In Reply: All Positives May Not Be the Same in Pancreatic Cancer: Lessons Learned From the Past
No abstract available (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - September 1, 2020 Category: Cancer & Oncology Tags: Letters to the Editor Source Type: research

All Positives May Not Be the Same in Pancreatic Cancer: Lessons Learned From the Past
No abstract available (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - September 1, 2020 Category: Cancer & Oncology Tags: Letters to the Editor Source Type: research

Transformational Changes Between Non–Small Cell and Small Cell Lung Cancer—Biological and Clinical Relevance—A Review
During the course of therapy, patients with small cell lung cancer have been noted to develop transformation to non–small cell lung cancer and conversely, patients with non–small cell lung cancer have had transformation to small cell lung cancer or other non–small cell histologies. Transformation may occur after prior tyrosine kinase inhibitors, chemotherapy, immunotherapy or radiation therapy. These changes reflect on the overlapping biology of these cell types and the clinical need for re-biopsy at times of disease progression. The optimum therapy after transformation will depend upon prior therapies re...
Source: American Journal of Clinical Oncology - September 1, 2020 Category: Cancer & Oncology Tags: Review Article Source Type: research

Radiotherapy for Adult Soft Tissue Sarcomas of the Head and Neck
Conclusion: Our study demonstrates that surgery and radiotherapy for STS of the head and neck have excellent disease outcomes. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - September 1, 2020 Category: Cancer & Oncology Tags: Original Articles: Head and Neck Source Type: research

Survivors’ Perceptions of Quality of Colorectal Cancer Care by Sexual Orientation
Conclusions: Sexual minority survivors’ ratings of quality of colorectal cancer care were comparable or even higher than heterosexual survivors. Sexual minority survivors’ reports of excellent care were not explained by their interpersonal care experiences. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - September 1, 2020 Category: Cancer & Oncology Tags: Original Articles: Gastrointestinal Source Type: research

Comparison of FOLFIRINOX and Gemcitabine Plus Nab-paclitaxel for Treatment of Metastatic Pancreatic Cancer: Using Korean Pancreatic Cancer (K-PaC) Registry
Conclusions: FFX and GNP showed similar efficacy and comparable toxicity in MPC patients. Although the GNP group had a higher chance to receive second-line chemotherapy, they did not have improved overall survival. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - September 1, 2020 Category: Cancer & Oncology Tags: Original Articles: Gastrointestinal Source Type: research

Comparison of Radiation Treatment Volumes for Borderline Resectable Pancreatic Cancer in Contemporary Clinical Trials
Conclusions: The wide range of DICE coefficients and coverage indicate heterogeneity in high risk vascular target coverage using symmetric Boolean expansions from the primary tumor. This approach may inadequately cover regions at high risk of local recurrence in BRPCa. A customized clinical target volume that specifically includes the superior mesenteric artery and celiac axis will improve coverage to this region and will account for individual and tumor variability. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - September 1, 2020 Category: Cancer & Oncology Tags: Original Articles: Gastrointestinal Source Type: research

Development of an Integer-based Risk Score to Predict 90-Day Mortality After Hepatectomy in Patients With Hepatocellular Carcinoma
Conclusions: The integer-based risk score we developed could easily quantify each patient’s risk level and predict 90-day mortality after hepatectomy. The stratified risk score could be a useful addition to perioperative risk management and a tool to improve 90-day mortality after hepatectomy. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - September 1, 2020 Category: Cancer & Oncology Tags: Original Articles: Gastrointestinal Source Type: research

Medical Cannabis in Cancer Patients: A Survey of a Community Hematology Oncology Population
Objectives: Cancer patients are using medical cannabis (MC) to address symptoms; however, little data exist to guide clinicians when counseling patients. We seek to define the patterns of MC use among cancer patients, as well as efficacy and safety of MC. Materials and Methods: Cancer patients attending oncology office visits at Beaumont Hospital, Michigan from July to December 2018 were anonymously surveyed. The survey included data regarding demographics, diagnosis, treatment, symptom burden, and MC use. Patients who reported MC use since their cancer diagnosis completed a section on patterns of use, efficacy, and s...
Source: American Journal of Clinical Oncology - September 1, 2020 Category: Cancer & Oncology Tags: Original Articles: Symptom Management Source Type: research

