Micro ‐structural bone changes are associated with broad‐spectrum autoimmunity and predict the onset of rheumatoid arthritis
ConclusionMicrostructural changes in RA at ‐risk individuals are associated with broad‐spectrum autoimmunity and predict the onset of RA. These data support the concept of structural priming of joints by autoimmunity before the onset of the inflammatory phase of the disease. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - February 27, 2020 Category: Rheumatology Authors: David Simon, Arnd Kleyer, Cong Duy Bui, Axel Hueber, Holger Bang, Andreas Ramming, Juergen Rech, Georg Schett Tags: FULL LENGTH Source Type: research

Comparison of Aortitis vs Non ‐Inflammatory Aortic Aneurysms Among Patients Who Undergo Open Aortic Aneurysm Repair
This study examined surgically diagnosed aortitis and identified patient characteristics and imaging findings associated with the disease.MethodsIn this case ‐control study, cases had biopsy proven, newly‐diagnosed, non‐infectious aortitis following open thoracic aortic aneurysm surgical repair. Five controls were matched by year of surgery and lacked significant inflammation on pathology. Comorbidities, demographics, laboratory, and imaging abnorm alities prior to surgery were collected. Associations between exposures and outcomes were evaluated using conditional logistic regression. Backward stepwise logistic regre...
Source: Arthritis and Rheumatology - February 27, 2020 Category: Rheumatology Authors: Laarni Quimson, Adam Mayer, Sarah Capponi, Bryan Rea, Rennie L. Rhee Tags: BRIEF REPORT Source Type: research

Myositis autoantibodies: Clinical significance of higher cut ‐ offs using the Euroimmun Research Line Blot
AbstractWe read with interest the article ‘’Myositis Autoantibodies: A Comparison of Results from the Oklahoma Medical Research Foundation Myositis Panel to the Euroimmun Research Line Blot’’ by Mecoli et al.1. The study showed that, by using the Euroimmun panel for myositis ‐specific autoantibodies (MSA), different cut‐offs should apply for all specificities tested in order to determine a true positive antibody status. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - February 27, 2020 Category: Rheumatology Authors: Ilir I Cinoku, Evangelia Zampeli, Clio P Mavragani, Fotini N Skopouli, Haralampos M Moutsopoulos Tags: LETTER TO THE EDITOR Source Type: research

Cell ‐bound complement activation products (CB‐CAPs) are superior to serum complement levels (C3, C4) to detect complement activation in SLE
AbstractThe recently published EULAR/ACR Criteria for the Classification of Systemic Lupus Erythematosus (SLE) combines clinical criteria with standard laboratory testing (1). One stated advantage of these new criteria is that they perform better than prior criteria in patients with early onset SLE. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - February 27, 2020 Category: Rheumatology Authors: Arthur Weinstein Tags: LETTER TO THE EDITOR Source Type: research

Positive effects of the young systemic environment and high GDF ‐11 levels on chondrocyte proliferation and cartilage matrix synthesis in old mice
AbstractObjectiveTo investigate the effects of a young systemic environment and GDF11 on aging cartilage.MethodsA heterochronic parabiosis model (2 ‐month‐old/12‐month‐old, Y/O), isochronic parabiosis model (12‐month‐old/12‐month‐old, O/O), and 12‐month‐old mice alone (O) were evaluated. Knee joints and chondrocytes of old mice were examined by X‐ray, histology, cell proliferation assays, immunohistochemistry, western blot ting, and qRT‐PCR 16 weeks after parabiosis surgery. GDF11 was injected into 12‐month‐old mouse joints daily for 16 weeks. Cartilage degeneration, cell proliferation, and OA...
Source: Arthritis and Rheumatology - February 27, 2020 Category: Rheumatology Authors: Lu Li, Xiaochun Wei, Dongming Wang, Zhi Lv, Xiang Geng, Pengcui Li, Jiangong Lu, Kaihang Wang, Xiaohu Wang, Jian Sun, Xiaoming Cao, Lei Wei Tags: FULL LENGTH Source Type: research

