A Novel human IL ‐23A Overexpressing Mouse Model of Systemic Lupus Erythematosus
ConclusionsWe have generated and characterized a novel genetic mouse model of SLE, providing proof-of-concept for the etiopathogenic role of hIL-23A. This new model has a normal lifespan and integrates several characteristics of the human disease's complexity and chronicity making it an attractive preclinical tool for studying IL23-dependent pathogenic mechanisms and assessing the efficacy of anti-hIL23A or modeled disease-related therapeutics. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - February 16, 2024 Category: Rheumatology Authors: Eleni Christodoulou ‐Vafeiadou,
Christina Geka,
Lida Iliopoulou,
Lydia Ntari,
Maria C. Denis,
Niki Karagianni,
George Kollias Tags: Full Length Source Type: research
Pulmonary damage biomarkers for risk of rheumatoid arthritis ‐associated interstitial lung disease: Enabling early detection and risk stratification
(Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - February 16, 2024 Category: Rheumatology Authors: Pierre ‐Antoine Juge,
Paul F. Dellaripa,
Jeffrey A. Sparks Tags: Editorial Source Type: research
Association of Combined Anti ‐Ro52/TRIM21 and Anti‐Ro60/SSA Antibodies With Increased Sjögren Disease Severity Through Interferon Pathway Activation
ConclusionThese results suggest that the combination of anti-Ro52/TRIM21 and anti-Ro60/SSA antibodies is associated with a clinical, biologic, and transcriptional profile linked to greater disease severity in SjD through the potentiation of the interferon pathway activation by anti-Ro52/TRIM21 antibodies. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - February 15, 2024 Category: Rheumatology Authors: El éonore Bettacchioli,
Alain Saraux,
Alice Tison,
Divi Cornec,
Maryvonne Dueymes,
Nathan Foulquier,
Sophie Hillion,
Anne‐Marie Roguedas‐Contios,
Anas‐Alexis Benyoussef,
Marta E. Alarcon‐Riquelme,
Jacques‐Olivier Pers,
Valérie Devau Tags: Full Length Source Type: research
The Exposome: What Is It, Really, and Does it Help to Understand Environmental Influences on Human Health and Rheumatic Disease?
(Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - February 15, 2024 Category: Rheumatology Authors: Christine G. Parks,
Karen H. Costenbader Tags: Editorial Source Type: research
Reply to comment on: Both disease activity and HLA ‐B27 status are associated with gut microbiome dysbiosis in spondyloarthritis patients, by Y Zheng, J He and L Li
(Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - February 14, 2024 Category: Rheumatology Authors: Magali Berland,
Dusko Ehrlich,
Maxime Breban Tags: Reply Source Type: research
Comment on: Anti ‐S100A4 monoclonal antibody treatment ameliorates experimental skin fibrosis and SSc‐specific transcriptional signatures in human skin
(Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - February 14, 2024 Category: Rheumatology Authors: An ‐Fang Huang,
Wang‐Dong Xu Tags: Letters Source Type: research
Reply
(Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - February 14, 2024 Category: Rheumatology Authors: J örg H.W. Distler,
Jonas Hallén Tags: Reply Source Type: research
DNA Damage and Cellular Senescence in Osteoarthritis: An Unexpected Role for Interferon Regulatory Factor 1 in Chondrocyte DNA Repair
(Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - February 13, 2024 Category: Rheumatology Authors: Brian O. Diekman,
Richard F. Loeser Tags: Editorial Source Type: research
Comment on: Both disease activity and HLA ‐B27 status are associated with gut microbiome dysbiosis in spondyloarthritis patients
(Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - February 13, 2024 Category: Rheumatology Authors: Yi Zheng,
Jun He,
Liqi Li Tags: Letters Source Type: research
