Archives of Disease in Childhood - Fetal and Neonatal Edition This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Prophylactic cyclo-oxygenase inhibitor drugs for the prevention of morbidity and mortality in extremely preterm infants: a clinical practice guideline incorporating family values and preferences
Importance Prophylactic cyclo-oxygenase inhibitors (COX-Is) such as indomethacin, ibuprofen and acetaminophen may prevent morbidity and mortality in extremely preterm infants (born ≤28 weeks’ gestation). However, there is controversy around which COX-I, if any, is the most effective and safest, which has resulted in considerable variability in clinical practice.  Our objective was to develop rigorous and transparent clinical practice guideline recommendations for the prophylactic use of COX-I drugs for the prevention of mortality and morbidity in extremely preterm infants.  The Grading of Recommendatio...
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - April 18, 2024 Category: Perinatology & Neonatology Authors: Mitra, S., Whitehead, L., Smith, K., Maclean, B., Nixon, R., Veysey, A., Campbell-Yeo, M., Kuhle, S., Gale, C., Soll, R., Dorling, J., Johnston, B. C. Tags: Reviews Source Type: research

New guidelines for congenital diaphragmatic hernia: what is next?
Developing treatment guidelines for rare diseases is always a challenge, especially when the quality of care varies due to differences in the experience of treatment teams, the low annual number of patients and the presence or absence of high-level evidence. The heterogeneity of the underlying disease makes it even harder to compare results and identify best practices based on core outcome sets. Congenital diaphragmatic hernia (CDH) serves as an excellent example of such a ‘disease’. Both clinicians as well as researchers have recognised this challenge and have extensively worked on different aspects to achieve...
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - April 18, 2024 Category: Perinatology & Neonatology Authors: Tibboel, D. Tags: Editorials Source Type: research

Fantoms
Diagnosis and management of congenital diaphragmatic hernia Editor’s choice for this issue is the updated guideline from the Canadian Congenital Diaphragmatic Hernia Collaborative. This is a very comprehensive document with a rigorous methodology that updates the previous version published in 2018. The revision incorporates new evidence to inform 20 changes to existing recommendations including aspects related to prenatal diagnosis, echocardiographic evaluation, pulmonary hypertension management, surgical readiness criteria, the type of surgical repair and long-term health surveillance. 15 new care recommendations we...
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - April 18, 2024 Category: Perinatology & Neonatology Authors: Stenson, B. J. Tags: Highlights from this issue Source Type: research

Impact of adopting a neonatal sepsis risk calculator in a diverse population in Birmingham, UK
Background Kaiser-Permanente Sepsis Risk Calculator (KP-SRC) has safely reduced antibiotic use in the management of early-onset neonatal sepsis (EONS) in the USA and has been endorsed by the American Academy of Pediatrics.1 However, the updated UK National Institute for Health and Care Excellence (NICE) guidance 2021 (NG195) is risk factor based. It does permit the use of KP-SRC, but only with prospective audit, due to reservations regarding its applicability and safety in the UK setting.2 A recent Welsh study demonstrated the effectiveness of KP-SRC; however, Birmingham has significant inherent population differences (hig...
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - February 19, 2024 Category: Perinatology & Neonatology Authors: Yew, R., Macaskill, L., Brown, S., Dixie, M., Dogar, D., Checketts, E., Surana, P. Tags: PostScript Source Type: research

Prolonged use of closed-loop inspired oxygen support in preterm infants: a randomised controlled trial
Conclusion A-FiO2 control was superior to manual control in keeping preterm infants on non-invasive respiratory support in a prespecified TR over a period of 28 days. This improvement may come at the expense of increased time below the TR in the first days after initiating A-FiO2 control. Trial registration number NTR6731. (Source: Archives of Disease in Childhood - Fetal and Neonatal Edition)
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - February 19, 2024 Category: Perinatology & Neonatology Authors: Schouten, T. M. R., Abu-Hanna, A., van Kaam, A. H., van den Heuvel, M. E. N., Bachman, T. E., van Leuteren, R. W., Hutten, G. J., Onland, W. Tags: Original research Source Type: research

