Reply to Elmali and Colleagues
No abstract available (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - January 25, 2019 Category: Cancer & Oncology Tags: Letters to the Editor Source Type: research

Challenging the Requirement to Treat the Contralateral Neck in Cases With >4 mm Tumor Thickness in Patients Receiving Postoperative Radiation Therapy for Squamous Cell Carcinoma of the Oral Tongue or Floor of Mouth
No abstract available (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - January 25, 2019 Category: Cancer & Oncology Tags: Letters to the Editor Source Type: research

Cabergoline in the Management of Residual Nonfunctioning Pituitary Adenoma: A Single-Center, Open-Label, 2-Year Randomized Clinical Trial
Conclusions: Cabergoline was an effective drug for treating residual NFPA, and its use was associated with a high rate of tumor shrinkage (ClinicalTrials.gov NCT03271918). (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - January 25, 2019 Category: Cancer & Oncology Tags: Original Articles: Central Nervous System Source Type: research

Overall Survival of Men and Women With Breast Cancer According to Tumor Subtype: A Population-based Study
Objectives: To analyze differences in overall survival (OS) between male breast cancer (MBC) and female breast cancer (FBC) according to tumor subtype compared with other factors. Materials and Methods: We evaluated men and women with breast cancer between 2010 and 2013 with known hormone receptor (HR) status and human epidermal growth factor receptor 2 (HER2) status reported to the National Cancer Institute’s Surveillance, Epidemiology, and End Results program. Patient characteristics were compared between groups. Univariate and multivariate analyses were performed to determine the effect of each variable on OS...
Source: American Journal of Clinical Oncology - January 25, 2019 Category: Cancer & Oncology Tags: Original Articles: Breast Source Type: research

Concurrent Radiation and Immunotherapy: Survey of Practice Patterns in the United States
The objective of this study was to report on US radiation oncologists’ (ROs) practice patterns and perceptions of concurrent radiation (RT) and immunotherapy (IT) (CRI). Methods: A 22-question survey was emailed to radiation oncologists in February 2018. CRI was defined as RT completed within 1 week before initial IT infusion through 4 weeks after final IT infusion. Results: Of the 323 respondents from 45 states, 88% had experience treating a patient with CRI, including 51% private and 48% academic physicians. The most common reason for not offering CRI was concerns of increased toxicity (50%). Although 84% to ...
Source: American Journal of Clinical Oncology - January 25, 2019 Category: Cancer & Oncology Tags: Original Articles: Experimental Therapeutics Source Type: research

The Value of Prognostic Nutritional Index in Follicular Lymphoma
Conclusions: PNI was shown to be independent prognostic factor of PFS in FL. It is a cheap and widely available biomarker. Future study is needed to validate its prognostic value and clinical utility in a prospective cohort. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - January 25, 2019 Category: Cancer & Oncology Tags: Original Articles: Hematopoietic Source Type: research

Outcomes and Characteristics of Patients Receiving Second-line Therapy for Advanced Pancreatic Cancer
Conclusions: In this population-based cohort, first-line FOLFIRINOX was the strongest predictor of second-line chemotherapy. Duration of therapy remains short and novel treatments are urgently needed. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - January 25, 2019 Category: Cancer & Oncology Tags: Original Articles: Gastrointestinal Source Type: research

Identification of Adenosquamous Carcinoma as a Rare Aggressive HER2-negative Subgroup of Esophageal/Gastroesophageal Junction Adenocarcinoma
Conclusion: ASC identifies a rare aggressive HER2-negative subgroup of esophageal/gastroesophageal junction adenocarcinoma. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - January 25, 2019 Category: Cancer & Oncology Tags: Original Articles: Gastrointestinal Source Type: research

A Phase Ib Study of the FGFR/VEGFR Inhibitor Dovitinib With Gemcitabine and Capecitabine in Advanced Solid Tumor and Pancreatic Cancer Patients
Conclusions: Dovitinib 300 mg daily is the recommended dose when combined with gemcitabine and capecitabine, achieving clinically relevant plasma concentrations. The study combination demonstrated encouraging efficacy signals in advanced pancreatic cancer. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - January 25, 2019 Category: Cancer & Oncology Tags: Original Articles: Gastrointestinal Source Type: research