Involvement of Tumor Necrosis Factor Receptor Type II in FoxP3 Stability and as a Marker of Treg Cells Specifically Expanded by Anti –Tumor Necrosis Factor Treatments in Rheumatoid Arthritis
ObjectiveTo study the involvement of Treg cells expressing tumor necrosis factor receptor type II (TNFRII) in exerting control of inflammation in experimental models and in the response to anti ‐TNF treatments in patients with rheumatoid arthritis (RA) or spondyloarthritis (SpA).MethodsThe role of TNFRII in Treg cells was explored using a multilevel translational approach. Treg cell stability was evaluated by analyzing the methylation status of theFoxp3 locus using bisulfite sequencing. Two models of inflammation (imiquimod ‐induced skin inflammation and delayed‐type hypersensitivity arthritis [DTHA]) were induced in...
Source: Arthritis and Rheumatology - February 27, 2020 Category: Rheumatology Authors: Fran çois Santinon, Maxime Batignes, Majda Lyna Mebrek, Jerôme Biton, Gaëlle Clavel, Roxane Hervé, Delphine Lemeiter, Magali Breckler, Florence Busato, Jorg Tost, Marianne Ziol, Marie‐Christophe Boissier, Patrice Decker, Luca Semerano, Tags: Original Article Source Type: research

The patient and parent perspective on methotrexate in recent Juvenile Idiopathic Arthritis guidelines
AbstractWe confirm that there are was no financial support or other benefits from commercial sources for the work reported on in the manuscript, or any other financial interests that any of the authors may have, which could create a potential conflict of interest or the appearance of a conflict of interest with regard to the work. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - February 27, 2020 Category: Rheumatology Authors: Casper G Schoemaker, Nico M Wulffraat, Sebastiaan J Vastert Tags: LETTER TO THE EDITOR Source Type: research

2020 American College of Rheumatology Guideline for the Management of Reproductive Health in Rheumatic and Musculoskeletal Diseases
ConclusionThis guideline provides evidence ‐based recommendations developed and reviewed by panels of experts and RMD patients. Many recommendations are conditional, reflecting a lack of data or low‐level data. We intend that this guideline be used to inform a shared decision‐making process between patients and their physicians on issu es related to reproductive health that incorporates patients’ values, preferences, and comorbidities. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - February 27, 2020 Category: Rheumatology Authors: Lisa R. Sammaritano, Bonnie L. Bermas, Eliza E. Chakravarty, Christina Chambers, Megan E. B. Clowse, Michael D. Lockshin, Wendy Marder, Gordon Guyatt, D. Ware Branch, Jill Buyon, Lisa Christopher ‐Stine, Rachelle Crow‐Hercher, John Cush, Tags: Original Article Source Type: research

Achievement of remission in two early rheumatoid arthritis cohorts implementing different treat ‐to‐target strategies
AbstractObjectiveTo compare achievement of remission in two early rheumatoid arthritis (RA) treat ‐to‐target (TTT) cohorts, one tight control cohort targeting stringent remission in a randomized controlled strategy trial and one observational cohort targeting a looser definition of remission in clinical practice.MethodsWe analyzed data from the ARCTIC trial and the NOR ‐VEAC observational study. Both were Norwegian multicenter studies including disease modifying anti‐rheumatic drug (DMARD)‐naïve RA‐patients and implementing TTT. The target in ARCTIC was remission defined as a Disease Activity Score (DAS44)
Source: Arthritis and Rheumatology - February 27, 2020 Category: Rheumatology Authors: Vibeke Norvang, Gina H. Brinkmann, Kazuki Yoshida, Siri Lillegraven, Anna ‐Birgitte Aga, Joseph Sexton, Sara K. Tedeschi, Houchen Lyu, Ellen S. Norli, Till Uhlig, Tore K. Kvien, Maria D. Mjaavatten, Daniel H. Solomon, Espen A. Haavardsholm, Tags: FULL LENGTH Source Type: research

Association between Race and Radiographic, Symptomatic, and Clinical Hand Osteoarthritis: A Propensity Score ‐Matched Study Using Osteoarthritis Initiative Data
ConclusionsIn contrast to the well ‐established association between black race and knee or hip OA, odds of hand OA are lower in black versus nonblack subjects, which is not mediated by known hand OA risk factors. Future mechanistic works are warranted to determine the mediating protective factors for hand OA among the black subject s. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - February 27, 2020 Category: Rheumatology Authors: Farhad Pishgar, Robert M. Kwee, Arya Haj ‐Mirzaian, Ali Guermazi, Ida K. Haugen, Shadpour Demehri Tags: FULL LENGTH Source Type: research

