Competing Mortality in Patients With Neuroendocrine Tumors: Erratum
No abstract available (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - January 25, 2020 Category: Cancer & Oncology Tags: Erratum Source Type: research

Vincristine Shortage: What Other Options We Have?
No abstract available (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - January 25, 2020 Category: Cancer & Oncology Tags: Letter to the Editor Source Type: research

Genomic and Molecular Abnormalities in Gynecologic Clear Cell Carcinoma
Gynecologic clear cell carcinoma is a rare histology, accounting for ~5% of all ovarian and endometrial cancers in the United States. Compared to other types of gynecologic cancer, they are generally less responsive to standard therapy and have an overall worse prognosis. In addition, mounting evidence suggests that the landscape of genetic and molecular abnormalities observed in these tumors is distinct from other cancers that arise from the same sites of origin. On a molecular level, these tumors characteristically display upregulation of the PI3K-AKT-mTOR and RAS-RAF-MAPK signaling axes, frequent loss of ARID1a, and ove...
Source: American Journal of Clinical Oncology - January 25, 2020 Category: Cancer & Oncology Tags: Review Article Source Type: research

Tumor Deposits in Stage III Colon Cancer: Correlation With Other Histopathologic Variables, Prognostic Value, and Risk Stratification—Time to Consider “N2c”
This study analyzes the impact of tumor deposits (TDs), T and N status, poor differentiation (PD), perineural invasion (PNI), and lymphovascular invasion (LVI) on survival. Materials and Methods: A retrospective analysis (2010-2015) of the National Cancer Database of stage III colon cancer patients treated with both surgery and chemotherapy was conducted. Data was extracted on sex, race, age at diagnosis, Charlson-Deyo Score, histopathologic variables, and survival rates. Statistical analysis used the test of proportions, log-rank test for Kaplan-Meier curves, and Cox proportional hazard models. Results: For the 42,9...
Source: American Journal of Clinical Oncology - January 25, 2020 Category: Cancer & Oncology Tags: Original Articles: Gastrointestinal Source Type: research

Expanding the Spectrum of Radiation Necrosis After Stereotactic Radiosurgery (SRS) for Intracranial Metastases From Lung Cancer: A Retrospective Review
Conclusions: This review of outcomes of RT for ICM in LC demonstrates a higher rate of RN than previously reported in the literature in those having had a surgical resection plus stereotactic radiosurgery. Our observation of RN as late as 5 years post-RT for ICM necessitates clinician awareness. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - January 25, 2020 Category: Cancer & Oncology Tags: Original Articles: Thoracic Source Type: research

The Reliability of Intraoperative Assessment on Predicting Tumor Size, Myometrial Invasion, and Cervical Involvement in Patients With a Preoperative Diagnosis of Complex Atypical Hyperplasia or (Clinical Stage I) Endometrial Cancer: A Prospective Cohort Study
Conclusions: Despite only a fair correlation in the myometrial invasion, intraoperative assessment of cervical involvement and especially tumor size is more readily identified and overall accurate. Therefore, intraoperative evaluation is an additional tool to use when making the decision to proceed with surgical staging. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - January 25, 2020 Category: Cancer & Oncology Tags: Original Articles: Gynecologic Source Type: research

Sequencing Ipilimumab Immunotherapy Before or After Chemotherapy (Nab-Paclitaxel and Bevacizumab) for the Treatment of BRAFwt (BRAF Wild-Type) Metastatic Malignant Melanoma: Results of a Study of Academic and Community Cancer Research United (ACCRU) RU261206I
Conclusion: Albeit limited in scope, our data suggest that cytotoxic therapy with nab-paclitaxel and bevacizumab appear to favorably alter systemic parameters of immune function of potential benefit in combination T-cell directed immune checkpoint inhibitor therapy. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - January 25, 2020 Category: Cancer & Oncology Tags: Original Articles: Cutaneous Source Type: research