Accelerated Hypofractionated Radiation Therapy for Elderly Frail Bladder Cancer Patients Unfit for Surgery or Chemotherapy
Conclusions: Accelerated hypofractionated radiotherapy alone provides good local control in elderly patients unfit for chemoradiotherapy. Contemporary radiation techniques such as VMAT were associated with reduced bowel toxicity compared with 3D CRT. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - January 25, 2019 Category: Cancer & Oncology Tags: Original Articles: Genitourinary Source Type: research

Factors Associated With Head and Neck Cancer Hospitalization Cost and Length of Stay—A National Study
Conclusions: Admissions that involve higher number of comorbidities, metastasis, bacterial infection, radiation, and chemo procedures had longer hospital stay and higher cost whereas admissions are rural hospitals had shorter hospital stay and lower cost. Understanding these factors associated with increased LOS and hospitalization cost will help efforts to decrease health care cost and improve quality of care. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - January 25, 2019 Category: Cancer & Oncology Tags: Original Articles: Head and Neck Source Type: research

The Outcome of Patients With Localized Undifferentiated Pleomorphic Sarcoma of the Lower Extremity Treated at Stanford University
Conclusions: Positive surgical margins are an important prognostic factor for predicting relapse in UPS. Relapse of any kind led to worse OS. Radiation therapy improved local control of disease but had no statistically significant effect on DFS, highlighting the need for improved diagnostics to identify those at highest risk for hematogenous metastasis and for selection of patients for adjuvant systemic treatment. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - January 25, 2019 Category: Cancer & Oncology Tags: Original Articles: Soft Tissue Source Type: research

An Evaluation of the Eighth Edition of the American Joint Committee on Cancer (AJCC) Staging System for Retroperitoneal Sarcomas Using the National Cancer Data Base (NCDB): Does Size Matter?
Objectives: Retroperitoneal sarcomas (RPS) are often large at diagnosis calling into question the seventh edition AJCC size classification of (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - January 25, 2019 Category: Cancer & Oncology Tags: Original Articles: Soft Tissue Source Type: research

Management of Unresectable T4b Esophageal Cancer: Practice Patterns and Outcomes From the National Cancer Data Base
This study sought to evaluate national practice patterns and outcomes for this population and evaluated 3 primary cohorts: patients receiving chemotherapy (CT) with or without subtherapeutic radiotherapy (RT), definitive chemoradiotherapy (CRT), or CT with or without RT followed by definitive surgery. Materials and Methods: The National Cancer Data Base was queried for cT4b Nany M0 EC. Exclusion criteria were patients with unspecified staging, palliative treatment, improper, or no histologic confirmation, or lack of CT. Multivariable logistic regression determined factors predictive of receiving surgical therapy. Kaplan...
Source: American Journal of Clinical Oncology - January 25, 2019 Category: Cancer & Oncology Tags: Original Articles: Thoracic Source Type: research

Factors Affecting Racial Disparities in End-of-Life Care Costs Among Lung Cancer Patients: A SEER-Medicare–based Study
Conclusions: Geographic differences in access to timely and appropriate care, and provider practice patterns, should be examined to understand the reasons behind geographic variations in racial disparity. Provider-level educational interventions to reduce small area practice variations and differential management of patients by race, as well as racially sensitive patient-level educational and navigational interventions might be critical in improving quality of care and reducing costs during end-of-life. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - January 25, 2019 Category: Cancer & Oncology Tags: Original Articles: Thoracic Source Type: research

Prospective Evaluation of Multinational Association of Supportive Care in Cancer Risk Index Score for Gynecologic Oncology Patients With Febrile Neutropenia
Conclusions: This pilot data suggests that MASCC score may be a promising tool for determining suitability of outpatient management of FN in gynecologic oncology patients. Larger studies are warranted to achieve statistically significant results, which may enable us to effectively utilize this risk stratification tool for cost containment and avoidance of nosocomial infections. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - January 25, 2019 Category: Cancer & Oncology Tags: Original Articles: Gynecologic Source Type: research

