American Journal of Clinical Oncology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

ACR-ABS-ASTRO Practice Parameter for the Performance of Low-Dose-Rate Brachytherapy
Conclusions: This practice parameter is a tool to guide the use of LDR brachytherapy and does not assess relative clinical indication for LDR brachytherapy when compared with other forms of brachytherapy or external beam therapy, but to focus on the best practices required to deliver LDR brachytherapy safely and effectively, when clinically indicated. Comparative costs of versus other modalities therapy may also need to be considered. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - May 26, 2022 Category: Cancer & Oncology Tags: Original Articles: Practice Parameters Source Type: research

ACR-ACNM-ASTRO-SNMMI Practice Parameter for Lutetium-177 (Lu-177) DOTATATE Therapy
Conclusions: Lu-177 DOTATATE is available for therapy of inoperable and/or advanced GEP-NETs when conventional therapy had failed. It can reduce tumor size, improve symptoms, and increase the progression free survival. The PP document provides clinical guidance for authorized users to assure an appropriate, consistent, and safe practice of Lu-177 DOTATATE. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - May 26, 2022 Category: Cancer & Oncology Tags: Original Articles: Practice Parameters Source Type: research

Comprehensive Understanding and Evolutional Therapeutic Schemes for Pseudomyxoma Peritonei: A Literature Review
Pseudomyxoma peritonei is an infrequent solid tumor in clinical practice. The low morbidity and deficient understanding of this mucus-secreting malignant disease increase the risks of delayed identification or uncontrollable deterioration. In quite a lot cases, patients go through complete cytoreduction surgery and hyperthermic intraperitoneal chemotherapy could receive a long time survival over 5 years. But the recurrence rate is also hard to overlook. Unlike other types of cancer, the standard treatment for this considerable groups has not been confirmed yet. With the advanced medical progression, studies have been carry...
Source: American Journal of Clinical Oncology - April 27, 2022 Category: Cancer & Oncology Tags: Review Article Source Type: research

A Proposal to Modify the 8th IASLC System: Is it Suitable for T4N2M0 Lung Adenocarcinoma to Be Placed in Stage IIIB?
Purpose: The International Association for the Study of Lung Cancer (IASLC) of TNM staging system has been well accepted as a precise model. However, the latest American Joint Committee on Cancer (AJCC) staging system to solve the different survival and prognosis of lung adenocarcinoma in the same period is still controversial. Therefore, it is necessary to thoroughly explore the applicability between the new system and survival prediction in terms of lung adenocarcinoma. Methods: We recruited 52,517 patients with lung adenocarcinoma from the Surveillence, Epidemiology, and End Results database. Cox regression a...
Source: American Journal of Clinical Oncology - April 27, 2022 Category: Cancer & Oncology Tags: Original Articles: Thoracic Source Type: research

Changes in Survival Outcomes of Patients With Neuroendocrine Neoplasms Over the Past 15 Years: A Real-World Study
Conclusions: Over the study period (2004 to 2019), patients diagnosed during later periods did not appear to experience better OS compared with patients diagnosed at an earlier time. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - April 27, 2022 Category: Cancer & Oncology Tags: Original Articles: Neuroendocrine Source Type: research

Prospective Study of PET/MRI Tumor Response During Chemoradiotherapy for Patients With Low-risk and Intermediate-risk p16-positive Oropharynx Cancer
The objective of this study was to examine tumor response with positron emission tomography (PET)/magnetic resonance imaging (MRI) during chemoradiotherapy as a predictor of outcome in patients with p16-positive oropharynx cancer. Materials and Methods: Patients with p16-positive oropharynx cancer were treated with chemoradiotherapy. Low-risk (LR) disease was defined as T1-T3 and N0-2b and ≤10 pack-years and intermediate-risk (IR) disease as T4 or N2c-3 or>10 pack-years. Patients underwent a PET/MRI scan pretreatment and at fraction 10. Change in value of imaging means were analyzed by analysis of variance. K-mean...
Source: American Journal of Clinical Oncology - April 27, 2022 Category: Cancer & Oncology Tags: Original Articles: Head and Neck Source Type: research

Stereotactic Body Radiation Therapy (SBRT) for Spinal Metastases: Real-world Outcomes From an International Multi-institutional SBRT Registry
The objective of this study was to compare clinical outcomes following single fraction versus fractionated stereotactic body radiotherapy (SBRT) for spinal metastases. Materials and Methods: A multi-institutional registry was queried for patients with spinal metastases treated with single-fraction or fractionated SBRT. Potential predictive factors of local control (LC) and overall survival were evaluated. Pretreatment and posttreatment Visual Analog Scale scores were analyzed to examine initial and durable pain responses and complete response (CR) rates. Logistic regression was utilized to assess potential correlati...
Source: American Journal of Clinical Oncology - April 27, 2022 Category: Cancer & Oncology Tags: Original Articles: Central Nervous System Source Type: research

Short-term ADT and Dose-escalated IMRT in Patients With Intermediate-risk Prostate Cancer: Benefit or Caution?
Conclusions: In our 15-year experience treating IR prostate cancer with dose-escalated IMRT with daily image-guided RT, short-term concurrent ADT was associated with a statistically significant worse OS. Additional studies are needed to determine if ADT is beneficial or detrimental for patients with IR prostate cancer treated with dose-escalated radiation. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - April 27, 2022 Category: Cancer & Oncology Tags: Original Articles: Genitourinary Source Type: research

