Targeting the mechanistic target of rapamycin complex 1 restricts pro ‐inflammatory T cell differentiation and ameliorates Takayasu's arteritis
AbstractObjectiveTakayasu's arteritis (TAK) is a progressive autoimmune large vessel vasculitis with infiltration of pro ‐inflammatory T cells, while the etiology is largely unknown. Here we explore the involvement of mechanistic target of rapamycin (mTOR) in pro‐inflammatory T cell differentiation and disease progression of TAK patients.Methods95 patients with TAK, 26 patients with small vessel vasculitis and 40 healthy donors were enrolled. Na ïve and memory CD4+ T cells were activated with anti ‐CD3/CD28 beads and analyzed for lineage differentiations. mTORC1 activity was determined by quantifying intracellul...
Source: Arthritis and Rheumatology - August 20, 2019 Category: Rheumatology Authors: Jifeng Zhang, Lei Zhao, Jing Wang, Zhihua Cheng, Mengyao Sun, Jiayi Zhao, Bin Liu, Xiyu Liu, Zhenke Wen, Zhibo Li Tags: Full Length Source Type: research

Epigenetic Defects in the B cell lineage of Systemic Lupus Erythematosus Patients Display Population ‐Specific Patterns
AbstractObjectiveDetermine the stage in B cell development that a Systemic Lupus Erythematosus (SLE) ‐associated DNA methylation signature originates in African American (AA) and European American (EA) individuals and assess its ability to predict SLE status in individual and mixed immune cells.MethodsB cells from AA (n = 31) and EA (n = 49) patients were sorted using fluorescence activated cell sorting (FACS) into five subsets. DNA methylation measured at ~460,000 CpG sites was interrogated in each subset. Enrichment analysis of transcription factor interaction at SLE ‐associated methylation sites was performed. A ran...
Source: Arthritis and Rheumatology - August 20, 2019 Category: Rheumatology Authors: Megan Breitbach, Ryne C. Ramaker, Kevin Roberts, Robert P. Kimberly, Devin Absher Tags: Full Length Source Type: research

High blood pressure and OA: friends or foes?
This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - August 20, 2019 Category: Rheumatology Authors: Chunyi Wen Tags: Letter to the Editor Source Type: research

Myositis Autoantibodies: A Comparison of Results from the Oklahoma Medical Research Foundation Myositis Panel to the Euroimmun Research Line Blot
This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - August 20, 2019 Category: Rheumatology Authors: Christopher A. Mecoli, Maria Casal ‐Dominguez, Katherine Pak, Iago Pinal‐Fernandez, Jemima Albayda, Eleni Tiniakou, Julie J. Paik, Umar Zahid, Sonye K. Danoff, Andrew L. Mammen, Livia Casciola‐Rosen, Lisa Christopher‐Stine Tags: Concise Communication Source Type: research

Five ‐year outcome of operative and non‐operative management of meniscal tear in persons greater than 45 years old
ConclusionPain improved considerably in both arms over 60 months. While ITT analysis revealed no statistically significant differences in TKR use, greater TKR utilization in those receiving APM merits further study. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - August 20, 2019 Category: Rheumatology Authors: Jeffrey N. Katz, Swastina Shrestha, Elena Losina, Morgan H. Jones, Robert G. Marx, Lisa A. Mandl, Bruce A. Levy, Lindsey A. MacFarlane, Kurt P. Spindler, Genevieve S. Silva, MeTeOR Investigators, Jamie E. Collins, Robert Brophy, Brian J. Cole Tags: Full Length Source Type: research

Clinical Images: Takotsubo and Takayasu —a reason to rhyme?
Arthritis&Rheumatology, EarlyView. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - August 19, 2019 Category: Rheumatology Authors: Shir Lynn Lim, Ching Ching Ong, D. P. S. Dissanayake, Lynette Li San Teo, Sen Hee Tay Tags: Clinical Images Source Type: research

Phenotypes Determined by Cluster Analysis and Their Survival in the Prospective European Scleroderma Trials and Research Cohort of Patients With Systemic Sclerosis
ConclusionOur findings suggest that restricting subsets of SSc patients to only those based on cutaneous involvement may not capture the complete heterogeneity of the disease. Organ damage and antibody profile should be taken into consideration when individuating homogeneous groups of patients with a distinct prognosis. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - August 12, 2019 Category: Rheumatology Authors: Vincent Sobanski, Jonathan Giovannelli, Yannick Allanore, Gabriela Riemekasten, Paolo Air ò, Serena Vettori, Franco Cozzi, Oliver Distler, Marco Matucci‐Cerinic, Christopher Denton, David Launay, Eric Hachulla, the EUSTAR Collaborators, Se Tags: Original Article Source Type: research

