and thus affect determination of trial eligibility. With kits producing a significant frequency of ANA negativity, ANA status can be associated with other serological measures as well as the presence of the interferon signature, potentially affecting responsiveness to a trial agent.This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - April 17, 2019 Category: Rheumatology Authors: David S. Pisetsky, Dana Kathryn Thompson, Joseph Wajdula, Annette Diehl, Sudhakar Sridharan Tags: Brief Report Source Type: research

Risk Factors for Major Adverse Cardiovascular Events in Phase III and Long ‐Term Extension Studies of Tofacitinib in Patients with Rheumatoid Arthritis
ConclusionIn this post ‐hoc analysis, after 24 weeks of tofacitinib, increased HDL‐c, but not increases in LDL‐c or TC, appeared to be associated with lower future MACE risk. Further data are needed to test the cardiovascular safety of tofacitinib.This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - April 17, 2019 Category: Rheumatology Authors: Christina Charles ‐Schoeman, Ryan DeMasi, Hernan Valdez, Koshika Soma, Lie‐Ju Hwang, Mary G. Boy, Pinaki Biswas, Iain B. McInnes Tags: Full Length Source Type: research

Gastro ‐esophageal reflux and serum biomarkers in systemic sclerosis‐related interstitial lung disease
This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - April 17, 2019 Category: Rheumatology Authors: Sergey Moiseev, Antonina Sosnovskaya, Fatima Chotchaeva, Elena Shchegoleva, Pavel Novikov Tags: Letter to the Editor Source Type: research

Efficacy and Safety of Belimumab and Azathioprine for Maintenance of Remission in Antineutrophil Cytoplasmic Antibody –Associated Vasculitis: A Randomized Controlled Study
ConclusionBelimumab plus azathioprine and glucocorticoids for the maintenance of remission in AAV did not reduce the risk of relapse. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - April 16, 2019 Category: Rheumatology Authors: David Jayne, Daniel Blockmans, Raashid Luqmani, Sergey Moiseev, Beulah Ji, Yulia Green, Leanne Hall, David Roth, Robert B. Henderson, Peter A. Merkel, Jose Alfaro Lozano, Heidemarie Becker, Armando Calvo Quiroz, Simon Carette, Sandra Carrill Tags: Original Article Source Type: research

Dual ‐energy computed tomography for the noninvasive diagnosis of coexisting gout and calcium pyrophosphate deposition disease
This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - April 15, 2019 Category: Rheumatology Authors: Rami Hajri, Steven D. Hajdu, Thomas H ügle, Pascal Zufferey, Laurent Guiral, Fabio Becce Tags: Clinical Image Source Type: research