Archives of Disease in Childhood - Fetal and Neonatal Edition This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Early-onset sepsis in very preterm neonates in Australia and New Zealand, 2007-2018
Conclusion Early-onset sepsis remains an important condition among very preterm populations. Furthermore, E. coli is a dominant microorganism of very preterm early-onset sepsis in Australia and New Zealand. Rates of E. coli have been increasing in recent years, while GBS-associated mortality has decreased. (Source: Archives of Disease in Childhood - Fetal and Neonatal Edition)
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - December 15, 2022 Category: Perinatology & Neonatology Authors: Duggan, H. L., Chow, S. S. W., Austin, N. C., Shah, P. S., Lui, K., Tan, K., on behalf of the Australian and New Zealand Neonatal Network Tags: Original research Source Type: research

Clinical outcomes of preterm infants while using automated controllers during standard care: comparison of cohorts with different automated titration strategies
Conclusions In this propensity score-matched retrospective study, the OxyGenie epoch was associated with less morbidity when compared with the CLiO2 epoch. There were significantly fewer infants that received treatment for ROP, received less intensive respiratory support and, although there were more supplemental oxygen days, the duration of stay in the NICU was shorter. A larger study will have to replicate these findings. (Source: Archives of Disease in Childhood - Fetal and Neonatal Edition)
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - December 15, 2022 Category: Perinatology & Neonatology Authors: Salverda, H. H., Beelen, D. M. L., Cramer, S. J. E., Pauws, S. C., Schalij-Delfos, N., te Pas, A. B. Tags: Original research Source Type: research

Short-term pulmonary and systemic effects of hydrocortisone initiated 7-14 days after birth in ventilated very preterm infants: a secondary analysis of a randomised controlled trial
Conclusions Systemic hydrocortisone initiated between 7 and 14 days after birth in ventilated preterm infants improves pulmonary condition, thereby facilitating weaning and extubation from invasive ventilation. The effects of hydrocortisone on blood glucose levels and blood pressure were mild and of limited clinical relevance. Trial registration number Netherlands Trial Register (NTR2768; https://www.trialregister.nl/trial/2640) and European Union Clinical Trials Register (EudraCT, 2010-023777-19). (Source: Archives of Disease in Childhood - Fetal and Neonatal Edition)
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - December 15, 2022 Category: Perinatology & Neonatology Authors: Halbmeijer, N. M., Onland, W., Cools, F., Kroon, A., van der Heide-Jalving, M., Dijk, P., van Straaten, H. L. M., te Pas, A. B., Mohns, T., Bruneel, E., van Heijst, A. F. J., Kramer, B., Debeer, A., Zonnenberg, I. A., Marechal, Y., Blom, H., Plaskie, K., Tags: Original research Source Type: research

Comparison of regional versus global growth charts for the classification of small-for-gestational age neonates
Conclusions Compared with AIIMS and Lubchenco charts, Intergrowth 21st runs the risk of overdiagnosing SGA neonates who may not be at a higher risk of short-term morbidities. (Source: Archives of Disease in Childhood - Fetal and Neonatal Edition)
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - December 15, 2022 Category: Perinatology & Neonatology Authors: Anand, P., Thomas, D., Agarwal, R., Thukral, A., Deorari, A. K., Paul, V. K., Sankar, M. J. Tags: Original research Source Type: research

Whats new in the management of neonatal early-onset sepsis?
The expert guidelines highlighted in this review provide an evidence-based framework for approaching at-risk infants and allow for a more limited and standardised approach to antibiotic use. While these guidelines have significantly reduced antibiotic utilisation worldwide, optimally each unit would individualise their approach to early onset sepsis (EOS) based on the neonatal population they serve and available resources. As advancements in EOS research continue and limitations with sepsis prediction tools are addressed, it is inevitable that our risk stratification and management guidelines will become more precise. (Sou...
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - December 15, 2022 Category: Perinatology & Neonatology Authors: Fleiss, N., Schwabenbauer, K., Randis, T. M., Polin, R. A. Tags: Editor's choice Reviews Source Type: research

Optimising growth in very preterm infants: reviewing the evidence
This article offers a narrative review of recent evidence for the competing definitions of optimal growth in this cohort. It examines recent advances in the determination of macronutrient and micronutrient intake targets along with common barriers to achieving good nutrition and growth. Finally, key implications for clinical practice are set out and a recommendation for structured multidisciplinary management of nutrition and growth is illustrated. (Source: Archives of Disease in Childhood - Fetal and Neonatal Edition)
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - December 15, 2022 Category: Perinatology & Neonatology Authors: Young, A., Beattie, R. M., Johnson, M. J. Tags: Reviews Source Type: research

Fantoms
What’s new in the management of neonatal early-onset sepsis? Noa Fleiss and colleagues compare and contrast professional guidelines for the management of early onset neonatal sepsis from the UK and the USA. Although these are evidence based, the limitations of the evidence are such that several different approaches combining risk factors and clinical findings are supported that are associated with marked differences in the proportion of infants who are considered to require investigation and treatment. None is clearly superior and none will identify all affected infants before they become ill, so clinical vigilance i...
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - December 15, 2022 Category: Perinatology & Neonatology Authors: Stenson, B. J. Tags: Highlights from this issue Source Type: research

