Primary azoospermia factor C duplication associated with spermatogenic impariment: a case –control study based on Y‐chromosome haplogrouping in a Han Chinese population
ConclusionThe results suggest that, in the Han Chinese population, the gr/gr duplication is a predisposing genetic factor for spermatogenic impairment in males harboring Y-hg O3*. Meanwhile, the b2/b3 duplication may be fixed on a yet-unidentified subbranch of Y-hg Cα2* without significantly deleterious effect on spermatogenesis. Our findings provide evidence that the difference in the Y-hg composition may cause the discrepancy on the association of AZFc duplication with spermatogenic failure among the studied population s.
Source: Andrology - Category: Urology & Nephrology Authors: Shengyu Xie,
Yongyi Ma,
Yunqiang Liu,
Dachang Tao,
Zhaokun Wang,
Yuan Yang Tags: ORIGINAL ARTICLE Source Type: research
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