Volume-targeted mask ventilation during simulated neonatal resuscitation
Conclusion During neonatal simulation, VTV-PPV reduced mask leak and allowed for consistent VT delivery compared with T-piece with and without RFM guidance. (Source: Archives of Disease in Childhood - Fetal and Neonatal Edition)
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - February 19, 2024 Category: Perinatology & Neonatology Authors: Law, B. H. Y., Schmölzer, G. M. Tags: Original research Source Type: research

Neurodevelopmental outcomes of preterm neonates receiving rescue inhaled nitric oxide in the first week of age: a cohort study
Conclusions In preterm neonates <29 weeks GA with HRF, rescue iNO use was not associated with worse neurodevelopmental outcomes among survivors who were assessed at 18–24 months CA. (Source: Archives of Disease in Childhood - Fetal and Neonatal Edition)
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - February 19, 2024 Category: Perinatology & Neonatology Authors: Gurram Venkata, S. K. R., Lodha, A., Hicks, M., Jain, A., Lapointe, A., Makary, H., Kanungo, J., Lee, K.-S., Ye, X., Shah, P. S., Soraisham, A. S., the Canadian Neonatal Network and Canadian Neonatal Follow Up Network Tags: Original research Source Type: research

2% chlorhexidine gluconate aqueous versus 2% chlorhexidine gluconate in 70% isopropyl alcohol for skin disinfection prior to percutaneous central venous catheterisation: the ARCTIC randomised controlled feasibility trial
Conclusions A definitive comparative efficacy trial is feasible, but the very low catheter colonisation rate would make a large-scale RCT challenging due to the very large sample size required. ARCTIC provides preliminary reassurance supporting potential safe use of 2% CHG-70% IPA and 2% CHG-aqueous in preterm neonates. Trial registration number ISRCTN82571474. (Source: Archives of Disease in Childhood - Fetal and Neonatal Edition)
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - February 19, 2024 Category: Perinatology & Neonatology Authors: Clarke, P., Soe, A., Nichols, A., Harizaj, H., Webber, M. A., Linsell, L., Bell, J. L., Tremlett, C., Muthukumar, P., Pattnayak, S., Partlett, C., King, A., Juszczak, E., Heath, P. T. Tags: Open access Original research Source Type: research

Perspectives of extremely prematurely born adults on what to consider in prenatal decision-making: a qualitative focus group study
Conclusions Insights into the perspectives of adults born extremely premature deepened our understanding of values considered in decision-making at the limit of viability. Results point out the need for a more individualised prediction of the prognosis and more extensive information on the lifelong impact of an extremely premature birth on both the infant and the family. This could help future parents and healthcare professionals in value-laden decision-making. (Source: Archives of Disease in Childhood - Fetal and Neonatal Edition)
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - February 19, 2024 Category: Perinatology & Neonatology Authors: de Boer, A., De Proost, L., de Vries, M., Hogeveen, M., Verweij, E. J. T., Geurtzen, R. Tags: Original research Source Type: research

Neurodevelopmental outcomes at age 3 years after moderate preterm, late preterm and early term birth: the Japan Environment and Childrens Study
Conclusion Moderate preterm, late preterm and early term births were associated with developmental impairment at age 3 years compared with full-term births, with increasing prematurity. Careful follow-up of non-full-term children by paediatricians and other healthcare providers is necessary for early detection of neurodevelopmental impairment and implementation of available intervention. (Source: Archives of Disease in Childhood - Fetal and Neonatal Edition)
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - February 19, 2024 Category: Perinatology & Neonatology Authors: Hirata, K., Ueda, K., Wada, K., Ikehara, S., Tanigawa, K., Kimura, T., Ozono, K., Sobue, T., Iso, H., the Japan Environment and Childrens Study Group Tags: Original research Source Type: research

