Integration of hepatitis B virus into patients ’ sperm genome and its clinical risks

ConclusionOur findings suggest that hepatitis B virus infection can lead to sperm quality deterioration and reduced fertilization capacity. Furthermore, viral integration causes instability in the sperm genome, increasing the potential risk of termination, miscarriage, and stillbirth. This study identified an unconventional mode of hepatitis B virus transmission through genes rather than virions. The presence of viral sequences in the embryonic genome poses a risk of liver inflammation and cancer.

Source: Andrology - March 20, 2024 Category: Urology & Nephrology Authors: Ting ‐Ting Han, Ji‐Hua Huang, Ling‐Xiao Li, Xue Liao, Xiang‐Qian Meng, Zi‐Na Wen, Qian Sun, Jian Ma, Tian‐Hua Huang Tags: ORIGINAL ARTICLE Source Type: research