Stereotactic Body Radiation Therapy for Intermediate-risk Prostate Cancer With VMAT and Real-time Electromagnetic Tracking: A Phase II Study
Conclusion: Ultrahypofractionated radiotherapy, delivered with flattening filter free-volumetric modulated arc therapy and gated by electromagnetic transponders, is a valid option for intermediate-risk prostate cancer. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - September 1, 2020 Category: Cancer & Oncology Tags: Original Articles: Genitourinary Source Type: research

Prospective Translational Study Investigating Molecular PrEdictors of Resistance to First-Line PazopanIb in Metastatic reNal CEll Carcinoma (PIPELINE Study)
Conclusion: Changes in levels of selected CAFs were associated with response/resistance to pazopanib in mRCC patients. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - September 1, 2020 Category: Cancer & Oncology Tags: Original Articles: Genitourinary Source Type: research

Population-based Treatment Patterns and Outcomes for Stage III Non–Small Cell Lung Cancer Patients: A Real-world Evidence Study
In this study, we describe contemporary treatment patterns and outcomes for a population-based cohort of stage III NSCLC patients from a large Canadian province. Methods: On the basis of the provincial cancer registry, all adult patients diagnosed with stage III NSCLC from April 1, 2010 to March 31, 2015 were identified. Analyses of these patients’ existing electronic medical records and administrative claims data were conducted to describe patient characteristics, treatment patterns, and survival outcomes. Results: In total, we screened 6438 patients diagnosed with NSCLC, of whom 1151 (17.9%) had stage III dis...
Source: American Journal of Clinical Oncology - September 1, 2020 Category: Cancer & Oncology Tags: Original Articles: Thoracic Source Type: research

Development and Validation of an Individualized Nomogram for Predicting Overall Survival in Patients With Typical Lung Carcinoid Tumors
Conclusion: The nomogram brings us closer to personalized medicine and the maximization of predictive accuracy in the prediction of OS in patients with typical lung carcinoid tumors. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - September 1, 2020 Category: Cancer & Oncology Tags: Original Articles: Thoracic Source Type: research

Does the Interval Between Hysterectomy and Start of Adjuvant Radiation Treatment Influence Survival in Women With Endometrial Carcinoma?: A National Cancer Database analysis
Conclusion: Our study suggests that TI between hysterectomy and initiation of ART was not an independent predictor of OS in women with early stage EC. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - July 30, 2020 Category: Cancer & Oncology Tags: Original Articles: Gynecologic Source Type: research

“Was It Worth It?”: A Pilot Study in Patient Perspectives on the Worthwhileness of Radiation Therapy
Conclusions: The r-WIWI survey was feasible to administer and most patients reported treatment being worthwhile on the last day of treatment and at first follow-up. Morning treatment times and longer treatment duration as measured in elapsed days were predictive of higher satisfaction in this pilot study. A broader study of factors associated with patient satisfaction with radiotherapy using the r-WIWI is indicated. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - July 30, 2020 Category: Cancer & Oncology Tags: Original Articles: Communication Source Type: research

Impact of Pain, Opioids, and the Mu-opioid Receptor on Progression and Survival in Patients With Newly Diagnosed Stage IV Pancreatic Cancer
We examined the impact of pain, opioid use, and the mu-opioid receptor (MOP-R) expression in tumor tissue on progression-free survival and overall survival of patients with metastatic pancreatic cancer. Methods: We identified 103 patients with metastatic pancreatic adenocarcinoma receiving chemotherapy and abstracted data from Tumor Registry, in addition to pain, opioid exposure, carbohydrate antigen 19-9 values, survival, and imaging response. MOP-R expression was evaluated using an immunohistochemistry assay. The association of variables with progression-free survival and overall survival was analyzed in univariate an...
Source: American Journal of Clinical Oncology - July 30, 2020 Category: Cancer & Oncology Tags: Original Articles: Gastrointestinal Source Type: research

