American Journal of Clinical Oncology 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Radiographic Response of Vessel Involvement and Resectability After Neoadjuvant Chemoradiation in Patients With Locally Advanced Pancreatic Cancer
Objectives:
Survival of patients with locally advanced pancreatic cancer (LAPC) is improved when neoadjuvant chemoradiation enables subsequent surgical resection. Here, the authors assess changes in vessel involvement as a possible indicator of resectability.
Methods:
Pancreatic gross tumor and all major abdominal vessels were contoured for 49 patients with unresectable LAPC before and after neoadjuvant chemoradiation. Changes were compared by paired t tests. Tumor-vessel relationships were automatically quantified using Medical Imaging Interaction Toolkit and examined for correlation with resectability and outcome.
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Source: American Journal of Clinical Oncology - October 23, 2020 Category: Cancer & Oncology Tags: Original Articles: Gastrointestinal Source Type: research
Radiotherapy in Early-stage Gastric MALT: Improved Survival Without Increased Cardiac Death
Purpose:
Radiotherapy (RT) is an effective treatment for localized gastric mucosa-associated lymphoid tissue (MALT) lymphomas unresponsive to antibiotic therapy; however, irradiating the stomach can result in significant radiation to the heart, a risk factor for cardiac disease. We analyzed the Surveillance, Epidemiology, and End Results database to evaluate outcomes related to cardiac disease among patients treated with RT for stage I gastric MALT.
Materials and Methods:
We identified adult patients treated between 1993 and 2014. The relationship between treatment modality (RT, chemotherapy, combination, and no treat...
Source: American Journal of Clinical Oncology - October 23, 2020 Category: Cancer & Oncology Tags: Original Articles: Gastrointestinal Source Type: research
Racial Disparities in Time to Treatment Initiation and Outcomes for Early Stage Anal Squamous Cell Carcinoma
Objectives:
Although cure rates for early stage anal squamous cell cancer (ASCC) are overall high, there may be racial disparities in receipt of treatment and outcome precluding favorable outcomes across all patient demographics. Therefore, the authors aimed to assess the time to treatment initiation and overall survival (OS) in Black and White patients receiving definitive chemoradiation for early stage ASCC.
Materials and Methods:
The authors identified patients diagnosed with early stage (stage I-II) ASCC and treated with chemoradiation diagnosed between 2004 and 2016 in the National Cancer Database. Clinical and t...
Source: American Journal of Clinical Oncology - October 23, 2020 Category: Cancer & Oncology Tags: Original Articles: Gastrointestinal Source Type: research
Sequencing of Adjuvant Chemoradiation for Advanced Stage Endometrial Cancer: Outcomes and Toxicity Profiles
Objectives:
Radiation is frequently added to chemotherapy for adjuvant treatment of advanced stage endometrial cancer. Multiple adjuvant therapy sequencing options exist, and little data is available to compare these. We compared outcomes and toxicities after “sandwich” chemoradiation (chemotherapy, then radiation, then chemotherapy) and nonsandwich sequences (chemotherapy then radiation, radiation then chemotherapy, or concurrent chemoradiation).
Materials and Methods:
We recorded baseline characteristics, adjuvant treatment details, clinical outcomes, and toxicities for stage III to IVA patients who underwent su...
Source: American Journal of Clinical Oncology - October 23, 2020 Category: Cancer & Oncology Tags: Original Articles: Gynecologic Source Type: research
Commentary on Neoadjuvant Versus Surgery First Approach in Resectable Pancreatic Ductal Adenocarcinoma
No abstract available (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - September 24, 2020 Category: Cancer & Oncology Tags: Letters to the Editor Source Type: research
Neoadjuvant Therapy Versus Immediate Surgery for Resectable Pancreas Cancer: Still Open for Debate
No abstract available (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - September 24, 2020 Category: Cancer & Oncology Tags: Letters to the Editor Source Type: research
Pelvic Reirradiation Utilizing Pulsed Low-dose Rate Radiation Therapy
Pulsed low-dose rate radiation therapy has been shown to reduce normal tissue damage while decreasing DNA damage repair in tumor cells. In a cohort of patients treated with palliative or definitive pelvic reirradiation using pulsed low-dose rate radiation therapy, we observed substantial local control and low rates of toxicity. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - September 24, 2020 Category: Cancer & Oncology Tags: Cancer Management Controversy Source Type: research
Disparities in Surgical Recommendation for Stage I Non–Small Cell Lung Cancer
This study explores disparities in surgical recommendations in stage I NSCLC, when surgery is considered curative.
Materials and Methods:
Patients diagnosed with primary stage I NSCLC from 2007 to 2016 were identified from the Surveillance, Epidemiology, and End Results database (N=56,534). Associations between sociodemographic variables and surgical recommendation were assessed using multivariable logistic regression models. Survival impact was investigated using Cox-proportional hazards regression and propensity matching techniques.
Results:
Of the 76.9% patients recommended surgery, 95% underwent surgery. Recommen...
