Antiinflammatory Effect of High ‐Density Lipoprotein Blunted by Delivery of Altered MicroRNA Cargo in Patients With Rheumatoid Arthritis

ConclusionHDL-miR-1246 was increased in RA versus control participants and delivery of miR-1246 to macrophages increased IL-6 expression by targetingDUSP3. The altered HDL-miRNA cargo in RA blunted HDL's anti-inflammatory effect.

https://onlinelibrary.wiley.com/doi/10.1002/art.42782?af=R

Source: Arthritis and Rheumatology - January 25, 2024 Category: Rheumatology Authors: Qiong Wu, Quanhu Sheng, Danielle Michell, Marisol Ramirez ‐Solano, Olivia Posey, Anastasiia Phothisane, Shahensha Shaik, Kasey C. Vickers, Michelle J. Ormseth Tags: Full Length Source Type: research