An integrated approach for improving clinical management of non ‐obstructive azoospermia
ConclusionThe full use of testicular biopsy is beneficial for the diagnosis of azoospermia, as it avoids the risk of multiple biopsies. Moreover, in combination with whole-exome sequencing, clinicians can obtain more information regarding the pathogenesis of non-obstructive azoospermia, which may guide treatment. (Source: Andrology)
Source: Andrology - January 15, 2024 Category: Urology & Nephrology Authors: Fu Shi,
Ye Liu,
Zheng Chen,
Dongliang Li,
Yuanqing Yao,
Meixun Zhou,
Yumin Zhuo,
Xin Ma,
Dandan Cao Tags: ORIGINAL ARTICLE Source Type: research
Issue Information
(Source: Andrology)
Source: Andrology - January 15, 2024 Category: Urology & Nephrology Tags: ISSUE INFORMATION Source Type: research
Knockdown of programmed cell death factor 4 restores erectile function by attenuating apoptosis in rats with bilateral cavernous nerve crush injury
Discussion and conclusionElevated programmed cell death factor 4 expression may be an important pathogenetic mechanism for erectile dysfunction after bilateral cavernous nerve crush, and the knockdown of programmed cell death factor 4 enhanced erectile function in 18-month-old rats after cavernous nerve damage. The potential mechanism may be the stimulation of the PI3K/AKT pathway to attenuate the cavernous apoptosis level. (Source: Andrology)
Source: Andrology - January 14, 2024 Category: Urology & Nephrology Authors: Yunlong Ge,
Tian Xia,
Zejia Feng,
Yuhang Xi,
Daoyuan Hu,
Yude Hong,
Bowen Tang,
Jianjie Wu,
Jialiang Chen,
Hengjun Xiao Tags: ORIGINAL ARTICLE Source Type: research
Sex hormones and the total testosterone:estradiol ratio as predictors of severe acute respiratory syndrome coronavirus 2 infection in hospitalized men
Discussion and conclusionOur results suggest that men with severe acute respiratory syndrome coronavirus 2 infection, decreased androgen levels and increased estradiol levels have a higher likelihood of developing an unfavorable outcome. The total testosterone:estradiol ratio showed the best predictive ability. (Source: Andrology)
Source: Andrology - January 12, 2024 Category: Urology & Nephrology Authors: David Ruiz ‐Ochoa,
Armando‐Raúl Guerra‐Ruiz,
María‐Teresa García‐Unzueta,
Pedro Muñoz‐Cacho,
Bryan Rodriguez‐Montalvan,
Carlos Antonio Amado‐Diago,
Bernardo‐Alio Lavín‐Gómez,
María‐Eliecer Cano‐García,
Daniel Pablo Tags: ORIGINAL ARTICLE Source Type: research
Association of abstinence time with semen quality and fertility outcomes: a systematic review and dose –response meta‐analysis
ConclusionsShort-term abstinence may be associated with limited improvements in semen quality in healthy men but could be more beneficial for infertile men, especially within the first 4 days of abstinence. Caution is urged in making definitive conclusions about the causal relationship between abstinence time and semen quality changes due to potential confounding and interactions. (Source: Andrology)
Source: Andrology - January 11, 2024 Category: Urology & Nephrology Authors: Chengchao Du,
Yi Li,
Chongyang Yin,
Xuefeng Luo,
Xiangcheng Pan Tags: REVIEW ARTICLE Source Type: research
The emergence of natural products as potential therapeutics for male infertility
AbstractInfertility is a major reproductive health problem. Approximately 50% of all documented cases of infertility are attributable to male factors, such as poor testicular function and semen quality. The recent significant global decline in sperm counts has serious implications for male fertility, but the armamentarium for improving testicular function and semen quality is limited. Natural products have a wide range of activities and are a major source of drugs for disease prevention and treatment. To provide ideas and a theoretical basis for the research and development of therapeutic drugs for male infertility, this r...
