American Journal of Clinical Oncology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

The Segmentation of Neuroendocrine Neoplasms According to Histology
No abstract available (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - December 23, 2020 Category: Cancer & Oncology Tags: Letters to the Editor Source Type: research

Characterization of a Novel Entity of G3 (High-grade Well-differentiated) Colorectal Neuroendocrine Tumors (NET) in the SEER Database
No abstract available (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - December 23, 2020 Category: Cancer & Oncology Tags: Letters to the Editor Source Type: research

Systematic Review and Meta-Analysis on the Use of Photon-based Stereotactic Radiosurgery Versus Fractionated Stereotactic Radiotherapy for the Treatment of Uveal Melanoma
Conclusions: Our meta-analysis showed no difference in tumor control, survival and toxicities, as defined in this paper, between SRS and fSRT for uveal melanoma. Confounding biases remain an expected limitation in this study of novel treatment modalities deployed in rare tumors. Further investigation is needed to validate outcomes and compare stereotactic treatment techniques. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - December 23, 2020 Category: Cancer & Oncology Tags: Original Articles: Ocular Source Type: research

Modern Management of High-risk Soft Tissue Sarcoma With Neoadjuvant Chemoradiation: A Single-center Experience
Conclusions: This single-institution series of NA-CRT demonstrates favorable disease control. Delay in surgical resection was associated with inferior LC, a finding that deserves further evaluation in a larger cohort. Level of Evidence: Level III—retrospective cohort study. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - December 23, 2020 Category: Cancer & Oncology Tags: Original Articles: Soft Tissue Source Type: research

Prior Treatment for Non–small Cell Lung Cancer Is Associated With Improved Survival in Patients who Undergo Definitive Stereotactic Body Radiation Therapy for a Subsequent Lung Malignancy: A Retrospective Multivariate and Matched Pair Analysis
Background: Despite occurring commonly, the prognoses of second early-stage non–small cell lung cancers (NSCLC) are not well known. Methods: The authors retrospectively reviewed the charts of inoperable patients who underwent thoracic stereotactic body radiation therapy (SBRT) from February 2007 to April 2019. Those with previous small cell lung cancers or SBRT treatments for tumors other than NSCLC were excluded. Multivariate Cox regression and a matched pair cohort analyses evaluated the prognoses of patients undergoing definitive SBRT for a new second primary. Results: Of 438 patients who underwent d...
Source: American Journal of Clinical Oncology - December 23, 2020 Category: Cancer & Oncology Tags: Original Articles: Thoracic Source Type: research

Outcome of Locally Advanced Esophageal Cancer Patients Treated With Perioperative Chemotherapy and Chemoradiotherapy Followed by Surgery
Conclusions: C-RT was associated with a higher degree of pathologically tumor regression. Patients with major tumor regression had a better outcome than those with minimal to poor response. There was a trend toward improved TTR with C-RT but no difference in OS or RFS. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - December 23, 2020 Category: Cancer & Oncology Tags: Original Articles: Thoracic Source Type: research

Which Lymph Node Staging System Better Predicts Prognosis in Patients With Gastric Carcinoma? A Comparative Study Between 3 Different Lymph Node Classifications for Resected Gastric Cancer in a Western Tertiary Center
Introduction: Gastric cancer (GC) is an aggressive disease with high mortality rates. Lymph node (LN) staging of GC is a major source of controversy. The aim of this study is to compare the prognostic value of 3 different LN classifications for patients with resected GC: the eighth TNM staging system, lymph node ratio (LNR, ratio between positive and total LN) and a new anatomic-based classification (Choi classification). Materials and Methods: A retrospective study of all cases of GC resected in a tertiary hospital in Spain (n=377). Clinical data were collected; histologic slides were reviewed; and univariate a...
Source: American Journal of Clinical Oncology - December 23, 2020 Category: Cancer & Oncology Tags: Original Articles: Gastrointestinal Source Type: research

In Reply: Comparing Late-line Treatment Sequence of Regorafenib and Reduced-intensity FOLFOXIRI for Refractory Metastatic Colorectal Cancer
No abstract available (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - November 26, 2020 Category: Cancer & Oncology Tags: Letters to the Editor Source Type: research