Nonsteroidal Antiinflammatory Drugs as Potential Disease ‐Modifying Medications in Axial Spondyloarthritis
Nonsteroidal antiinflammatory drugs (NSAIDs) are the first ‐line pharmacotherapy for patients with axial spondyloarthritis (SpA). In recent years, treatment options have expanded with the availability of biologic agents, including tumor necrosis factor inhibitors and interleukin‐17 inhibitors. However, a treatment strategy that clearly prevents syndesmo phyte formation has not been established. Observational studies of patients with ankylosing spondylitis indicated potential disease‐modifying effects of NSAIDs, but two randomized trials came to different conclusions. More broadly, whether any of the currently availab...
Source: Arthritis and Rheumatology - February 27, 2020 Category: Rheumatology Authors: Runsheng Wang, Joan M. Bathon, Michael M. Ward Tags: New Perspectives in Rheumatology Source Type: research

Reply
AbstractWe thank Dr. Vuilleumier for his interest in our review paper on high ‐density lipoproteins (HDLs) in systemic lupus erythematosus (SLE) and his comments on anti‐apolipoprotein A‐1 (apoA‐1) autoantibodies. Dr. Vuilleumier raises an important point that the prevalence of high anti‐apoA‐1 IgG levels is not specific to SLE, which we fully agree with. The prev alence of anti‐apoA‐1 autoantibodies in different disease settings has been summarized in Table 1. Inconsistent results could be attributed to the assay‐to‐assay differences introduced by different enzyme‐linked immunosorbent assay (ELISA) a...
Source: Arthritis and Rheumatology - February 27, 2020 Category: Rheumatology Authors: Minzhi Yu, Sang Y. Kim, Emily E. Morin, Anna Schwendeman Tags: REPLY TO LETTER TO THE EDITOR Source Type: research

Reply to letter by Dr. Schoemaker et al
AbstractIn their letter, Dr. Schoemaker et al. highlight the importance of patient and parent involvement in the development of treatment guidelines using an example from the guideline recently developed by the Paediatric Association of The Netherlands. The American College of Rheumatology (ACR) and the team members involved in the recent ACR/Arthritis Foundation (AF) guideline agree that parents and patients have unique and valuable expertise that is necessary for the guideline development process. This response provides some clarifications regarding points made by Dr. Schoemaker et al. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - February 27, 2020 Category: Rheumatology Authors: Sarah Ringold, Suzanne Schrandt, Emily L. Creek, Timothy Beukelman, Sheila T. Angeles ‐Han, Daniel J. Lovell Tags: REPLY TO LETTER TO THE EDITOR Source Type: research

Commentary on a previous review article published by Kim SY et al
AbstractI read with great interest the literature review proposed by Kim SY and colleagues in the Journal issue dedicated to the role of HDL as potential disease biomarkers and therapeutic targets in systemic lupus erythematosus (SLE) (1) and felt that the part dedicated to anti ‐apoA‐I autoantibodies would certainly benefit from the following comments. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - February 27, 2020 Category: Rheumatology Authors: Nicolas Vuilleumier Tags: LETTER TO THE EDITOR Source Type: research

Endothelial and inflammatory biomarker profile at diagnosis reflects clinical heterogeneity of juvenile dermatomyositis and is prognostic for response to treatment in two independent cohorts
AbstractObjectivesIn juvenile dermatomyositis (JDM), a heterogeneous systemic immune ‐mediated vasculopathy, we aim to 1) identify inflammation/endothelial dysfunction‐related biomarker profiles reflecting disease severity at diagnosis; 2) establish if biomarker profiles can predict response to treatment.Methods39 markers related to endothelial activation, dysfunction and inflammation were measured in treatment ‐naive JDM patient serum from two independent cohorts (n=30/n=29) by multiplex technology. Data were analyzed by unsupervised hierarchical clustering, non‐parametric tests with correction for multiple testin...
Source: Arthritis and Rheumatology - February 27, 2020 Category: Rheumatology Authors: Judith Wienke, Lauren M. Pachman, Gabrielle A. Morgan, Joo Guan Yeo, Maria C. Amoruso, Victoria Hans, Sylvia S.M. Kamphuis, Esther P.A.H. Hoppenreijs, Wineke Armbrust, J. Merlijn van den Berg, Petra C.E. Hissink Muller, Kyra A. Gelderman, Thas Tags: FULL LENGTH Source Type: research

