American Journal of Clinical Oncology 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Use of the Toxicity Index in Evaluating Adverse Events in Anal Cancer Trials: Analysis of RTOG 9811 and RTOG 0529
Novel toxicity metrics that account for all adverse event (AE) grades and the frequency of may enhance toxicity reporting in clinical trials. The Toxicity Index (TI) accounts for all AE grades and frequencies for categories of interest. We evaluate the feasibility of using the TI methodology in 2 prospective anal cancer trials and to evaluate whether more conformal radiation (using Intensity Modulated Radiation Therapy) results in improved toxicity as measured by the TI. Patients enrolled on NRG/RTOG 0529 or nonconformal RT enrolled on the 5-Fluorouracil/Mitomycin arm of NRG/RTOG 9811 were compared using the TI. Patients t...
Source: American Journal of Clinical Oncology - November 23, 2022 Category: Cancer & Oncology Tags: Original Articles: Gastrointestinal Source Type: research
Preoperative Computed Tomography Radiomics Analysis for Predicting Receptors Status and Ki-67 Levels in Breast Cancer
Conclusion:
This study indicated preopreative chest CT radiomics analysis might be able to assess ER, PR, HER2+, and Ki-67 status of breast cancer. The findings need further to be verified in future larger studies. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - November 23, 2022 Category: Cancer & Oncology Tags: Original Articles: Breast Source Type: research
Impact of Low-dose Chest CT Screening on the Association Between Rurality and Lung Cancer Outcomes
Conclusions:
In a majority-rural United States population undergoing LDCT, most screen-detected lung cancers were early-stage. There were no significant differences observed between rural and nonrural patients in lung cancer diagnosis rate or early-stage lung cancer survival. Increased implementation of LDCT might blunt the historical association between rural United States populations and worse lung cancer outcomes. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - November 23, 2022 Category: Cancer & Oncology Tags: Original Articles: Thoracic Source Type: research
Predicting Factors for a Favorable Pathologic Response to Neoadjuvant Therapy in Esophageal Cancer
Conclusions:
FPR is a predictor of improved OS. SCC and radiation therapy-based protocol were identified as major prediction factors of FPR in patients with esophageal and GEJ cancers. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - November 23, 2022 Category: Cancer & Oncology Tags: Original Articles: Thoracic Source Type: research
Does Examined Lymph Node Count Influence Survival in Surgically Resected Early‑stage Pulmonary Typical Carcinoid Tumors?
Objectives:
We aimed to evaluate the prognostic impact of the number of examined lymph nodes (ELNs) in resected early‑stage pulmonary typical carcinoid tumors (TC).
Methods:
Patients who underwent sublobar resection and lobectomy for stage T1N0M0 TC between 2004 and 2016 were identified from the Surveillance, Epidemiology, and End Results database and enrolled in the ELNs≥4 or ELNs (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - November 23, 2022 Category: Cancer & Oncology Tags: Original Articles: Thoracic Source Type: research
Evaluation of 5 Fraction Stereotactic Body Radiation Therapy (SBRT) for Osseous Renal Cell Carcinoma Metastases
Conclusions:
Patients with osseous RCC metastases undergoing 5 fractions of SBRT had favorable LC outcomes. There was no difference in survival or LC between the 40 Gy and 30 Gy treatment arms. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - November 23, 2022 Category: Cancer & Oncology Tags: Original Articles: Genitourinary Source Type: research
Extragonadal Germ Cell Tumors of the Mediastinum and Retroperitoneum: A Surveillance, Epidemiology, and End Results-based Study
Conclusions:
Despite a decreasing incidence observed in recent decades, EGCT continues to represent a challenge for oncologists. The prognosis of choriocarcinoma and embryonal carcinoma of the mediastinum remains poor and treatment strategies need to be improved urgently. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - November 23, 2022 Category: Cancer & Oncology Tags: Original Articles: Genitourinary Source Type: research
The Logistics of Starting a Radiotheranostics Center in An Academic Institution: Practical Lessons From Real-life Experience
No abstract available (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - November 23, 2022 Category: Cancer & Oncology Tags: Editorial Source Type: research
Preliminary Analysis of Cervical Cancer Immunotherapy
Cervical cancer is one of the most common gynecologically malignancies worldwide. Although vaccine and cervical cancer screening including human papillomavirus testing, cytology testing, and colposcopy have developed rapidly in recent years, effectively reducing cervical cancer mortality, cervical cancer remains a malignancy with higher female fatality rates worldwide and has a high risk for socioeconomically disadvantaged groups. The combination of platinum-paclitaxel and chemotherapy, possibly with the addition of bevacizumab, is currently the treatment of choice for advanced cervical cancer, but it only has remission pu...