Long ‐Term Outcome of Ustekinumab Therapy for Behçet's Disease
ObjectiveOral ulcers, the hallmark lesion of Beh çet's disease (BD), can be disabling and resistant to conventional treatment, and there is a need for safe and effective treatment. We undertook this study to investigate the long‐term safety and efficacy of ustekinumab therapy for BD‐related oral ulcers that are resistant to colchicine.MethodsThis multicenter, prospective, open ‐label study included 30 patients who fulfilled the criteria of the International Study Group for BD and who were diagnosed as having active oral ulcers resistant to colchicine. Patients were treated subcutaneously with ustekinumab 90 mg...
Source: Arthritis and Rheumatology - August 12, 2019 Category: Rheumatology Authors: Adrien Mirouse, St éphane Barete, Anne‐Claire Desbois, Cloé Comarmond, Damien Sène, Fanny Domont, Bahram Bodaghi, Yasmina Ferfar, Patrice Cacoub, David Saadoun, for the French Behçet's Network Tags: Original Article Source Type: research

Effects of Allopurinol Dose Escalation on Bone Erosion and Urate Volume in Gout: A Dual ‐Energy Computed Tomography Imaging Study Within a Randomized, Controlled Trial
ObjectiveTo examine whether allopurinol dose escalation to achieve serum urate (SU) target can influence bone erosion or monosodium urate (MSU) crystal deposition, as measured by dual ‐energy computed tomography (DECT) in patients with gout.MethodsWe conducted an imaging study of a 2 ‐year randomized clinical trial that compared immediate allopurinol dose escalation to SU target with conventional dosing for 1 year followed by dose escalation to target, in gout patients who were receiving allopurinol and who had an SU level of ≥0.36 mmoles/liter. DECT scans of feet and radiog raphs of hands and feet were obtained at ...
Source: Arthritis and Rheumatology - August 12, 2019 Category: Rheumatology Authors: Nicola Dalbeth, Karen Billington, Anthony Doyle, Christopher Frampton, Paul Tan, Opetaia Aati, Jordyn Allan, Jill Drake, Anne Horne, Lisa K. Stamp Tags: Original Article Source Type: research

Cardiovascular risk assessment in patients with ANCA ‐associated vasculitis
This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - August 12, 2019 Category: Rheumatology Authors: Sergey Moiseev, Pavel Novikov, Nikolai Bulanov, Anastasiia Zykova, Elizaveta Safonova Tags: Letter to the Editor Source Type: research

Neutrophil Extracellular Traps in Tissue and Periphery in Juvenile Dermatomyositis
AbstractObjectiveNeutrophils are key immune cells participating in host defense through several mechanisms, including the formation of neutrophil extracellular traps (NETs). The role of neutrophils in juvenile dermatomyositis (JDM) is not known.MethodsElectron microscopy was used to identify neutrophils in tissue. NETs were also imaged using fluorescence microscopy, and quantified by an MPO ‐DNA ELISA in plasma from healthy children (n=20), disease controls (n=29), JDM patients (n=66), and JDM patients with history of calcifications (n=20). Clinical data included disease activity scores and complement C4 levels. Levels o...
Source: Arthritis and Rheumatology - August 12, 2019 Category: Rheumatology Authors: Bhargavi Duvvuri, Lauren M. Pachman, Gabrielle Morgan, Amer M. Khojah, Marisa Klein ‐Gitelman, Megan L. Curran, Stephen Doty, Christian Lood Tags: Full Length Source Type: research

Genetic and non ‐genetic mimics should be considered before applying interstitial pneumonia with autoimmune features (IPAF) criteria
This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - August 12, 2019 Category: Rheumatology Authors: Erin M. Wilfong, Leslie J. Crofford, Jonathan A. Kropski Tags: Reply to Letter to the Editor Source Type: research

Reply to: Cardiovascular risk assessment in patients with ANCA ‐associated vasculitis
This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - August 12, 2019 Category: Rheumatology Authors: Zachary S. Wallace, John H. Stone Tags: Reply To Letter To The Editor Source Type: research