Novel Dose Escalation Approaches for Stereotactic Body Radiotherapy to Adrenal Oligometastases: A Single-Institution Experience
Conclusions: Adrenal SBRT for oligometastatic disease is a feasible, noninvasive option with excellent LC and minimal toxicity. Lesions in close proximity to radiosensitive organs may benefit from dynamic patient positioning and selective simultaneous-integrated boost techniques to allow for dose escalation, while also limiting toxicity risks. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - January 25, 2020 Category: Cancer & Oncology Tags: Original Articles: Endocrine Source Type: research

Association of Diabetes and Other Clinical and Sociodemographic Factors With Guideline-concordant Breast Cancer Treatment for Breast Cancer
Background: Women with breast cancer have worse health outcomes with co-occurring type 2 diabetes, possibly due to suboptimal breast cancer treatment. Methods: We created a cohort of women ages 66 to 85 y with stage I to III breast cancer from 1993 to 2012 from an integrated health care delivery system (n=1612) and fee-for-service Medicare beneficiaries (n=98,915), linked to Surveillance, Epidemiology, and End Results (SEER) data (total n=100,527). We evaluated associations between type 2 diabetes and other factors with undergoing guideline-concordant cancer treatment. We estimated χ2 tests for univariate a...
Source: American Journal of Clinical Oncology - January 25, 2020 Category: Cancer & Oncology Tags: Original Articles: Breast Source Type: research

Black Patients Experience Highest Rates of Cancer-associated Venous Thromboembolism
We examined whether black cancer patients are at a higher risk of VTE and whether these differences are present in specific cancer types. Design: A retrospective study was performed in the largest safety net hospital of New England using a cohort of cancer patients characterized by a substantial number of nonwhites. Results: We identified 16,498 subjects with solid organ and hematologic malignancies from 2004 to 2018. Among them, we found 186 unique incident VTE events, of which the majority of the events accrued within the first 2 years of cancer diagnosis. Overall, blacks showed a 3-fold higher incidence of VTE (1....
Source: American Journal of Clinical Oncology - January 25, 2020 Category: Cancer & Oncology Tags: Original Articles: Complications of Cancer Source Type: research

A Limited-Versus-Extensive Staging Strategy for Small Cell Prostate Cancer
Introduction: Small cell prostate cancer (SCPC) is a rare histologic subtype of prostate cancer, for which the optimal staging strategy remains unclear. Method: The Surveillance, Epidemiology, and End Results database was used to analyze the incidence and outcomes of SCPC between the years 2004 through 2016. Limited-stage SCPC (LS-SCPC) was defined as SCPC without any metastasis regardless of local invasion. Extensive stage SCPC (ES-SCPC) was defined as any metastasis to lymph nodes and/or to distant organs. Result: A total of 403 SCPC patients were included in the study cohort, accounting for 0.056% of all prostat...
Source: American Journal of Clinical Oncology - January 25, 2020 Category: Cancer & Oncology Tags: Original Articles: Genitourinary Source Type: research

A Pilot Study of Radiation Therapy in Combination With Pembrolizumab in Patients With Metastatic Renal Cell Cancer
Conclusion: Combining RT with pembrolizumab in pretreated mRCC is well-tolerated and appears to have comparable efficacy with single-agent nivolumab. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - January 25, 2020 Category: Cancer & Oncology Tags: Original Articles: Genitourinary Source Type: research

Stereotactic Body Radiotherapy for Oligometastatic Prostate Cancer Recurrence: A Meta-analysis
Purpose: The purpose of this study was to evaluate the treatment efficacy of stereotactic body radiotherapy (SBRT) in oligometastatic prostate cancer recurrence and to assess whether there is any relationship between biologically effective dose (BED) and local control (LC). Materials and Methods: Eligible studies were identified on Medline, Embase, and the Cochrane Library, and the proceedings of annual meetings through May 2019 were also identified. A meta-regression analysis was performed to assess whether there is a relationship between BED and LC. In the univariate analysis, studies were separated by the study des...
Source: American Journal of Clinical Oncology - January 25, 2020 Category: Cancer & Oncology Tags: Original Articles: Genitourinary Source Type: research