Physician Prescribing Patterns and Risk for Future Chronic Opioid Use among Patients with Rheumatoid Arthritis: A Prospective Observational Cohort Study
ConclusionsRates of opioid prescriptions varied widely. Baseline opioid prescribing rates were a strong predictor of whether a patient would become a chronic opioid user in the future, after controlling for patient characteristics. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - February 27, 2020 Category: Rheumatology Authors: Yvonne C Lee, Bing Lu, Hongshu Guan, Jeffrey D Greenberg, Joel Kremer, Daniel H Solomon Tags: FULL LENGTH Source Type: research

Structural entheseal lesions in patients with psoriasis are associated with an increased risk of progression to psoriatic arthritis
ConclusionPresence of structural entheseal lesions as well as low cortical vBMD at entheseal segments are associated with an increased risk of developing PsA in patients with psoriasis. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - February 27, 2020 Category: Rheumatology Authors: David Simon, Koray Tascilar, Arnd Kleyer, Sara Bayat, Eleni Kampylafka, Maria Sokolova, Ana Zevkovic, Axel J Hueber, J ürgen Rech, Louis Schuster, Klaus Engel, Michael Sticherling, Georg Schett Tags: FULL LENGTH Source Type: research

Regulation of the Inflammatory Synovial Fibroblast Phenotype by Metastasis ‐Associated Lung Adenocarcinoma Transcript 1 Long Noncoding RNA in Obese Patients With Osteoarthritis
ObjectiveTo identify long noncoding RNAs (lncRNAs) associated with the inflammatory phenotype of synovial fibroblasts from obese patients with osteoarthritis (OA), and to explore the expression and function of these lncRNAs.MethodsSynovium was collected from normal ‐weight patients with hip fracture (non‐OA; n = 6) and from normal‐weight (n = 8) and obese (n = 8) patients with hip OA. Expression of RNA was determined by RNA‐sequencing and quantitative reverse transcription–polymerase chain reaction. Knockdown of lncRNA was performed using LNA‐based GapmeRs. Synovial fibroblast cytokine production was measur...
Source: Arthritis and Rheumatology - February 27, 2020 Category: Rheumatology Authors: Dominika E. Nanus, Susanne N. Wijesinghe, Mark J. Pearson, Marina R. Hadjicharalambous, Alex Rosser, Edward T. Davis, Mark A. Lindsay, Simon W. Jones Tags: Original Article Source Type: research

Is it useful to repeat magnetic resonance imaging after three months or one year in patients with back pain and suspected axial spondylarthritis?
AbstractBakker et al found a change in the magnetic resonance imaging (MRI) findings in 29 of 188 patients, when the examination was repeated at three months and at one year (1). The patients were all being investigated on account of back pain, with presumably varying degrees of concern about the possibility of inflammatory spondyloarthritis.Twelve (6.8%) patients were negative at the initial examination but became positive on subsequent testing. A percentage that was lower, but not dissimilar to Van Onna et al's report of 15% at two years (2). (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - February 18, 2020 Category: Rheumatology Authors: Gabor Attilla Major Tags: LETTER TO THE EDITOR Source Type: research

Additional analyses to confirm relationship of hydroxychloroquine blood levels to retinopathy: comment on the article by Petri et  al
Arthritis&Rheumatology, EarlyView. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - February 13, 2020 Category: Rheumatology Authors: Wen ‐hui Xie, Zhuo‐li Zhang Tags: Letters Source Type: research

Reply
Arthritis&Rheumatology, EarlyView. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - February 13, 2020 Category: Rheumatology Authors: Michelle Petri, Jessica Li, Laurence S. Magder, Daniel W. Goldman Tags: Letters Source Type: research

Does leukopenia influence performance of the new European League Against Rheumatism/American College of Rheumatology classification criteria in an African ‐descendent population with childhood‐onset systemic lupus erythematosus? Comment on the article by Aringer et al
Arthritis&Rheumatology, EarlyView. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - February 13, 2020 Category: Rheumatology Authors: Adriana R. Fonseca, Marta C. F. Rodrigues, Flavio Sztajnbok, Marcelo G. P. Land, Sheila K. F. Oliveira Tags: Letters Source Type: research

Reply
Arthritis&Rheumatology, EarlyView. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - February 11, 2020 Category: Rheumatology Authors: Martin Aringer, Karen H. Costenbader, Thomas D örner, Sindhu R. Johnson Tags: Letters Source Type: research

