The role of hepatitis B virus surface protein in inducing Sertoli cell ferroptosis
ConclusionHBs can decrease human Sertoli cell viability by promoting ferroptosis induced by the loss of glutathione peroxidase 4 activity through TRIM37-mediated ubiquitination of glutathione peroxidase 4. The findings highlight the role of TRIM37/glutathione peroxidase 4 signaling responsible for ferroptosis regulation in hepatitis B virus-infected Sertoli cells. (Source: Andrology)
Source: Andrology - August 30, 2023 Category: Urology & Nephrology Authors: Chengshuang Pan,
Xiangbin Kong,
Zhigang Wu,
Qianjin Fei Tags: ORIGINAL ARTICLE Source Type: research
New aspects of activin biology in epididymal function and immunopathology
AbstractThe activins (A and B) and their binding protein, follistatin, play crucial roles in development, immunoregulation and inflammation throughout the body. In the male reproductive tract of the mouse, activin A and B production is largely confined to the initial segment and proximal caput of the epididymis and the efferent ducts, under normal conditions, with very low expression in the corpus, cauda and vas deferens. However, activin A protein is present throughout the epididymis and vas deferens and is largely associated with the epithelium and interstitial macrophages. Conversely, the activin-binding protein follist...
Source: Andrology - August 30, 2023 Category: Urology & Nephrology Authors: Rukmali Wijayarathna,
Mark P. Hedger Tags: REVIEW ARTICLE Source Type: research
Increases in computationally predicted deleterious variants of unknown significance and sperm mtDNA copy numbers may be associated with semen quality
Discussion and conclusionThe increases in the number of computationally predicted deleterious VUS and mtDNA copies in spermatozoa may be associated with semen quality. Exposure to environmental mutation pressure that causes novel mtDNA variants with low-level heteroplasmy may occur during spermatogenesis. Furthermore, when a certain harmful threshold is reached, male germ cells may degrade mtDNA with mutations and replicate the correct mtDNA sequence to maintain the mitochondrial function in spermatozoa. (Source: Andrology)
Source: Andrology - August 26, 2023 Category: Urology & Nephrology Authors: Yuze Pi,
Zhuo Huang,
Xilin Xu,
Huan Zhang,
Miao Jin,
Shuoping Zhang,
Ge Lin,
Liang Hu Tags: ORIGINAL ARTICLE Source Type: research
Exploring rat corpus cavernosum alterations induced by finasteride treatment and withdrawal
AbstractDespite its efficacy for treating androgenetic alopecia, finasteride, an inhibitor of 5 α-reductase (i.e., the enzyme converting testosterone, T, into dihydrotestosterone, DHT), is associated with several side effects including sexual dysfunction (e.g., erectile dysfunction). These side effects may persist after drug suspension, inducing the so-called post-finasteride syndrome (PFS). The effects of subchronic treatment with finasteride (i.e., 20 days) and its withdrawal (i.e., 1 month) in rat corpus cavernosum have been explored here. Data obtained show that the treatment was able to decrease the levels of the enz...