Genetic Disorders should be Considered before Diagnosing Interstitial Pneumonia with Autoimmune Features (IPAF): Comment on the Article by Wilfong et al
This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - August 12, 2019 Category: Rheumatology Authors: Manuel Silva ‐Carmona, Tiphanie P. Vogel Tags: Letter to the Editor Source Type: research

Pro ‐inflammatory histidyl‐tRNA synthetase‐specific CD4+ T cells in the blood and lung of patients with idiopathic inflammatory myopathies
AbstractObjectivesAutoantibodies targeting histidyl ‐tRNA synthetase (HisRS, or anti‐Jo1) are common in idiopathic inflammatory myopathies (IIM) and anti‐synthetase syndrome (ASS). We aimed to investigate immunity against HisRS in blood and lungs of patients with IIM/ASS.MethodsBronchoalveolar lavage fluid (BALF), BALF cells and peripheral blood mononuclear cells (PBMCs) from IIM/ASS (n=24) patients were stimulated with full ‐length HisRS‐protein or a HisRS‐derived peptide (HisRS11 ‐23). BALF and PBMCs from sarcoidosis patients (n=7) and healthy controls (HCs, n=12) were included as controls. CD4+ T ‐cell r...
Source: Arthritis and Rheumatology - August 12, 2019 Category: Rheumatology Authors: Angeles S. Galindo ‐Feria, Inka Albrecht, Cátia Fernandes‐Cerqueira, Antonella Notarnicola, Eddie A. James, Jessica Herrath, Maryam Dastmalchi, Tatyana Sandalova, Lars Rönnblom, Per‐Johan Jakobsson, Maryam Fathi, Adnane Achour, Johan G Tags: Full Length Source Type: research

Genetic deficiency of IFN γ reveals IFNγ‐independent manifestations of murine Hemophagocytic Lymphohistiocytosis
AbstractObjectiveFamilial hemophagocytic lymphohistiocytosis (FHL) is a complex cytokine storm syndrome caused by genetic abnormalities rendering CD8+ T cells and NK cells incapable of cytolytic killing. Murine models of FHL have identified interferon ‐gamma (IFNγ) made by CD8+ T cells as a critical mediator of disease, with an IFNγ‐blocking antibody (Emapalumab) recently receiving FDA approval. However, development of hemophagocytic lymphohistiocytosis (HLH)/macrophage activation syndrome (MAS) in patients who are genetically unresponsive to IFNγ questions the absolute necessity of IFNγ in driv...
Source: Arthritis and Rheumatology - August 9, 2019 Category: Rheumatology Authors: Thomas N Burn, Lehn Weaver, Julia E Rood, Niansheng Chu, Aaron Bodansky, Portia A Kreiger, Edward M Behrens Tags: Full Length Source Type: research

Disordered Antigens and Epitope Overlap Between Anti ‐Citrullinated Protein Antibodies and Rheumatoid Factor in Rheumatoid Arthritis
AbstractObjectiveAnti ‐citrullinated protein antibodies (ACPAs) and rheumatoid factor (RF) are commonly present in rheumatoid arthritis without clear rationale for their coexistence. Moreover, autoantibodies develop against proteins with different post‐translational modifications and native proteins without obvious u nifying characteristics of the antigens. Our objective was to broadly evaluate autoantibody binding in seronegative and seropositive rheumatoid arthritis to identify novel features of reactivity.MethodsAn array was created with 172,828 native, citrulline ‐containing, and homocitrulline‐containing pepti...
Source: Arthritis and Rheumatology - August 8, 2019 Category: Rheumatology Authors: Zihao Zheng, Aisha M. Mergaert, Lauren M. Fahmy, Mandar Bawadekar, Caitlyn L. Holmes, Irene M. Ong, Alan J. Bridges, Michael A. Newton, Miriam A. Shelef Tags: Full Length Source Type: research

Peripheral nervous system disease in Systemic Lupus Erythematosus: Results from an international, inception cohort study
ConclusionPNS disease is an important component of total NPSLE and has a significant negative impact on health related quality of life. The outcome is favourable for most patients, but we noted several factors associated with longer time to resolution.This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - August 7, 2019 Category: Rheumatology Authors: John G. Hanly, Qiuju Li, Li Su, Murray B. Urowitz, Caroline Gordon, Sang ‐Cheol Bae, Juanita Romero‐Diaz, Jorge Sanchez‐Guerrero, Sasha Bernatsky, Ann E. Clarke, Daniel J Wallace, David A. Isenberg, Anisur Rahman, Joan T. Merrill, Paul Tags: Full Length Source Type: research

