American Journal of Clinical Oncology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Systematic Review of Treatments for Colorectal Metastases in Elderly Patients to Guide Surveillance Cessation Following Hepatic Resection for Colorectal Liver Metastases
Discussion: The survival benefit of treating CRC metastases with surgery or chemotherapy decreases with advancing age and QoL may decline in the elderly. The relatively lower efficacy and detrimental QoL impact of multimodal therapy options for detected CRC metastases in the elderly questions the benefit of surveillance in some elderly patients. Care of elderly patients should thus be customized based on their preference, formal geriatric assessment, natural life-expectancy, and the perceived risk-benefit balance of treating recurrent CRC metastases. Clinicians may consider surveillance cessation in patients aged 75 ye...
Source: American Journal of Clinical Oncology - April 30, 2021 Category: Cancer & Oncology Tags: Review Article Source Type: research

Intercostobrachial Nerve (ICBN) Preservation Versus Sacrifice in Axillary Dissection: Randomized Controlled Trial
Conclusion: This study can conclude that preservation of ICBN during axillary dissection in patients with breast CA can save these patients’ additional suffering from inner arm numbness. That is at the expense of surgery duration, around 20 minutes longer, for the surgeon to take his/her time in carefully dissecting the axilla properly without injuring these ICBN. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - April 30, 2021 Category: Cancer & Oncology Tags: Original Articles: Breast Source Type: research

Clinical Outcomes of Patients With pT1-T2N0 Oral Tongue Squamous Cell Carcinoma
Conclusion: Local regional recurrence remains modest in early-stage OTSCC, but salvage is possible with high survival rates. Level of Evidence: Level III—retrospective cohort study. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - April 30, 2021 Category: Cancer & Oncology Tags: Original Articles: Head and Neck Source Type: research

Surveillance Only for High-risk FIGO Stage IA/IB Malignant Ovarian Germ Cell Tumors: Results From a National Cancer Database
Conclusions: A surveillance only strategy for patients with stage I malignant ovarian germ cell tumors is associated with excellent survival outcomes for patients with grade 2 or 3 immature teratoma or mixed germ cell tumors. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - April 30, 2021 Category: Cancer & Oncology Tags: Original Articles: Gynecologic Source Type: research

Trends and Factors Associated With Receipt of Upfront Surgery for Stage II to III Rectal Adenocarcinoma in the United States, 2006 to 2016
Introduction: The German rectal study published in 2004 established neoadjuvant chemoradiation as a standard of care for locally advanced rectal cancer and current National Comprehensive Cancer Network guidelines endorse several preoperative regimens. Upfront surgery, however, is considered substandard care. In the era of evolving treatment paradigms for locally advanced rectal cancer, we sought to assess trends and predictors of receipt of upfront surgery for stage II to III rectal cancer. Methods: The National Cancer Database was used to identify patients diagnosed with clinical stage II to III rectal adenocar...
Source: American Journal of Clinical Oncology - April 30, 2021 Category: Cancer & Oncology Tags: Original Articles: Gastrointestinal Source Type: research

Early Palliative Care Is Associated With Reduced Emergency Department Utilization in Pancreatic Cancer
Objectives: Most patients with pancreatic cancer have high symptom burden and poor outcomes. Palliative care (PC) can improve the quality of care through expert symptom management, although the optimal timing of PC referral is still poorly understood. We aimed to assess the association of early PC on health care utilization and charges of care for pancreatic cancer patients. Materials and Methods: We selected patients with pancreatic cancer diagnosed between 2000 and 2009 who received at least 1 PC encounter using the Surveillance, Epidemiology, and End Results (SEER)-Medicare. Patients who had unknown follow-up...
Source: American Journal of Clinical Oncology - April 30, 2021 Category: Cancer & Oncology Tags: Original Articles: Gastrointestinal Source Type: research