Source: American Journal of Clinical Oncology - November 1, 2022 Category: Cancer & Oncology Tags: Review Article Source Type: research
Proton Pump Inhibitors and Cancer Risk: An Umbrella Review and Meta-analysis of Observational Studies
Conclusions:
These findings suggested that clinicians should pay more attention to the occurrence of gastric cancer, pancreatic cancer, colorectal cancer, and liver cancer in patients who used PPIs, and PPI prescription should be written only when an accurate specific diagnosis has been made. Furthermore, additional PPIs to the treatment regimen may be benefit for women with a higher-than-average risk of breast cancer. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - November 1, 2022 Category: Cancer & Oncology Tags: Original Articles: Cancer Risk Factors Source Type: research
Laparoscopic Versus Abdominal Radical Hysterectomy for Cervical Cancer: A Meta-analysis of Randomized Controlled Trials
Conclusions:
LRH has more advantages over ARH in the treatment of cervical cancer. Still, the long-term effects and safety of LRH and ARH need more high-quality, large-sample RCTs to be further verified. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - November 1, 2022 Category: Cancer & Oncology Tags: Original Articles: Gynecologic Source Type: research
Factors Associated With Lymph Node Yield and Effects of Lymph Node Density on Survival of Patients With Pulmonary Sarcomatoid Carcinoma
The objective of this study was to identify factors associated with lymph node yield (LNY) during surgeries for pulmonary sarcomatoid carcinoma (PSC) and to determine effects of lymph node density (LND) on the overall survival (OS) of patients with PSC.
Materials and Methods:
The SEER Research Plus database was searched for data on patients with PSC from 1988 to 2018. Poisson regression was used of all patients with PSC to identify relevant factors associated with LNY. Univariate and multivariate Cox regression analyses were adopted for lymph node (LN)-positive patients to evaluate the impact of LND on OS. The 5-yea...
Source: American Journal of Clinical Oncology - November 1, 2022 Category: Cancer & Oncology Tags: Original Articles: Thoracic Source Type: research
Multiagent Chemotherapy Followed by Stereotactic Body Radiotherapy Versus Conventional Radiotherapy for Resected Pancreas Cancer
Background and Purpose:
Chemotherapy followed by margin-negative resection (R0) is the treatment of choice for patients with localized pancreatic ductal adenocarcinoma (PDAC). Neoadjuvant multiagent chemotherapy (MAC) or MAC then radiotherapy (RT) may optimize surgical candidacy. The purpose of this study was to compare pathologic outcomes of MAC followed by conventionally fractionated radiotherapy (CRT) versus stereotactic body radiotherapy (SBRT) for patients with resected PDAC.
Methods:
Patients diagnosed with nonmetastatic PDAC between 2012 and 2017 and who received preoperative MAC or MAC+RT were identified...
Source: American Journal of Clinical Oncology - November 1, 2022 Category: Cancer & Oncology Tags: Original Articles: Gastrointestinal Source Type: research
Radiographic Response of Solitary Plasmacytomas After Conformal Radiotherapy May Be Delayed: Outcomes in the 3D Era
Conclusions:
More conformal dose distribution with proton therapy does not appear to alter patterns of recurrence. Although response rates differ based on criteria by both RECIST and PERCIST assessments, the radiographic response may be slow and requires validation in other cohorts. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - November 1, 2022 Category: Cancer & Oncology Tags: Original Articles: Hematopoeitic Source Type: research
Crossover in Adjuvant Trastuzumab Trials: Sparing Toxicity in Patient Care
Conclusions:
Trials for adjuvant trastuzumab did not disambiguate between crossover (1) in the adjuvant setting or (2) at recurrence. Due to the low reported rate of crossover, it is questionable if participants received the standard of care. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - October 1, 2022 Category: Cancer & Oncology Tags: Review Article Source Type: research