A Simplified Risk Stratification Method for Women With Stage I Endometrial Carcinoma
Conclusions: On the basis of 3 well-known prognostic factors, we have developed and externally validated a simplified prognostic model that accurately predicts cancer recurrence in women with stage I endometrial carcinoma. This simplified predictive tool may be helpful in estimating individualized risk of recurrence and guide counseling with regard to adjuvant treatment. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - January 25, 2019 Category: Cancer & Oncology Tags: Original Articles: Gynecologic Source Type: research

Role of Stereotactic Body Radiation Therapy in Early Stage Small Cell Lung Cancer in the Era of Lung Cancer Screening: A Systematic Review
With the obvious benefit from low dose computed tomography to reduce the lung cancer-specific mortality, lung cancer screening is on the rise. With the implementation of the screening programs, diagnosis of early stage lung cancer is expected to increase, and small cell lung cancer (SCLC) would account for 10% of screen-detected lung cancer. Apart from Concurrent chemoradiation (CRT), the present guidelines virtually do not support other options for radiation (RT). There is a paucity of data addressing the role of Stereotactic Body Radiation Therapy (SBRT) in SCLC and we conducted the current systematic review on this topi...
Source: American Journal of Clinical Oncology - January 25, 2019 Category: Cancer & Oncology Tags: Review Articles Source Type: research

MGMT Testing in Glioblastomas: Pitfalls and Opportunities
Gliomas, that do not respond to alkylating agent chemotherapy, can be made more sensitive to chemotherapy through promotor mediated epigenetic silencing of the MGMT gene. MGMT is one of the important markers in glioblastomas as it not only predicts response to therapy but may also be used as an independent prognostic marker. As such, MGMT is gaining increasing traction in diagnosis, prognostication, and therapeutic decision-making for these highly malignant gliomas. Although, MGMT promotor methylation status is becoming more commonly used in neuro-oncology; this test remains imperfect. Because of its increasing use in clin...
Source: American Journal of Clinical Oncology - January 25, 2019 Category: Cancer & Oncology Tags: Review Articles Source Type: research

How to Optimize Cancer Treatment in Older Patients: An Overview of Available Geriatric Tools
Cancer is a disease of older people, but this age group has often been excluded from clinical trials of cancer, which leads to poor transportability of standardized treatments in older cancer patients. One of the main reasons for the exclusion is the heterogeneity of older people in several domains: social environment, comorbidities, dependency, functional status, nutritional status, cognition status, and mood status. Comprehensive geriatric assessment aims to assess this heterogeneity and has identified frequent health problems often unknown before therapeutic decisions, which allows for targeted geriatric interventions w...
Source: American Journal of Clinical Oncology - January 25, 2019 Category: Cancer & Oncology Tags: Review Articles Source Type: research

Contemporary Approaches to High-risk, Early-Stage Serous Endometrial Cancer: Clinical Equipoise Persists
No abstract available (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - January 25, 2019 Category: Cancer & Oncology Tags: Editorial: Opinion Source Type: research

Nuclear Medicine Therapy With 223Radium-dichloride for Osseous Metastases in Prostate Carcinoma
Painful osseous metastasis resulting from castration-resistant prostate carcinoma is a common clinical problem. Historically, nuclear medicine offered several palliative beta-emitting radiopharmaceuticals targeting the skeleton with the goal of decreasing pain. However, these have largely been replaced by the alpha-emitting agent 223radium (Ra). 223Ra received Food and Drug Administration approval in 2013 for the treatment of metastatic castration-resistant prostate cancer with symptomatic bone metastases without visceral metastases. 223Ra offers an improved therapeutic profile due to its alpha-particle emissions resulting...
Source: American Journal of Clinical Oncology - December 23, 2018 Category: Cancer & Oncology Tags: Review Articles Source Type: research

The University of Florida Department of Radiation Oncology Guidelines for Treatment of Differentiated Thyroid Cancer With I-131 or External-beam Radiotherapy
This article is not meant to compete with the many excellent book chapters and consensus guidelines that present comprehensive discussions of treatment options. This is a streamlined, “How we do it?” reference without substantial discussion of background or supporting data. To serve as a treatment reference, the great majority of the information is presented in topic-specific tables. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - December 23, 2018 Category: Cancer & Oncology Tags: Review Articles Source Type: research