A Chitosan-Coated Chamomile Microparticles Formulation to Prevent Radiodermatitis in Breast: A Double-blinded, Controlled, Randomized, Phase II Clinical Trial
Conclusions: Although no effect was observed with chamomile to reduce any grade of RD, it was effective to reduce grade 2 or>toxicity, to improve skin recovery and to diminish high-intensity local symptoms. Trial Registration: Brazilian Registry of Clinical Trials (ReBEC): RBR-9hnftg, April 29, 2019. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - April 27, 2022 Category: Cancer & Oncology Tags: Original Articles: Breast Source Type: research

Yttrium-90 Radioembolization of Colorectal Cancer Liver Metastases: A Systematic Review of Clinical Evidence
The present work aims to review the clinical evidence of survival outcome after treatment of colorectal cancer liver metastases using yttrium-90 radioembolization, existence, and relevance of clinical, imaging, and genomic predictors of treatment efficacy and the amount of administered activity. Publications listed in PubMed between July 2016 and May 2021 were screened. Predictors of overall survival were reported and distinguished in clinical, imaging, and genomic variables. Administered activity is reported as median and mean value; overall survival is presented as a median value from the treatment. Fourteen papers resul...
Source: American Journal of Clinical Oncology - March 24, 2022 Category: Cancer & Oncology Tags: Review Articles Source Type: research

Use of “Repurposed” Drugs in the Treatment of Epithelial Ovarian Cancer: A Systematic Review
Epithelial ovarian cancer has poor outcomes with standard therapy and limited options for treatment of recurrent disease. This systematic review summarizes the data on the clinical use of repurposed drugs. We searched for clinical studies using “repurposed” agents for the treatment of ovarian cancer in the following databases: PubMed, clinicaltrials.gov, Clinical Trial Registry of India, European Clinical Trials Registry, and Chinese Clinical Trial Registry. We excluded reviews, preclinical studies, and non-English language studies. We assessed the quality of included studies. The following agents/class of agents were ...
Source: American Journal of Clinical Oncology - March 24, 2022 Category: Cancer & Oncology Tags: Review Articles Source Type: research

Incidence and Predictors of Persistent Opioid Use in Survivors of Head and Neck Cancer Treated With Curative Radiation
Purpose: We sought to characterize the incidence of chronic opioid dependence among head and neck cancer survivors treated by radiation, as well as to identify patient and treatment factors associated with persistent use. Materials and Methods: The medical records of patients with head and neck cancer who received radiation therapy from January 2012 to July 2016 were reviewed. All patients received 60 to 70 Gy with curative intent. Patients who progressed or died within 1 year were intentionally excluded. Opioid doses were calculated in morphine equivalent daily doses in milligrams (mg). Univariate and multiva...
Source: American Journal of Clinical Oncology - March 24, 2022 Category: Cancer & Oncology Tags: Original Articles: Head and Neck Source Type: research

Cardiovascular Diseases Following Breast Cancer: Towards a Case-by-Case Assessment Through a Prediction Risk Score Model in 943 Patients
Objectives: To identify patients at high risk of developing cardiovascular disease through the identification of risk factors among a large population of breast cancer women and to assess the performance of Abdel-Qadir risk prediction model score. Materials and Methods: The medical records and baseline characteristics of all patients/tumors diagnosed with breast cancer from 2010 to 2011 in a French comprehensive cancer center were collected. Cardiovascular events were defined as arterial and cardiac events, atrial fibrillation and venous thromboembolism occurring during the 5-year follow-up. Abdel-Qadir multivar...
Source: American Journal of Clinical Oncology - March 24, 2022 Category: Cancer & Oncology Tags: Original Articles: Breast Source Type: research

Patterns of Use of Stereotactic Body Radiation Therapy Compared With Surgery for Definitive Treatment of Primary Early-stage Non–small Cell Lung Cancer
Objective: As stereotactic body radiation therapy (SBRT) becomes widely available for early-stage non–small cell lung cancer (NSCLC), there may be concerns in the surgical community that SBRT is being offered for patients with operable tumors, even though surgery is standard of care. We evaluated the trends in SBRT and surgery over time for patients with NSCLC. Materials and Methods: The National Cancer Database was queried for patients with node-negative NSCLC ≤5 cm from 2004 to 2016. The relationships between definitive local treatment modalities and year were analyzed using a multinomial regression mode...
Source: American Journal of Clinical Oncology - March 24, 2022 Category: Cancer & Oncology Tags: Original Articles: Thoracic Source Type: research

Uptake of Adjuvant Durvalumab After Definitive Concurrent Chemoradiotherapy for Stage III Nonsmall-cell Lung Cancer
Conclusion: Adjuvant durvalumab for stage III NSCLC treated with definitive chemoradiation was rapidly and successfully incorporated into clinical care across a range of community and academic settings in the state of Michigan, with over 90% of potentially eligible patients starting durvalumab in more recent months. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - March 24, 2022 Category: Cancer & Oncology Tags: Original Articles: Thoracic Source Type: research