Differential responsiveness of monocyte and macrophage subsets to interferon
This study examined an unexpected influence of macrophages/monocytes on the interferon signature.MethodsProinflammatory (classical) and anti ‐inflammatory (non‐classical) macrophages were sorted from mice and analyzed by RNA‐sequencing and quantitative PCR (qPCR). Type I interferon receptor (IFNAR) expression was determined by qPCR and flow cytometry. Macrophages were stimulatedin vitro with IFN α and p‐Stat‐1was measured.ResultsTranscriptional profiling of peritoneal macrophages from mice with pristane ‐induced lupus unexpectedly indicated a strong interferon signature in classical, but not non‐classic...
Source: Arthritis and Rheumatology - August 7, 2019 Category: Rheumatology Authors: Shuhong Han, Haoyang Zhuang, Pui Y. Lee, Mingjia Li, Lijun Yang, Peter A. Nigrovic, Westley H. Reeves Tags: Full Length Source Type: research

Storm warning: lung disease in systemic juvenile idiopathic arthritis
This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - August 7, 2019 Category: Rheumatology Authors: Peter A. Nigrovic Tags: Editorial Source Type: research

Cognitive Dysfunction in Systemic Lupus Erythematosus: A Case for Initiating Trials
Cognitive dysfunction (CD) is an insidious and underdiagnosed manifestation of systemic lupus erythematosus (SLE) that has a considerable impact on quality of life, which can be devastating. Given the inconsistencies in the modes of assessment and the difficulties in attribution to SLE, the reported prevalence of CD ranges from 5% to 80%. Although clinical studies of SLE ‐related CD have been hampered by heterogeneous subject populations and a lack of sensitive and standardized cognitive tests or other validated objective biomarkers for CD, there are, nonetheless, strong data from mouse models and from the clinical arena...
Source: Arthritis and Rheumatology - August 7, 2019 Category: Rheumatology Authors: Nina Kello, Erik Anderson, Betty Diamond Tags: Review Source Type: research

2019 European League Against Rheumatism/American College of Rheumatology Classification Criteria for Systemic Lupus Erythematosus
ConclusionThese new classification criteria were developed using rigorous methodology with multidisciplinary and international input, and have excellent sensitivity and specificity. Use of ANA entry criterion, hierarchically clustered, and weighted criteria reflects current thinking about SLE and provides an improved foundation for SLE research. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - August 6, 2019 Category: Rheumatology Authors: Martin Aringer, Karen Costenbader, David Daikh, Ralph Brinks, Marta Mosca, Rosalind Ramsey ‐Goldman, Josef S. Smolen, David Wofsy, Dimitrios T. Boumpas, Diane L. Kamen, David Jayne, Ricard Cervera, Nathalie Costedoat‐Chalumeau, Betty Diam Tags: Special Article Source Type: research

Role of Non ‐Steroidal Anti‐Inflammatory Drugs (NSAIDs) in the Association between Osteoarthritis and Cardiovascular Diseases: A Longitudinal Study
ConclusionFindings of this first study to evaluate NSAID's mediating role in OA ‐CVD relationship suggest that NSAID use substantially contributes to the OA‐CVD association.This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - August 6, 2019 Category: Rheumatology Authors: Mohammad Atiquzzaman, Mohammad E. Karim, Jacek Kopec, Hubert Wong, Aslam H. Anis Tags: Full Length Source Type: research

Enhanced Programmed Death 1 and Diminished Programmed Death Ligand 1 Up ‐Regulation Capacity of Post‐Activated Lupus B Cells
ObjectiveTo assess the expression of programmed death 1 (PD ‐1), PD ligand 1 (PD‐L1), and PD‐L2 by B cells from patients with systemic lupus erythematosus (SLE) at baseline and after in vitro stimulation and to analyze their functional relationship to B cell proliferation.MethodsPeripheral blood mononuclear cells obtained from 29 SLE patients and 27 healthy donors were stimulated with interleukin ‐2 (IL‐2)/IL‐10, anti–B cell receptor (anti‐BCR), CpG, and CD40L alone or in combination. Expression of PD‐1, PD‐L1, and PD‐L2 on defined B cell subsets as well as on CD3+ T cells was analyzed by flow cyt...
Source: Arthritis and Rheumatology - August 6, 2019 Category: Rheumatology Authors: Ana ‐Luisa Stefanski, Annika Wiedemann, Karin Reiter, Falk Hiepe, Andreia C. Lino, Thomas Dörner Tags: Brief Report Source Type: research

