Integration of hepatitis B virus into patients ’ sperm genome and its clinical risks
ConclusionOur findings suggest that hepatitis B virus infection can lead to sperm quality deterioration and reduced fertilization capacity. Furthermore, viral integration causes instability in the sperm genome, increasing the potential risk of termination, miscarriage, and stillbirth. This study identified an unconventional mode of hepatitis B virus transmission through genes rather than virions. The presence of viral sequences in the embryonic genome poses a risk of liver inflammation and cancer. (Source: Andrology)
Source: Andrology - March 20, 2024 Category: Urology & Nephrology Authors: Ting ‐Ting Han,
Ji‐Hua Huang,
Ling‐Xiao Li,
Xue Liao,
Xiang‐Qian Meng,
Zi‐Na Wen,
Qian Sun,
Jian Ma,
Tian‐Hua Huang Tags: ORIGINAL ARTICLE Source Type: research
Leading at the vanguard of andrology: The Network for Young Researchers in Andrology joins forces with the European Academy of Andrology
(Source: Andrology)
Source: Andrology - March 20, 2024 Category: Urology & Nephrology Authors: Alberto de la Iglesia,
Dorte L. Egeberg,
Daniel Marcu,
Guillaume Richer,
Brendan J. Houston,
Omar Ammar,
G ülizar Saritas,
Emily Delgouffe,
Davor Jezek,
Csilla Krausz,
Ewa Rajpert‐De Meyts,
Hermann M. Behre Tags: SOCIETY NEWS Source Type: research
A Mendelian randomization study on causal effects of leisure sedentary behavior on the risk of erectile dysfunction
ConclusionThe present study offered substantial evidence for a positive causal association between computer use and the risk of erectile dysfunction. However, a definitive causal association needs to be established by further research. (Source: Andrology)
Source: Andrology - March 20, 2024 Category: Urology & Nephrology Authors: Zhao Huangfu,
Xinxin Gan,
Yiren Yang,
Qingyang Pang,
Baohua Zhu,
Xiao Zhang,
Linhui Wang Tags: ORIGINAL ARTICLE Source Type: research
Regional modulation of toll ‐like receptor signaling pathway genes in acute epididymitis in mice
ConclusionThe dynamic modulation of TLR4 and TLR2/TLR6 signaling pathways gene expression during epididymitis indicates bacterial-derived antigens elicit an increased tissue sensitivity to combat microbial infection in a spatial manner in the epididymis. Differential activation of TLR-associated signaling pathways may contribute to fine-tuning inflammatory responses along the epididymis. (Source: Andrology)
Source: Andrology - March 19, 2024 Category: Urology & Nephrology Authors: Alexandre D. Andrade,
Priscila G. C. Almeida,
Noemia A. P. Mariani,
Natalia C. M. Santos,
Isabela A. Camargo,
Poliana V. Martini,
Helio Kushima,
Dingding Ai,
Maria Christina W. Avellar,
Andreas Meinhardt,
Christiane Pleuger,
Erick J. R. Silva Tags: ORIGINAL ARTICLE Source Type: research
Testosterone therapy in men with classical versus functional hypogonadism: results from a controlled 9 ‐years, real‐world registry study
Discussion and conclusionThe therapeutic outcomes of TTh across distinct hypogonadal populations demonstrate heterogeneous responses, significantly influenced by diagnostic categorization, age, and baseline risk factor profiles. (Source: Andrology)
Source: Andrology - March 16, 2024 Category: Urology & Nephrology Authors: Michael Zitzmann,
Jann ‐Frederik Cremers,
Claudia Krallmann,
Armin Soave,
Sabine Kliesch Tags: ORIGINAL ARTICLE Source Type: research
Maternal use of nitrosatable drugs during pregnancy and adult male reproductive health: A population ‐based cohort study
ConclusionsThe results suggest that maternal use of nitrosatable drugs does not have a harmful influence on the male fecundity of the offspring. (Source: Andrology)
Source: Andrology - March 15, 2024 Category: Urology & Nephrology Authors: Pernille Jul Clemmensen,
Nis Brix,
J örg Schullehner,
Gunnar Toft,
Sandra Søgaard Tøttenborg,
Karin Sørig Hougaard,
Anne Ahrendt Bjerregaard,
Thorhallur Ingi Halldorsson,
Sjurdur Frodi Olsen,
Birgitte Hansen,
Leslie Thomas Stayner,
Torben S Tags: ORIGINAL ARTICLE Source Type: research
TRACK_9: Testosterone replacement assessment: Classical vs. functional hypogonadism ‐knowledge from a 9‐year study
Discussion and conclusionThe therapeutic outcomes of TTh across distinct hypogonadal populations demonstrate heterogeneous responses, significantly influenced by diagnostic categorization, age, and baseline risk factor profiles. (Source: Andrology)
Source: Andrology - March 15, 2024 Category: Urology & Nephrology Authors: Michael Zitzmann,
Jann ‐Frederik Cremers,
Claudia Krallmann,
Armin Soave,
Sabine Kliesch Tags: ORIGINAL ARTICLE Source Type: research
Pubertal testicular volume references for ruler, orchidometer, and ultrasonography measurements based on a longitudinal follow ‐up
ConclusionThe present study provides reference values for pubertal testicular volume measured with a ruler enabling an age-dependent assessment of testicular size. Comparison with measurements by an orchidometer and ultrasonography is also presented. (Source: Andrology)