Survival Benefit of Combination Chemotherapy in Elderly Patients With Metastatic Pancreatic Ductal Adenocarcinoma
Objectives: Survival benefit of combination over single-agent chemotherapy for metastatic pancreatic ductal adenocarcinoma (PDAC) was demonstrated in younger patients in clinical trials. The authors aimed to evaluate whether this survival benefit of combination chemotherapy is present in elderly patients with metastatic PDAC. Materials and Methods: The authors identified elderly patients (age 65 y or older) with stage IV PDAC and extracted available clinical information from a prospectively maintained institutional pancreatic cancer registry from 2007 to 2016. The primary endpoint was overall survival. Cox prop...
Source: American Journal of Clinical Oncology - July 30, 2020 Category: Cancer & Oncology Tags: Original Articles: Gastrointestinal Source Type: research

Analyzing the Time From Discovery to Definitive Surgical Therapy for Lung Cancer Based on Referral Patterns
Conclusions: When comparing time from CT detection of a lung nodule to surgery, no significant difference was found between patients sent to nonthoracic specialists first and those referred directly to a thoracic surgeon. There was a significant decrease in time from CT to surgery for patients with private insurance compared with Medicare/Medicaid. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - July 30, 2020 Category: Cancer & Oncology Tags: Original Articles: Thoracic Source Type: research

Effectiveness and Safety of Reirradiation With Stereotactic Ablative Radiotherapy of Lung Cancer After a First Course of Thoracic Radiation: A Meta-analysis
Conclusions: Re-SABR produces satisfactory LC and OS rates with an acceptable rate of toxicity. The balancing between the re-SABR dose and the tumor location has the potential to reduce severe and fatal toxicity. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - July 30, 2020 Category: Cancer & Oncology Tags: Original Articles: Thoracic Source Type: research

The Effect of Systemic Chemotherapy on Survival in Patients With Localized, Regional, or Metastatic Adenocarcinoma of the Urinary Bladder
Objectives: To test the effect of systemic chemotherapy on cancer-specific mortality (CSM) in patients with adenocarcinoma of the urinary bladder (ADKUB). Materials and Methods: Within the Surveillance, Epidemiology, and End Results registry (2004 to 2016), we identified patients with localized (T2-3N0M0), regional (T4N0M0/TanyN1-3M0), and metastatic (TanyNanyM1) ADKUB. Temporal trends, Kaplan-Meier plots, and multivariable Cox regression models were used before and after 1:1 propensity score matching and inverse probability of treatment weighting. Results: Of 1537 patients with ADKUB, 834 (54.0%), 363 (23.5%), and...
Source: American Journal of Clinical Oncology - July 30, 2020 Category: Cancer & Oncology Tags: Original Articles: Genitourinary Source Type: research

Eligibility Criteria and Endpoints in Metastatic Renal Cell Carcinoma Trials
Conclusions: Key eligibility criteria were somewhat inconsistent across the phase 3 mRCC trials studied. Endpoints in the newer trials did not align with DATECAN’s recommendations. Not only is greater standardization needed to facilitate meta-analyses and cross-trial comparisons, but as evident from lack of adherence to DATECAN’s recommendations, greater promotion and adoption of recommendations are needed to better harmonize trial design. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - July 30, 2020 Category: Cancer & Oncology Tags: Original Articles: Genitourinary Source Type: research