Stereotactic Body Radiotherapy for Palliation of Hematuria Arising From Urothelial Carcinoma of the Kidney in Unfavorable Surgical Candidates
Conclusions: SBRT appears to be an effective and well-tolerated means of palliating gross hematuria secondary to UC of the renal pelvis or calyces in patients who are unfavorable candidates for nephrectomy or ureteroscopic ablation. Treatment was associated with a moderate decline in renal function. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - April 30, 2021 Category: Cancer & Oncology Tags: Original Articles: Genitourinary Source Type: research

The Effect of Adjuvant Pelvic Radiotherapy on Distant Metastasis for Uterine Carcinosarcoma
Conclusions: RT may offer a potential benefit in reducing the rate of distant metastases, though there were no statistically significant improvements in survival metrics. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - March 30, 2021 Category: Cancer & Oncology Tags: Original Articles: Gynecologic Source Type: research

Tumor Necrotic Debris and High Nuclear Grade: Newly Identified High-risk Factors for Early-stage Endocervical Adenocarcinoma
Conclusions: NTD-N3, a novel pathologic finding, may be used to further stratify overall recurrence risk, and may play a role in individualization of patient care in early-stage EAC. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - March 30, 2021 Category: Cancer & Oncology Tags: Original Articles: Gynecologic Source Type: research

Outcomes of Ramucirumab Plus Paclitaxel Among Patients With Previously Treated Metastatic Gastric/Lower Esophageal Cancer: A Real-world Study
Conclusions: Use of paclitaxel/ramucirumab combination beyond first-line treatment is associated with improved OS among patients with metastatic gastric/lower esophageal adenocarcinoma in this real-world study. Further work is needed to reduce disparity in our health care system between individuals living in rural versus urban areas. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - March 30, 2021 Category: Cancer & Oncology Tags: Original Articles: Gastrointestinal Source Type: research

Lower Levels of Trust in the Medical Profession Among White, Younger, and More-educated Individuals With Cancer
Introduction: Levels of medical mistrust have historically been higher among racial/ethnic minority patients compared with whites, largely owing to societal and health system inequities and history of discrimination or experimentation. However, recently trust in physicians has declined in the United States in general. We investigated trust in physicians among a large cohort of cancer patients residing in Texas. Methods: A sample of recently diagnosed cancer patients in Texas were identified from the Texas Cancer Registry with 1344 patients returning surveys between March 2017 and March 2020. The multiscale inven...
Source: American Journal of Clinical Oncology - March 30, 2021 Category: Cancer & Oncology Tags: Original Articles: The Profession Source Type: research

Benefits of a Multidisciplinary Women’s Sexual Health Clinic in the Management of Sexual and Menopausal Symptoms After Pelvic Radiotherapy
Conclusions: This study highlights the importance of multidisciplinary care in improving the sexual and menopausal symptoms of women after PRT. Future work examining the impact of intervention timing with respect to PRT and measures of patient satisfaction is warranted. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - March 30, 2021 Category: Cancer & Oncology Tags: Original Articles: Symptom Management Source Type: research

Testosterone for Managing Treatment-related Fatigue in Patients With Metastatic Renal Cell Carcinoma: A Phase 2 Randomized Study FARETES
Conclusion: Male patients with metastatic RCC and hypogonadism receiving testosterone had less fatigue and better symptom control during targeted therapy. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - March 30, 2021 Category: Cancer & Oncology Tags: Original Articles: Genitourinary Source Type: research

Patient-reported Quality of Life After SBRT, LDR, and HDR Brachytherapy for Prostate Cancer: A Comparison of Outcomes
Conclusions: In a cohort of patients treated with modern radiotherapy techniques, HDR and SBRT resulted in clinically meaningful improved urinary PRQOL compared with LDR. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - March 30, 2021 Category: Cancer & Oncology Tags: Original Articles: Genitourinary Source Type: research

Multiple Site SBRT in Pediatric, Adolescent, and Young Adult Patients With Recurrent and/or Metastatic Sarcoma
Conclusions: SBRT was well tolerated in the majority of patients with favorable local control outcomes. Additional studies will be required to determine the optimal SBRT dose and fractionation, treatment volume, and appropriate concurrent therapies. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - March 1, 2021 Category: Cancer & Oncology Tags: Original Articles: Soft Tissue Source Type: research