Source: Andrology - March 14, 2024 Category: Urology & Nephrology Authors: Mikael Koskela,
Helena E. Virtanen,
Wiwat Rodprasert,
Kirsi Jahnukainen,
Jorma Toppari,
Jaakko J. Koskenniemi Tags: ORIGINAL ARTICLE Source Type: research
Effects of edaravone on testicular torsion –detorsion injury in rats
ConclusionTaken together, the findings indicate that pretreatment of edaravone has protective effect against testicular T/D injury. (Source: Andrology)
Source: Andrology - March 14, 2024 Category: Urology & Nephrology Authors: Ya şar Şahin,
Evren Üstüner,
Hidayet Tutun,
Ebru Yildirim,
Oğuz Eroğlu,
Efe Kurtdede,
Yasin Ozkabadayi,
Enes Güncüm,
Kürşat Kutluca,
Ahmet Bilgehan Bilge Tags: ORIGINAL ARTICLE Source Type: research
Effects of chronic mild stress induced from peripuberty on sexual behavior in male rats, with or without escitalopram treatment
ConclusionChronic mild stress induced from peripuberty, associated or not to escitalopram treatment, altered the testosterone levels and testicular histoarchitecture and seems to be related to the reduction in male sexual motivation. (Source: Andrology)
Source: Andrology - March 14, 2024 Category: Urology & Nephrology Authors: Leonardo Wensing Fischer,
Marina Nunes,
Talita Biude Mendes,
Joana Nogu ères Simas,
Maria Martha Bernardi,
Samara Urban de Oliva,
Sandra Maria Miraglia Tags: ORIGINAL ARTICLE Source Type: research
Summer heat during spermatogenesis reduces in vitro blastocyst rates and affects sperm quality of next generation bulls
ConclusionFrom our data, we conclude that (i) natural summer heat stress during spermatogenesis can affect in vitro fertility parameters and (ii) the observed effects on sperm motility of F1 semen samples suggest intergenerational paternal transmission. (Source: Andrology)
Source: Andrology - March 13, 2024 Category: Urology & Nephrology Authors: Jens Vanselow,
Claudia Wesenauer,
Anja Eggert,
Arpna Sharma,
Frank Becker Tags: ORIGINAL ARTICLE Source Type: research
Associations between a paternal healthy lifestyle score and its individual components with childhood overweight and obesity
Discussion and conclusionAlmost half of the fathers had unfavorable lifestyle factors around pregnancy. A low paternal HLS was associated with a greater child WHtR at 9 years but not with a higher risk of childhood OWOB when measured by BMIz-scores or IOTF categories. (Source: Andrology)
Source: Andrology - March 13, 2024 Category: Urology & Nephrology Authors: Adrien M. Aubert,
Alexander Douglass,
Celine M. Murrin,
Cecily C. Kelleher,
Catherine M. Phillips,
and the Lifeways Cross ‐Generation Cohort Study Tags: ORIGINAL ARTICLE Source Type: research
Sex differences on constitutive long non ‐coding RNA expression: Modulatory effect of estradiol and testosterone in muscle cells
ConclusionsTaken together, results obtained evidenced sex differences on constitutive long non-coding RNA expression and suggested an influence of steroid hormones complementary to other possible factors. These findings emphasize the importance of including both sexes in experimental design to minimize any potential sex bias. (Source: Andrology)
Source: Andrology - March 13, 2024 Category: Urology & Nephrology Authors: Tresa L ópez‐Royo,
Laura Moreno‐Martínez,
Leticia Moreno‐García,
Ana Cristina Calvo,
Raquel Manzano,
Rosario Osta Tags: ORIGINAL ARTICLE Source Type: research
Transmission electron microscopy reveals the presence of SARS ‐CoV‐2 in human spermatozoa associated with an ETosis‐like response
Discussion and conclusionAlthough severe acute syndrome coronavirus 2 was not present in the infected men's semen, it was intracellularly present in the spermatozoa till 3 months after hospital discharge. The Electron microscopy (EM) findings also suggest that spermatozoa produce nuclear DNA-based extracellular traps, probably in a cell-free DNA-dependent manner, similar to those previously described in the systemic inflammatory response to COVID-19. In moderate-to-severe cases, the blood –testes barrier grants little defence against different pathogenic viruses, including the severe acute syndrome coronavirus 2. The vir...
Source: Andrology - March 12, 2024 Category: Urology & Nephrology Authors: Jorge Hallak,
Elia G. Caldini,
Thiago A. Teixeira,
Maria Cassia Mendes Correa,
Amaro N. Duarte ‐Neto,
Fabiola Zambrano,
Anja Taubert,
Carlos Hermosilla,
Joël R. Drevet,
Marisa Dolhnikoff,
Raul Sanchez,
Paulo H. N. Saldiva Tags: ORIGINAL ARTICLE Source Type: research
Swimming trapper decreases the proportion of chromosomally unbalanced spermatozoa in human Robertsonian translocation carriers
ConclusionsUse of swimming trapper (STM) is superior for enriching high-motile and genetically competent sperm in comparison with SSUM. (Source: Andrology)
Source: Andrology - March 12, 2024 Category: Urology & Nephrology Authors: Xiao ‐Nan Liu,
Mei‐Yi Li,
Qing‐Ling Ma,
Juan Chen,
Shuai Liu,
Yang Yu,
Ling Sun Tags: ORIGINAL ARTICLE Source Type: research