ACR–ASTRO Practice Parameter for Communication: Radiation Oncology
Conclusions: The radiation oncologist’s participation in the multidisciplinary management of patients is reflected in timely, medically appropriate, and informative communication with the referring physician and other members of the health care team. The ACR–ASTRO Practice Parameter for Communication: Radiation Oncology is an educational tool designed to assist practitioners in providing appropriate communication regarding radiation oncology care for patients. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - July 30, 2020 Category: Cancer & Oncology Tags: Original Articles: ACR-ASTRO Practice Parameters Source Type: research

ACR–ASTRO Practice Parameter for the Performance of Stereotactic Body Radiation Therapy
Conclusions: This practice parameter assists practitioners in providing safe and appropriate SBRT treatment and care for patients when clinically indicated. As technologies and techniques continue to evolve, this document will be reviewed, revised and renewed accordingly to a 5 year or sooner timeline specified by the ACR. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - July 30, 2020 Category: Cancer & Oncology Tags: Original Articles: ACR-ASTRO Practice Parameters Source Type: research

ACR-ACNM-ASTRO-SNMMI Practice Parameter for the Performance of Therapy With Radium-223
Conclusions: This practice parameter is intended as a tool to guide clinical use of radium-223 with the goal of facilitating safe and effective medical care based on current knowledge, available resources and patient needs. The sole purpose of this document is to assist practitioners in achieving this objective. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - July 30, 2020 Category: Cancer & Oncology Tags: Original Articles: ACR-ASTRO Practice Parameters Source Type: research

Community-based Cancer Care Quality and Expertise in a COVID-19 Era and Beyond
No abstract available (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - July 30, 2020 Category: Cancer & Oncology Tags: Editorial Source Type: research

Characterizing Urban-Rural Differences in Colon Cancer Outcomes: A Population-based Analysis Based on Travel Distance to Cancer Center
Objective: We aimed to explore possible drivers for urban-rural disparities in colon cancer outcomes in a single-payer health care system where all patients had access to universal health care coverage. Methods: Patients diagnosed with stage II/III colon cancer between 2004 and 2015 in Alberta, Canada were reviewed. On the basis of postal code, patients were categorized as living in urban, rural, or suburban areas based on travel distance to the cancer center. Kaplan-Meier methods and Cox regression models assessed the associations among the area of residence, receipt of treatment, and overall survival (OS). Results:...
Source: American Journal of Clinical Oncology - June 26, 2020 Category: Cancer & Oncology Tags: American Journal of Clinical Oncology Source Type: research

Stage-specific Conditional Survival Among Young (Age Below 50 y) Versus Older (Age 50 y and Above) Adults With Colorectal Cancer in the United States
Conclusions: Prognosis for CRC improves over time for all patients, although the increase in survival appears to be less for young than older adults. Up to 10 years after diagnosis, the primary cause of death in young adults with CRC remains their incident cancer. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - June 26, 2020 Category: Cancer & Oncology Tags: Original Articles: Gastrointestinal Source Type: research

Tyrosine Kinase Inhibitors and the Relationship With Adherence, Costs, and Health Care Utilization in Commercially Insured Patients With Newly Diagnosed Chronic Myeloid Leukemia: A Retrospective Claims-Based Study
Objective: To examine the association among tyrosine kinase inhibitor (TKI) out-of-pocket costs, adherence, and health care costs and utilization in a large group of commercially insured patients with chronic myeloid leukemia (CML). Materials and Methods: Patients with CML aged 18 to 64 years were identified using IBM MarketScan Commercial Database between April 1, 2011 and December 31, 2014. Patients were required to be continuously enrolled 3 months before and 12 months after TKI (imatinib, dasatinib, or nilotinib) initiation. TKI adherence is estimated using the proportion of days covered (PDC), defined as the perc...
Source: American Journal of Clinical Oncology - June 26, 2020 Category: Cancer & Oncology Tags: Original Articles: Hematopoietic Source Type: research

