Archives of Disease in Childhood - Fetal and Neonatal Edition This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Laryngeal mask airway versus face mask ventilation or intubation for neonatal resuscitation in low-and-middle-income countries: a systematic review and meta-analysis
Conclusion LMA is more effective than FM in delivering PPV with less failure rates and reduced need for intubation during neonatal resuscitation in term infants and in LMIC without any difference in the incidence of encephalopathy or death. Studies comparing LMA to ETT are scarce with important methodological limitations. PROSPERO registration number CRD42021283478. (Source: Archives of Disease in Childhood - Fetal and Neonatal Edition)
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - February 17, 2023 Category: Perinatology & Neonatology Authors: Diggikar, S., Krishnegowda, R., Nagesh, K. N., Lakshminrusimha, S., Trevisanuto, D. Tags: Original research Source Type: research

Growth trajectory during the first 1000 days and later overweight in very preterm infants
Conclusions Change in length Z-score during hospitalisation, a putative proxy of quality of neonatal growth, was negatively associated with risk of later OWO when change in BMI between discharge and at 2 years was included in the multivariable model. (Source: Archives of Disease in Childhood - Fetal and Neonatal Edition)
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - February 17, 2023 Category: Perinatology & Neonatology Authors: Simon, L., Hadchouel, A., Arnaud, C., Frondas-Chauty, A., Marret, S., Flamant, C., Darmaun, D., Delacourt, C., Marchand-Martin, L., Ancel, P. Y., Roze, J.-C. Tags: Original research Source Type: research

Bronchopulmonary dysplasia and neurobehavioural outcomes at birth and 2 years in infants born before 30 weeks
Conclusions BPD severity presents risks for poor neurodevelopment at NICU discharge and at age 2 years. Early identification of poorly regulated behaviour can provide critical information for early preventive and targeted interventions with potential to improve long-term outcomes. (Source: Archives of Disease in Childhood - Fetal and Neonatal Edition)
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - February 17, 2023 Category: Perinatology & Neonatology Authors: Martin, M., Smith, L., Hofheimer, J. A., McGowan, E. C., O'Shea, T. M., Pastyrnak, S., Carter, B. S., Helderman, J., Check, J., Neal, C., Roberts, M. B., Dansereau, L. M., Della Grotta, S. A., Lester, B. M. Tags: Original research Source Type: research

Cheap, easily replicable neonatal chest drain model
When setting up a local neonatal training day we wanted to create an easily reproducible, cheap but realistic enough model for Seldinger pigtail chest drain insertion. Chest drain training manikins are prohibitively expensive for most departments. Using animal carcasses, although realistic, may not be practical or palatable to all individuals, and previous articles describing various do-it-yourself approaches1 2 still involved specialised materials and significant degrees of construction. Our solution was the ‘pepper chest’, which is easily constructed with commonly available materials—a bell pepper and a...
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - February 17, 2023 Category: Perinatology & Neonatology Authors: Winckworth, L. C. Tags: Images in neonatal medicine Source Type: research

Automatic oxygen control for reducing extremes of oxygen saturation: a randomised controlled trial
Conclusion A-Fio2 was associated with statistically significant reduction in the percentage of time spent in severe hypoxaemia when compared with M-Fio2 in preterm infants receiving respiratory support. Trial registration number NCT04223258. (Source: Archives of Disease in Childhood - Fetal and Neonatal Edition)
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - February 17, 2023 Category: Perinatology & Neonatology Authors: Nair, V., Kannan Loganathan, P., Lal, M. K., Pringleton, H., Bachman, T. E., Brodlie, M., Dixon, P. Tags: Original research Source Type: research

Low dose paracetamol for management of patent ductus arteriosus in very preterm infants: a randomised non-inferiority trial
Conclusion In very preterm infants on significant respiratory support, low dose-short course intravenous paracetamol treatment was non-inferior to a conventional dosing regime of paracetamol for closure of hsPDA in the first week of postnatal age. Larger studies with narrow margins of non-inferiority are required to confirm our findings. Trial registration number CTRI/2017/10/010012. (Source: Archives of Disease in Childhood - Fetal and Neonatal Edition)
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - February 17, 2023 Category: Perinatology & Neonatology Authors: Balasubramanian, H., Jain, V., Bhalgat, P., Parikh, S., Kabra, N., Mohan, D., Sheth, K. Tags: Original research Source Type: research

Perinatal onset of severe congenital erythropoietic porphyria
Female full-term (39 weeks’ gestation) neonate born of non-consanguineous healthy young white couple is admitted to neonatal intensive care unit with an acute respiratory distress syndrome. Prenatal ultrasound at 25 weeks of gestation revealed an increased nuchal translucency and a myocardial hypertrophy. The antenatal explorations found no aetiology (fetal DNA was analysed by comparative genomic hybridisation-array platform). At birth, she had multiple ecchymosis all over her body, her skin coloration was grey (figure 1) and her urine reddish (figure 2). Initial laboratory data demonstrated pancytopenia, high serum ...
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - February 17, 2023 Category: Perinatology & Neonatology Authors: Khalouaoui, A., Piarroux, J., Sorin, G., Oger, M., Nicaise, C., Tosello, B. Tags: Images in neonatal medicine Source Type: research

Outcome at 4.5 years after dextrose gel treatment of hypoglycaemia: follow-up of the Sugar Babies randomised trial
Conclusions Treatment of neonatal hypoglycaemia (<2.6 mol/L) with dextrose gel does not alter neurosensory impairment at 4.5 years. However, further assessment of visual processing and growth may be warranted. Trial registration number ACTRN1260800062392. (Source: Archives of Disease in Childhood - Fetal and Neonatal Edition)
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - February 17, 2023 Category: Perinatology & Neonatology Authors: Harris, D. L., Gamble, G. D., Harding, J. E., on behalf of the CHYLD Study Group Tags: Original research Source Type: research