Congenital duodenal obstruction repair with and without transanastomotic tube feeding: a systematic review and meta-analysis
Conclusion TAT feeding following CDO repair appears beneficial, without increased risk of adverse events; however, certainty of available evidence is low. Earlier enteral feeding and reduced PN use are known to decrease central venous catheter-associated risks while significantly reducing cost of care. PROSPERO registration number CRD42022328381. (Source: Archives of Disease in Childhood - Fetal and Neonatal Edition)
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - February 19, 2024 Category: Perinatology & Neonatology Authors: Bethell, G. S., Neville, J. J., Johnson, M. J., Turnbull, J., Hall, N. J. Tags: Open access Original research Source Type: research

Preliminary results on validity and reliability from two prospective cohort studies on a new Neonatal Coma Score
Conclusions The NCS has good intraobserver agreement in well full-term babies, with a normal NCS 14–15. The NCS in preterm neonates depended on gestational age, and deterioration from baseline was associated with illness. Further work is needed to determine normal scores each gestational age, reliability at lower levels, how early the NCS identifies deterioration and comparison with other assessment tools to demonstrate criterion validity. (Source: Archives of Disease in Childhood - Fetal and Neonatal Edition)
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - February 19, 2024 Category: Perinatology & Neonatology Authors: Hart, A. R., Kieran, M., Matthews, E., Mandefield, L., Williams, T., Johnson, K., English, S., Evans, D., Cutsey, L., Goodden, J. Tags: Original research Source Type: research

First-year growth trajectory and early nutritional requirements for optimal growth in infants with congenital diaphragmatic hernia: a retrospective cohort study
Conclusions Growth patterns of CDH infants suggest that nutritional risk stratification and feeding practices may influence growth outcomes. Our results support individualised and active nutritional management based on CDH severity, with energy requirements as high as 140% of recommended intakes for healthy term infants. (Source: Archives of Disease in Childhood - Fetal and Neonatal Edition)
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - February 19, 2024 Category: Perinatology & Neonatology Authors: Coignard, M., Mellul, K., Stirnemann, J., Khen-Dunlop, N., Lapillonne, A., Kermorvant-Duchemin, E. Tags: Original research Source Type: research

Identifying effect modifiers of systemic hydrocortisone treatment initiated 7-14 days after birth in ventilated very preterm infants on long-term outcome: secondary analysis of a randomised controlled trial
Conclusion This secondary analysis suggests that in infants <27 weeks’ GA, systemic hydrocortisone may improve the outcome death or NDI, mainly driven by its component death. There was insufficient evidence for other selected candidate effect modifiers. (Source: Archives of Disease in Childhood - Fetal and Neonatal Edition)
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - February 19, 2024 Category: Perinatology & Neonatology Authors: Halbmeijer, N. M., Sonnaert, M., Swarte, R. M., Koopman-Esseboom, C., van Stuijvenberg, M., Mulder-de Tollenaer, S., Tan, R. N. G. B., Mohns, T., Bruneel, E., Steiner, K., Kramer, B. W., Debeer, A., van Weissenbruch, M. M., Marechal, Y., Blom, H., Plaskie Tags: Original research Source Type: research

Neuroimaging in infants with congenital cytomegalovirus infection and its correlation with outcome: emphasis on white matter abnormalities
Conclusions Categorisation of neuroimaging severity correlates with outcome in cCMV. In infants with IWMAs, TPWMAs provide a guide to prognosis. (Source: Archives of Disease in Childhood - Fetal and Neonatal Edition)
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - February 19, 2024 Category: Perinatology & Neonatology Authors: Alarcon, A., de Vries, L. S., Parodi, A., Arnaez, J., Cabanas, F., Steggerda, S. J., Rebollo, M., Ramenghi, L., Dorronsoro, I., Lopez-Azorin, M., Schneider, J., Noguera-Julian, A., Rios-Barnes, M., Recio, M., Bickle-Graz, M., Martinez-Biarge, M., Fortuny, Tags: Open access Original research Source Type: research