Nicolau syndrome or 'embolia cutis medicamentosa in a newborn: successful treatment with a surgical intervention
A 3-day-old male newborn was referred to a quaternary hospital with pain, pallor and cyanosis of the left lower limb for the past 2 days of admission. These signs and symptoms started immediately after intramuscular injection of 50 000 IU of benzathine penicillin G at the lateral face of his left thigh to treat possible congenital syphilis. After diagnosis of acute compartment syndrome secondary to Nicolau syndrome (NS) (figure 1A), the assistant team immediately performed a fasciotomy of the left lower limb (figure 1B). After the procedure, unfractionated heparin, prostaglandin and antibiotics were administered, and the p...
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - October 19, 2022 Category: Perinatology & Neonatology Authors: Santos, B. C., Correia, R. M., Kuramoto, D. A. B., Carvalho, A. A. G., Avila, R. B., Amorim, J. E., Flumignan, R. L. G., Nakano, L. C. U. Tags: Images in neonatal medicine Source Type: research

Efficacy of occlusive wraps used for delivery room care
Discussion Large differences in heat and water retention capacity warrant a careful choice of the type of wrap as some might be counterproductive. Wraps containing polyurethane should not be used. (Source: Archives of Disease in Childhood - Fetal and Neonatal Edition)
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - October 19, 2022 Category: Perinatology & Neonatology Authors: Reuter, C., Ehlers, F., Vana, P., Küster, H. Tags: Open access Short reports Source Type: research

Congenital self-healing reticulohistiocytosis in a neonate
A full-term 1-day-old boy was admitted to the neonatal intensive care unit for assessment of clustered purplish brown rashes on the right foot (figure 1A,B) since birth. There was no mucous membrane lesion, hepatosplenomegaly or lymphadenopathy. He was born by spontaneous vaginal delivery at 38+5 weeks of gestation to a healthy mother without perinatal infections. A punch biopsy revealed a dense infiltration of Langerhans cells with increased eosinophils in the dermis (figure 1C), which was confirmed by immunohistochemical staining with S100, CD1a and langerin (CD207). Complete blood counts, liver function tests, urinalysi...
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - October 19, 2022 Category: Perinatology & Neonatology Authors: Zhang, B., Weng, J., Ma, L. Tags: Images in neonatal medicine Source Type: research

Online clinical tool to estimate risk of bronchopulmonary dysplasia in extremely preterm infants
Conclusion The probability of BPD or death in extremely preterm infants can be estimated with reasonable accuracy using a limited amount of readily available clinical information. This tool may aid clinical prognostication, future research, and center-specific quality improvement surrounding BPD prevention. Trial registration number NCT00063063 (Source: Archives of Disease in Childhood - Fetal and Neonatal Edition)
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - October 19, 2022 Category: Perinatology & Neonatology Authors: Greenberg, R. G., McDonald, S. A., Laughon, M. M., Tanaka, D., Jensen, E., Van Meurs, K., Eichenwald, E., Brumbaugh, J. E., Duncan, A., Walsh, M., Das, A., Cotten, C. M., On behalf of Eunice Kennedy Shriver National Institute of Child Health and Human Dev Tags: Original research Source Type: research

Congenital cutaneous candidiasis in one infant among a twin sibling pair
Two infants were delivered by an emergency cesarean section at 27 weeks of gestation due to active labour in a woman with dichorionic diamniotic twin pregnancy. Candida albicans had already been detected in the mother’s vaginal culture. In the uterus, the patient was located on the vaginal side without premature rupture of the membrane. At birth, the patient (a male infant) had diffuse erythema, pustules, papules and desquamation all over his body (figure 1). The other infant had no skin lesions (figure 2). Mycelial growth was confirmed by direct potassium hydroxide microscopy of the skin lesion; therefore, intraveno...
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - October 19, 2022 Category: Perinatology & Neonatology Authors: Akutsu, A., Otsubo, Y., Suzumura, H., Yoshihara, S. Tags: Images in neonatal medicine Source Type: research

Vestibular and balance dysfunction in children with congenital CMV: a systematic review
Conclusions Vestibular dysfunction is found in children with symptomatic and asymptomatic cCMV and in those with and without hearing loss. Audiovestibular assessments should be performed as part of neurodevelopmental follow-up in children with cCMV. Case–controlled longitudinal studies are required to more precisely characterise vestibular dysfunction and help determine the efficacy of early supportive interventions. PROSPERO registration CRD42019131656. (Source: Archives of Disease in Childhood - Fetal and Neonatal Edition)
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - October 19, 2022 Category: Perinatology & Neonatology Authors: Shears, A., Yan, G., Mortimer, H., Cross, E., Sapuan, S., Kadambari, S., Luck, S., Heath, P. T., Walter, S., Fidler, K. J. Tags: Open access Original research Source Type: research

Effects of the SARS-CoV-2 pandemic on perinatal activity in Yorkshire and the Humber region during 2020: an interrupted time series analysis
Conclusions Lower rates of antenatal transfer and extreme preterm birth were identified, alongside an apparent increase in stillbirth over time. The findings provide evidence that effects on perinatal activity related to the pandemic changed over time. (Source: Archives of Disease in Childhood - Fetal and Neonatal Edition)
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - October 19, 2022 Category: Perinatology & Neonatology Authors: Morgan, A. S., Bradford, C., Farrow, H., Draper, E. S., Harrison, C. Tags: COVID-19 Original research Source Type: research

SIDS is associated with prenatal drug use: a meta-analysis and systematic review of 4 238 685 infants
Conclusion Exposure to any drug of dependency during pregnancy is associated with an increased risk of SIDS after controlling for socioeconomic factors. Further study to evaluate mechanisms and contribution of other confounders (eg, smoking) is warranted. (Source: Archives of Disease in Childhood - Fetal and Neonatal Edition)
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - October 19, 2022 Category: Perinatology & Neonatology Authors: Makarious, L., Teng, A., Oei, J. L. Tags: Original research Source Type: research