American Journal of Clinical Oncology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Gemcitabine Plus Cisplatin Chemotherapy Prolongs the Survival in Advanced Hilar Cholangiocarcinoma: A Large Multicenter Study
Objectives: Gemcitabine plus cisplatin (GC) is recommended as first-line treatment for advanced cholangiocarcinoma. We investigated the impact of GC in patients with unresectable hilar cholangiocarcinoma (HC) based on the time taken for effective biliary drainage (EBD). Materials and Methods: We retrospectively enrolled 113 patients with unresectable HC. Thirty-nine and 74 patients received GC chemotherapy and best supportive care (BSC), respectively. EBD was defined as a reduction in total bilirubin>50% or to a value (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - May 27, 2020 Category: Cancer & Oncology Tags: Original Articles: Gastrointestinal Source Type: research

Brain Metastases From Gynecologic Malignancies: Prevalence and Management
Conclusions: The incidence of BM among patients with gynecologic malignancies is rare and associated with poor survival. For select patients, SRS may be associated with prolonged survival. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - May 27, 2020 Category: Cancer & Oncology Tags: Original Articles: Gynecologic Source Type: research

Association Between Metabolic Syndrome and Endometrial Cancer Survival in a SEER-Medicare Linked Database
Conclusions: In elderly early stage endometrial cancer patients, metabolic syndrome is associated with worse CSS. Control of metabolic syndrome through lifestyle and pharmacologic therapies may improve cancer prognosis in this population. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - May 27, 2020 Category: Cancer & Oncology Tags: Original Articles: Gynecologic Source Type: research

Refusal of Radiation Results in Inferior Survival in Endometrial Cancer
Objective: We sought to understand factors associated with refusal of adjuvant radiotherapy in endometrial cancer and its impact on outcomes. Methods: Data from the National Cancer Database for patients who underwent surgery for nonmetastatic endometrial cancer between 2004 and 2015 were pooled. The Pearson χ2 test and multivariate logistic regression analyses were used to assess demographic, clinical, and treatment factors. Inverse probability of treatment weighting was used to account for differences in baseline characteristics. Kaplan-Meier analyses and doubly-robust estimation with multivariate Cox proportional h...
Source: American Journal of Clinical Oncology - May 27, 2020 Category: Cancer & Oncology Tags: Original Articles: Gynecologic Source Type: research

Diagnostic Test Accuracy of Glasgow Prognostic Score as a Prognostic Factor for Renal Cell Carcinoma: A Meta-Analysis
Conclusion: GPS demonstrated a good diagnostic accuracy as a prognostic factor for RCC and especially in the case of nonmetastatic RCC. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - May 27, 2020 Category: Cancer & Oncology Tags: Original Articles: Genitourinary Source Type: research

Prognostic Significance of Preoperative Prognostic Nutritional Index in Patients Undergoing Nephrectomy for Nonmetastatic Renal Cell Carcinoma
The objective of this study was to assess the value of a preoperative Prognostic Nutritional Index (PNI) for predicting the survival of patients with nonmetastatic renal cell carcinoma (RCC) treated with partial or radical nephrectomy. Materials and Methods: The medical records of 480 patients with RCC who underwent partial or radical nephrectomy at 2 institutions between June 1994 and July 2017 were retrospectively reviewed. After the exclusion of 21 patients with lymph node or distant metastasis, the data of 459 patients with nonmetastatic RCC were included. The PNI was calculated using a combination of serum albumin ...
Source: American Journal of Clinical Oncology - May 27, 2020 Category: Cancer & Oncology Tags: Original Articles: Genitourinary Source Type: research

Modified-BEP Chemotherapy in Patients With Germ-Cell Tumors Treated at a Comprehensive Cancer Center
Conclusion: In GCT patients, our mBEP-schedule would suggest an effective treatment modality without suffering meaningful pulmonary toxicity. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - May 27, 2020 Category: Cancer & Oncology Tags: Original Articles: Genitourinary Source Type: research

Pattern of Marginal Local Failure in a Phase II Trial of Neoadjuvant Chemotherapy and Stereotactic Body Radiation Therapy for Resectable and Borderline Resectable Pancreas Cancer: Erratum
No abstract available (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - April 25, 2020 Category: Cancer & Oncology Tags: Erratum Source Type: research

Speak to Us of Love
No abstract available (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - April 25, 2020 Category: Cancer & Oncology Tags: Editorial Source Type: research