Use of Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitors in Statin ‐Associated Immune‐Mediated Necrotizing Myopathy: A Case Series
ConclusionPCSK9 inhibitors are safe for long ‐term use as a cholesterol‐lowering agent in patients with statin‐associated IMNM. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - August 6, 2019 Category: Rheumatology Authors: Eleni Tiniakou, Erika Rivera, Andrew L. Mammen, Lisa Christopher ‐Stine Tags: Brief Report Source Type: research

Variability in Antinuclear Antibody Testing to Assess Patient Eligibility for Clinical Trials of Novel Treatments for Systemic Lupus Erythematosus
ConclusionThese findings indicate that, when used for screening, IFAs can vary because of performance characteristics of kits and thus can affect determination of trial eligibility. With kits producing a significant frequency of ANA negativity, ANA status can be associated with other serologic measures as well as the presence of the IFN signature, potentially affecting responsiveness to a trial agent. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - August 5, 2019 Category: Rheumatology Authors: David S. Pisetsky, Dana Kathryn Thompson, Joseph Wajdula, Annette Diehl, Sudhakar Sridharan Tags: Brief Report Source Type: research

Is Immune Check Point Inhibitor Treatment an Option for Patients with Rheumatic Diseases and Cancer?
This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - August 5, 2019 Category: Rheumatology Authors: Lenore M. Buckley, Maria E. Suarez ‐Almazor Tags: Editorial Source Type: research

Safety and Efficacy of Immune Checkpoint Inhibitors in Patients with Cancer and Preexisting Autoimmune Disease: A Nationwide Multicenter Cohort Study
ConclusionThe occurrence of a flare/IRAE is frequent but mostly manageable without ICI discontinuation in patients with PAD. Immunosuppressive therapy at baseline was associated with poorer outcomes.This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - August 5, 2019 Category: Rheumatology Authors: Alice Tison, Gilles Qu éré, Laurent Misery, Elisa Funck‐Brentano, François‐Xavier Danlos, Emilie Routier, Caroline Robert, Yohann Loriot, Olivier Lambotte, Bertille Bonniaud, Camille Scalbert, Sarah Maanaoui, Thierry Lesimple, Stéphan Tags: Full Length Source Type: research

Reply
This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - August 5, 2019 Category: Rheumatology Authors: Hyon Choi, Tuhina Neogi, Lisa Stamp, Nicola Dalbeth, Robert Terkeltaub Tags: Reply to Letter to the Editor Source Type: research

Xanthine oxidase inhibitor withdrawal syndrome?
This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - August 5, 2019 Category: Rheumatology Authors: Todd A. Johnson, Masanari Kuwabara, Naoyuki Kamatani Tags: Letter to the Editor Source Type: research

Inflammation is associated with pro ‐nociceptive brain connections in rheumatoid arthritis patients with concomitant fibromyalgia
AbstractObjectiveRheumatoid arthritis (RA) patients with comorbid fibromyalgia (FM) manifest alterations in brain connectivity synonymous with central sensitization. Here we consider how peripheral inflammation, the principal nociceptive stimulus in RA, interacts with brain connectivity in RA patients with comorbid FM.MethodsRA patients with (FM+, n=27) and without (FM ‐, n=27) comorbid FM completed functional connectivity magnetic resonance imaging. Seed to whole‐brain functional connectivity analyses were conducted using left mid/posterior insula and left inferior parietal lobule (IPL) seeds, regions previously linke...
Source: Arthritis and Rheumatology - August 5, 2019 Category: Rheumatology Authors: Chelsea M. Kaplan, Andrew Schrepf, Eric Ichesco, Tony Larkin, Steven E. Harte, Richard E. Harris, Alison D. Murray, Gordon D. Waiter, Daniel J. Clauw, Neil Basu Tags: Brief Report Source Type: research