Challenging the Requirement to Treat the Contralateral Neck in Cases With >4 mm Tumor Thickness in Patients Receiving Postoperative Radiation Therapy for Squamous Cell Carcinoma of the Oral Tongue or Floor of Mouth
Conclusion: While delivering postoperative RT for oral tongue or floor of mouth cancer with pathologic neck stage N0-2b, the risk of not irradiating the contralateral neck is very low when the primary tumor does not cross the midline, regardless of other factors at the primary site, such as TT and DOI. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - December 23, 2018 Category: Cancer & Oncology Tags: Original Articles: Head and Neck Source Type: research

Differential Outcomes Among Immunosuppressed Patients With Merkel Cell Carcinoma: Impact of Immunosuppression Type on Cancer-specific and Overall Survival
Conclusions: Among immunosuppressed MCC patients, recurrent MCC is the major cause of mortality. The risk of death from MCC differs among immunosuppression types, suggesting important biological differences in host-tumor immune interactions. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - December 23, 2018 Category: Cancer & Oncology Tags: Original Articles: Cutaneous Source Type: research

Comparison of Clinical Characteristics and Outcomes in Relapsed Versus De Novo Metastatic Non–Small Cell Lung Cancer
Objectives: To compare the clinical characteristics and outcomes between relapsed and de novo metastatic non–small cell lung cancer (NSCLC). Materials and Methods: We reviewed all NSCLC diagnoses between January 1999 and December 2013 in the institutional Glans-Look Lung Cancer Database, which contains demographic, clinical, pathologic, treatment, and outcome information. Patients with distant metastasis at diagnosis (American Joint Committee on Cancer [AJCC] eighth edition, stage IV), the “de novo” cohort, were compared with the “relapsed” cohort, consisting of patients diagnosed with ea...
Source: American Journal of Clinical Oncology - December 23, 2018 Category: Cancer & Oncology Tags: Original Articles: Thoracic Source Type: research

Patterns of Care and Outcomes of Elderly Esophageal Cancer Patients Not Meeting Age-based Criteria of the CROSS Trial
This study of a large, contemporary national database evaluated practice patterns in elderly patients ineligible for CROSS, and analyzed overall survival (OS) between nCRT+S, S, and definitive CRT (dCRT). Materials and Methods: The National Cancer Data Base was queried for EC patients with cT1N1M0/T2-3N0-1M0 EC (per the CROSS trial) but 76 years and above of age. Multivariable logistic regression ascertained factors associated with nCRT+S (vs. S). Kaplan-Meier analysis evaluated OS; Cox multivariate analysis determined variables associated with OS. Propensity matching aimed to address group imbalances and indication bia...
Source: American Journal of Clinical Oncology - December 23, 2018 Category: Cancer & Oncology Tags: Original Articles: Thoracic Source Type: research

Treatment Patterns and Survival of Elderly Patients With Breast Cancer Brain Metastases
Objectives: The main objective of this study was to analyze treatment patterns of elderly patients with breast cancer brain metastases (BCBM), evaluate characteristics associated with treatment selection, and to analyze trends in overall survival (OS) over time. Materials and Methods: We included women with BCBM reported to the Surveillance, Epidemiology, and End Results Medicare Program from 1992 to 2012. Treatments were recorded from Medicare claims from the date of brain metastases diagnosis until 60 days after. Treatments included resection, radiation, and chemotherapy. Cochran-Armitage tests were used for analysi...
Source: American Journal of Clinical Oncology - December 23, 2018 Category: Cancer & Oncology Tags: Original Articles: Breast Source Type: research

