Congenital self-healing reticulohistiocytosis in a neonate

A full-term 1-day-old boy was admitted to the neonatal intensive care unit for assessment of clustered purplish brown rashes on the right foot (figure 1A,B) since birth. There was no mucous membrane lesion, hepatosplenomegaly or lymphadenopathy. He was born by spontaneous vaginal delivery at 38+5 weeks of gestation to a healthy mother without perinatal infections. A punch biopsy revealed a dense infiltration of Langerhans cells with increased eosinophils in the dermis (figure 1C), which was confirmed by immunohistochemical staining with S100, CD1a and langerin (CD207). Complete blood counts, liver function tests, urinalysis and Tzanck smear were normal. No anomalies were detected on skeletal survey, chest radiographs, ultrasound of the abdomen and head MRI. BRAF V600E mutation was negative in both tissue and blood. Based on the patient’s age, clinical manifestations, clinicopathological features and immunohistochemical results, a diagnosis of congenital self-healing reticulohistiocytosis (CSHR) was made. Spontaneous...
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - Category: Perinatology & Neonatology Authors: Tags: Images in neonatal medicine Source Type: research