Source: Andrology - August 25, 2023 Category: Urology & Nephrology Authors: Silvia Diviccaro,
Monika Herian,
Lucia Cioffi,
Matteo Audano,
Nico Mitro,
Donatella Caruso,
Silvia Giatti,
Roberto Cosimo Melcangi Tags: SHORT COMMUNICATION Source Type: research
Perceived intravaginal ejaculation latency time: The diagnosis of premature ejaculation among Vietnamese men
ConclusionThe impact of PE is dramatic both from a social and a personal perspective. PE(+) patients married significantly less and have significantly lower sexual activity compared to a PE(-) population. Furthermore, a PIELT of ≤ 3.5 min predicts PE demonstrating the need to revise its taxonomy and definition. (Source: Andrology)
Source: Andrology - August 24, 2023 Category: Urology & Nephrology Authors: Hoai Bac Nguyen,
Cao Thang Nguyen,
Minh Quan Pham,
Long Hoang,
Andrea Sansone,
Emmanuele A. Jannini Tags: ORIGINAL ARTICLE Source Type: research
Long ‐acting glucagon‐like peptide 1 receptor agonists boost erectile function in men with type 2 diabetes mellitus complaining of erectile dysfunction: A retrospective cohort study
ConclusionDue to the retrospective nature of the study, a potential cause –effect relationship between the use of GLP-1RAs plus metformin over metformin alone in improving ED cannot be verified and confirmed. Randomized clinical trials are needed to provide evidence supporting the use of GLP-1RAs for treating ED in T2D. (Source: Andrology)
Source: Andrology - August 24, 2023 Category: Urology & Nephrology Authors: Lisco Giuseppe,
Bartolomeo Nicola,
De Tullio Anna,
De Pergola Giovanni,
Guastamacchia Edoardo,
Emilio Jirillo,
Giuseppina Piazzolla,
Triggiani Vincenzo,
Vito Angelo Giagulli Tags: ORIGINAL ARTICLE Source Type: research
Cryopreservation of equine spermatozoa reduces plasma membrane integrity and phospholipase C zeta 1 content as associated with oocyte activation
Discussion and conclusionSperm PLCZ1 content associates with cleavage rates after ICSI. Cryopreservation is detrimental to sperm plasma membrane integrity and PLCZ1 retention. However, refreezing did not result in additional PLCZ1 loss. Refreezing stallion spermatozoa at a low temperature resulted in better survival but did not improve PLCZ1 retention. (Source: Andrology)
Source: Andrology - August 23, 2023 Category: Urology & Nephrology Authors: Raul A. Gonzalez ‐Castro,
Luke A. Whitcomb,
Emma C. Pinsinski,
Elaine M. Carnevale Tags: ORIGINAL ARTICLE Source Type: research
Scrutinizing the human TEX genes in the context of human male infertility
ConclusionOur findings concerning the X-linked genesTEX13B,TEX13C, andFAM9A (TEX39A) contradict previous reports and will decrease false-positive reports in genetic diagnostics of azoospermic men. (Source: Andrology)
Source: Andrology - August 19, 2023 Category: Urology & Nephrology Authors: Marie. H. Sieper,
Avinash S. Gaikwad,
Marion Fros,
Philipp Weber,
Sara Di Persio,
Manon S. Oud,
Sabine Kliesch,
Nina Neuhaus,
Birgit Stallmeyer,
Frank T üttelmann,
Margot J. Wyrwoll Tags: ORIGINAL ARTICLE Source Type: research
Primary azoospermia factor C duplication associated with spermatogenic impariment: a case –control study based on Y‐chromosome haplogrouping in a Han Chinese population
ConclusionThe results suggest that, in the Han Chinese population, the gr/gr duplication is a predisposing genetic factor for spermatogenic impairment in males harboring Y-hg O3*. Meanwhile, the b2/b3 duplication may be fixed on a yet-unidentified subbranch of Y-hg Cα2* without significantly deleterious effect on spermatogenesis. Our findings provide evidence that the difference in the Y-hg composition may cause the discrepancy on the association of AZFc duplication with spermatogenic failure among the studied population s. (Source: Andrology)
Source: Andrology - August 18, 2023 Category: Urology & Nephrology Authors: Shengyu Xie,
Yongyi Ma,
Yunqiang Liu,
Dachang Tao,
Zhaokun Wang,
Yuan Yang Tags: ORIGINAL ARTICLE Source Type: research
Current trends in non ‐surgical management of Peyronie's disease—A narrative review
AbstractPeyronie's disease (PD) is a connective tissue disorder affecting the tunica albuginea. It can cause pain and penile deformation, and its prevalence increases with age. Although surgery is the gold standard for the chronic phase of the disease, there are several conservative treatment methods available, and the optimal management of the acute phase of the disease remains a matter of debate. In this article, we aim to summarize the recent trends in research on the subject of non-surgical treatment of PD. The search was performed in PubMed, Scopus, and Web of Science databases and included studies in English publishe...