Systemic Juvenile Idiopathic Arthritis ‐Lung Disease: Characterization and Risk Factors
AbstractObjectiveSystemic Juvenile Idiopathic Arthritis (SJIA) is associated with a recently recognized albeit poorly defined and characterized lung disease (LD). Our objective is to describe clinical characteristics, risk factors, histopathologic and immunologic features of SJIA ‐associated LD (SJIA‐LD).MethodsClinical data was abstracted from medical records, and epidemiologic, cellular, biochemical, genomic analysis, and transcriptional profiling analyses were performed.Main ResultsEighteen patients with SJIA ‐LD have been evaluated since 2010. Radiographic findings included diffuse ground‐glass opacities, subpl...
Source: Arthritis and Rheumatology - August 5, 2019 Category: Rheumatology Authors: Grant S. Schulert, Shima Yasin, Brenna Carey, Claudia Chalk, Thuy Do, Andrew H. Schapiro, Ammar Husami, Allen Watts, Hermine I. Brunner, Jennifer Huggins, Elizabeth D. Mellins, Esi M. Morgan, Tracy Ting, Bruce C. Trapnell, Kathryn A. Wikenhe Tags: Full Length Source Type: research

Rheumatoid Arthritis Disease Activity Predicting Incident Clinically Apparent Rheumatoid Arthritis –Associated Interstitial Lung Disease: A Prospective Cohort Study
ConclusionActive articular RA was associated with an increased risk of developing RA ‐ILD. These results suggest that decreasing systemic inflammation may alter the natural history of RA‐ILD development. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - August 4, 2019 Category: Rheumatology Authors: Jeffrey A. Sparks, Xintong He, Jie Huang, Elaine A. Fletcher, Alessandra Zaccardelli, H. Maura Friedlander, Ritu R. Gill, Hiroto Hatabu, Mizuki Nishino, David J. Murphy, Christine K. Iannaccone, Taysir G. Mahmoud, Michelle L. Frits, Bing Lu, Tags: Original Article Source Type: research

Exploring the Lipid Paradox Theory in Rheumatoid Arthritis: Associations of Low Circulating Low ‐Density Lipoprotein Concentration With Subclinical Coronary Atherosclerosis
ObjectiveRheumatoid arthritis (RA) patients with the lowest circulating low ‐density lipoprotein (LDL) concentrations are at heightened risk of cardiovascular events. However, the atherosclerosis burden within this subgroup is unknown.MethodsRA patients pooled from 4 cohort studies of cardiovascular disease (CVD; n = 546) were compared with non ‐RA controls from the Multi‐Ethnic Study of Atherosclerosis (n = 5,279). Those taking lipid‐lowering medications were excluded. Differences in cardiac computed tomography–derived Agatston coronary artery calcium (CAC) scores between the RA and control groups were compa...
Source: Arthritis and Rheumatology - August 1, 2019 Category: Rheumatology Authors: Jon T. Giles, Mary Chester M. Wasko, Cecilia P. Chung, Moyses Szklo, Roger S. Blumenthal, Amy Kao, Sabahat Bokhari, Afshin Zartoshti, C. Michael Stein, Joan M. Bathon Tags: Original Article Source Type: research

The Epidemiology of Antiphospholipid Syndrome: A Population ‐Based Study
ConclusionAPS occurred in ~2 persons per 100,000 population per year. The estimated prevalence was 50 per 100,000 population. Overall mortality was not notably different from that observed in the general population. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - August 1, 2019 Category: Rheumatology Authors: Ali Duarte ‐García, Michael M. Pham, Cynthia S. Crowson, Shreyasee Amin, Kevin G. Moder, Rajiv K. Pruthi, Kenneth J. Warrington, Eric. L. Matteson Tags: Original Article Source Type: research

Protective Effect Against Cancer of Antibodies to the Large  Subunits of Both RNA Polymerases I and III in Scleroderma
ConclusionAnti ‐RPA194 antibodies are enriched in anti‐RPC155–positive scleroderma patients without cancer. Since somatic mutations in the gene encodingRPC155 in cancer in scleroderma patients appears to play a role in immune response initiation against RPC155 in those patients, these data raise the possibility that the development of immune responses to both RPC155 and RPA194 may influence clinical cancer emergence. Further study is required to define whether different autoantibody combinations have utility as tools for cancer risk stratification in scleroderma. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - August 1, 2019 Category: Rheumatology Authors: Ami A. Shah, Marikki Laiho, Antony Rosen, Livia Casciola ‐Rosen Tags: Original Article Source Type: research