Visceral adiposity is associated with pain, but not structural osteoarthritis
ConclusionVisceral fat was associated with an increased risk of musculoskeletal and widespread pain. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - February 11, 2020 Category: Rheumatology Authors: Shanshan Li, Ann V. Schwartz, Michael P. Lavalley, Na Wang, Nancy Desai, Xianbang Sun, Tuhina Neogi, Michael Nevitt, Cora E. Lewis, Ali Guermazi, Frank Roemer, Neil Segal, David Felson, The Multicenter Osteoarthritis Study Group Tags: FULL LENGTH Source Type: research

Type 2 Polarized T Cell Phenotype is Associated with Methotrexate Non ‐response in Patients with Rheumatoid Arthritis
AbstractObjectiveRheumatoid arthritis (RA) is a chronic inflammatory disease mediated through complex immunologic pathways. Approximately half of RA patients exhibit meaningful clinical response within the first 6 months of starting low ‐dose methotrexate (MTX) monotherapy. Whether baseline immune phenotypes differ between subsequent MTX‐responders and non‐responders is unknown. We employed comprehensive T cell immune phenotyping to identify specific immunologic pathways associated with MTX‐non‐responsive joint inflammati on.Methods32 patients with recent ‐onset RA were treated with MTX therapy. After 6 months,...
Source: Arthritis and Rheumatology - February 11, 2020 Category: Rheumatology Authors: Drew Slauenwhite, Sarah M. McAlpine, John G. Hanly, Anik ó Malik, Ian D. Haidl, Jean S. Marshall, Thomas B. Issekutz Tags: FULL LENGTH Source Type: research

Evaluation of financial conflicts of interest among physician ‐authors of American College of Rheumatology clinical practice guidelines
ConclusionsLess than half the US ‐based physician CPG authors received relevant payments. Nonetheless, a substantial proportion of money received was not disclosed. Conflict of interest disclosure is a bare minimum requirement, and more permanent solutions may include divestiture or inclusion of more non‐conflicted authors. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - February 11, 2020 Category: Rheumatology Authors: Cole Wayant, Corbin Walters, Zachary Zaaza, Carrie Gilstrap, Tyler Combs, Hanna Crow, Matt Vassar Tags: FULL LENGTH Source Type: research

Reply
Arthritis&Rheumatology, EarlyView. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - February 11, 2020 Category: Rheumatology Authors: Xiyu Liu, Wanwan Jiang, Ying Wang, Mengyao Sun, Zhibo Li, Zhenke Wen Tags: Letters Source Type: research

Jaccoud's arthropathy
Arthritis&Rheumatology, EarlyView. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - February 11, 2020 Category: Rheumatology Authors: Wen Shi, Yang Jiao Tags: Clinical Image Source Type: research

CD4+ T cells as key players in the immunopathology of Takayasu arteritis: comment on the article by Zhang et al
Arthritis&Rheumatology, EarlyView. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - February 11, 2020 Category: Rheumatology Authors: Ryu Watanabe Tags: Letters Source Type: research

Disease Severity Linked to Increase in Autoantibody Diversity in IgG4 ‐Related Disease
ConclusionAntibodies against prohibitin, annexin A11, and laminin 511 ‐E8 were found in only a small portion of patients with IgG4‐RD. A subset of IgG4‐RD patients, however, had IgG4 antibodies against ≥2 autoantigens. These patients presented with robust IgG subclass elevations, complement consumption, and visceral organ involvement. This broader break in imm unologic tolerance in IgG4‐RD was associated with more severe disease. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - February 11, 2020 Category: Rheumatology Authors: Hang Liu, Cory A. Perugino, Musie Ghebremichael, Zachary S. Wallace, Sydney B. Montesi, John H. Stone, Shiv Pillai Tags: Original Article Source Type: research

Comparative Profiling of Serum Protein Biomarkers in Rheumatoid Arthritis –Associated Interstitial Lung Disease and Idiopathic Pulmonary Fibrosis
ConclusionComparative serum protein biomarker profiling represents a viable method for distinguishing RA ‐ILD from RA–no ILD and identifying population‐specific mediators shared with IPF. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - February 5, 2020 Category: Rheumatology Authors: Daniel J. Kass, Mehdi Nouraie, Marilyn K. Glassberg, Nitya Ramreddy, Karen Fernandez, Lisa Harlow, Yingze Zhang, Jean Chen, Gail S. Kerr, Andreas M. Reimold, Bryant R. England, Ted R. Mikuls, Kevin F. Gibson, Paul F. Dellaripa, Ivan O. Rosas Tags: Original Article Source Type: research