Dynamic Angiogenic Switch as Predictor of Response to Chemotherapy-Bevacizumab in Patients With Metastatic Colorectal Cancer
Background: Previous studies have shown that metastatic colorectal carcinoma (mCRC) patients treated with bevacizumab, experience variation in the plasma levels of angiogenesis growth factors and related cytokines, called angiogenic switch (AS). The aim of the present study was to analyze the relationship between AS and the clinical response during standard chemotherapy-bevacizumab treatment. Patients and Methods: Patients with Eastern Cooperative Oncology Group 0-1 mCRC were eligible. Patients received treatment with standard dose capecitabine plus either oxaliplatin or irinotecan and bevacizumab for 6 cycles. Initia...
Source: American Journal of Clinical Oncology - December 23, 2018 Category: Cancer & Oncology Tags: Original Articles: Gastrointestinal Source Type: research

Dose Escalation in Stereotactic Body Radiation Therapy for Pancreatic Cancer: A Meta-Analysis
Objective: To determine whether increasing biologically effective dose (BED) with stereotactic body radiation therapy (SBRT) is associated with improved local control (LC) or toxicities in patients with locally advanced pancreatic cancer. Methods: A PICOS/PRISMA/MOOSE selection protocol was used to identify 15 studies across 12 institutions in 5 countries where patients received definitive SBRT for nonmetastatic disease. Biologically equivalent doses were calculated with an α/β of 10 (ie, BED10) for LC and acute toxicity and 3 (ie, BED3) for late toxicity. Fixed and random effects models were used to charac...
Source: American Journal of Clinical Oncology - December 23, 2018 Category: Cancer & Oncology Tags: Original Articles: Gastrointestinal Source Type: research

Safety and Efficacy of Cabozantinib for Metastatic Nonclear Renal Cell Carcinoma: Real-world Data From an Italian Managed Access Program
Conclusions: Our data showed that, cabozantinib is a active and feasible treatment in patient with nonclear cell RCC. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - December 23, 2018 Category: Cancer & Oncology Tags: Original Articles: Genitourinary Source Type: research

Comparison of Outcomes in Patients With Muscle-invasive Bladder Cancer Treated With Radical Cystectomy Versus Bladder Preservation
Purpose: Radical cystectomy currently remains the standard of care for muscle-invasive bladder cancer. However, surgery can be associated with considerable morbidity and mortality, including the removal of the bladder. An alternative strategy is to preserve the bladder through concurrent chemoradiation following a maximal transurethral resection of the tumor. National protocols using a bladder-preservation approach have demonstrated disease-specific outcomes comparable to radical cystectomy in selected patients, but these results have not been replicated in previously reported population-based series. Here, we describe a...
Source: American Journal of Clinical Oncology - December 23, 2018 Category: Cancer & Oncology Tags: Original Articles: Genitourinary Source Type: research

Clinical and Molecular Recursive Partitioning Analysis of High-grade Glioma Treated With IMRT
Introduction: Despite multimodal treatment for high-grade gliomas, prognosis remains grim. Prior Radiation Therapy Oncology Group-Recursive Partitioning Analysis (RTOG-RPA) reports indicate based on pretreatment and treatment-related factors, a subset of patients experience a significantly improved survival. Since the development of the RTOG-RPA, high-grade gliomas have seen the widespread introduction of temozolomide and tumor oncogenetics. Here we aimed to determine whether the RTOG-RPA retained prognostic significance in the context of modern treatment, as well as generate an updated RPA incorporating both clinical an...
Source: American Journal of Clinical Oncology - December 23, 2018 Category: Cancer & Oncology Tags: Original Articles: Central Nervous System Source Type: research

Disparities Predict for Higher Rates of Cut-through Hysterectomies in Locally Advanced Cervical Cancer
The objectives of this study were to determine factors associated with cut-through hysterectomies and evaluate OS outcomes. Materials and Methods: The National Cancer Database (NCDB) was queried for patients 18 years and older with clinical Federation of Gynecology and Obstetrics stage IB2 to IVA. All patients underwent upfront hysterectomy and had known margin status. Cut-through hysterectomy was classified as presence of microscopic or macroscopic disease at the margin. Results: A total of 11,638 patients were included; 993 (8.5%) had positive margins. In patients with positive margins, 560 (56.4%) received postope...
Source: American Journal of Clinical Oncology - December 23, 2018 Category: Cancer & Oncology Tags: Original Articles: Gynecologic Source Type: research

