Is varicocoelectomy indicated in infertile men with isolated teratozoospermia? a systematic review and meta ‐analysis
ConclusionThis meta-analysis reported that varicocoelectomy may increase pregnancy rates by improving semen parameters in infertile men with isolated teratozoospermia, although this conclusion requires further evidence. (Source: Andrology)
Source: Andrology - February 13, 2024 Category: Urology & Nephrology Authors: Murat Dursun,
H üseyin Beşiroğlu,
Reşat Aydın,
Turgay Kaçan,
Ahmet Halil Sevinç,
Ateş Kadıoğlu Tags: REVIEW ARTICLE Source Type: research
The paternal role in pregnancy loss
AbstractIn this comprehensive review, the intricate relationship between paternal factors and pregnancy loss is examined. While pregnancy loss has historically been predominantly attributed to maternal factors, recent research underscores the significant contribution of the male partner. The review delves into various aspects of paternal influence, including paternal age, health, chromosome abnormalities, Y chromosome deletions, and sperm DNA fragmentation. Notably, advanced paternal age is found to be associated with an increased risk of recurrent pregnancy loss, shedding light on the importance of understanding the impac...
Source: Andrology - February 10, 2024 Category: Urology & Nephrology Authors: Wade Muncey,
Michael Scott,
Ruth B. Lathi,
Michael L. Eisenberg Tags: REVIEW ARTICLE Source Type: research
The association between ambient temperature and semen quality in a Northern Peninsular Province, China
Discussion and conclusionExposure to non-optimal temperature is associated with decreased semen quality in North China, with the epididymal storage and sperm motility development periods more sensitive to cold exposure than heat. Older males and those with higher educations may need particular awareness. (Source: Andrology)
Source: Andrology - January 31, 2024 Category: Urology & Nephrology Authors: Li Wang,
Yinan Qu,
Wenkai Han,
Meng Cai,
Wei Ma,
Qi Zhao,
Zi ‐Jiang Chen Tags: ORIGINAL ARTICLE Source Type: research
3 ‐Hydroxy‐3‐methylglutaryl‐CoA synthase 2 facilitates erectile dysfunction via inhibiting autophagy by enhancing the mammalian target of rapamycin pathway in type 1 diabetic mellitus rats
Discussion and conclusionHMGCS2 upregulation in T1DM rats inhibited autophagy and eNOS activity by activating the mTOR pathway and led to a decrease in the erectile function. (Source: Andrology)
Source: Andrology - January 26, 2024 Category: Urology & Nephrology Authors: Zhiqiang Dai,
Yang Zeng,
Xiao Tan,
Tao Zhou,
Xiong Li,
Qingfu Deng Tags: ORIGINAL ARTICLE Source Type: research
Cost ‐effectiveness of testosterone treatment utilising individual patient data from randomised controlled trials in men with low testosterone levels
Conclusions and future researchOur data suggest that testosterone is cost-effective in men<75 years when Beck depression index-derived quality-adjusted life years data are considered; cost-effectiveness in men>75 years is dependent on cardiovascular safety. However, more robust and longer-term cost-utility data are needed to verify our conclusion. (Source: Andrology)
Source: Andrology - January 18, 2024 Category: Urology & Nephrology Authors: Rodolfo Hern ández,
Nipun Lakshitha de Silva,
Jemma Hudson,
Moira Cruickshank,
Richard Quinton,
Paul Manson,
Waljit S. Dhillo,
Siladitya Bhattacharya,
Miriam Brazzelli,
Channa N. Jayasena Tags: ORIGINAL ARTICLE Source Type: research
A global perspective: characteristics of infertility ‐related randomized clinical trials
ConclusionBased on the current status of infertility RCT studies, greater attention should be paid to infertile men and populations in underdeveloped regions like Africa in future studies, together with a standardized registration and implementation procedures. (Source: Andrology)
Source: Andrology - January 17, 2024 Category: Urology & Nephrology Authors: Yu Xi,
Ya ‐Lei Cao,
Li‐Yuan Tao,
Song‐Zhan Gao,
Zi‐Run Jin,
Jian‐Xing Cheng,
Hui Jiang,
Zhe Zhang Tags: ORIGINAL ARTICLE Source Type: research
Heme ‐induced corpus cavernosum relaxation and its implications for priapism in sickle cell disease: a mechanistic insight
Discussion and conclusionThe HO –CO–sGC–cGMP pathway appears to play a crucial role in promoting CC relaxation. Our study provides novel insight into the role of group heme in CC relaxation and its potential contribution to priapism in SCD. Heme may serve as a pharmacological target for new therapies to prevent priapism. (Source: Andrology)
Source: Andrology - January 17, 2024 Category: Urology & Nephrology Authors: Dalila Andrade Pereira,
Danillo Andrade Pereira,
Tammyris Helena Rebecchi Silveira,
Fabiano Beraldi Calmasini,
Arthur L. Burnett,
Fernando Ferreira Costa,
F ábio Henrique Silva Tags: ORIGINAL ARTICLE Source Type: research
Repetitive transcranial magnetic stimulation via the hippocampal brain ‐derived neurotrophic factor–tyrosine kinase receptor B pathway to affect sexual behavior and neuroplasticity in rapid ejaculation rats
ConclusionRTMS upregulates BDNF, SYN, and PSD95 expression through activation of the BDNF –TrkB pathway and increases brain 5-hydroxytryptamine thereby regulating neuroplasticity and improving ejaculation. (Source: Andrology)
Source: Andrology - January 17, 2024 Category: Urology & Nephrology Authors: Qiushi Liu,
Ming Wang,
