Calprotectin impairs platelet survival in patients with primary antiphospholipid syndrome
ConclusionsThese data suggest that calprotectin has the potential to be a functional biomarker and a new therapeutic target for APS thrombocytopenia. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - January 16, 2024 Category: Rheumatology Authors: Claire K. Hoy,
Somanathapura K. NaveenKumar,
Sherwin A. Navaz,
Kavya Sugur,
Srilakshmi Yalavarthi,
Cyrus Sarosh,
Tristin Smith,
Katarina Kmetova,
Emily Chong,
Noah F. Peters,
Christine E. Rysenga,
Gary L. Norman,
Gabriel Figueroa ‐Parra,
Da Tags: Brief Report Source Type: research
Analysis of 245,368 diverse individuals in NIH All of Us Program finds incomplete penetrance of VEXAS ‐defining UBA1 p.Met41Leu somatic variant
ConclusionWe report the largest cohort to date of persons with the VEXAS-associated p.Met41Leu somatic variant. This cohort differed substantially from reported cohorts of patients with clinical VEXAS, having a higher proportion of persons who were young, female, and of diverse ancestry. Variant allele fractions were lower than reported in clinical VEXAS cohorts and bioinformatic analysis detected no clinical manifestations of VEXAS. Thus, theUBA1 p.Met41Leu somatic variant displayed incomplete penetrance for VEXAS. Further study is needed to determine the natural history of VEXAS-associated somatic variants in the pre-dis...
Source: Arthritis and Rheumatology - January 16, 2024 Category: Rheumatology Authors: Robert W. Corty,
James Brogan,
Kevin Byram,
Jason Springer,
Peter C. Grayson,
Alexander Bick Tags: Brief Report Source Type: research
Reply: Domain specificity and stochasticity of large language models
(Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - January 15, 2024 Category: Rheumatology Authors: Carrie Ye Tags: Reply Source Type: research
Analysis of 245,368 diverse individuals in NIH All of Us Program finds incomplete penetrance of VEXAS ‐defining UBA1 p.Met41Leu somatic variant
ConclusionWe report the largest cohort to date of persons with the VEXAS-associated p.Met41Leu somatic variant. This cohort differed substantially from reported cohorts of patients with clinical VEXAS, having a higher proportion of persons who were young, female, and of diverse ancestry. Variant allele fractions were lower than reported in clinical VEXAS cohorts and bioinformatic analysis detected no clinical manifestations of VEXAS. Thus, theUBA1 p.Met41Leu somatic variant displayed incomplete penetrance for VEXAS. Further study is needed to determine the natural history of VEXAS-associated somatic variants in the pre-dis...
Source: Arthritis and Rheumatology - January 15, 2024 Category: Rheumatology Authors: Robert W. Corty,
James Brogan,
Kevin Byram,
Jason Springer,
Peter C. Grayson,
Alexander Bick Tags: Brief Report Source Type: research
Doctor versus AI: Patient and physician evaluation of LLMs responses to rheumatology patient questions: comment on the article by Ye et al.
(Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - January 15, 2024 Category: Rheumatology Authors: Gang Wang,
Ning Zhuo,
Zhichun Liu Tags: Letters Source Type: research
Rheum at the Table for Everyone: A Call to Expand Rheumatology Knowledge for Primary Care Providers
(Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - January 15, 2024 Category: Rheumatology Authors: Mary E. Margaretten,
Jinoos Yazdany,
Jennifer Mandal Tags: Notes from the Field Source Type: research
Fractures in Patients with Acute CPP Crystal Arthritis Versus Matched Comparators in a Large Cohort Study
ConclusionIn this first published study of fractures and CPPD, fracture risk was nearly doubled in patients with acute CPP crystal arthritis. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - January 15, 2024 Category: Rheumatology Authors: Sara K. Tedeschi,
Keigo Hayashi,
Ann Rosenthal,
Muneet Gill,
Javier Marrugo,
Sho Fukui,
Ellen Gravallese,
Daniel H. Solomon Tags: Brief Report Source Type: research
Epigenetic regulatory axis MIR22 ‐TET3‐MTRNR2L2 represses fibroblast‐like synoviocyte‐mediated inflammation in Rheumatoid Arthritis
ConclusionThe key role of the MIR22-TET3-MTRNR2L2 pathway in RA-FLS provided an experimental basis for further studies into the pathogenesis and related targets of RA from the perspective of FLS. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - January 15, 2024 Category: Rheumatology Authors: Yilong Fang,
Wei Huang,
Xiangling Zhu,
Xinming Wang,
Xuming Wu,
Huihui Wang,
Wenming Hong,
Shangxue Yan,
Lingling Zhang,
Yujie Deng,
Wei Wei,
Jiajie Tu,
Chen Zhu Tags: Full Length Source Type: research
Renal Response Outcomes of the EuroLupus and National Institutes of Health Cyclophosphamide Dosing Regimens in Childhood ‐Onset Proliferative Lupus Nephritis
ConclusionOur study failed to demonstrate a benefit of the NIH regimen over the EuroLupus CYC regimen in childhood-onset proliferative LN. However, future prospective outcome studies are needed. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - January 12, 2024 Category: Rheumatology Authors: Christine S. Wang,
Rebecca E. Sadun,
Wenru Zhou,
Kristen R. Miller,
Laura Pyle,
Stacey P. Ardoin,
Christine Bacha,
Emily Hause,
Joyce Hui ‐Yuen,
Nicole Ling,
Maria Pereira,
Meredith Riebschleger,
Kelly Rouster‐Stevens,
Aliese Sarkissian, Tags: Full Length Source Type: research
α‐Ketoglutarate–Dependent KDM6 Histone Demethylases and Interferon‐Stimulated Gene Expression in Lupus
ConclusionOur study suggests long-term IFN α exposure alters the epigenetic regulation of ISG expression in SLE monocytes via changes in immunometabolism, a mechanism reflecting trained immunity to type I IFN. Importantly, it opens the possibility that targeting histone-modifying enzymes, such as KDM6A/B, may reduce IFN responses in SLE. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - January 12, 2024 Category: Rheumatology Authors: Erica N. Montano,
Moumita Bose,
Lihong Huo,
Gantsetseg Tumurkhuu,
Gabriela De Los Santos,
Brianna Simental,
Aleksandr B. Stotland,
Janet Wei,
C. Noel Bairey Merz,
Jo Suda,
Gislaine Martins,
Sarfaraz Lalani,
Kate Lawrenson,
Yizhou Wang,
Sarah Tags: Full Length Source Type: research