A Prospective Study About Trastuzumab-induced Cardiotoxicity in HER2-positive Breast Cancer
Conclusion: In patients with BC treated with trastuzumab, in addition to the evaluation of the LVEF, systolic longitudinal strain, TNI, and NT pro-BNP measured at the completion of anthracyclines are useful in the prediction of subsequent TIC. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - June 26, 2020 Category: Cancer & Oncology Tags: Original Articles: Breast Source Type: research

Racial and Geographic Disparities in Endocrine Therapy Adherence Among Younger Breast Cancer Survivors
Objectives: African American (AA) women with breast cancer (BrCA) have higher mortality than any other race. Differential mortality has been attributed to nonadherence to endocrine therapy (ET). ET can lower the risk of dying by one third; yet 50% to 75% of all women are nonadherent to ET. Despite the wealth of research examining adherence to ET, understanding which groups of women at risk for poor adherence is not well established. The aim of this investigation was to describe ET adherence by race and geographic location among a cohort of younger BrCA survivors. Materials and Methods: Cancer registry records were lin...
Source: American Journal of Clinical Oncology - June 26, 2020 Category: Cancer & Oncology Tags: Original Articles: Breast Source Type: research

The Population-based Impact of Adjuvant Chemotherapy on Outcomes in T2N0M0 Non–Small Cell Lung Cancer
Objectives: The value of adjuvant chemotherapy in T2N0M0 non–small-cell lung cancer (NSCLC) is unclear. Some current guidelines suggest adjuvant chemotherapy be considered for patients with tumors ≥4 cm. Prior population-based evaluations lacked lung cancer-specific survival (LCSS) and health insurance status. The authors aimed to identify predictors of adjuvant chemotherapy use and assess its real-world benefit in T2N0M0 NSCLC. Materials and Methods: The authors included patients who underwent surgery for T2N0M0 NSCLC in a large Canadian province with universal health care between 2004 and 2015, group...
Source: American Journal of Clinical Oncology - June 26, 2020 Category: Cancer & Oncology Tags: Original Articles: Thoracic Source Type: research

Six-Week Interval Between Preoperative Radiation and Surgery Is Associated With Fewer Major Wound Complications in Soft Tissue Sarcoma
Conclusions: This study presents a cohort of STS patients with an extended preRT-surgery interval of ~6 weeks. MWCs in this population occurred at a lower rate than historical controls. Overall these findings support the exploration of a longer interval to reduce MWCs and their associated morbidity. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - June 26, 2020 Category: Cancer & Oncology Tags: Original Articles: Soft Tissue Source Type: research

A Phase 1 Study of SLC-0111, a Novel Inhibitor of Carbonic Anhydrase IX, in Patients With Advanced Solid Tumors
Conclusions: SLC-0111 was safe in patients with previously treated, advanced solid tumors. The safety and pharmacokinetic data support 1000 mg/d as the recommended phase 2 dose for SLC-0111. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - June 26, 2020 Category: Cancer & Oncology Tags: Original Articles: Experimental Therapeutics Source Type: research

Combination Therapy for Metastatic Renal Cell Carcinoma: A Systematic Review and Network Meta-analysis
Conclusions: This network meta-analysis demonstrates that combination of pembrolizumab plus axitinib may be the preferred option based on efficacy and side effect profile compared with avelumab plus axitinib or atezolizumab plus bevacizumab. However, all the 3 combination strategies were superior to sunitinib alone in improving PFS in patients with mRCC. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - June 26, 2020 Category: Cancer & Oncology Tags: Original Articles: Genitourinary Source Type: research

Heterogenous Dose-escalated Prostate Stereotactic Body Radiation Therapy for All Risk Prostate Cancer: Quality of Life and Clinical Outcomes of an Institutional Pilot Study
Conclusions: Heterogeneous dose-escalated prostate stereotactic body radiation therapy is feasible with low rates of acute and late toxicities and favorable QOL outcomes in patients with predominantly intermediate-risk and high-risk prostate cancer. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - June 26, 2020 Category: Cancer & Oncology Tags: Original Articles: Genitourinary Source Type: research