Early-onset neonatal sepsis in the Paris area: a population-based surveillance study from 2019 to 2021
Conclusion In neonates ≥34 WG born in the Paris area, GBS was twice as frequent as E. coli in term infants. EOS was six times more frequent in late preterm than in term infants and was due to E. coli in 60% of cases. Prevention of GBS EOS and empiric antibiotic treatment of EOS could be improved. (Source: Archives of Disease in Childhood - Fetal and Neonatal Edition)
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - February 17, 2023 Category: Perinatology & Neonatology Authors: Sikias, P., Biran, V., Foix-L'Helias, L., Plainvert, C., Boileau, P., Bonacorsi, S., the EOS study group Tags: Open access Original research Source Type: research

Caffeine to prevent intermittent hypoxaemia in late preterm infants: randomised controlled dosage trial
Conclusion Caffeine reduces IH in late preterm infants at 2 weeks of age, with 20 mg/kg/day being the most effective dose. Trial registration number ACTRN12618001745235. (Source: Archives of Disease in Childhood - Fetal and Neonatal Edition)
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - February 17, 2023 Category: Perinatology & Neonatology Authors: Oliphant, E. A., McKinlay, C. J., McNamara, D., Cavadino, A., Alsweiler, J. M. Tags: Open access Original research Source Type: research

Future of clinical trials in the delivery room: time for pragmatism
Despite increased amounts of research, most of the evidence that supports treatment of newborns in the delivery room is rated ‘low’ rather than ‘high’ quality. This assessment stems largely from a lack of evidence from clinical trials. When trials have been performed, the evidence has often been downgraded due to enrolment of small or poorly representative samples, and for lack of blinding of caregivers and outcome assessors. Delivery room trials present particular challenges when obtaining consent, enrolling participants, taking measures to limit bias and identifying appropriate outcome measures. W...
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - February 17, 2023 Category: Perinatology & Neonatology Authors: O'Donnell, C. P. F., Dekker, J., Rüdiger, M., te Pas, A. B. Tags: Reviews Source Type: research

Ductus arteriosus and the preterm brain
As the approach to the patent ductus arteriosus (PDA) in the preterm infant remains controversial, the potential consequences of a significant ductal shunt on the brain should be evaluated. In this population at high risk of adverse outcomes, including intraventricular haemorrhage and white matter injury, as well as longer-term neurodevelopmental impairment, it is challenging to attribute sequelae to the PDA. Moreover, individual patient characteristics including gestational age and timing of PDA intervention factor into risks of brain injury. Haemodynamic assessment of the ductus combined with bedside neuromonitoring tech...
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - February 17, 2023 Category: Perinatology & Neonatology Authors: Chock, V. Y., Bhombal, S., Variane, G. F. T., Van Meurs, K. P., Benitz, W. E. Tags: Reviews Source Type: research

Fantoms
Caffeine for late preterm infants? Elizabeth Oliphant and colleagues report the outcomes of a double-blind placebo controlled randomised dosage trial of caffeine for late preterm infants. Their focus was on finding a suitable dose to prevent intermittent hypoxaemic (IH) events between 34 weeks gestation and term equivalent age in infants born between 34+0 and 36+6 weeks gestation. Intermittent hypoxic events were defined as falls in SpO2 of 10% or more lasting less than 2 min. Four dosing regimens were evaluated. Compared with placebo, IH was significantly reduced in the combined groups of infants treated with caffeine. Th...
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - February 17, 2023 Category: Perinatology & Neonatology Authors: Stenson, B. J. Tags: Highlights from this issue Source Type: research

Response to: 'Comment on 'Direct swallowing training and oral sensorimotor stimulation in preterm infants: a randomised controlled trial by Heo et al by Harding et al
We would like to thank Harding et al for their comments on our paper.1 However, contrary to their understanding, the combined direct swallowing training (DST) and oral sensorimotor stimulation group in our study reached independent oral feeding at 35+1 weeks’ postmenstrual age (PMA), which was earlier than the DST group of our study as well as that of Lau and Smith’s study.2 And even when only the DST groups of the two studies were compared, the DST group of our study reached the independent oral feeding earlier than that of Lau and Smith’s study.2 These results might be related to the timing of initiatio...
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - December 15, 2022 Category: Perinatology & Neonatology Authors: Heo, J. S., Kim, E.-K., Kim, S. Y., Song, I. G., Yoon, Y. M., Cho, H., Lee, E. S., Shin, S. H., Oh, B.-M., Shin, H. I., Kim, H.-S. Tags: PostScript Source Type: research

Healthcare professionals views to inform revision of the BAPM newborn early warning trigger and track system
Early identification of impending deterioration could prevent irreversible damage and save life of vulnerable newborn infants.1 Inspired by the popular implementation of early warning scores (EWS) and trigger and track charts in other areas, similar tools were designed for newborn infants. In 2015, the British Association of Perinatal Medicine (BAPM) published a framework for practice: the BAPM Newborn Early Warning Trigger and Track (NEWTT) chart. This framework is being revised. A review of EWS in neonates found four tools, all based on limited evidence and none adequately validated.2 For many clinical questions, publish...
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - December 15, 2022 Category: Perinatology & Neonatology Authors: Ojha, S., MacAllister, K., Abdula, S., Madar, J., Rackham, O., Tyler, W. Tags: PostScript Source Type: research