Current Status of Chimeric Antigen Receptor T-Cell Therapy in Multiple Myeloma
Multiple myeloma (MM) is an incurable malignancy of plasma cells. Recently multiple new therapeutic options have been introduced which was able to improve overall survival but ultimately patient become refractory specifically in patients with poor cytogenetics. Therefore, novel therapeutic options like immunotherapy are needed to improve outcomes. Chimeric antigen receptor (CAR) T-cell therapy is immunotherapy in which T cell are genetically engineered against a tumor-specific antigen and transfused back to the patient to mount major histocompatibility complex-independent cancer-specific immune response. The success of CAR...
Source: American Journal of Clinical Oncology - April 25, 2020 Category: Cancer & Oncology Tags: Review Article Source Type: research

Risk of Recurrence and 10-Year Outcomes in Surgically Treated Nonmelanoma Skin Cancer in Cardiac and Liver Transplant Recipients
Objectives: To report long-term outcomes of nonmelanoma skin cancer (NMSC) in immunosuppressed cardiac and liver transplant recipients (CLTR). Materials and Methods: The authors reviewed CLTR at the Mayo Clinic in Arizona from 1986 to 2013. Patient and tumor characteristics were recorded. Survival rates were calculated using the Kaplan-Meier method. Patient-specific and lesion-specific analyses were performed. Univariate and multivariate cox regressions were performed for comparisons. Results: Seven-hundred and forty-seven patients underwent cardiac (138) or liver (609) transplantation and of these, 97 patients (13...
Source: American Journal of Clinical Oncology - April 25, 2020 Category: Cancer & Oncology Tags: Original Articles: Cutaneous Source Type: research

Treatment Timing in Small Cell Lung Cancer, a National Cancer Database Analysis
This study evaluated TCI in SCLC on a national level. Materials and Methods: The National Cancer Database identified 64,491 SCLC patients treated with chemotherapy from 2010 to 2014. Factors associated with TCI were identified with multiple linear regression analyses. TCI was categorized into 4 groups using cutoff points of 7, 14, and 28 days. Using these categories, median overall survival and log-rank test was used for univariate analysis of the survival outcome and the Cox model was used for multivariate analysis. Results: Median TCI was 18 days with 21% treated ≤7 days, 21% in 8 to 14 days, 30% 15 to 28 days, a...
Source: American Journal of Clinical Oncology - April 25, 2020 Category: Cancer & Oncology Tags: Original Articles: Thoracic Source Type: research

Outcomes and the Role of Primary Histology Following LINAC-based Stereotactic Radiation for Sarcoma Brain Metastases
Objectives: The brain is a rare site for sarcoma metastases. Sarcoma’s radioresistance also makes standard whole-brain radiotherapy less appealing. We hypothesize that stereotactic radiation techniques (stereotactic radiosurgery [SRS]/stereotactic fractionated radiotherapy [FSRT]) may provide effective local control. Materials and Methods: This single-institution retrospective analysis evaluated our experience with linear acceleator-based SRS/FSRT for sarcoma brain metastases. Time to event analysis was estimated via Kaplan-Meier. Univariable/multivariable Cox regression analyses followed to assess the impact of pat...
Source: American Journal of Clinical Oncology - April 25, 2020 Category: Cancer & Oncology Tags: Original Articles: Central Nervous System Source Type: research

Recent Health Care Expenditure Trends Among Adult Cancer Survivors in United States, 2009-2016
This study was a retrospective analysis of 193,003 adults, ≥18 years of age, using the Medical Expenditure Panel Survey during the years 2009-2016. Manning and Mullahy two-part model was used to calculate adjusted mean and incremental medical expenditures after adjusting for covariates. Results: The mean direct annual health care expenditure among cancer survivors ($13,025.0 [$12,572.0 to $13,478.0]) was nearly 3 times greater than noncancer participants ($4689.3 [$4589.2 to $4789.3]) and were mainly spent on inpatient services, office-based visits, and prescription medications. Cancer survivors had an additional heal...
Source: American Journal of Clinical Oncology - April 25, 2020 Category: Cancer & Oncology Tags: Original Articles: Health Policy Source Type: research

First-Line Treatment With Atezolizumab Plus Nab-Paclitaxel for Advanced Triple-Negative Breast Cancer: A Cost-Effectiveness Analysis
Conclusion: AnP is not a cost-effective choice as the first-line treatment for advanced triple-negative breast cancer in the United States and China. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - April 25, 2020 Category: Cancer & Oncology Tags: Original Articles: Breast Source Type: research