Source: Andrology - January 9, 2024 Category: Urology & Nephrology Authors: Xiuyun Li,
Bin Zhang,
Huijun Yang,
Liuping Zhang,
Hongxiang Lou,
Shicun Zheng Tags: REVIEW ARTICLE Source Type: research
The habits of European urologists in the field of cryopreservation before the urological cancers treatment
ConclusionOur study showed variable country specific tendencies in terms of fertility preservation in the period of treatment of urological cancers. These differences seem to be related to national guidelines recommendations. Standardization of international guidelines is urgently needed in the field of fertility for urological cancer patients. (Source: Andrology)
Source: Andrology - January 7, 2024 Category: Urology & Nephrology Authors: Amandine Degraeve,
Thierry Roumeguere,
Gilles Tilmans,
Marie ‐Laura Marotta,
Eric Huyghe,
Georges Fournier,
Antoine Faix,
Anne‐Françoise Spinoit,
Karel Decaestecker,
François Herve,
Florence Boitrelle,
Kanerva Lahdensuo,
Lorenzo Tosco,
Tags: ORIGINAL ARTICLE Source Type: research
For the penile length —how shall we choose the straightening procedures in hypospadias repair?
ConclusionFor hypospadias, the 30 ° after degloving may serve as the cut-off for the selection of the straightening method from the perspective of the penile length. For those with < 30°, methods such as DP or UP transection can either be selected. In patients with > 30°, DP should be used with caution because of the potential risk to shorten the penis. In contrast, UP transection effectively corrects the penile curvature and increases the penile length concurrently, which should be primarily recommended in those patients. (Source: Andrology)
Source: Andrology - January 4, 2024 Category: Urology & Nephrology Authors: Yan Liang,
Yiqing Lyu,
Yichen Huang,
Min Wu,
Xiaoxi Li,
Hua Xie,
Fang Chen Tags: ORIGINAL ARTICLE Source Type: research
6 ‐Nitrodopamine is an endogenous mediator of the rabbit corpus cavernosum relaxation
Discussion and conclusion6-Nitrodopamine is the most potent endogenous relaxant agent in RbCC ever described and represents a novel mechanism by which NO causes corpus cavernosum smooth muscle relaxation. The finding that 6-ND acts as a truly selective dopamine D2-receptor antagonist indicates that the balance of dopamine and 6-ND release/synthesis may be the main mechanism that modulates corpus cavernosum smooth muscle tonus in vivo. (Source: Andrology)
Source: Andrology - December 30, 2023 Category: Urology & Nephrology Authors: Antonio Tiago Lima,
Jos é Britto‐Júnior,
Manoel Odorico Moraes,
Maria Elisabete A. Moraes,
Adriano Fregonesi,
Fabíola Z. Monica,
Edson Antunes,
Gilberto De Nucci Tags: ORIGINAL ARTICLE Source Type: research
Comparing Western and traditional Chinese medicine for male sexual dysfunction: can Klotho represent a silk road?
AbstractTraditional Chinese medicine (TCM) and Western Medicine both have shown efficacy in treating male sexual dysfunction (MSD). The aim of this perspective paper is to discuss a possible link between Western medicine and TCM in the MSD field as represented by the entity of Klotho. Klotho is a recently discovered protein, mainly expressed in the kidney, encoded by the anti-aging gene klotho. Not only is Klotho significantly correlated with the development and progression of kidney diseases and their complications, but increasing evidence indicates that it is also closely related to MSD. A comprehensive search within Pub...