Does Early Chemotherapy Improve Survival in Advanced Endometrial Cancer?: Erratum
No abstract available (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - December 17, 2019 Category: Cancer & Oncology Tags: Erratum Source Type: research

Targeting the Mevalonate Pathway for Treating Lung Cancer
The mevalonate (MVA) pathway is a key metabolic pathway involved in various important cellular functions. Its downstream products are critical for cell-signaling, cell membrane integrity, protein synthesis, and cellular respiration. The rate-limiting enzyme of this pathway is targeted by statins, a class of medications best known for their lipid-lowering effects. Many studies have shown that a variety of cancerous cells have a dysregulated MVA pathway. Lung cancer is responsible for a third of all cancer-related deaths worldwide. As our understanding of the molecular mechanisms driving the pathogenesis of lung cancer impro...
Source: American Journal of Clinical Oncology - December 17, 2019 Category: Cancer & Oncology Tags: Review Article Source Type: research

Differential Efficacy of Anti-VEGF Antibodies Based on Sex and Race in a Diverse Cohort of Advanced Nonsquamous Non–Small Cell Lung Cancer
Conclusions: In a diverse cohort of patients with advanced NS-NSCLC, a survival benefit was confirmed with AVA. The greatest magnitude of benefit was in blacks and non-Hispanic whites. A significant survival benefit was limited to female patients. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - December 17, 2019 Category: Cancer & Oncology Tags: Original Articles: Thoracic Source Type: research

Survival Outcomes After Adding Stereotactic Body Radiotherapy to Metastatic Renal Cell Carcinoma Patients Treated With Tyrosine Kinase Inhibitors
Conclusions: Adding SBRT to TKI is safe and seems to improve survival in mRCC. Patients irradiated before TKI failure have higher CR rate, and the favorable local response might turn into survival benefit. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - December 17, 2019 Category: Cancer & Oncology Tags: Original Articles: Genitourinary Source Type: research

Long-Term Survival Rates and Prognostic Factors of Cervix Cancer Treated by Different Modalities
Objective: To assess the overall survival (OS) and prognostic factors in patients with cervix cancer treated by different modalities. Material and Methods: The authors studied a cohort of patients with cervix cancer International Federation of Gynecology and Obstetrics stage I-IVa treated in the last 15 years. Patients were treated with surgery followed by radiotherapy (S+RT), or surgery plus chemoradiation (S+CRT), or radiotherapy alone (RT), or chemoradiation alone (CRT). Univariate and multivariate analyses were conducted to identify significant prognostic factors (P (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - December 17, 2019 Category: Cancer & Oncology Tags: Original Articles: Gynecologic Source Type: research

Prognostic Significance of Nuclear Factor Kappa B Expression in Locally Advanced Cervical Cancer Patients Treated Definitively With Concurrent Chemoradiation
Conclusions: Our study demonstrated that cytoplasmic NFkB-p65 expression (H-index ≥180) was associated with a nonstatistically significant trend toward poor clinical outcomes in locally advanced cervical cancer patients treated definitively with CRT. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - December 17, 2019 Category: Cancer & Oncology Tags: Original Articles: Gynecologic Source Type: research

Disparities in the Use of Adjuvant External Beam Radiation Therapy in Node-positive Cervical Cancer Patients Following Hysterectomy
The objective of this study was to investigate the use of adjuvant external beam radiation therapy (EBRT) among patients with early-stage cervical carcinoma metastatic to regional lymph nodes (LNs). Materials and Methods: The National Cancer Database was accessed and patients with early-stage cervical carcinoma diagnosed between 2004 and 2015 were identified. Those with regional LN metastases who had a hysterectomy were selected and administration of adjuvant EBRT was evaluated. Travel distance from the reporting facility was categorized into short (49.9 miles). Results: A total of 3436 patients met the inclusion cri...
Source: American Journal of Clinical Oncology - December 17, 2019 Category: Cancer & Oncology Tags: Original Articles: Gynecologic Source Type: research