Weinan Wang,
Shaoyu Yue,
Tommaso B. Jannini,
Emmanuele A. Jannini,
Hui Jiang,
Xiansheng Zhang Tags: ORIGINAL ARTICLE Source Type: research
Novel variations in TENT5D lead to teratozoospermia in infertile patients
ConclusionsOur results showed further evidence of a relationship betweenTENT5D mutation and human male infertility, providing new genetic insight for use in the diagnosis and treatment of male infertility. (Source: Andrology)
Source: Andrology - January 17, 2024 Category: Urology & Nephrology Authors: Ying ‐Teng Zhang,
Gan Shen,
Liang‐Chai Zhuo,
Xue Yang,
Su‐Yan Wang,
Tie‐Chao Ruan,
Chuan Jiang,
Xiang Wang,
Yan Wang,
Yi‐Hong Yang,
Ying Shen Tags: ORIGINAL ARTICLE Source Type: research
Trends in the use of testicular prostheses in Germany: a total population analysis from 2006 –2021
ConclusionThis study shows that implantation of testicular prostheses is steadily increasing. Explantation rates are low. Besides testicular cancer transgender surgeries were the main driver for increasing case numbers in recent years. (Source: Andrology)
Source: Andrology - January 17, 2024 Category: Urology & Nephrology Authors: Cem Aksoy,
Philipp Reimold,
Philipp Karschuck,
Christer Groeben,
Rainer Koch,
Nicole Eisenmenger,
Smita Thoduka,
Aristeidis Zacharis,
Hans Schmelz,
Johannes Huber,
Luka Flegar Tags: ORIGINAL ARTICLE Source Type: research
MiRNA ‐100 ameliorates diabetes mellitus‐induced erectile dysfunction by modulating autophagy, anti‐inflammatory, and antifibrotic effects
ConclusionMiR-100 can improve the erectile function by inhibiting mTOR and thus inducing autophagy, improving the endothelial function through the eNOS/NO/cGMP axis, and exerting antifibrotic and anti-inflammatory effects, which may provide new ideas and directions for the treatment of DMED. (Source: Andrology)
Source: Andrology - January 16, 2024 Category: Urology & Nephrology Authors: Beining Li,
Peng Hu,
Kang Liu,
Wenchao Xu,
Jiaxin Wang,
Qinyu Li,
Bingliang Chen,
Yuxuan Deng,
Chenglin Han,
Taotao Sun,
Xinqi Liu,
Mingchao Li,
Tao Wang,
Jihong Liu,
Huang Lin,
Ke Rao Tags: ORIGINAL ARTICLE Source Type: research
Impact of sexual function domains on sexual satisfaction and quality of life: Importance across the age spectrum
ConclusionsThe erectile function was independently associated with sexual satisfaction and quality of life across all age strata and predictive of both sexual satisfaction and global HRQoL. Low overall rates of sexual satisfaction across cohorts highlight the critical importance of evaluation and treatment of sexual health, regardless of age. (Source: Andrology)
Source: Andrology - January 16, 2024 Category: Urology & Nephrology Authors: Jackson J. Cabo,
Melissa R. Kaufman,
Niels V. Johnsen Tags: ORIGINAL ARTICLE Source Type: research
Comparative analysis of surgical modalities for the gynecomastia treatment: efficiency and aesthetic outcomes
AbstractThis retrospective study rigorously compares the clinical efficacy of three surgical methodologies for treating gynecomastia while providing guidance for future surgical modality selection. We analyzed records of 77 gynecomastia patients treated between January 2015 and October 2022. Patients were categorized into three groups: Group A (subcutaneous gland resection via areola incision), Group B (liposuction combined with single-hole endoscopic gland resection), and Group C (liposuction combined with three-hole endoscopic gland resection). Parameters assessed included patient demographics, intraoperative bleeding, s...
Source: Andrology - January 16, 2024 Category: Urology & Nephrology Authors: Debo Chen,
Jialin Chen,
Yiqin Huang,
Chengye Hong,
Liangqiang Li,
Bimei Cai,
Zhipeng Hong Tags: ORIGINAL ARTICLE Source Type: research
New insights into sperm physiology regulation: Enlightenment from G ‐protein‐coupled receptors
ConclusionThe present review provides a comprehensive overview of studies describing G-protein-coupled receptors and their potential action in sperm function. We also present a critical discussion of these issues, and a possible framework for future investigations on the diverse ligands, biological functions and cell signalling of G-protein-coupled receptors in spermatozoa. Here, the G-protein-coupled receptors and their related G proteins that specifically were identified in spermatozoa were summarised, and provided references valuable for further illumination, despite the evidence that is not overwhelming in most cases. (Source: Andrology)
Source: Andrology - January 16, 2024 Category: Urology & Nephrology Authors: Pengyuan Dai,
Chen Chen,
Jingyan Yu,
Chaoye Ma,
Xiaoning Zhang Tags: REVIEW ARTICLE Source Type: research
Sperm selection by zona adhesion improves assisted reproductive treatment outcomes
Discussion and conclusionThe application of solubilised zonae pellucidae in the sperm selection for ICSI benefits ART outcomes in couples with unexplained infertility. Moreover, sperm –zona selection significantly reduces the risk of miscarriages. (Source: Andrology)
Source: Andrology - January 16, 2024 Category: Urology & Nephrology Authors: Rumiana Ganeva,
Dimitar Parvanov,
Nina Vidolova,
Maria Handzhiyska,
Margarita Ruseva,
Magdaleva Vasileva,
Kristina Nikolova,
Ivka Ivanova,
Miray Shaban,
Joanna Shabarkova,
Rayna Hristova,
Milena Miladinova,
Georgi Stamenov Tags: ORIGINAL ARTICLE Source Type: research