Source: Andrology - August 18, 2023 Category: Urology & Nephrology Authors: Anna Kozub,
Agata Suleja,
Marcin Ch łosta,
Andrzej Kupilas,
Benjamin Pradere,
Juan Gómez Rivas,
Paweł Rajwa,
Marcin Miszczyk Tags: REVIEW ARTICLE Source Type: research
Immunoregulatory mechanisms between epithelial clear cells and mononuclear phagocytes in the epididymis
Discussion and conclusionNotably, we provide an in-depth characterization of clear cell-mononuclear phagocyte communication networks in the steady-state epididymis and in the presence of injury. This review highlights crucial concepts of mucosal immunology and cellcell interactions, all of which are critical but understudied facets of human male reproductive health. (Source: Andrology)
Source: Andrology - August 13, 2023 Category: Urology & Nephrology Authors: Maria Agustina Battistone,
Maia L Elizagaray,
Ferran Barrachina,
Kiera Ottino,
Alexandra C Mendelsohn,
Sylvie Breton Tags: REVIEW ARTICLE Source Type: research
Unrecognised orgasmic phase disorders in men presenting with new ‐onset erectile dysfunction—Findings from a real‐life, cross‐sectional study
ConclusionsAlmost one in three men seeking first medical help for erectile dysfunction depicted criteria suggestive of unreported orgasmic phase disorder. Men with unreported orgasmic phase disorder were older and had higher rates of severe erectile dysfunction and concomitant depressive symptoms. These real-life findings outline the clinical relevance of a comprehensive investigation of concomitant sexual dysfunction in men only complaining of erectile dysfunction to more effectively tailor patient management. (Source: Andrology)
Source: Andrology - August 9, 2023 Category: Urology & Nephrology Authors: Simone Cilio,
Edoardo Pozzi,
Giuseppe Fallara,
Federico Belladelli,
Massimiliano Raffo,
Francesco Lanzaro,
Alessandro Bertini,
Luca Boeri,
Paolo Capogrosso,
Alessia d'Arma,
Alessandro Palmieri,
Ciro Imbimbo,
Vincenzo Mirone,
Francesco Montors Tags: ORIGINAL ARTICLE Source Type: research
Effects of vitamin D on sex steroids, luteinizing hormone, and testosterone to luteinizing hormone ratio in 307 infertile men
ConclusionVitamin D + calcium supplementation did not alter sex steroid production in infertile men. However, vitamin D insufficient men treated with vitamin D supplementation had a significantly higher testosterone/LH ratio compared with placebo-treated men, suggesting that optimal Leydig cell function are dependen t on adequate vitamin D status. (Source: Andrology)
Source: Andrology - August 9, 2023 Category: Urology & Nephrology Authors: Rune Holt,
Sam Kafai Yahyavi,
Ireen Kooij,
Nadia Nicholine Poulsen,
Anders Juul,
Niels J ørgensen,
Martin Blomberg Jensen Tags: ORIGINAL ARTICLE Source Type: research
CUB domains are not required for OVCH2 function in sperm maturation in the mouse epididymis
ConclusionsOur studies demonstrate that the CUB domains are not required for fertility in male mice, at least under the normal animal housing conditions our mice were tested in, and suggest that the enzymatic activity of the OVCH2 protease, in the absence of its CUB domains, is sufficient for normal sperm processing in the epididymis. Although our findings do not preclude the possibility that OVCH2 CUB domains are required under a yet-identified stress condition, our findings demonstrate that the most likely region for deleterious mutations in men with idiopathic infertility and the most vulnerable site for inhibition of O...
Source: Andrology - August 8, 2023 Category: Urology & Nephrology Authors: Katarzyna Kent,
Kaori Nozawa,
Courtney Sutton,
Frey Daniel,
Masahito Ikawa,
Thomas X. Garcia,
Martin M. Matzuk Tags: ORIGINAL ARTICLE Source Type: research
Evaluation of androgen receptor markers in erectile dysfunction
ConclusionThese data showed a significant decrease in the expression of proteins downstream of the androgen receptor at lower serumT levels. This suggests a potential correlation between serum T concentration and androgen receptor signaling and supports a potential saturation value between 200 and 300 ng/dL. (Source: Andrology)
Source: Andrology - August 8, 2023 Category: Urology & Nephrology Authors: Kajal Khodamoradi,
Katherine Campbell,
Himanshu Arora,
Ranjith Ramasamy Tags: SHORT COMMUNICATION Source Type: research
