Archives of Disease in Childhood - Fetal and Neonatal Edition This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Fantoms
Outcomes of preterm infants In 2010, the Dutch practice regarding initiation of active treatment in extremely preterm infants was lowered from 25 completed weeks’ to 24 completed weeks’ gestation. The Editor’s choice for this issue is the EPI-DAF study, reported by Pauline E van Beek and colleagues. The study provides contemporary population-based neurodevelopmental outcome data for all Dutch live-born infants, born between 240/7 weeks’ and 266/7 weeks’ gestational age, who reached 2 years’ corrected age in 2018–2020. Assessments included medical history taking, physical and neurol...
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - August 18, 2022 Category: Perinatology & Neonatology Authors: Stenson, B. J. Tags: Highlights from this issue Source Type: research

Neonatal outcome following maternal infection with SARS-CoV-2 in Germany: COVID-19-Related Obstetric and Neonatal Outcome Study (CRONOS)
SARS-CoV-2 infections in pregnant women and the consequences for their offspring are summarised in various reviews,1 2 but data on the impact of time of SARS-CoV-2 infection during pregnancy on neonatal morbidity are still inconclusive.3 4 CRONOS (COVID-19-Related Obstetric and Neonatal Outcome Study) is a prospective German registry enrolling pregnant women with confirmed SARS-CoV-2 infection during their pregnancy.5 SARS-CoV-2 infection is defined as detection of viral RNA by PCR testing or detection of maternal SARS-CoV-2 antibodies. Neonatal infection is defined as detection of viral RNA by PCR testing of a nasopharyng...
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - June 17, 2022 Category: Perinatology & Neonatology Authors: Mand, N., Iannaccone, A., Longardt, A.-C., Hutten, M., Mense, L., Oppelt, P., Maier, R. F., Pecks, U., Rüdiger, M., on behalf of the CRONOS Network Tags: COVID-19 PostScript Source Type: research

Neonatal videolaryngoscopy: a new scope offering improved direct airway views
Neonatal intubation is currently a mandatory skill to acquire for all paediatric trainees in the UK.1 In recent years, the opportunity for junior trainees to learn this challenging skill is diminishing, in part due to changing practices in the respiratory management of preterm infants and the popularity of less invasive surfactant administration techniques. As such, each intubation attempt needs to be a valuable learning experience for the trainee, which is safe for the patient. Videolaryngoscopy has been shown to improve neonatal intubation success rates when used as a training tool,2 but trainees may still need to intuba...
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - June 17, 2022 Category: Perinatology & Neonatology Authors: Kirolos, S., O'Shea, J. Tags: PostScript Source Type: research

Impact of human donor milk on maternal milk use at discharge: assessment using control charts
The number of human milk banks is increasing around the world.1 In many countries, preterm infants born at <32 weeks’ gestation routinely receive donor milk as supplementary feeds. High-quality evidence supports this practice in reducing the risk of necrotising enterocolitis.2 However, there are concerns donor milk could displace lactation support with unintentional adverse effects on maternal breastfeeding rates on discharge home.1 A recent systematic review found small improvements in any breastmilk intake on discharge. Pooled estimates of four observational studies examining this outcome preintroduction and pos...
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - June 17, 2022 Category: Perinatology & Neonatology Authors: Keir, A. K., Summers, L., Gillis, J., McPhee, A. J., Rumbold, A. Tags: PostScript Source Type: research

Oral cavity masses in a newborn
A term healthy female baby born via normal vaginal delivery was referred to us for oral cavity masses noticed soon after birth. On examination, there were two pedunculated red round masses attached to hard palate near the gingiva with no other associated anomalies (figure 1). All antenatal scans of the mother were normal. Based on the clinical examination, diagnosis of congenital epulis (CE) was made and the patient was scheduled for surgical correction. Excision of the masses followed by cauterisation of the peduncles was done under general anaesthesia. Postoperatively, diagnosis was confirmed by histological exam (H&...
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - June 17, 2022 Category: Perinatology & Neonatology Authors: Rai, V. K., Kumar, A. Tags: Images in neonatal medicine Source Type: research

