Expansion of HLA ‐DR Positive Peripheral Helper T and Naive B cells in Anticitrullinated Protein Antibody‐Positive Individuals At Risk for Rheumatoid Arthritis
ConclusionThe expansion of HLA-DR+ Tph cells and CXCR5−CD11c−CD38+ naive B cells in ACPA+ individuals, including those who developed inflammatory arthritis and classified RA, supports a key role of these cells in transition from pre-RA to classified RA. These findings may identify a new mechanistic target for treatment and prevention in RA. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - April 6, 2024 Category: Rheumatology Authors: Hideto Takada,
M. Kristen Demoruelle,
Kevin D. Deane,
Shohei Nakamura,
Yasuhiro Katsumata,
Katsunori Ikari,
Jane H. Buckner,
William H. Robinson,
Jennifer A. Seifert,
Marie L. Feser,
LauraKay Moss,
Jill M. Norris,
Masayoshi Harigai,
Elena W. Tags: Full Length Source Type: research
“Rounding Third Base and Heading Home”: Arthritis & Rheumatology in 2024
(Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - April 4, 2024 Category: Rheumatology Authors: Daniel H. Solomon,
Mariana J. Kaplan,
Peter A. Nigrovic,
Richard Bucala Tags: Notes from the Field Source Type: research
Professional antigen ‐presenting Tbet+CD11c+ B cells correlate with bone destruction in untreated rheumatoid arthritis
ConclusionThis study suggests that Tbet+CD11c+ MBCs contribute to the pathogenesis of RA by promoting bone destruction through antigen presentation, T-cell activation and Th17 polarisation. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - April 4, 2024 Category: Rheumatology Authors: Sarah McGrath,
Kristoffer Grimstad,
Katrin Thorarinsdottir,
Kristina Forslind,
Daniel Glinatsi,
Monica Leu Agelii,
Alaitz Aranburu,
Timothy Sundell,
Charlotte A. Jonsson,
Alessandro Camponeschi,
Anna ‐Karin Hultgård Ekwall,
Andreas Tilevik, Tags: Full Length Source Type: research
A Novel Human Interleukin ‐23A Overexpressing Mouse Model of Systemic Lupus Erythematosus
ConclusionWe have generated and characterized a novel genetic mouse model of SLE, providing proof-of-concept for the etiopathogenic role of human IL-23A. This new model has a normal life span and integrates several characteristics of the human disease's complexity and chronicity, making it an attractive preclinical tool for studying IL-23 –dependent pathogenic mechanisms and assessing the efficacy of anti–human IL-23A or modeled disease-related therapeutics. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - April 3, 2024 Category: Rheumatology Authors: Eleni Christodoulou ‐Vafeiadou,
Christina Geka,
Lida Iliopoulou,
Lydia Ntari,
Maria C. Denis,
Niki Karagianni,
George Kollias Tags: Full Length Source Type: research
Dysregulated NUB1 and neddylation enhances rheumatoid arthritis fibroblast ‐like synoviocyte inflammatory responses
ConclusionCUL1 neddylation andNUB1 induction is dysregulated in RA, which increases FLS activation. Inhibition of neddylation is an effective therapy in an animal model of arthritis. These data suggest that neddylation system contributes to the pathogenesis of RA and that regulation of neddylation could be a novel therapeutic approach. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - April 3, 2024 Category: Rheumatology Authors: Sho Sendo,
Camilla R. L. Machado,
David L Boyle,
Robert J. Benschop,
Narayanan B. Perumal,
Eunice Choi,
Wei Wang,
Gary S Firestein Tags: Full Length Source Type: research
Intra ‐Articular Mineralization on Computerized Tomography of the Knee and Risk of Cartilage Damage: The Multicenter Osteoarthritis Study
ConclusionCT-detected IA mineralization in the cartilage was associated with higher risk of MRI cartilage worsening in the same compartment and subregion over two years. These findings suggest potential localized, tissue-specific effects of IA mineralization on cartilage pathology in knee OA. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - April 3, 2024 Category: Rheumatology Authors: Jean W. Liew,
Mohammed Jarraya,
Ali Guermazi,
John Lynch,
David Felson,
Michael Nevitt,
Cora E. Lewis,
James Torner,
Frank W. Roemer,
Michel D. Crema,
Na Wang,
Fabio Becce,
Gabriela Rabasa,
Tristan Pascart,
Tuhina Neogi Tags: Full Length Source Type: research
Performance of DETECT Pulmonary Arterial Hypertension Algorithm According to the Hemodynamic Definition of Pulmonary Arterial Hypertension in the 2022 European Society of Cardiology and the European Respiratory Society Guidelines
ConclusionThe performance of the DETECT algorithm to screen for PAH in patients with SSc is maintained when PAH is defined according to the 2022 ESC/ERS hemodynamic definition, indicating that DETECT remains applicable to screen for PAH in patients with SSc. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - April 2, 2024 Category: Rheumatology Authors: Oliver Distler,
Diana Bonderman,
J. Gerry Coghlan,
Christopher P. Denton,
Ekkehard Gr ünig,
Dinesh Khanna,
Vallerie V. McLaughlin,
Ulf Müller‐Ladner,
Janet E. Pope,
Madelon C. Vonk,
Lilla Di Scala,
Jean‐Christophe Lemarie,
Loïc Perchene Tags: Brief Report Source Type: research