Impact of Brachytherapy Boost and Dose-escalated External Beam Radiotherapy in Margin Positive Cervical Cancer Treated With Chemotherapy and Radiation
Conclusion: The addition of BB to standard CRT improved OS for women with cervical cancer and a positive margin after hysterectomy. No consistent survival benefit was seen to EBRT dose-escalation beyond 5040 cGy. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - December 17, 2019 Category: Cancer & Oncology Tags: Original Articles: Gynecologic Source Type: research

Comparing Late-line Treatment Sequence of Regorafenib and Reduced-intensity FOLFOXIRI for Refractory Metastatic Colorectal Cancer
This study was a single-center retrospective cohort study that reviewed data from patients at Taipei Veterans General Hospital, Taiwan, with mCRC refractory to fluorouracil, irinotecan, oxaliplatin, cetuximab (wild-type RAS), and bevacizumab. Patients were divided into 2 groups: a regorafenib-first group and a riFOLFOXIRI-first group. The Kaplan-Meier method and log-rank test were used to analyze survival, and a Cox proportional hazards model was used for univariate, multivariate, and subgroup analyses. Results: A total of 136 and 55 patients followed a regorafenib-first or riFOLFOXIRI-first treatment strategy, respecti...
Source: American Journal of Clinical Oncology - December 17, 2019 Category: Cancer & Oncology Tags: Original Articles: Gastrointestinal Source Type: research

Prognostic Nomogram for Hepatitis B Virus–related Hepatocellular Carcinoma With Adjuvant Transarterial Chemoembolization After Radical Resection
The objective of this study was to establish a reliable and effective nomogram for predicting prognosis of hepatitis B virus (HBV)–related hepatocellular carcinoma (HCC) with postoperative adjuvant transarterial chemoembolization (TACE). Patients and Methods: A derivation cohort of 370 HCC patients treated with postoperative TACE in the Eastern Hepatobiliary Surgery Hospital from January 2009 to December 2012 were retrospectively analyzed. Univariate and multivariate analysis were performed by Cox regression and independent prognostic factors for overall survival were determined to construct the nomogram. Concorda...
Source: American Journal of Clinical Oncology - December 17, 2019 Category: Cancer & Oncology Tags: Original Articles: Gastrointestinal Source Type: research

“Pleurex Desalination” in Malignancy-related Ascites: A Novel Mechanism of Hyponatremia
Conclusion: “Pleurex desalination” is an under-recognized cause of hyponatremia; at-risk patients require close observation and periodic resuscitation with intravenous, volume-expanding fluids. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - December 17, 2019 Category: Cancer & Oncology Tags: Original Articles: Gastrointestinal Source Type: research

Prognostic Value of Serum NPY Hypermethylation in Neoadjuvant Chemoradiotherapy for Rectal Cancer: Secondary Analysis of a Randomized Trial
Conclusions: Meth-ctDNA could be a potential prognostic marker in the neoadjuvant setting and may, if validated, identify patients at increased risk of distant metastases. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - December 17, 2019 Category: Cancer & Oncology Tags: Original Articles: Gastrointestinal Source Type: research

Evaluation of Genetic Variants in MIR3142HG in Susceptibility to and Prognosis of Glioma
Conclusion: Our study provided the first evidence for the impact of rs1582417, rs17057846, rs2431689, rs2961920, rs58747524, and rs7727115 polymorphisms in MIR3142HG on the susceptibility to and/or prognosis of glioma in the Chinese Han population. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - December 17, 2019 Category: Cancer & Oncology Tags: Original Articles: Central Nervous System Source Type: research

Incidence of Neonatal Neutropenia, Leukopenia, and Anemia After In Utero Exposure to Chemotherapy For Maternal Cancer: Erratum
No abstract available (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - December 1, 2019 Category: Cancer & Oncology Tags: Erratum Source Type: research

Emerging Role of Multikinase Inhibitors in Desmoid Tumor Management
No abstract available (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - December 1, 2019 Category: Cancer & Oncology Tags: Letter to the Editor Source Type: research

