American Journal of Clinical Oncology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

The Older Adults With Rectal Cancer—Does Age Matter?: A Single-center Experience
Objectives: Oncological treatments of older patients have many unresolved questions mainly because of the fact that these patients were not eligible to be included in most clinical trials. The aim of this study was to evaluate the treatment approach to localized rectal cancer in the older population, including complication rates and overall survival in patients treated with curative intent. Materials and Methods: A retrospective review of patients older than 80 years old (group A) who were treated for clinical stages II to III rectal cancer. The data collection included demographics, comorbidities, treatment pro...
Source: American Journal of Clinical Oncology - November 26, 2020 Category: Cancer & Oncology Tags: Original Articles: Gastrointestinal Source Type: research

Adjuvant FOLFOX+Nab-Paclitaxel (FOLFOX-A) for Pancreatic Cancer: A Brown University Oncology Research Group Phase II Study (BrUOG295)
Conclusions: Adjuvant FOLFOX-A is a feasible multi-agent adjuvant treatment regimen and, with further validation, could be an alternative to FOLFIRINOX. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - November 26, 2020 Category: Cancer & Oncology Tags: Original Articles: Gastrointestinal Source Type: research

Trends in Primary Surgical Resection and Chemotherapy for Metastatic Colorectal Cancer, 2000-2016
Background: When, whether, and in whom primary tumor resection (PTR) for patients with metastatic colorectal cancer (CRC) is indicated remains unknown. With advances in multiagent systemic chemotherapy, PTR may be undertaken less frequently. The aim of this study was to obtain estimates of changes in the utilization of PTR and chemotherapy for metastatic CRC. Methods: Patients diagnosed with metastatic CRC between 2000 and 2016 were identified from Surveillance Epidemiology, and End Results (SEER) registry. Multivariable logistic regression defined odds of undergoing PTR. The analysis was also stratified by prim...
Source: American Journal of Clinical Oncology - November 26, 2020 Category: Cancer & Oncology Tags: Original Articles: Gastrointestinal Source Type: research

Characterization of a Novel Entity of G3 (High-grade Well-differentiated) Colorectal Neuroendocrine Tumors (NET) in the SEER Database
Objectives: Small studies suggest that a new entity of high-grade (HG) (G3, by Ki-67 or mitotic index) well-differentiated (histologically) gastrointestinal neuroendocrine tumors (NETs) exists, but prognosis and characteristics are unknown. We further characterized demographics and prognosis of patients with colorectal G3 NETs. Materials and Methods: We used the Surveillance Epidemiology and End Results (SEER) database to study colorectal NETs diagnosed from 2000 to 2015. We evaluated demographic, clinical, and tumor characteristics. We compared overall survival (OS) for G1-2 NET, G3 NET, and NEC (neuroendocrine...
Source: American Journal of Clinical Oncology - November 26, 2020 Category: Cancer & Oncology Tags: Original Articles: Gastrointestinal Source Type: research

Brain Radiation Induced Extracranial Abscopal Effects in Metastatic Melanoma
Historically, the brain has been viewed as a specialized neurovascular inert organ with a distinctive immune privilege. Therefore, radiation-induced extracranial abscopal effects would be considered an unusual phenomenon due to the difficulty of the immunogenic signaling molecules to travel across the blood-brain barrier (BBB). However, it is now possible that localized central nervous system radiation has the ability to disrupt the structural integrity of the BBB and increase its endothelial permeability allowing the free passage of immunogenic responses between the intracranial and extracranial compartments. Thus, the na...
Source: American Journal of Clinical Oncology - November 26, 2020 Category: Cancer & Oncology Tags: Original Articles: Cutaneous Source Type: research

Is There a Role for Statins and Metformin in Cancer Therapy?
No abstract available (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - November 26, 2020 Category: Cancer & Oncology Tags: Editorial Source Type: research

Incidental Coronary Artery Calcium on Breast Radiation Therapy Planning Scans Identifies Patients for Cardiac Preventive Therapy
Conclusion: Observation of incidental CAC on breast radiation-planning CT scans identified patients who could benefit from cardiac-related preventive strategies. By increasing attention, awareness, and reporting of incidental CAC visible on CT sims, radiation oncologists may fulfill a unique role to bridge a potential gap in cardiovascular preventive medicine. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - October 23, 2020 Category: Cancer & Oncology Tags: Original Articles: Breast Source Type: research