Comparing Late-line Treatment Sequence of Regorafenib and Reduced-intensity FOLFOXIRI for Refractory Metastatic Colorectal Cancer
No abstract available (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - November 26, 2020 Category: Cancer & Oncology Tags: Letters to the Editor Source Type: research

Palliative Irradiation of Sacral Metastases: Must the Entire Bone Be Treated?
Conclusions: The distal part of the sacrum is rarely involved in the metastatic process. Avoidance of radiation therapy to the lower sacrum simultaneously enables effective palliation and sparing of the adjacent rectum. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - November 26, 2020 Category: Cancer & Oncology Tags: Original Articles: Paliation Source Type: research

Adjuvant Trastuzumab Emtansine (T-DM1) and Concurrent Radiotherapy for Residual Invasive HER2-positive Breast Cancer: Single-center Preliminary Results
Conclusions: The acute toxicity rate especially focusing on skin and cardiac toxicity were assumed acceptable in our cohort. To safely administer this concomitant treatment, further examination and prospective data are needed. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - November 26, 2020 Category: Cancer & Oncology Tags: Original Articles: Breast Source Type: research

Concurrent β-blocker Use is Associated With Improved Outcome in Esophageal Cancer Patients Who Undergo Chemoradiation: A Retrospective Matched-pair Analysis
Background: β-blocker use has been associated with improved outcomes in a number of different malignancies; however, the impact of β-blockade in esophageal cancer is not been well characterized. We compared the outcomes of esophageal cancer patients based on β-blocker usage. Methods: The charts of all 418 patients treated with radiation for esophageal cancer at our institution from April 2010 to October 2018 were analyzed. Patients who underwent treatment with palliative intent or did not finish treatment were excluded. β-blocker use was determined from the medication list at time of pretreatment consultatio...
Source: American Journal of Clinical Oncology - November 26, 2020 Category: Cancer & Oncology Tags: Original Articles: Thoracic Source Type: research

Effect of Age on Cancer-specific Mortality in Patients With Urothelial Carcinoma of the Urinary Bladder: A Population-based Competing-risks Analysis Across Disease Stages
The objective of the study is to test the effect of age on cancer-specific mortality (CSM) in patients with urothelial carcinoma of the urinary bladder (UCUB), across all disease stages. Materials and Methods: Within the Surveillance, Epidemiology, and End Results (SEER) registry (2004-2016), we identified 207,714 patients. Age was categorized as: below 60 versus 60 to 69 versus 70 to 79 versus 80 years and above. Multivariable competing-risks regression (CRR) models were used according to disease stage (low-risk nonmuscle invasive: TaN0M0 low grade, high-risk nonmuscle invasive: Ta high grade or Tis-1N0M0, muscle i...
Source: American Journal of Clinical Oncology - November 26, 2020 Category: Cancer & Oncology Tags: Original Articles: Genitourinary Source Type: research

Long-term Oncologic Impact of Positive Anterior and Posterior Surgical Margins After Radical Prostatectomy
Conclusions: In our study, we found that prostate cancer patients with anterior-PSM showed a more favorable BCR prognosis similar to those with apex-PSM when comparing to patients with posterior-PSM. Our study results may help physicians to choose different treatment options for patients diagnosed with different PSM status including considering further adjuvant treatment for patients with posterior-PSM. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - November 26, 2020 Category: Cancer & Oncology Tags: Original Articles: Genitourinary Source Type: research

Population-based Assessment of Intermittent Androgen Deprivation Therapy Utilization for Relapsed, Nonmetastatic, Hormone-sensitive Adenocarcinoma of the Prostate
Objectives: Androgen deprivation therapy (ADT) is the standard of care for men with nonmetastatic hormone-sensitive prostate cancer (nmHSPC) after treatment failure. Although intermittent ADT (iADT) is noninferior to continuous ADT for prostate cancer outcomes, with superior quality of life and cost-to-benefit ratio, little is known regarding its real-world utilization. The authors aimed to determine the utilization of iADT in a Canadian Provincial Cancer Program for relapsed nmHSPC and identified risk factors associated with the nonreceipt of iADT. Materials and Methods: This retrospective population-based coho...
Source: American Journal of Clinical Oncology - November 26, 2020 Category: Cancer & Oncology Tags: Original Articles: Genitourinary Source Type: research