Extracranial Abscopal Effects Induced by Brain Radiation in Advanced Lung Cancer
An extracranial abscopal effect induced by central nervous system (CNS)-radiation therapy is considered an unusual event because of the belief that brain has a distinctive immune microenvironment. Regular immune responses from radiation therapy or other interventions were thought to be very limited in the CNS. In addition, CNS autoimmunity and neurodegeneration were presumed automatic consequences of immune cell encounters with CNS antigens. Moreover, the traditional assumption is that nascent tumor-associated antigens produced by radiation therapy could not pass through the blood-brain barrier back into the rest of the bo...
Source: American Journal of Clinical Oncology - December 1, 2019 Category: Cancer & Oncology Tags: Review Article Source Type: research

The Prognostic Role of Pretreatment Neutrophil to Lymphocyte Ratio (NLR) in Malignant Adrenal Lesions Treated With Stereotactic Body Radiation Therapy (SBRT)
Conclusions: These results support the limited existing literature, demonstrating that SBRT provides adequate LC for adrenal lesions with minimal toxicity. Pretreatment neutrophil to lymphocyte ratio may serve as a prognostic factor in these patients. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - December 1, 2019 Category: Cancer & Oncology Tags: Original Articles: Endocrine Source Type: research

Definitive Radiation Treatment Patterns and Outcomes for Low and Intermediate Risk Prostate Cancer Patients: A Cross-Continental Comparative Study
Purpose: To evaluate early-stage prostate cancer (PCa) radiotherapy treatment patterns and outcomes among Ghanaian men (GM) compared with US men (USM). Materials and Methods: This retrospective study consists of 987 National Comprehensive Cancer Network low risk, favorable intermediate risk, and unfavorable intermediate risk PCa patient subgroups; GM (173) and USM (814). Differences in baseline covariates and clinical characteristics between GM and USM were analyzed using χ2 and Mann-Whitney test while Cox Proportional Hazards model was used to assess freedom from biochemical failure differences between the study ...
Source: American Journal of Clinical Oncology - December 1, 2019 Category: Cancer & Oncology Tags: Original Articles: Genitourinary Source Type: research

The Role of Partial Breast Radiation in the Previously Radiated Breast
Conclusion: EB PBI after lumpectomy seems to be a safe and effective RT treatment option for selected patients with prior RT and localized early-stage breast cancer. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - December 1, 2019 Category: Cancer & Oncology Tags: Original Articles: Breast Source Type: research

Role of Perioperative Chemotherapy in Lymph Node-negative Esophageal Cancer After Resection: A Population-based Study With Propensity Score-matched Analysis
Background: Multimodality treatment is increasingly accepted and becoming the standard care for local advanced esophageal cancer (EC) patients. However, for early stage lymph node-negative EC patients, surgery alone is still the primary treatment approach, and the role of perioperative chemotherapy remains unclear. Methods: Patients with lymph node-negative EC were identified from the Surveillance, Epidemiology, and End Results (SEER) database from 2004 to 2013. Survival was compared by the log-rank test. Cox proportional hazards analysis was used to identify covariates associated with overall survival (OS). Propensit...
Source: American Journal of Clinical Oncology - December 1, 2019 Category: Cancer & Oncology Tags: Original Articles: Thoracic Source Type: research

Modern Outcomes Following Treatment of Hepatocellular Carcinoma in Hereditary Hemochromatosis: A Matched Cohort Study
Conclusions: Patients with HCC and HH can achieve comparable survival rates following curative or LRT modalities to other liver diseases. The BCLC staging system accurately stratifies survival and excellent 5-year survival is possible following LT in selected patients. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - December 1, 2019 Category: Cancer & Oncology Tags: Original Articles: Gastrointestinal Source Type: research

The Effect of Metformin on Prognosis in Patients With Locally Advanced Gastric Cancer Associated With Type 2 Diabetes Mellitus
Conclusions: Metformin improves the survival of patients with gastric cancer and type 2 DM. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - December 1, 2019 Category: Cancer & Oncology Tags: Original Articles: Gastrointestinal Source Type: research

