Regional modulation of toll ‐like receptor signaling pathway genes in acute epididymitis in mice

ConclusionThe dynamic modulation of TLR4 and TLR2/TLR6 signaling pathways gene expression during epididymitis indicates bacterial-derived antigens elicit an increased tissue sensitivity to combat microbial infection in a spatial manner in the epididymis. Differential activation of TLR-associated signaling pathways may contribute to fine-tuning inflammatory responses along the epididymis.

Source: Andrology - March 19, 2024 Category: Urology & Nephrology Authors: Alexandre D. Andrade, Priscila G. C. Almeida, Noemia A. P. Mariani, Natalia C. M. Santos, Isabela A. Camargo, Poliana V. Martini, Helio Kushima, Dingding Ai, Maria Christina W. Avellar, Andreas Meinhardt, Christiane Pleuger, Erick J. R. Silva Tags: ORIGINAL ARTICLE Source Type: research