Neoadjuvant Chemotherapy Treatment Modifications in Ovarian Carcinoma: The Impact on Surgical Outcome and Progression-free Survival
Conclusions: NACT treatment modifications did not affect surgical outcome and PFS. We conclude that when clinically indicated, dose alteration and scheduling can be implemented without apparent detriment to outcome. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - December 23, 2018 Category: Cancer & Oncology Tags: Original Articles: Gynecologic Source Type: research

Utilization of an Alternative Docetaxel-based Intraperitoneal Chemotherapy Regimen in Patients With Ovarian, Fallopian Tube or Primary Peritoneal Carcinoma: A Continued Need for Ovarian Cancer Patients
Conclusions: This docetaxel-based IP chemotherapy regimen demonstrates an improved tolerability profile compared with GOG172. Additional evaluations on alternative IP regimens remain warranted. Short follow-up time limits survival assessment, but results are encouraging. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - December 23, 2018 Category: Cancer & Oncology Tags: Original Articles: Gynecologic Source Type: research

Survival Outcome and Prognostic Factors After Pulmonary Metastasectomy in Sarcoma Patients: A 18-Year Experience at a Single High-volume Referral Center
Background: Metastatic sarcoma patients have a poor prognosis with 3-year survival rate of 25%. About 30% of them present isolated lung metastases. We aimed to analyze the clinical outcome of sarcoma patients undergoing pulmonary metastasectomy (PM) and prognostic factors associated with local control, disease-free, and overall survival (OS). Patients and Methods: All sarcoma patients undergoing PM at Humanitas Cancer Center were retrospectively reviewed. Analyzed variables included clinicopathologic, surgical, and survival data. Exclusion criterion comprised a follow-up period inferior to 1 year. A univariable and mu...
Source: American Journal of Clinical Oncology - December 23, 2018 Category: Cancer & Oncology Tags: Original Articles: Soft Tissue Source Type: research

Neoadjuvant Interdigitated Chemoradiotherapy Using Mesna, Doxorubicin, and Ifosfamide for Large, High-grade, Soft Tissue Sarcomas of the Extremity: Improved Efficacy and Reduced Toxicity
Conclusions: Neoadjuvant interdigitated MAI radiotherapy followed by resection and 3 cycles of adjuvant MAI has resulted in acceptable and manageable toxicity and highly favorable survival in patients at greatest risk for treatment failure. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - December 23, 2018 Category: Cancer & Oncology Tags: Original Articles: Soft Tissue Source Type: research

Upgrading the Diagnostic Assessment in Primary Pulmonary Carcinoids: The Tumor-infiltrating Lymphocytes (TILs)
No abstract available (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - November 21, 2018 Category: Cancer & Oncology Tags: Letter to the Editor Source Type: research

Literature Review of Spinal Cord Glioblastoma
Conclusions: These data elucidate the characteristics of patients with scGBM. For more sophisticated and in-depth analyses in the future, it is imperative that time-of-treatment information is recorded in future case reports. In addition, all case reports should be made available to prevent publication bias. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - November 21, 2018 Category: Cancer & Oncology Tags: Review Articles Source Type: research

Parameters Associated With Mandibular Osteoradionecrosis
The objective of this review is to discuss factors related to the risk of osteoradionecrosis (ORN) and how to minimize the likelihood of this complication. A PubMed search for publications pertaining to ORN within the last 3 years was conducted revealing 44 publications. The bibliographies of these publications were reviewed to identify additional references spanning a longer time period. The incidence of ORN is 5% to 10% with a median latency period of 1 to 2 years or less. The likelihood of ORN depends on a number of factors including primary site and extent of disease, dental status, treatment modality, radiotherapy (RT...
Source: American Journal of Clinical Oncology - November 21, 2018 Category: Cancer & Oncology Tags: Review Articles Source Type: research

Single-agent Bevacizumab in Recurrent Glioblastoma After Second-line Chemotherapy With Fotemustine: The Experience of the Italian Association of Neuro-Oncology
Conclusions: On the basis of our data, in patients with recurrent GBM, the failure of a second-line chemotherapy with cytotoxic agents might not exclude the administration of bevacizumab as third-line chemotherapy. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - November 21, 2018 Category: Cancer & Oncology Tags: Original Articles: Central Nervous System Source Type: research