Real-world Outcomes Among Patients Treated With Gemcitabine-based Therapy Post-FOLFIRINOX Failure in Advanced Pancreatic Cancer
Objectives: Limited evidence exists for chemotherapy selection in advanced pancreatic cancer (APC) after first-line FOLFIRINOX. Second-line gemcitabine/nab-paclitaxel (GEMNAB) is publicly funded in the Canadian provinces of Alberta (AB) and Manitoba (MB), but not in British Columbia (BC). We compared population-based outcomes by region to examine the utility of second-line GEMNAB versus gemcitabine (GEM) alone. Methods: We identified patients treated with first-line FOLFIRINOX between 2013 and 2015 across BC, AB, and MB. Baseline characteristics and treatment regimens were compared between AB/MB and BC. Survival outco...
Source: American Journal of Clinical Oncology - December 1, 2019 Category: Cancer & Oncology Tags: Original Articles: Gastrointestinal Source Type: research

CA 19-9 Response: A Surrogate to Predict Survival in Patients With Metastatic Pancreatic Adenocarcinoma
Conclusions: In patients with a CA 19-9 ≥1000 U/mL, serial CA 19-9 levels may be considered as a surrogate for serial imaging to evaluate treatment response, with a ≥75% decline indicating the greatest survival benefit. Survival was improved further in the setting of a slower decline to nadir with the highest benefit seen in patients with a nadir occurring at 4 months or longer. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - December 1, 2019 Category: Cancer & Oncology Tags: Original Articles: Gastrointestinal Source Type: research

An Update to Changing Patterns of Anal Carcinoma in the United States
Conclusions: The previously observed rise in anal SCC/CIS incidence slowed in 2010, largely due to a decline in CIS rates. Patients were more likely to present with CIS than SCC at any stage. Future studies are necessary to determine if this decline in CIS precedes a decline in invasive SCC. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - December 1, 2019 Category: Cancer & Oncology Tags: Original Articles: Gastrointestinal Source Type: research

On the Importance of Rural Health: Mistaking a Forest for a Few Trees
No abstract available (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - October 26, 2019 Category: Cancer & Oncology Tags: Letters to the Editor Source Type: research

Rural-urban Disparities in Lung Cancer Mortality: Missing the Forest for the Trees?
No abstract available (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - October 26, 2019 Category: Cancer & Oncology Tags: Letters to the Editor Source Type: research

Incidence of Neonatal Neutropenia and Leukopenia After In Utero Exposure to Chemotherapy for Maternal Cancer
No abstract available (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - October 26, 2019 Category: Cancer & Oncology Tags: Letters to the Editor Source Type: research

Determining the Impact of a Cancer Diagnosis on Diabetes Management: A Systematic Literature Review
Conclusions: Although the effects of a cancer diagnosis on diabetes management are mixed, when results across studies were synthesized together, diabetes management appeared to generally decline after a cancer diagnosis. Declines in diabetes management seem to be primarily due to shifts in the priority of care from diabetes management to cancer. A next critical step in this line of work is to identify patient and provider level predictors of better or worse diabetes management to design and test interventions aimed at improving effective diabetes management for cancer patients. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - October 26, 2019 Category: Cancer & Oncology Tags: Review Article Source Type: research

Phase I Study of IGF-Methotrexate Conjugate in the Treatment of Advanced Tumors Expressing IGF-1R
Conclusions: IGF-MTX is well tolerated. IGF-MTX pharmacokinetics suggest rapid cellular uptake. The activity of IGF-MTX in Hodgkin lymphoma should be explored. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - October 26, 2019 Category: Cancer & Oncology Tags: Original Articles: Experimental Therapeutics Source Type: research