Source: American Journal of Clinical Oncology - September 24, 2020 Category: Cancer & Oncology Tags: Original Articles: Thoracic Source Type: research
The Perceptions of Cancer Patients Regarding the Causes and Preventability of Unplanned Hospital Admissions
Conclusions:
These results differ from previous results that use methods other than a direct patient survey to determine the preventability or root causes of unplanned hospital admissions/ or readmissions. Accordingly, patient support programs may not address the root causes of unplanned admissions. The use of the emergency department for unplanned care may represent local culture and institutions planning reduction efforts should include patent perceptions to plan a holistic solution. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - September 24, 2020 Category: Cancer & Oncology Tags: Original Articles: Health Policy Source Type: research
Psychiatric Disturbance or Parkinsonism as a Presentation of CNS Lymphoma: Observational Retrospective Study and Review of Literature
Conclusions:
Neuropsychiatric symptoms are a rare but notable symptom before the presentation of CNSL. There is an increasing awareness of neurological illness presenting as pure psychiatric disturbance, prompting the need to exclude organic and treatable diseases, particularly in elderly patients. Acknowledgment and diagnosis are important for an appropriate management as there is a significant impact on patient and caregiver quality of life. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - September 24, 2020 Category: Cancer & Oncology Tags: Original Articles: Central Nervous System Source Type: research
Nationwide Patterns of Pathologic Fractures Among Patients Hospitalized With Bone Metastases
Objectives:
Pathologic fractures from bone metastases can significantly affect quality-of-life, although it is unclear which patients may be at high risk of this outcome. We aim to determine risk factors for pathologic fracture among patients admitted with bone metastases and to evaluate the association of pathologic fracture with clinical and economic outcomes.
Methods:
The Healthcare Cost and Utilization Project National Inpatient Sample was queried for all patients hospitalized with bone metastases in 2016. Baseline differences between patients with and without pathologic fractures were assessed by χ2 and analysis...
Source: American Journal of Clinical Oncology - September 24, 2020 Category: Cancer & Oncology Tags: Original Articles: Palliative Care Source Type: research
Prognostic Value of Preoperative Imaging: Comparing 18F-Fluorodeoxyglucose Positron Emission Tomography-Computed Tomography to Computed Tomography Alone for Preoperative Planning in High-risk Histology Endometrial Carcinoma
The objective of this investigation was to determine the prognostic value of preoperative PET-CT compared with computed tomography (CT) alone for high-risk endometrial carcinoma.
Materials and Methods:
We performed a retrospective review of high-risk histology endometrial cancer from 2008 to 2015. Clinical variables including surgical procedure, preoperative imaging modality, and outcome were collected. Survival analysis was performed utilizing the Kaplan-Meier and Cox proportional hazards methodologies.
Results:
Of the 555 women treated for high-risk histology endometrial cancer, 88 (16%) had preoperative PET-CT, an...
Source: American Journal of Clinical Oncology - September 24, 2020 Category: Cancer & Oncology Tags: Original Articles: Gynecologic Source Type: research
Long-term Outcomes After Definitive Radiation Therapy for Solitary Plasmacytoma
Objective:
Definitive radiotherapy (RT) with or without surgery is the standard of care for solitary plasmacytoma. Here, we report clinical outcomes for this rare malignant neoplasm.
Patients and Methods:
We retrospectively reviewed the medical records of adults with solitary plasmacytoma treated with definitive RT between 1963 and 2015 at a single institution, and assessed disease control, survival, and toxicity per Common Terminology Criteria for Adverse Events (CTCAE), version 4.
Results:
A total of 42 patients with solitary plasmacytoma of the bone (SPB, n=27) or extramedullary plasmacytoma (EMP, n=15) were tre...
Source: American Journal of Clinical Oncology - September 24, 2020 Category: Cancer & Oncology Tags: Original Articles: Hematopoietic Source Type: research
Feasibility and Outcome of Routine Use of Concurrent Chemoradiation in HIV-positive Patients With Squamous Cell Anal Cancer
Conclusions:
Radiation therapy with concurrent 5-fluorouracil and mitomycin C chemotherapy is reasonably well-tolerated as curative treatment for HIV+ patients with SCAC, and no significant difference in outcomes was noted relative to HIV− patients. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - September 24, 2020 Category: Cancer & Oncology Tags: Original Articles: Gastrointestinal Source Type: research
Recent Trends and Overall Survival of Young Versus Older Adults With Stage II to III Rectal Cancer Treated With and Without Surgery in the United States, 2010-2015
Background:
The omission of surgery via nonoperative management (NOM) for rectal cancer may be increasing, and this strategy could be particularly attractive for younger patients, whose incidence of rectal cancer has been rising. We sought to assess trends in NOM in young (younger than 55 y) versus older adult (55 y and older) rectal cancer cohorts.
Methods:
The National Cancer Database was used to identify patients diagnosed with stage II to III rectal cancer between 2010 and 2015. Multivariable logistic regression defined the association between sociodemographic variables and odds of NOM, including an age (18 to...
Source: American Journal of Clinical Oncology - September 24, 2020 Category: Cancer & Oncology Tags: Original Articles: Gastrointestinal Source Type: research