Do serum urate ‐associated genetic variants differentially contribute to gout risk according to body mass index? Analysis of the UK Biobank
AbstractObjectiveTo examine whether urate ‐associated genetic variants differ in their influence on gout risk according to body mass index (BMI).MethodsThis research was conducted using the UK Biobank Resource (n=358,728). Participants were divided into three BMI groups (BMI
Source: Arthritis and Rheumatology - February 5, 2020 Category: Rheumatology Authors: Vicky Tai, Ravi K. Narang, Greg Gamble, Murray Cadzow, Lisa K. Stamp, Tony R. Merriman, Nicola Dalbeth Tags: FULL LENGTH Source Type: research

Ophthalmic inflammation on positron emission tomography in vision ‐threatening giant cell arteritis
AbstractThe patient, a 77 ‐year‐old male with two weeks of bitemporal headache, lethargy and dyspnoea was admitted with findings of large pulmonary emboli. During the admission he developed pyrexia, scalp tenderness, jaw claudication, and elevated inflammatory markers. He reported a 10‐minute episode of sequential bila teral complete vision loss with full recovery. Investigations for suspected transient ischaemic attack including magnetic resonance imaging of the brain and orbits were normal. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - February 5, 2020 Category: Rheumatology Authors: Hugh C. Caterson, Parth R. Shah, Eva A. Wegner, Anthony M. Sammel Tags: CLINICAL IMAGE Source Type: research

Aberrant salience? Brain hyperactivation in response to pain onset and offset in fibromyalgia
ConclusionsOur results suggest that the increased sensitivity exhibited by FM patients in response to painful stimuli may reflect a more generalized hypersensitivity to salient sensory events, and that brain hyperactivation may be a mechanism potentially involved in the generalized hypervigilance to salient stimuli in FM. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - February 5, 2020 Category: Rheumatology Authors: Catherine S. Hubbard, Asimina Lazaridou, Christine M. Cahalan, Jieun Kim, Robert R. Edwards, Vitaly Napadow, Marco L. Loggia Tags: FULL LENGTH Source Type: research

A spatial ‐temporal analysis of organ‐specific lupus flares in relation to atmospheric variables and fine particulate matter pollution
AbstractObjectivesWe performed a spatial ‐time cluster analysis of the Hopkins Lupus Cohort with the goal of identifying potential clusters of SLE organ specific flares and their relation to temperature changes and fine particulate matter pollution (PM2.5).Methods1261 patients who fulfilled the SLICC classification criteria for SLE and who had recorded home addresses were included in the analysis. Disease activity was expressed as the Lupus Activity Index. Assessment of rash, joint involvement, serositis, neurologic, pulmonary, renal, and hematologic activity was quantified on a 0 ‐3 visual analogue scale (VAS). An org...
Source: Arthritis and Rheumatology - February 5, 2020 Category: Rheumatology Authors: George Stojan, Anton Kvit, Frank C. Curriero, Michelle Petri Tags: FULL LENGTH Source Type: research

Tissue ‐Resident Memory T Cells: Sequestered Immune Sensors and Effectors of Inflammation in Spondyloarthritis
Arthritis&Rheumatology, EarlyView. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - February 5, 2020 Category: Rheumatology Authors: Christopher Ritchlin Tags: Editorial Source Type: research

Polyfunctional, Proinflammatory, Tissue ‐Resident Memory Phenotype and Function of Synovial Interleukin‐17A+CD8+ T Cells in Psoriatic Arthritis
This study was undertaken to determine the immunopheno type, molecular profile, and function of synovial Tc17 cells in order to elucidate their role in PsA/SpA pathogenesis.MethodsPeripheral blood (PB) and SF mononuclear cells were isolated from patients with PsA or other types of SpA. Cells were phenotypically, transcriptionally, and functionally analyzed by flow cytometry (n = 6 –18), T cell receptor β (TCRβ) sequencing (n = 3), RNA‐Seq (n = 3), quantitative reverse transcriptase–polymerase chain reaction (n = 4), and Luminex or enzyme‐linked immunosorbent assay (n = 4–16).ResultsIL ‐17A...
Source: Arthritis and Rheumatology - February 5, 2020 Category: Rheumatology Authors: Kathryn J. A. Steel, Ushani Srenathan, Michael Ridley, Lucy E. Durham, Shih ‐Ying Wu, Sarah E. Ryan, Catherine D. Hughes, Estee Chan, Bruce W. Kirkham, Leonie S. Taams Tags: Original Article Source Type: research