Source: Andrology - December 29, 2023 Category: Urology & Nephrology Authors: Fu Wang,
Elena Colonnello,
Hui Zhang,
Andrea Sansone,
Chunlin Wang,
Susanna Dolci,
Jun Guo,
Emmanuele A. Jannini Tags: REVIEW ARTICLE Source Type: research
Paternal and maternal preconception and maternal pregnancy urinary concentrations of parabens in relation to child behavior
ConclusionIn this cohort, paternal preconception urinary concentrations of propyl and methyl paraben were associated with worse parent-reported child behaviors. (Source: Andrology)
Source: Andrology - December 28, 2023 Category: Urology & Nephrology Authors: Jordana Leader,
Lidia M ínguez‐Alarcón,
Paige L. Williams,
Jennifer B. Ford,
Ramace Dadd,
Olivia Chagnon,
David C. Bellinger,
Emily Oken,
Antonia M. Calafat,
Russ Hauser,
Joseph M. Braun Tags: ORIGINAL ARTICLE Source Type: research
Testosterone replacement therapy: association with mortality in high ‐risk patient subgroups
ConclusionsThis study with long follow-up confirms that TTh is associated with lower mortality in men with adult-onset TD. This association was evident only in men with greater cardio-metabolic risk factors who demonstrated greater benefit. (Source: Andrology)
Source: Andrology - December 27, 2023 Category: Urology & Nephrology Authors: Amar Mann,
Richard C Strange,
Carola S K önig,
Geoffrey Hackett,
Ahmad Haider,
Karim Sultan Haider,
Peter Desnerck,
Sudarshan Ramachandran Tags: ORIGINAL ARTICLE Source Type: research
Microfluidics: The future of sperm selection in assisted reproduction
ConclusionFuture work needs to be performed on numerical simulation of the microfluidics chip prior to fabrication as well as relevant clinical assessment after the selection procedure. This would require a close collaboration and understanding among engineers, biologists, and medical professionals. It is interesting that in spite of two decades of microfluidics sperm selection, numerical simulation and clinical studies are lagging behind. It is expected that microfluidic sperm selection platforms will play a major role in the development of fully integrated start-to-finish assisted reproductive technology systems. (Source: Andrology)
Source: Andrology - December 27, 2023 Category: Urology & Nephrology Authors: Ali Reza Jahangiri,
Niloofar Ziarati,
Ehsan Dadkhah,
Mustafa Numan Bucak,
Pegah Rahimizadeh,
Abdolhossein Shahverdi,
Mohammad Ali Sadighi Gilani,
Tohid Rezaei Topraggaleh Tags: REVIEW ARTICLE Source Type: research
Causal relationship between worry, tension, insomnia, sensitivity to environmental stress and adversity, and erectile dysfunction: a study using Mendelian randomization
ConclusionIndividuals with insomnia and SESA are at higher risk for developing ED. Clinical evaluation should be more thorough for these individuals. Insomnia can be treated simultaneously with psychological counseling to reduce the risk of ED. In addition, there is no evidence to suggest that worry and tension increase the risk of ED. (Source: Andrology)
Source: Andrology - December 23, 2023 Category: Urology & Nephrology Authors: Hao Zhang,
Shiqi Wang,
Sicheng Ma,
Chenming Zhang,
Zulong Wang,
Peiyu Yan Tags: ORIGINAL ARTICLE Source Type: research
Cryopreservation of highly extended pig spermatozoa remodels its proteome and counteracts polyspermic fertilization in vitro
AbstractBackgroundCurrently, high polyspermy remains a significant obstacle to achieving optimal efficiency in in vitro fertilization (IVF) and in vitro embryo production (IVP) systems in pigs. Developing strategies that would prevent polyspermy is essential in overcoming this challenge and maximizing the potential of this reproductive biotechnology. Previous results have demonstrated that using boar spermatozoa subjected to a high-extension and reconcentration procedure and then cryopreserved resulted in significant improvements in IVF/IVP systems with high rates of monospermy and penetration.ObjectiveThe aim of the prese...
Source: Andrology - December 22, 2023 Category: Urology & Nephrology Authors: Inmaculada Parrilla,
Josep M. Cambra,
Cristina Cuello,
Heriberto Rodriguez ‐Martinez,
Maria A. Gil,
Emilio A. Martinez Tags: ORIGINAL ARTICLE Source Type: research