Quality of Life Perception, Cognitive Function, and Psychological Status in a Real-world Population of Glioblastoma Patients Treated With Radiotherapy and Temozolomide: A Single-center Prospective Study
Conclusions: In routine neurooncology practice, HRQoL, cognitive function, and psychological status did not worsen during first-line treatment in glioblastoma patients receiving standard radiotherapy and temozolomide treatment. However, some patient subgroups, such as elderly and female patients, may have different experiences with treatment, and further investigation is required. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - November 21, 2018 Category: Cancer & Oncology Tags: Original Articles: Central Nervous System Source Type: research

Randomized, Prospective, Open-label Phase III Trial Comparing Mebo Ointment With Biafine Cream for the Management of Acute Dermatitis During Radiotherapy for Breast Cancer
Conclusions: This study showed no difference between Mebo and Biafine in the incidence and severity of breast skin dermatitis during radiation therapy. However, the use of Mebo ointment was associated with decreased severe pruritus and pain which could positively affect patient comfort and quality of life. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - November 21, 2018 Category: Cancer & Oncology Tags: Original Articles: Breast Source Type: research

BRCA1 Mutations Associated With Increased Risk of Brain Metastases in Breast Cancer: A 12 Matched-pair Analysis
Conclusions: Breast cancer patients with germline BRCA1 mutations appear to have a shorter interval to brain progression while accounting for confounding factors. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - November 21, 2018 Category: Cancer & Oncology Tags: Original Articles: Breast Source Type: research

Breast-conservation Therapy After Neoadjuvant Chemotherapy Does Not Compromise 10-Year Breast Cancer–specific Mortality
Conclusions: This study is consistent with previous research showing that breast-conserving surgery after neoadjuvant chemotherapy does not reduce breast cancer–specific survival. In fact, patients undergoing breast-conservation after neoadjuvant therapy appeared to have better survival than patients undergoing mastectomy without radiation. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - November 21, 2018 Category: Cancer & Oncology Tags: Original Articles: Breast Source Type: research

Rectal Culture and Sensitivity Analysis for Reducing Sepsis Risk After Fiducial Marker Placement
Conclusion: Rectal C&S to identify FQ resistant E. coli before placement of fiducial markers for prostate RT likely reduces the risk of bacterial UTI necessitating hospitalization. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - November 21, 2018 Category: Cancer & Oncology Tags: Original Articles: Genitourinary Source Type: research

Nivolumab in the Treatment of Metastatic Renal Cell Carcinoma: A Cost-Utility Analysis
Conclusions: Compared with everolimus, nivolumab is unlikely to be cost-effective for the treatment of mRCC from a Canadian health care perspective with its current price assuming a WTP of $50,000/QALY. Although mRCC patients derive a meaningful clinical benefit from nivolumab, considerations should be given to avoid drug wastage and increase the WTP threshold to render this strategy more affordable. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - November 21, 2018 Category: Cancer & Oncology Tags: Original Articles: Genitourinary Source Type: research

The Utility of Diagnostic Laparoscopy in Patients Being Evaluated for Cytoreductive Surgery and Hyperthermic Peritoneal Chemotherapy
Conclusions: Laparoscopic assessment of PC is a useful tool to assess the complete resectability of peritoneal surface disease in patients for whom there is inadequate information concerning disease extent. DL also helps selected patients to avoid an unnecessary laparotomy. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - November 21, 2018 Category: Cancer & Oncology Tags: Original Articles: Gynecologic Source Type: research

The Significance of Para-Aortic Nodal Size and the Role of Adjuvant Systemic Chemotherapy in Cervical Cancer: An Institutional Experience
Conclusions: Over half of patients with cervical cancer metastatic to the PALN failed extended-field chemoradiation. Most failures occurred outside the radiated field suggesting PALN involvement is a surrogate marker of systemic disease. These findings underscore the need for effective systemic therapy, especially in patients with PALN ≥1 cm in size. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - November 21, 2018 Category: Cancer & Oncology Tags: Original Articles: Gynecologic Source Type: research