Muscle weakness in myositis: microRNAs mediate dystrophin reduction in MHC class I transgenic mouse model and human muscle biopsies
AbstractObjectiveMuscle inflammation is a feature in myositis and Duchenne Muscular Dystrophy (DMD). Autoimmune mechanisms are thought to contribute to myositis muscle weakness. However, the lack of correlation between inflammatory infiltrates and muscle weakness indicates a role for non ‐immune pathological mechanisms. We previously identified two microRNA sets elevated in DMD muscle. One is an “inflammatory” set that is dampened with glucocorticoids; the other is a “dystrophin‐targeting” set that inhibits dystrophin translation. Here we test the hypothesis that these m iRNAs are similarly dysr...
Source: Arthritis and Rheumatology - February 3, 2020 Category: Rheumatology Authors: Travis B. Kinder, Christopher R. Heier, Christopher B. Tully, Jack H. Van der Muelen, Eric P. Hoffman, Kanneboyina Nagaraju, Alyson A. Fiorillo Tags: FULL LENGTH Source Type: research

Teenaged Boy With Lipoma Arborescens of the Knee and Elbow and Presumed Juvenile Idiopathic Arthritis
Arthritis&Rheumatology, Volume 72, Issue 2, Page 315-315, February 2020. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - January 29, 2020 Category: Rheumatology Authors: Cody S. Dail, Kelly R. Dietz, Michael A. Murati, Colleen K. Correll Tags: Clinical Image Source Type: research

Issue Information
Arthritis&Rheumatology, Volume 72, Issue 2, February 2020. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - January 29, 2020 Category: Rheumatology Tags: Issue Information Source Type: research

Clinical Connections
Arthritis&Rheumatology, Volume 72, Issue 2, February 2020. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - January 29, 2020 Category: Rheumatology Tags: Clinical Connections Source Type: research

ACR Announcements
Arthritis&Rheumatology, Volume 72, Issue 2, February 2020. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - January 29, 2020 Category: Rheumatology Tags: ACR Announcements Source Type: research

In This Issue
Arthritis&Rheumatology, Volume 72, Issue 2, February 2020. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - January 29, 2020 Category: Rheumatology Tags: In This Issue Source Type: research

Sarcoid dactylitis
AbstractA 74 year ‐old woman was diagnosed with sarcoidosis in 2012 with cutaneous and pulmonary granulomatous lesions, as well as mediastinal lymph nodes. She was initially treated with topical steroids, hydroxychloroquine, and minocycline for cutaneous lesions with poor efficacy over time. In 2018, thalidomide wa s started for unsightly cutaneous sarcoids on the face and hands. This treatment was discontinued in March 2019 due to hepatitis. The cutaneous sarcoids became painful, especially on the fingers with progressive dactylitis (Figure 1). (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - January 28, 2020 Category: Rheumatology Authors: Victor H émar, Estibaliz Lazaro, Thylbert Deltombe, Gonzague Martin‐Lecamp, Irène Machelart, Jean‐François Viallard, Carine Greib, Etienne Rivière Tags: CLINICAL IMAGE Source Type: research

Role of Low ‐density Lipoprotein in Early Vascular Aging Associated With Systemic Lupus Erythematosus
AbstractObjectivePatients with systemic lupus erythematosus (SLE) often have atherosclerotic complications at a young age but normal low ‐density lipoprotein (LDL) levels. We investigated the role of LDL composition in promoting early vascular aging in SLE patients.MethodsWe chromatographically divided plasma LDL from 45 SLE patients (SLE ‐LDL) and 37 normal controls (N‐LDL) into 5 subfractions (L1‐L5) and analyzed their composition. Correlations between subfraction levels and signs of early vascular aging were assessed. Invitro assays and mice were used to identify mechanisms of lipid ‐mediated endothelial dysfu...
Source: Arthritis and Rheumatology - January 28, 2020 Category: Rheumatology Authors: Hua ‐Chen Chan, Hsiu‐Chuan (Bonnie) Chan, Chan‐Jung Liang, Hsiang‐Chun Lee, Hung Su, An‐Sheng Lee, Jentaie Shiea, Wen‐Chan Tsai, Tsan‐Teng Ou, Cheng‐Chin Wu, Chih‐Sheng Chu, Richard A. Dixon, Liang‐Yin Ke, Jeng‐Hsien Yen Tags: FULL LENGTH Source Type: research