Timing of neonatal stoma closure: a survey of health professional perspectives and current practice
In this study, we aimed to establish current practice and illustrate multidisciplinary perspectives on timing of stoma closure using an online survey sent to all 27 UK neonatal surgical units, as part of a research programme to determine the feasibility of a clinical trial comparing ‘early’ and ‘late’ stoma closure. 166 responses from all 27 units demonstrated concordance of opinion in target time for closure (6 weeks most commonly stated across scenarios), although there was a high variability in practice. A sizeable proportion (41%) of respondents use weight, rather than time, to determine when to...
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - June 17, 2022 Category: Perinatology & Neonatology Authors: Ducey, J., Kennedy, A. M., Linsell, L., Woolfall, K., Hall, N. J., Gale, C., Battersby, C., Penman, G., Knight, M., Lansdale, N. Tags: Open access Short reports Source Type: research

Pericardial effusion and pulmonary vein stenosis in severe bronchopulmonary dysplasia
A female infant with antenatally diagnosed trisomy 21 was delivered at 27 weeks. She was intubated at birth and given surfactant. A day 3 echocardiogram three showed a structurally normal heart, but severe pulmonary hypertension (PH). She required oscillation, nitric oxide and inotropes. At 1 week, she developed necrotising enterocolitis (NEC) and a perforation requiring resection and ileostomy formation. A subsequent echocardiogram showed resolved PH. She was extubated on day 34 and weaned to nasal cannulae oxygen by day 80. At 42 weeks post-conceptual age, she acutely deteriorated with increasing oxygen requirement needi...
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - June 17, 2022 Category: Perinatology & Neonatology Authors: Williams, E. E., Nanjundappa, M., Babla, K., Wong, J., Dassios, T., Greenough, A. Tags: Images in neonatal medicine Source Type: research

Five-minute Apgar score and outcomes in neonates of 24-28 weeks gestation
Conclusions In neonates of 24–28 weeks’ gestation admitted to neonatal units, higher 5 min Apgar score was associated with lower mortality in a graded manner, while the association with SNI remained relatively constant at all scores. Among survivors, low Apgar scores did not predict SNI. (Source: Archives of Disease in Childhood - Fetal and Neonatal Edition)
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - June 17, 2022 Category: Perinatology & Neonatology Authors: Shah, P. S., Norman, M., Rusconi, F., Kusuda, S., Reichman, B., Battin, M., Bassler, D., Modi, N., Hakansson, S., Yang, J., Lee, S. K., Helenius, K., Vento, M., Lehtonen, L., Adams, M., Isayama, T., Lui, K., Gagliardi, L., on behalf of International Netwo Tags: Original research Source Type: research

Predicting neurodevelopmental outcomes in fetuses with isolated mild ventriculomegaly
Background Fetal ventriculomegaly is the the most common intracranial abnormality detected antenatally. When ventriculomegaly is mild and the only, isolated, abnormality detected (isolated mild ventriculomegaly (IMVM)) the prognosis is generally considered to be good. We aim to determine if there are features on in utero MRI (iuMRI) that can identify fetuses with IMVM who have lower risks of abnormal neurodevelopment outcome. Methods We studied cases recruited into the MRI to enhance the diagnosis of fetal developmental brain abnormalities in utero (MERIDIAN) study, specifically those with: confirmed IMVM, 3D volume imagi...
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - June 17, 2022 Category: Perinatology & Neonatology Authors: Griffiths, P. D., Jarvis, D., Connolly, D. J., Mooney, C., Embleton, N., Hart, A. R. Tags: Original research Source Type: research

Randomised crossover trial comparing algorithms and averaging times for automatic oxygen control in preterm infants
Conclusions Irrespective of SpO2-averaging time, Target% was higher with both SPOC algorithms compared to RMC. Despite limiting the maximum FiO2, SPOCnew remained significantly better at maintaining SpO2 within target range compared to RMC. Trial registration NCT03785899 (Source: Archives of Disease in Childhood - Fetal and Neonatal Edition)
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - June 17, 2022 Category: Perinatology & Neonatology Authors: Schwarz, C. E., Kreutzer, K. B., Langanky, L., Wolf, N. S., Braun, W., O'Sullivan, M. P., Poets, C. F., Franz, A. R. Tags: Original research Source Type: research

