American Journal of Clinical Oncology 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Tyrosine Kinase Inhibitors and the Relationship With Adherence, Costs, and Health Care Utilization in Commercially Insured Patients With Newly Diagnosed Chronic Myeloid Leukemia: A Retrospective Claims-Based Study
Objective:
To examine the association among tyrosine kinase inhibitor (TKI) out-of-pocket costs, adherence, and health care costs and utilization in a large group of commercially insured patients with chronic myeloid leukemia (CML).
Materials and Methods:
Patients with CML aged 18 to 64 years were identified using IBM MarketScan Commercial Database between April 1, 2011 and December 31, 2014. Patients were required to be continuously enrolled 3 months before and 12 months after TKI (imatinib, dasatinib, or nilotinib) initiation. TKI adherence is estimated using the proportion of days covered (PDC), defined as the perc...
Source: American Journal of Clinical Oncology - June 26, 2020 Category: Cancer & Oncology Tags: Original Articles: Hematopoietic Source Type: research
A Prospective Study About Trastuzumab-induced Cardiotoxicity in HER2-positive Breast Cancer
Conclusion:
In patients with BC treated with trastuzumab, in addition to the evaluation of the LVEF, systolic longitudinal strain, TNI, and NT pro-BNP measured at the completion of anthracyclines are useful in the prediction of subsequent TIC. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - June 26, 2020 Category: Cancer & Oncology Tags: Original Articles: Breast Source Type: research
Racial and Geographic Disparities in Endocrine Therapy Adherence Among Younger Breast Cancer Survivors
Objectives:
African American (AA) women with breast cancer (BrCA) have higher mortality than any other race. Differential mortality has been attributed to nonadherence to endocrine therapy (ET). ET can lower the risk of dying by one third; yet 50% to 75% of all women are nonadherent to ET. Despite the wealth of research examining adherence to ET, understanding which groups of women at risk for poor adherence is not well established. The aim of this investigation was to describe ET adherence by race and geographic location among a cohort of younger BrCA survivors.
Materials and Methods:
Cancer registry records were lin...
Source: American Journal of Clinical Oncology - June 26, 2020 Category: Cancer & Oncology Tags: Original Articles: Breast Source Type: research
The Population-based Impact of Adjuvant Chemotherapy on Outcomes in T2N0M0 Non–Small Cell Lung Cancer
Objectives:
The value of adjuvant chemotherapy in T2N0M0 non–small-cell lung cancer (NSCLC) is unclear. Some current guidelines suggest adjuvant chemotherapy be considered for patients with tumors ≥4 cm. Prior population-based evaluations lacked lung cancer-specific survival (LCSS) and health insurance status. The authors aimed to identify predictors of adjuvant chemotherapy use and assess its real-world benefit in T2N0M0 NSCLC.
Materials and Methods:
The authors included patients who underwent surgery for T2N0M0 NSCLC in a large Canadian province with universal health care between 2004 and 2015, grouping cases ...
Source: American Journal of Clinical Oncology - June 26, 2020 Category: Cancer & Oncology Tags: Original Articles: Thoracic Source Type: research
Six-Week Interval Between Preoperative Radiation and Surgery Is Associated With Fewer Major Wound Complications in Soft Tissue Sarcoma
Conclusions:
This study presents a cohort of STS patients with an extended preRT-surgery interval of ~6 weeks. MWCs in this population occurred at a lower rate than historical controls. Overall these findings support the exploration of a longer interval to reduce MWCs and their associated morbidity. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - June 26, 2020 Category: Cancer & Oncology Tags: Original Articles: Soft Tissue Source Type: research
A Phase 1 Study of SLC-0111, a Novel Inhibitor of Carbonic Anhydrase IX, in Patients With Advanced Solid Tumors
Conclusions:
SLC-0111 was safe in patients with previously treated, advanced solid tumors. The safety and pharmacokinetic data support 1000 mg/d as the recommended phase 2 dose for SLC-0111. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - June 26, 2020 Category: Cancer & Oncology Tags: Original Articles: Experimental Therapeutics Source Type: research
Combination Therapy for Metastatic Renal Cell Carcinoma: A Systematic Review and Network Meta-analysis
Conclusions:
This network meta-analysis demonstrates that combination of pembrolizumab plus axitinib may be the preferred option based on efficacy and side effect profile compared with avelumab plus axitinib or atezolizumab plus bevacizumab. However, all the 3 combination strategies were superior to sunitinib alone in improving PFS in patients with mRCC. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - June 26, 2020 Category: Cancer & Oncology Tags: Original Articles: Genitourinary Source Type: research