Angiosarcoma of the Breast: Management and Outcomes
Objective: Angiosarcoma of the breast is rare and has a poor prognosis. We reviewed our institution’s experience with this disease to characterize presentation, identify management patterns, and report outcomes. Methods: Fifty-eight patients with nonmetastatic angiosarcoma were identified from 1998 to 2019 and retrospectively reviewed. Overall survival (OS) and recurrence-free survival (RFS) were calculated using the Kaplan-Meier analysis and log-rank test. Results: The median follow-up was 43.4 months (range: 1.8 to 203.3 mo). Twenty-four patients had primary angiosarcoma (PAS) and 34 patients had secondary an...
Source: American Journal of Clinical Oncology - October 23, 2020 Category: Cancer & Oncology Tags: Original Articles: Breast Source Type: research

Food Intake During Cancer Therapy: A Systematic Review
Conclusions: Available evidence suggests food can be effective at ameliorating cancer treatment-related toxicities and improving prognosis, but more research is needed. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - October 23, 2020 Category: Cancer & Oncology Tags: Original Articles: Palliative Care Source Type: research

Inpatient Palliative Care Use Among Critically III Brain Metastasis Patients in the United States
This study was a retrospective analysis of Nationwide Inpatient Sample data collected during 2005 to 2014. This study included critically ill patients, 18 years and above, diagnosed with brain metastasis, identified using International Classification of Diseases-Ninth Revision-Clinical Modification diagnosis and procedure codes. Multivariable logistic regression models were used for predicting factors associated with inpatient palliative care use. Results: Among 18,309 critically ill patients with brain metastasis, 3298 (18.0%) received inpatient palliative care. The rate of inpatient palliative care use among these pat...
Source: American Journal of Clinical Oncology - October 23, 2020 Category: Cancer & Oncology Tags: Original Articles: Palliative Care Source Type: research

False-positive 1p/19q Testing Results in Gliomas: Clinical and Research Consequences
Conclusions: Pathologists and neuro-oncologists should be aware of false-positive 1p19q FISH results as they can significantly change treatment and prognosis for glioma patients. Moreover, this issue should be taken into account when designing clinical trials specific to this disease cohort. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - October 23, 2020 Category: Cancer & Oncology Tags: Original Articles: Central Nervous System Source Type: research

Neuro-oncology Multidisciplinary Clinic and Improvements in Patient Outcome
The objective of this study was to evaluate the role of a neuro-oncology MDC on patient outcomes. Materials and Methods: Retrospective study was performed on consecutive patients who received radiosurgery for central nervous system (CNS) disease. We evaluated patients 2 years before and 2 years after the implementation of a MDC. Results: A total of 351 patients were analyzed, 163 patients before MDC and 188 after implementation of MDC. Before MDC the median follow-up was dependent on which department ordered follow-up radiographic imaging. This discrepancy decreased after the MDC. Overall survival for patients with C...
Source: American Journal of Clinical Oncology - October 23, 2020 Category: Cancer & Oncology Tags: Original Articles: Central Nervous System Source Type: research

Gender Differences in Outcomes of Patients With Mesothelioma
Conclusions: The study increases knowledge about gender differences in mesothelioma survival and is the first to directly examine this in the United Kingdom. It further disentangles the effects of age, histology, and health status. Increased estrogen may improve survival and could provide a potential target for future therapies. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - October 23, 2020 Category: Cancer & Oncology Tags: Original Articles: Thoracic Source Type: research

Eligibility for Second-line Therapy in Patients With Advanced Hepatocellular Carcinoma: A Population-based Study
Introduction: With an increasing number of systemic therapy options for hepatocellular carcinoma (HCC), optimal sequencing is an important consideration. There remains limited real-world data about the eligibility of patients for second-line therapies in advanced HCC. We characterized real-world eligibility and use of second-line therapies post sorafenib. Materials and Methods: We identified all patients with advanced HCC who received ≥1 cycle of first-line sorafenib between January 1, 2014 and December 31, 2017 in British Columbia, Canada. All patients were Child-Pugh class A for initiation of sorafenib. Baseline c...
Source: American Journal of Clinical Oncology - October 23, 2020 Category: Cancer & Oncology Tags: Original Articles: Gastrointestinal Source Type: research

Randomized Controlled Study to Compare Uncovered Stent Versus Covered Stent as Percutaneous Endoprosthesis for Malignant Biliary Obstruction (JIVROSG-0207)
Conclusions: There was no significant difference in the obstructive jaundice-free survival rate at 24 weeks between the 2 groups. Considering the technical difficulty and invasiveness of covered stent placement, the placement of covered stents may not be needed in patients with a short prognosis of (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - October 23, 2020 Category: Cancer & Oncology Tags: Original Articles: Gastrointestinal Source Type: research