Expression of Concern Regarding “Effects of Hypoxia on the Expression and Activity of Cyclooxygenase 2 in Fibroblast‐Like Synoviocytes: Interactions With Monocyte‐Derived Soluble Mediators” (Arthritis Rheum 2004;50:2441–9)
Arthritis&Rheumatology, Volume 71, Issue 8, Page 1376-1376, August 2019. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - July 28, 2019 Category: Rheumatology Tags: Expression of Concern Source Type: research

Issue Information
Arthritis&Rheumatology, Volume 71, Issue 8, August 2019. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - July 28, 2019 Category: Rheumatology Tags: Issue Information Source Type: research

Clinical Connections
Arthritis&Rheumatology, Volume 71, Issue 8, August 2019. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - July 28, 2019 Category: Rheumatology Tags: Clinical Connections Source Type: research

In This Issue
Arthritis&Rheumatology, Volume 71, Issue 8, August 2019. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - July 28, 2019 Category: Rheumatology Tags: In This Issue Source Type: research

In Memoriam: Shaun Ruddy, MD, 1935 –2019
Arthritis&Rheumatology, Volume 71, Issue 8, Page 1215-1216, August 2019. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - July 28, 2019 Category: Rheumatology Authors: Michael E. Weinblatt, William N. Kelley Tags: In Memoriam Source Type: research

A Neutrophil Activation Biomarker Panel in Prognosis and Monitoring of Patients with Rheumatoid Arthritis
AbstractObjectiveExaggerated neutrophil activation and formation of neutrophil extracellular traps (NETs) are linked to inflammation and autoimmunity, including rheumatoid arthritis (RA). However, whether NETs are present in the circulation of RA patients and contribute to inflammation and disease progression has not been carefully addressed. Here we assess markers of neutrophil activation and NET formation in plasma samples, asking whether they add clinical value in improving on determination of prognosis and monitoring in RA patients.MethodsMarkers of neutrophil activation (calprotectin) and cell death (NET) were analyze...
Source: Arthritis and Rheumatology - July 28, 2019 Category: Rheumatology Authors: Mary Bach, Jeonghun Moon, Richard Moore, Tiffany Pan, J. Lee Nelson, Christian Lood Tags: Full Length Source Type: research

Palate erosions in reactive arthritis
This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - July 28, 2019 Category: Rheumatology Authors: Stijn Michiels, Stefan Kerre Tags: Clinical Image Source Type: research

Increased adhesive potential of antiphospholipid syndrome neutrophils mediated by beta ‐2 integrin Mac‐1
AbstractObjectiveWhile the role of antiphospholipid antibodies in activating endothelial cells has been extensively studied, the impact of these antibodies on the adhesive potential of leukocytes has received less attention. Here, we investigated the extent to which antiphospholipid syndrome (APS) neutrophils adhered to resting endothelial cells under physiologic flow conditions, as well as the surface molecules required for that adhesion.MethodsPatients with primary APS (n=43), patients with history of venous thrombosis but negative testing for antiphospholipid antibodies (n=11), and healthy controls (n=38) were studied. ...
Source: Arthritis and Rheumatology - July 28, 2019 Category: Rheumatology Authors: Gautam Sule, William J. Kelley, Kelsey Gockman, Srilakshmi Yalavarthi, Andrew P. Vreede, Alison L. Banka, Paula L. Bockenstedt, Omolola Eniola ‐Adefeso, Jason S. Knight Tags: Full Length Source Type: research

Effects of conventional uric acid lowering therapy on monosodium urate crystal deposits
AbstractObjectiveFew studies have systematically and quantitatively addressed the impact of urate ‐lowering therapy on monosodium urate (MSU) deposition. Herein, we analyzed the effect of lifestyle measures and conventional uric acid lowering therapy on MSU deposits in gout patients.MethodsIn this prospective study, subjects with a diagnosis of gout according to ACR/EULAR classification criteria and presence of MSU deposits in dual energy computed tomography (DECT) scans received either lifestyle intervention or conventional urate ‐lowering therapy for a mean period of 18 months before follow‐up DECT scan. Detected M...
Source: Arthritis and Rheumatology - July 28, 2019 Category: Rheumatology Authors: Hanna Ellmann, Sara Bayat, Elizabeth Araujo, Bernhard Manger, Arnd Kleyer, Alexander Cavallaro, Michael Lell, Hannah Schenker, David Simon, Korey Tascilar, Herbert S.B. Baraf, Georg Schett, J ürgen Rech Tags: Full Length Source Type: research