Heterogenous Dose-escalated Prostate Stereotactic Body Radiation Therapy for All Risk Prostate Cancer: Quality of Life and Clinical Outcomes of an Institutional Pilot Study
Conclusions:
Heterogeneous dose-escalated prostate stereotactic body radiation therapy is feasible with low rates of acute and late toxicities and favorable QOL outcomes in patients with predominantly intermediate-risk and high-risk prostate cancer. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - June 26, 2020 Category: Cancer & Oncology Tags: Original Articles: Genitourinary Source Type: research
ACR–ASTRO Practice Parameter for Image-guided Radiation Therapy (IGRT)
Conclusions:
This practice parameter is a tool to guide clinical use of IGRT and does not make recommendations on site-specific IGRT directives. It focuses on the best practices and principles to consider when using IGRT effectively, especially with the significant increase in imaging data that is now available with IGRT. The clinical benefit and medical necessity of the imaging modality and frequency of IGRT should be assessed for each patient. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - June 26, 2020 Category: Cancer & Oncology Tags: Original Articles: ACR-ASTRO Practice Parameter Source Type: research
Sequencing Treatments for Cancer During the COVID-19 Pandemic
No abstract available (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - June 26, 2020 Category: Cancer & Oncology Tags: Editorial Source Type: research
The Impact of the COVID-19 Pandemic on Cancer Patients
In December 2019, a novel coronavirus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused an outbreak of coronavirus disease 2019 (COVID-19). Severe complications have been reported to occur in 33% of patients with COVID-19 and include acute respiratory distress syndrome, acute renal failure, acute respiratory injury, septic shock, and severe pneumonia. Currently, there is no specific treatment or approved vaccine against COVID-19 and many clinical trials are currently investigating potential medications to treat COVID-19. The immunosuppressed status of some cancer patients (whether caused by the dis...
Source: American Journal of Clinical Oncology - May 27, 2020 Category: Cancer & Oncology Tags: Review Article Source Type: research
Doxorubicin and Olaratumab Versus Doxorubicin, Ifosfamide, and Mesna for Treatment of Advanced Soft Tissue Sarcomas
Conclusions:
OD and AIM did not differ with respect to either OS or PFS. Although this study’s size initially appeared the most likely explanation, lack of significant activity of olaratumab was subsequently reported in the phase III trial of OD. Our results suggest that future conditional oncology drug approvals should be accompanied by mandated registries to monitor outcomes of patients treated after conditional approval, but before full approval. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - May 27, 2020 Category: Cancer & Oncology Tags: Original Articles: Soft Tissue Source Type: research
Twitter: A Platform for Dissemination and Discussion of Scientific Papers in Radiation Oncology
The objective of this study was to examine the correlation between Twitter mentions and the number of academic citations of radiation oncology articles.
Materials and Methods:
We reviewed all 178 clinical manuscripts of the 2 most important radiation oncology journals and “Brachytherapy,” and all clinical manuscripts relating to radiation oncology from the top 10 impact factor oncology journals, published between January and February 2018. We collected the record of citations utilizing Scopus and Google Scholar platforms and the number of times an article was tweeted about using the “Altmetric Bookmarklet.” χ2 ...
Source: American Journal of Clinical Oncology - May 27, 2020 Category: Cancer & Oncology Tags: Original Articles: Social Media in Oncology Source Type: research
Neoadjuvant Phase II Trial of Chemoradiotherapy in Patients With Resectable and Borderline Resectable Pancreatic Cancer
Conclusion:
Neoadjuvant therapy for borderline resectable and resectable pancreatic ductal adenocarcinoma with CRT facilitated R0 resection in 84% patients who underwent surgery. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - May 27, 2020 Category: Cancer & Oncology Tags: Original Articles: Gastrointestinal Source Type: research
Outcomes and Utilization of Adjuvant Chemotherapy for Stage II Colon Cancer in the Oxaliplatin Period: A SEER-Medicare Analysis
Conclusions:
After controlling for referral patterns, administration of AC provided no definitive survival benefit. Future studies may elucidate the elderly population who may benefit from AC. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - May 27, 2020 Category: Cancer & Oncology Tags: Original Articles: Gastrointestinal Source Type: research
