Archives of Disease in Childhood - Fetal and Neonatal Edition This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Safety and feasibility of platelet transfusion through long catheters in the neonatal intensive care unit: an in vitro study
Conclusions This study showed that in vitro platelet transfusion performed through 24 G and 28 G neonatal PICC lines and double-lumen UVCs is non-inferior to 24 G short cannulas, using outcome measures of platelet clumping, platelet activation and line occlusion. This suggests that where available these lines can be used if necessary for platelet transfusion. (Source: Archives of Disease in Childhood - Fetal and Neonatal Edition)
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - December 15, 2023 Category: Perinatology & Neonatology Authors: Moore, C. M., Lorusso, A., Morgan, L., Brazil, S., Croxon, H., Waters, A., Farrelly, A., Hervig, T., Curley, A. Tags: Open access Original research Source Type: research

Randomised control trial of oxygen assist module in preterm infants on high-flow nasal cannula support
Conclusion A-FiO2 was associated with statistically significant reduction in the percentage of time spent in extremes of saturation when compared with M-FiO2 in preterm infants receiving HFNC. Trial registration number NCT04687618. (Source: Archives of Disease in Childhood - Fetal and Neonatal Edition)
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - December 15, 2023 Category: Perinatology & Neonatology Authors: Nair, V., Kannan Loganathan, P., Lal, M. K., Bachman, T. E., Fantl, R. Tags: Original research Source Type: research

Family experiences of antenatal counselling of spina bifida: a systematic review
Conclusions Unlike other conditions where limited data on outcome exist or the spectrum is genuinely broad, the outcomes of children with spina bifida is well described. Poor aspects of antenatal counselling were described frequently by families, and further work is needed to capture the full spectrum of views on antenatal counselling, how it can be improved, and what training and resources healthcare professionals need to perform it better. (Source: Archives of Disease in Childhood - Fetal and Neonatal Edition)
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - December 15, 2023 Category: Perinatology & Neonatology Authors: Agrawal, S., Hobson, E. V., Hart, A. R. Tags: Original research Source Type: research

Prevalence of symptomatic tracheal morbidities after fetoscopic endoluminal tracheal occlusion: a systematic review and meta-analysis
Conclusion A significant proportion of FETO survivors have symptomatic tracheal morbidities of varying severity. Units that are planning to adopt FETO for managing CDH should consider ongoing surveillance of survivors to enable early identification of upper airway issues. Inventing FETO devices that minimise tracheal injury is needed. (Source: Archives of Disease in Childhood - Fetal and Neonatal Edition)
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - December 15, 2023 Category: Perinatology & Neonatology Authors: Tho, A. L. W., Rath, C. P., Tan, J. K. G., Rao, S. C. Tags: Original research Source Type: research

Mask ventilation using volume-targeted neonatal ventilator for neonatal resuscitation: a randomised cross-over simulation study
Conclusion Using a neonatal ventilator to perform volume-targeted PPV is feasible, but human factors need to be considered. (Source: Archives of Disease in Childhood - Fetal and Neonatal Edition)
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - December 15, 2023 Category: Perinatology & Neonatology Authors: Law, B. H. Y., Madani Kia, T., Trinh, F., Schmölzer, G. M. Tags: Original research Source Type: research

Predictive performance of multiple organ dysfunction in asphyxiated newborns treated with therapeutic hypothermia on 24-month outcome: a cohort study
Conclusion MOD has a low discriminating accuracy in predicting mortality or NDI at 24 months age and might not be useful for prognostication. Signs of acid–base disturbance and adrenalin use at birth are associated with the development of MOD. (Source: Archives of Disease in Childhood - Fetal and Neonatal Edition)
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - December 15, 2023 Category: Perinatology & Neonatology Authors: Langeslag, J., Onland, W., Visser, D., Groenendaal, F., de Vries, L., van Kaam, A. H., de Haan, T. R., The PharmaCool Study Group Tags: Original research Source Type: research

Switch from intravenous-to-oral antibiotics in neonatal probable and proven early-onset infection: a prospective population-based real-life multicentre cohort study
Conclusion In clinical practice, switch therapy was safe and used in 9 of 10 neonates with probable EOI. Knowledge of the safety of antibiotic de-escalation is important as home-based oral therapy ameliorates the treatment burden for neonates, caregivers and healthcare systems. Despite the ease of oral administration, implementation of switch therapy did not increase the overall use of antibiotics. (Source: Archives of Disease in Childhood - Fetal and Neonatal Edition)
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - December 15, 2023 Category: Perinatology & Neonatology Authors: Malchau Carlsen, E. L., Dungu, K. H. S., Lewis, A., Vissing, N. H., Aunsholt, L., Trautner, S., Stanchev, H., Dayani, G. K., Pedersen, A.-J. L., Bjerager, M., De Salas, M., Vestergaard, K., Pedersen, P., Frimodt-Moller, N., Greisen, G., Hansen, B. M., Nyg Tags: Original research Source Type: research

Neurodevelopment and healthcare utilisation at age 5-6 years in bronchopulmonary dysplasia: an EPIPAGE-2 cohort study
Conclusions BPD was strongly and independently associated with many neurodevelopmental disabilities. Improving medical and neurodevelopmental management of BPD in very preterm children should be a priority to reduce its long-term consequences. (Source: Archives of Disease in Childhood - Fetal and Neonatal Edition)
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - December 15, 2023 Category: Perinatology & Neonatology Authors: Treluyer, L., Nuytten, A., Guellec, I., Jarreau, P.-H., Benhammou, V., Cambonie, G., Truffert, P., Marchand-Martin, L., Ancel, P. Y., Torchin, H. Tags: Original research Source Type: research