ACR–ASTRO Practice Parameter for Image-guided Radiation Therapy (IGRT)
Conclusions: This practice parameter is a tool to guide clinical use of IGRT and does not make recommendations on site-specific IGRT directives. It focuses on the best practices and principles to consider when using IGRT effectively, especially with the significant increase in imaging data that is now available with IGRT. The clinical benefit and medical necessity of the imaging modality and frequency of IGRT should be assessed for each patient. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - June 26, 2020 Category: Cancer & Oncology Tags: Original Articles: ACR-ASTRO Practice Parameter Source Type: research

Sequencing Treatments for Cancer During the COVID-19 Pandemic
No abstract available (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - June 26, 2020 Category: Cancer & Oncology Tags: Editorial Source Type: research

The Impact of the COVID-19 Pandemic on Cancer Patients
In December 2019, a novel coronavirus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused an outbreak of coronavirus disease 2019 (COVID-19). Severe complications have been reported to occur in 33% of patients with COVID-19 and include acute respiratory distress syndrome, acute renal failure, acute respiratory injury, septic shock, and severe pneumonia. Currently, there is no specific treatment or approved vaccine against COVID-19 and many clinical trials are currently investigating potential medications to treat COVID-19. The immunosuppressed status of some cancer patients (whether caused by the dis...
Source: American Journal of Clinical Oncology - May 27, 2020 Category: Cancer & Oncology Tags: Review Article Source Type: research

Doxorubicin and Olaratumab Versus Doxorubicin, Ifosfamide, and Mesna for Treatment of Advanced Soft Tissue Sarcomas
Conclusions: OD and AIM did not differ with respect to either OS or PFS. Although this study’s size initially appeared the most likely explanation, lack of significant activity of olaratumab was subsequently reported in the phase III trial of OD. Our results suggest that future conditional oncology drug approvals should be accompanied by mandated registries to monitor outcomes of patients treated after conditional approval, but before full approval. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - May 27, 2020 Category: Cancer & Oncology Tags: Original Articles: Soft Tissue Source Type: research

Twitter: A Platform for Dissemination and Discussion of Scientific Papers in Radiation Oncology
The objective of this study was to examine the correlation between Twitter mentions and the number of academic citations of radiation oncology articles. Materials and Methods: We reviewed all 178 clinical manuscripts of the 2 most important radiation oncology journals and “Brachytherapy,” and all clinical manuscripts relating to radiation oncology from the top 10 impact factor oncology journals, published between January and February 2018. We collected the record of citations utilizing Scopus and Google Scholar platforms and the number of times an article was tweeted about using the “Altmetric Bookmark...
Source: American Journal of Clinical Oncology - May 27, 2020 Category: Cancer & Oncology Tags: Original Articles: Social Media in Oncology Source Type: research

Neoadjuvant Phase II Trial of Chemoradiotherapy in Patients With Resectable and Borderline Resectable Pancreatic Cancer
Conclusion: Neoadjuvant therapy for borderline resectable and resectable pancreatic ductal adenocarcinoma with CRT facilitated R0 resection in 84% patients who underwent surgery. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - May 27, 2020 Category: Cancer & Oncology Tags: Original Articles: Gastrointestinal Source Type: research

Outcomes and Utilization of Adjuvant Chemotherapy for Stage II Colon Cancer in the Oxaliplatin Period: A SEER-Medicare Analysis
Conclusions: After controlling for referral patterns, administration of AC provided no definitive survival benefit. Future studies may elucidate the elderly population who may benefit from AC. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - May 27, 2020 Category: Cancer & Oncology Tags: Original Articles: Gastrointestinal Source Type: research