Sepiapterin reductase inhibition selectively reduces inflammatory joint pain and increases urinary sepiapterin
AbstractObjectiveTo evaluate the anti ‐inflammatory and analgesic effect of sepiapterin reductase (SPR) inhibition in a mouse model of inflammatory joint disease and to evaluate sepiapterin as a non‐invasive, translational biomarker of SPR inhibition/target engagement in mice and healthy human volunteers.MethodsThe collagen antibody ‐induced arthritis (CAIA) mouse model was used to induce joint inflammation. The effect of pharmacological inhibition of SPR on heat, cold and mechanical threshold sensitivity and signs of inflammation was tested in mice. Urine from mice and healthy volunteers treated with SPR inhibitors ...
Source: Arthritis and Rheumatology - July 27, 2019 Category: Rheumatology Authors: Masahide Fujita, D ébora da Luz Scheffer, Bruna Lenfers Turnes, Shane J. F. Cronin, Alban Latrémolière, Michael Costigan, Clifford J. Woolf, Alexandra Latini, Nick A. Andrews Tags: Full Length Source Type: research

Dipeptidyl ‐peptidase‐4 as a marker of activated fibroblasts and a potential target for the treatment of fibrosis in Systemic Sclerosis
AbstractBackgroundDipeptidyl ‐peptidase‐4 (DPP4) identifies a dermal fibroblast lineage involved in scaring during wound healing. The role of DDP4 in tissue fibrosis, however, is unknown. The aim of the present study was to evaluate DPP4 as a potential target for the treatment of fibrosis in systemic sclerosis (SSc).MethodsThe expression of DPP4 was analyzed by real ‐time PCR, immunofluorescence and Western blot. The activity of DPP4 was modulated by overexpression, knockdown and pharmacological inhibition using Sitagliptin and Vildagliptin. The effects of DPP4 inhibition were analyzed in human dermal fibroblasts and...
Source: Arthritis and Rheumatology - July 26, 2019 Category: Rheumatology Authors: Alina Soare, Hermina A. Gy örfi, Alexandru E. Matei, Clara Dees, Simon Rauber, Thomas Wohlfahrt, Chih‐Wei Chen, Ingo Ludolph, Raymund E. Horch, Tobias Bäuerle, Stephan von Hörsten, Carina Mihai, Oliver Distler, Andreas Ramming, Georg Sc Tags: Full Length Source Type: research

High ‐Density Lipoprotein in Lupus: Disease Biomarkers and Potential Therapeutic Strategy
This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - July 26, 2019 Category: Rheumatology Authors: Sang Yeop Kim, Minzhi Yu, Emily E. Morin, Jukyung Kang, Mariana J. Kaplan, Anna Schwendeman Tags: Review Article Source Type: research

High prevalence and disease correlation of autoantibodies against p40 encoded by long interspersed nuclear elements (LINE ‐1) in systemic lupus erythematosus
AbstractObjectiveThe long interspersed nuclear element 1 (LINE ‐1) encodes two proteins, the RNA‐binding p40 and the endonuclease and reverse transcriptase (ORF2p); both required for LINE‐1 to retrotranspose. In cells expressing LINE‐1, these proteins assemble with the LINE‐1 RNA and additional RNA‐binding proteins, some of which are well‐known au toantigens in patients with systemic lupus erythematosus (SLE). We asked if SLE patients also make autoantibodies against the LINE‐1 p40.MethodsHighly purified p40 protein was used to quantitate IgG autoantibodies in the serum of 172 SLE patients, disease controls...
Source: Arthritis and Rheumatology - July 24, 2019 Category: Rheumatology Authors: Victoria Carter, John LaCava, Martin S. Taylor, Shu Ying Liang, Cecilia Mustelin, Kennedy C. Ukadike, Anders Bengtsson, Christian Lood, Tomas Mustelin Tags: Full Length Source Type: research

In Memoriam
This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - July 24, 2019 Category: Rheumatology Authors: Steven B. Abramson, Bruce Cronstein, Jill P. Buyon Tags: Special Source Type: research