Spontaneous Pulmonary Hypertension Associated With Systemic Sclerosis in P ‐Selectin Glycoprotein Ligand 1–Deficient Mice
ConclusionThe absence of PSGL ‐1 induces a reduction in Treg cells, NO production, and ERα expression and causes an increase in Ang II in the lungs of female mice, favoring the development of PAH. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - January 28, 2020 Category: Rheumatology Authors: Rafael Gonz ález‐Tajuelo, María Fuente‐Fernández, Daniel Morales‐Cano, Antonio Muñoz‐Callejas, Elena González‐Sánchez, Javier Silván, Juan Manuel Serrador, Susana Cadenas, Bianca Barreira, Marina Espartero‐Santos, Carlos Gamal Tags: Original Article Source Type: research

The first epidemiologic perspective on takotsubo syndrome in patients with Takayasu arteritis and its impact on inpatient outcomes: comment on the report by Lim et al
Arthritis&Rheumatology, EarlyView. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - January 27, 2020 Category: Rheumatology Authors: Rupak Desai, Sandeep Singh, Rajesh Sachdeva, Gautam Kumar Tags: Letters Source Type: research

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Arthritis&Rheumatology, EarlyView. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - January 27, 2020 Category: Rheumatology Authors: Sen Hee Tay, D. P. S. Dissanayake, Shir Lynn Lim, Weiqin Lin Tags: Letters Source Type: research

Improved Mitochondrial Metabolism and Reduced Inflammation Following Attenuation of Murine Lupus With Coenzyme Q10 Analog Idebenone
This study was undertaken to assess whether idebenone ameliorates lupus in murine models.MethodsIdebenone was administered orally to MRL/lpr mice at 2 different doses (1 gm/kg or 1.5 gm/kg idebenone ‐containing diet) for 8 weeks. At peak disease activity, clinical, immunologic, and metabolic parameters were analyzed and compared to those in untreated mice (n = 10 per treatment group). Results were confirmed in the lupus‐prone NZM2328 mouse model.ResultsIn MRL/lpr mice, idebenone ‐treated mice showed a significant reduction in mortality incidence (P
Source: Arthritis and Rheumatology - January 27, 2020 Category: Rheumatology Authors: Luz P. Blanco, Hege L. Pedersen, Xinghao Wang, Ya íma L. Lightfoot, Nickie Seto, Carmelo Carmona‐Rivera, Zu‐Xi Yu, Victoria Hoffmann, Peter S. T. Yuen, Mariana J. Kaplan Tags: Original Article Source Type: research

Multicenter Prospective Study of the Efficacy and Safety of Combined Immunosuppressive Therapy With High ‐Dose Glucocorticoid, Tacrolimus, and Cyclophosphamide in Interstitial Lung Diseases Accompanied by Anti–Melanoma Differentiation–Associated Gene 5–Positive Dermatomyositis
ObjectiveInterstitial lung disease (ILD) accompanied by anti –melanoma differentiation–associated gene 5 (anti–MDA‐5)–positive dermatomyositis (DM) is often rapidly progressive and associated with poor prognosis. Because there is no established treatment, we undertook this study to prospectively evaluate the efficacy and safety of a combined immunos uppressive regimen for anti–MDA‐5–positive DM patients with ILD.MethodsAdult Japanese patients with new ‐onset anti–MDA‐5–positive DM with ILD (n = 29) were enrolled at multiple study centers from 2014 to 2017. They were t...
Source: Arthritis and Rheumatology - January 27, 2020 Category: Rheumatology Authors: Hideaki Tsuji, Ran Nakashima, Yuji Hosono, Yoshitaka Imura, Masato Yagita, Hajime Yoshifuji, Shintaro Hirata, Takaki Nojima, Eiji Sugiyama, Kazuhiro Hatta, Yoshio Taguchi, Masaki Katayama, Kiminobu Tanizawa, Tomohiro Handa, Ryuji Uozumi, Sh Tags: Original Article Source Type: research