Gemcitabine Plus Cisplatin Chemotherapy Prolongs the Survival in Advanced Hilar Cholangiocarcinoma: A Large Multicenter Study
Objectives: Gemcitabine plus cisplatin (GC) is recommended as first-line treatment for advanced cholangiocarcinoma. We investigated the impact of GC in patients with unresectable hilar cholangiocarcinoma (HC) based on the time taken for effective biliary drainage (EBD). Materials and Methods: We retrospectively enrolled 113 patients with unresectable HC. Thirty-nine and 74 patients received GC chemotherapy and best supportive care (BSC), respectively. EBD was defined as a reduction in total bilirubin>50% or to a value (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - May 27, 2020 Category: Cancer & Oncology Tags: Original Articles: Gastrointestinal Source Type: research

Brain Metastases From Gynecologic Malignancies: Prevalence and Management
Conclusions: The incidence of BM among patients with gynecologic malignancies is rare and associated with poor survival. For select patients, SRS may be associated with prolonged survival. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - May 27, 2020 Category: Cancer & Oncology Tags: Original Articles: Gynecologic Source Type: research

Association Between Metabolic Syndrome and Endometrial Cancer Survival in a SEER-Medicare Linked Database
Conclusions: In elderly early stage endometrial cancer patients, metabolic syndrome is associated with worse CSS. Control of metabolic syndrome through lifestyle and pharmacologic therapies may improve cancer prognosis in this population. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - May 27, 2020 Category: Cancer & Oncology Tags: Original Articles: Gynecologic Source Type: research

Refusal of Radiation Results in Inferior Survival in Endometrial Cancer
Objective: We sought to understand factors associated with refusal of adjuvant radiotherapy in endometrial cancer and its impact on outcomes. Methods: Data from the National Cancer Database for patients who underwent surgery for nonmetastatic endometrial cancer between 2004 and 2015 were pooled. The Pearson χ2 test and multivariate logistic regression analyses were used to assess demographic, clinical, and treatment factors. Inverse probability of treatment weighting was used to account for differences in baseline characteristics. Kaplan-Meier analyses and doubly-robust estimation with multivariate Cox proportiona...
Source: American Journal of Clinical Oncology - May 27, 2020 Category: Cancer & Oncology Tags: Original Articles: Gynecologic Source Type: research

Diagnostic Test Accuracy of Glasgow Prognostic Score as a Prognostic Factor for Renal Cell Carcinoma: A Meta-Analysis
Conclusion: GPS demonstrated a good diagnostic accuracy as a prognostic factor for RCC and especially in the case of nonmetastatic RCC. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - May 27, 2020 Category: Cancer & Oncology Tags: Original Articles: Genitourinary Source Type: research

Prognostic Significance of Preoperative Prognostic Nutritional Index in Patients Undergoing Nephrectomy for Nonmetastatic Renal Cell Carcinoma
The objective of this study was to assess the value of a preoperative Prognostic Nutritional Index (PNI) for predicting the survival of patients with nonmetastatic renal cell carcinoma (RCC) treated with partial or radical nephrectomy. Materials and Methods: The medical records of 480 patients with RCC who underwent partial or radical nephrectomy at 2 institutions between June 1994 and July 2017 were retrospectively reviewed. After the exclusion of 21 patients with lymph node or distant metastasis, the data of 459 patients with nonmetastatic RCC were included. The PNI was calculated using a combination of serum albumin ...
Source: American Journal of Clinical Oncology - May 27, 2020 Category: Cancer & Oncology Tags: Original Articles: Genitourinary Source Type: research

Modified-BEP Chemotherapy in Patients With Germ-Cell Tumors Treated at a Comprehensive Cancer Center
Conclusion: In GCT patients, our mBEP-schedule would suggest an effective treatment modality without suffering meaningful pulmonary toxicity. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - May 27, 2020 Category: Cancer & Oncology Tags: Original Articles: Genitourinary Source Type: research

Pattern of Marginal Local Failure in a Phase II Trial of Neoadjuvant Chemotherapy and Stereotactic Body Radiation Therapy for Resectable and Borderline Resectable Pancreas Cancer: Erratum
No abstract available (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - April 25, 2020 Category: Cancer & Oncology Tags: Erratum Source Type: research