Early Exploratory Analysis for Patient-reported Quality of Life and Dosimetric Correlates in Hypofractionated Stereotactic Body Radiation Therapy (SBRT) for Low-risk and Intermediate-risk Prostate Cancer: Interim Results from a Prospective Phase II Clinical Trial
Conclusions: Higher dose volumes for the bladder and rectum predicted for poorer PR-QOL. In contrast to prostate brachytherapy data, neither prostate volume nor urethral dosimetry at this dose schedule correlated with urinary symptoms. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - October 26, 2019 Category: Cancer & Oncology Tags: Original Articles: Genitourinary Source Type: research

A Matter of Comprehensive Informed Consent: Short-Term Mortality Rates With Definitive Treatment Options in Elderly Stage I NSCLC
Background: Although lobectomy is the standard of care in stage I non–small cell lung cancer (NSCLC), medical comorbidities increase surgical risk in elderly patients. No population-based studies compare short-term mortality (STM) for surgery (STM-S), radiation (STM-R), and observation (STM-O) in elderly patients with stage I NSCLC. Methods: A total of 60,466 biopsy-proven stage I NSCLC cases diagnosed between 2004 and 2012 were retrieved from the Surveillance, Epidemiology, and End Results Program. Patient characteristics were compared using χ2 test. Age was divided into 5-year subsets (60 to 64 to 90+&thin...
Source: American Journal of Clinical Oncology - October 26, 2019 Category: Cancer & Oncology Tags: Original Articles: Practice of Oncology Source Type: research

Intrapatient Molecular and Histologic Heterogeneity After First-generation or Second-generation TKI Therapy of NSCLC Patients: Potential Clinical Impact on Subsequent third-generation TKI Treatment
Conclusions: Intrapatient molecular or histologic heterogeneity may be frequently found during routine treatment of non–small cell lung cancer patients. This biological aspect may have profound repercussions on subsequent therapeutic decisions, and therefore requires in-depth investigation. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - October 26, 2019 Category: Cancer & Oncology Tags: Original Articles: Thoracic Source Type: research

Cost-Effectiveness Analysis of Upfront SBRT for Oligometastatic Stage IV Non–Small Cell Lung Cancer Based on Mutational Status
Conclusion: Adding SBRT to maintenance therapy is not a cost-effective strategy for oligometastatic NSCLC compared with maintenance therapy alone for mutation-positive groups. However, this should be validated via randomized trials. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - October 26, 2019 Category: Cancer & Oncology Tags: Original Articles: Thoracic Source Type: research

National Burden of Hospitalization Due to Cutaneous Melanoma in Adolescents and Young Adults
The objective of this study was to elucidate sociodemographic/hospitalization characteristics of AYA CM inpatients, determine which factors lead to the greater length of stay (LOS) and cost of care for AYA CM inpatients, and evaluate trends in the prevalence, LOS, and cost of care for AYA CM hospitalizations. Materials and Methods: A retrospective cohort study of nationally representative data from the 2009 to 2015 National Inpatient Sample. Multivariable survey-weighted logistic regression models were used to determine sociodemographic factors associated with AYA CM hospitalization. Multivariable survey-weighted linear...
Source: American Journal of Clinical Oncology - October 26, 2019 Category: Cancer & Oncology Tags: Original Articles: Cutaneous Source Type: research

Prognosis and Management of Thick and Ultrathick Melanoma
Conclusions: Disease progression was higher in the ultrathick melanoma group. Thicker tumors, head/neck location, and positive lymph nodes were associated with decreased PFS. High NLR was associated with decreased OS. Ultrathick melanomas represent advanced malignancy; however, patients may derive benefit from surgical treatment to achieve locoregional control. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - October 26, 2019 Category: Cancer & Oncology Tags: Original Articles: Cutaneous Source Type: research

Paragangliomas of the Head and Neck: Local Control and Functional Outcome Following Fractionated Stereotactic Radiotherapy
Conclusions: State-of-the-art FSRT provides excellent control and favorable functional outcome in patients with paragangliomas of the head and neck. The volumetric analysis provides improved evidence for sustained tumor control. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - October 26, 2019 Category: Cancer & Oncology Tags: Original Articles: Head and Neck Source Type: research