Outcome of infants with 10 min Apgar scores of 0-1 in a low-resource setting
Conclusion Our study adds information from a low-resource setting to the recent evidence from high-resource settings about prolonging the resuscitation in infants with Apgar scores of 0–1 at 10 min. The vast majority died in the delivery room despite prolonged resuscitative efforts. We confirm that duration of resuscitation should be tailored to the setting, while the focus in low-resource settings should be improving the quality of antenatal and immediately after birth care. (Source: Archives of Disease in Childhood - Fetal and Neonatal Edition)
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - June 17, 2022 Category: Perinatology & Neonatology Authors: Tylleskär, T., Cavallin, F., Höök, S. M., Pejovic, N. J., Lubulwa, C., Byamugisha, J., Nankunda, J., Trevisanuto, D., NeoSupra Trial Team Tags: Original research Source Type: research

Cerebral perfusion and neurological examination characterise neonatal opioid withdrawal syndrome: a prospective cohort study
Conclusions Increased cerebral perfusion and neurological examination abnormalities characterise infants with NOWS compared with those without intrauterine drug exposure and suggest prenatal substance exposure affects fetal brain development. Identifying neurological and neuroimaging characteristics of infants with NOWS can contribute to understanding mechanisms underlying later outcomes and to designing potential new treatments. (Source: Archives of Disease in Childhood - Fetal and Neonatal Edition)
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - June 17, 2022 Category: Perinatology & Neonatology Authors: Benninger, K. L., Peng, J., Ho, M.-L., Newton, J., Wang, D. J. J., Hu, H. H., Stark, A. R., Rusin, J. A., Maitre, N. L. Tags: Original research Source Type: research

Reduced health-related quality of life in children born extremely preterm in 2006 compared with 1995: the EPICure Studies
Conclusions Using parent report, there was a clinically significant decline in HRQL ratings for EP children over time. Areas contributing the most to the decline were speech and dexterity. Trial registration number ISRCTN86323684. (Source: Archives of Disease in Childhood - Fetal and Neonatal Edition)
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - June 17, 2022 Category: Perinatology & Neonatology Authors: Ni, Y., Johnson, S., Marlow, N., Wolke, D. Tags: Open access Original research Source Type: research

Effect of chlorhexidine cleansing on healthcare-associated infections in neonates: a systematic review and meta-analysis
Background Healthcare-associated infections (HAIs) have a significant impact on neonatal morbidity, mortality and long-term prognosis, which have a high incidence in neonates. Many studies have shown that chlorhexidine cleansing is effective in reducing HAIs in adults, but the effect of chlorhexidine cleansing on HAIs in neonates remains controversial. Aim The purpose of this study was to conduct a systematic review and meta-analysis of the effect of chlorhexidine cleansing on HAIs in neonates. The protocol of this review has been registered with the PROSPERO international prospective register of systematic reviews. Meth...
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - June 17, 2022 Category: Perinatology & Neonatology Authors: Zhou, J., Mei, L., Chen, S. Tags: Original research Source Type: research

Surfactant therapy in late preterm and term neonates with respiratory distress syndrome: a systematic review and meta-analysis
Conclusions Current evidence base on surfactant therapy in LPT and term infants with RDS indicates a potentially decreased risk of mortality, air leak, PPHN and duration of respiratory support. In view of the low to very low CoE and widely varying thresholds for deciding on surfactant replacement in the included studies, further trials are needed. (Source: Archives of Disease in Childhood - Fetal and Neonatal Edition)
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - June 17, 2022 Category: Perinatology & Neonatology Authors: Ramaswamy, V. V., Abiramalatha, T., Bandyopadhyay, T., Boyle, E., Roehr, C. C. Tags: Original research Source Type: research