Hypoglycaemia and hyperglycaemia in neonatal encephalopathy: a systematic review and meta-analysis
Conclusions These data suggest that neonatal hypoglycaemia and hyperglycaemia may be associated with the neurodevelopmental outcome later on in infants with NE. Further studies with long-term follow-up are needed to optimise the metabolic management of these high-risk infants. PROSPERO registration number CRD42022368870. (Source: Archives of Disease in Childhood - Fetal and Neonatal Edition)
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - December 15, 2023 Category: Perinatology & Neonatology Authors: Puzone, S., Diplomatico, M., Caredda, E., Maietta, A., Miraglia Del Giudice, E., Montaldo, P. Tags: Original research Source Type: research

One-year survival and outcomes of infants born at 22 and 23 weeks of gestation in Sweden 2004-2007, 2014-2016 and 2017-2019
Conclusion Increased perinatal activity was associated with reduced mortality and increased chances of survival without MNM in infants born at 22 and 23 weeks of GA. (Source: Archives of Disease in Childhood - Fetal and Neonatal Edition)
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - December 15, 2023 Category: Perinatology & Neonatology Authors: Farooqi, A., Hakansson, S., Serenius, F., Kallen, K., Björklund, L., Normann, E., Domellöf, M., Aden, U., Abrahamsson, T., Elfvin, A., Sävman, K., Bergström, P. U., Stephansson, O., Ley, D., Hellstrom-Westas, L., Norman, M. Tags: Editor's choice Original research Source Type: research

Missed or delayed diagnosis of anorectal malformations: a review of the literature, current training and practice in the UK in relation to detection via the NIPE programme
Anorectal malformations (ARMs) are a spectrum of congenital anomalies where there is abnormal development of the anus and rectum. With an incidence of 1:5000 live births and affecting both males and females, these anomalies vary in their appearance and presentation, lack features enabling antenatal detection and should be detected at birth by the examining midwife or within 72 hours through the newborn and infant physical examination (NIPE) screening programme. However, it is recognised that the diagnosis of ARMs can be missed or delayed leading to morbidity and mortality. In the UK, despite the existence of the NIPE scree...
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - December 15, 2023 Category: Perinatology & Neonatology Authors: Murthi, G. V. S., McEwan, T., Walker, G. M., Bustani, P. Tags: Reviews Source Type: research

Perils of meta-analysis
In a recent issue of the Archives, Batra et al presented a systematic review and meta-analysis comparing two strategies for weaning neonates from positive pressure mechanical ventilation: synchronised intermittent mandatory ventilation (SIMV) and pressure support ventilation (PSV).1 With the former, some breaths are assisted and others are not, but with the latter, all breaths are synchronised with some positive pressure assistance. Analyses like this are valuable, as choices of ventilation strategies in our nurseries are typically based on personal preferences rather than carefully developed evidence. The small sizes of t...
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - December 15, 2023 Category: Perinatology & Neonatology Authors: Benitz, W. E. Tags: Editorials Source Type: research

Fantoms
Changing outcomes of infants born at 22 and 23 weeks in Sweden 2004-19 Aijaz Farooqi et al report survival and morbidity outcomes of infants born at 22-23 weeks of gestation in Sweden in three time windows, from 2004 to 2019. They relate these outcomes to the perinatal activity that was provided. A perinatal activity score was based on indicators of obstetric care (delivery at level III/IV hospital, any antenatal steroids, caesarean delivery) and neonatal care (intubation at birth, surfactant administration <2 hours of birth, delivery attended by a neonatologist and admission to a neonatal intensive care unit (NICU) of ...
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - December 15, 2023 Category: Perinatology & Neonatology Authors: Stenson, B. J. Tags: Highlights from this issue Source Type: research

Thermal care for preterm infants in the delivery room has not been compromised since the routine adoption of delayed cord clamping in our unit
It was with great interest that we read the work of Dunne et al describing higher rates of admission hypothermia in preterm infants following the introduction of delayed cord clamping (DCC) (6% to 54%).1 We share their concerns given the association between admission hypothermia and increased mortality.2 The 2021 National Neonatal Audit Programme (NNAP) data highlighted our tertiary, medical neonatal intensive care unit as a negative outlier—only 12.1% of preterm infants received DCC compared with the national average of 43.0%. A quality improvement project (QIP) followed, led by a multidisciplinary team (MDT) consis...
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - October 19, 2023 Category: Perinatology & Neonatology Authors: Clarke, R., Burgess-Shannon, J., Howarth, C., Rowell, V., Aladangady, N. Tags: PostScript Source Type: research

Vertical transmission of SARS-CoV-2 - are there differences in rates of neonatal SARS-CoV-2 infection in two classification systems?
Neonatal SARS-CoV-2 infection due to vertical transmission has been summarised in recent reviews.1 2 However, the comparability of the underlying case reports and case series might be limited because of the often inconsistent use of different classification systems.1 COVID-19-Related Obstetric and Neonatal Outcome Study (CRONOS) was a prospective German registry enrolling pregnant women with confirmed SARS-CoV-2 infection during their pregnancy.3 4 The registry collected data between 3 April 2020 and 10 February 2023 with 130 of 686 (18.9%) German obstetric hospitals actively participating.4 To classify the timing and the ...
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - October 19, 2023 Category: Perinatology & Neonatology Authors: Mand, N., Hutten, M., Maier, R. F., Mense, L., Pecks, U., Rüdiger, M., on behalf of the CRONOS Network Tags: COVID-19 PostScript Source Type: research