Vitamin D and Marine n ‐3 Fatty Acids for Autoimmune Disease Prevention: Outcomes at Two Years after VITAL Trial Completion
ConclusionsTwo years after trial termination, vitamin D 2000 IU/day's protective effects dissipated, but 1000 mg/day n-3 fatty acids had a sustained effect in reducing AD incidence. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - January 26, 2024 Category: Rheumatology Authors: Karen H. Costenbader,
Nancy R. Cook,
I ‐Min Lee,
Jill Hahn,
Joseph Walter,
Vadim Bubes,
Gregory Kotler,
Nicole Yang,
Sonia Friedman,
Erik K. Alexander,
JoAnn E. Manson Tags: Full Length Source Type: research
Myositis ‐associated autoantibodies in juvenile myositis are associated with refractory disease and mortality
ConclusionMAAs were prevalent in a large cohort of patients with juvenile myositis. ILD, refractory disease, and mortality were associated with MAA positivity. Prospective studies are needed to determine whether early detection of MAAs may lead to improved outcomes for patients with juvenile myositis. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - January 26, 2024 Category: Rheumatology Authors: Matthew A. Sherman,
Payam Noroozi Farhadi,
Katherine Pak,
Edward P. Trieu,
Kakali Sarkar,
Ira N. Targoff,
Megan L. Neely,
Andrew L. Mammen,
Lisa G. Rider,
for the Childhood Myositis Heterogeneity Collaborative Study Group,
Daniel A. Albert,
Bit Tags: Full Length Source Type: research
Hydroxychloroquine in lupus pregnancy and risk of preeclampsia
ConclusionUsing a large insurance-based database, we did not observe a decreased risk of preeclampsia associated with HCQ use in pregnancy, although we cannot rule out residual and unmeasured confounding and misclassification. Further studies leveraging large population-based data and prospective collection could characterize how HCQ influences preeclampsia risk in SLE pregnancy and among persons at greater risk of hypertensive disorders of pregnancy. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - January 26, 2024 Category: Rheumatology Authors: Amadeia Rector,
Ivana Mari ć,
Yashaar Chaichian,
Eliza Chakravarty,
Miranda Cantu,
Michael H Weisman,
Gary M Shaw,
Maurice Druzin,
Julia F Simard Tags: Full Length Source Type: research
The effect of recent antirheumatic drug on features of rheumatoid arthritis ‐associated lymphoproliferative disorders
ConclusionAntirheumatic drugs administered before LPD onset may influence the clinicopathological features of RA-LPD, with patterns changing over time. Furthermore, TCZ-only regimens are recommended after LPD onset. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - January 26, 2024 Category: Rheumatology Authors: Yoshihiko Hoshida,
Atsuko Tsujii,
Shiro Ohshima,
Yukihiko Saeki,
Masato Yagita,
Tomoya Miyamura,
Masao Katayama,
Tomonori Kawasaki,
Yasushi Hiramatsu,
Hisaji Oshima,
Toshihiko Murayama,
Shinji Higa,
Kazuya Kuraoka,
Fuminori Hirano,
Kenji Ich Tags: Full Length Source Type: research
Erosive tophaceous gout and uric acid nephrolithiasis: microscopic and 3D HRpQCT findings
(Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - January 26, 2024 Category: Rheumatology Authors: Giovanni Adami,
Francesca Ruzzon,
Angelo Fassio,
Davide Gatti,
Matteo Gatti,
Maurizio Rossini Tags: Clinical Image Source Type: research
Clinical characteristics of cryopyrin ‐associated periodic syndrome and long‐term real‐world efficacy and tolerability of canakinumab in Japan: results of a nationwide survey
ConclusionsThis study provides one of the largest epidemiologic datasets for CAPS. While early initiation of anti-IL-1 treatment with canakinumab is beneficial for improving disease prognosis, some patients do not achieve remission despite a high serum concentration of canakinumab. Moreover, IBD may develop in CAPS following canakinumab treatment. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - January 25, 2024 Category: Rheumatology Authors: Takayuki Miyamoto,
Kazushi Izawa,
Sho Masui,
Atsue Yamazaki,
Yuichi Yamasaki,
Tadashi Matsubayashi,
Mayuka Shiraki,
Hidenori Ohnishi,
Junko Yasumura,
Kawabe Tomohiro,
Takako Miyamae,
Tomoyo Matsubara,
Naoya Arakawa,
Takashi Ishige,
Takumi Ta Tags: Full Length Source Type: research
IRF1 deficiency predisposes cartilage to accumulate DNA damage and promotes osteoarthritis development
ConclusionIRF1 offers DNA damage surveillance in chondrocytes, protecting them from oxidative stress associated with OA risk factors. Our study provides a crucial and cautionary perspective that compromising IRF1 activity renders chondrocytes vulnerable to cellular senescence and promotes OA development. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - January 25, 2024 Category: Rheumatology Authors: Yongsik Cho,
Hyeonkyeong Kim,
Geunho Yook,
Sangmin Yong,
Soy Kim,
Narae Lee,
Yi ‐Jun Kim,
Jin‐Hee Kim,
Tae Woo Kim,
Moon Jong Chang,
Kyoung Min Lee,
Chong Bum Chang,
Seung‐Baik Kang,
Jin‐Hong Kim Tags: Full Length Source Type: research
Plasma Matrix Metalloproteinase Concentrations and Risk of Interstitial Lung Disease in a Prospective Rheumatoid Arthritis Cohort
ConclusionMMP-7 and MMP-9 were strongly associated with both prevalent and incident ILD in this large, multicenter RA cohort after adjustment for other RA-ILD risk factors. These population-level findings further support a potential pathogenic role for MMPs in RA-ILD and suggest that their measurement could facilitate RA-ILD risk stratification. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - January 25, 2024 Category: Rheumatology Authors: Brent A. Luedders,
Austin M. Wheeler,
Dana P. Ascherman,
Joshua F. Baker,
Michael J. Duryee,
Yangyuna Yang,
Punyasha Roul,
Katherine D. Wysham,
Paul Monach,
Andreas Reimold,
Gail S. Kerr,
Gary Kunkel,
Grant W. Cannon,
Jill A. Poole,
Geoffrey Tags: Full Length Source Type: research
CCL19 ‐positive lymph node stromal cells govern the onset of inflammatory arthritis via tropomyosin receptor kinase
ConclusionsCCL19+ lymph node stromal cells are crucially involved in the development of inflammatory arthritis. Therefore, targeting of CCL19+ lymph node stromal cells via TRK kinases could provide a tool to prevent arthritis. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - January 25, 2024 Category: Rheumatology Authors: Fabian Sch älter,
Vugar Azizov,
Michael Frech,
Kerstin Dürholz,
Eva Schmid,
Anna Hendel,
Ilann Sarfati,
Yuichi Maeda,
Maria Sokolova,
Ippei Miyagawa,
Kristin Focke,
Kerstin Sarter,
Lisa G M van Baarsen,
Stefan Krautwald,
Georg Schett,
Mar Tags: Full Length Source Type: research
n ‐3 Fatty Acids: Not Really Fishy; Lessons Learned
(Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - January 25, 2024 Category: Rheumatology Authors: Joel M Kremer Tags: Editorial Source Type: research
