American Journal of Clinical Oncology 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Patterns of Care in Maintenance Therapy in US Patients Undergoing Definitive Chemoradiation for Stage 3 Non–Small Cell Lung Cancer (NSCLC)
Conclusions:
The rate of durvalumab utilization was overall low in both the open and closed claims data sources (31% and 53%, respectively). It remains unknown what percent of eligible patients end up receiving durvalumab, as our analysis was unable to filter out patients who were unfit for durvalumab or if they had progression after chemoradiation. Future efforts are needed to increase maintenance durvalumab utilization and to determine how best to manage patients who are unfit for durvalumab. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - January 29, 2022 Category: Cancer & Oncology Tags: Original Articles: Thoracic Source Type: research
Definitive Chemoradiotherapy Results in Synchronous Oligometastatic Non–small Cell Lung Cancer Patients: Turkish Society for Radiation Oncology Group Study (TROD 10-003)
Objective:
It is aimed to investigate the survival outcomes and prognostic factors after curative treatment of patients diagnosed with synchronous oligometastatic non–small cell lung carcinoma.
Materials and Methods:
Fifty-two patients from 3 centers diagnosed between 2014 and 2019 were analyzed. The treatment results of thoracic and oligometastatic regions were retrospectively evaluated. The Kaplan-Meier method was used to determine the overall survival (OS) and progression-free survival (PFS) and log-rank tests for the factors affecting survival. Cox regression analysis was employed for multivariate analysis...
Source: American Journal of Clinical Oncology - January 1, 2022 Category: Cancer & Oncology Tags: Original Articles: Thoracic Source Type: research
Effect of Mismatch Repair Status on Outcome of Early-Stage Grade 1 to 2 Endometrial Cancer Treated With Vaginal Brachytherapy
Conclusions:
MMR deficiency in stage I to II grade 1 to 2 endometrial cancer patients treated with adjuvant VB alone was associated with statistically significant increased risk for any recurrence and worse OS. MMR status may be an important prognosticator in this cohort of patients warranting adjuvant treatment intensification in the clinical trial setting. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - January 1, 2022 Category: Cancer & Oncology Tags: Original Articles: Gynecologic Source Type: research
Fédération Nationale Des Centres de Lutte Contre Le Cancer (FNCLCC) Grading, Margin Status and Tumor Location Associate With Survival Outcomes in Malignant Peripheral Nerve Sheath Tumors
Conclusions:
Association between FNCLCC grading and survival outcomes in MPNST suggests potential value to routinely grading these neoplasms. However, the subjectivity of the grading system, particularly when assigning a tumor differentiation score, may pose a challenge, especially in low and intermediate grade lesions. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - January 1, 2022 Category: Cancer & Oncology Tags: Original Articles: Soft Tissue Source Type: research
Characteristics and Growth Rate of Lung Metastases in Patients With Primary Gastrointestinal Malignancies and Lung-dominant Metastatic Disease: A Retrospective Cohort Analysis
Conclusions:
Lung metastases from primary GI cancers have a variable but overall indolent natural history and are generally associated with prolonged survival outcomes. Further efforts to define patterns of growth of lung metastases, informed by size, number, and clinical/molecular features, are needed to guide appropriate timing and selection of therapy as well as surveillance strategies. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - January 1, 2022 Category: Cancer & Oncology Tags: Original Articles: Gastrointestinal Source Type: research
Factors Affecting Inpatient Mortality and Length of Stay in Nonmetastatic Colorectal Cancer: Insights from the National Inpatient Sample
The objective of this study was to assess the effect of opioid use and other factors on inpatient length of stay (LOS) and mortality among patients hospitalized with nonmetastatic colorectal cancer (NMCRC).
Materials and Methods:
We analyzed discharge encounters collected from the 2016 to 2017 National Inpatient Sample (NIS) to evaluate the effect of long-term opioid use (90 d or longer) and cancer-related complications on LOS and mortality among hospitalized patients with NMCRC.
Results:
A total of 94,535 patients with NMCRC were included in the analysis. Long-term opioid users had a shorter average LOS an...
Source: American Journal of Clinical Oncology - January 1, 2022 Category: Cancer & Oncology Tags: Original Articles: Gastrointestinal Source Type: research
Celecoxib and Myrtol: A Novel Therapy for Recurrent Appendiceal Mucinous Neoplasms With Extensive Peritoneal Dissemination
Conclusions:
Our feasibility study suggests that a regimen of Celecoxib-Myrtol is well tolerated and may prolong PFS and OS in patients with recurrent AMNs with peritoneal spread. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - January 1, 2022 Category: Cancer & Oncology Tags: Original Articles: Gastrointestinal Source Type: research
Rapid Initiation of Neoadjuvant Chemoradiotherapy After Diagnosis is Associated With Improved Pathologic Response in Locally Advanced Rectal Cancer
Introduction:
In rectal cancer, neoadjuvant chemoradiation (NCRT) is preferred because of toxicity profile, improved resectability and sphincter preservation, although with no impact on overall survival. Pathologic complete response (pCR) to NCRT has been linked with longer disease-free survival (DFS). The study purpose was to evaluate an association between clinical factors and treatment schedule with tumor response and treatment outcome, among patients with locally advanced rectal cancer.
Patients and Methods:
In this single-center retrospective study, conducted over 9 years (2011 to 2020), patients with stage...
Source: American Journal of Clinical Oncology - January 1, 2022 Category: Cancer & Oncology Tags: Original Articles: Gastrointestinal Source Type: research
Treatment and Prevention of Brain Metastases in Small Cell Lung Cancer
Central nervous system (CNS) metastasis will develop in 50% of small cell lung cancer (SCLC) patients throughout disease course. Development of CNS metastasis poses a particular treatment dilemma due to the accompanied cognitive changes, poor permeability of the blood-brain barrier to systemic therapy and relatively advanced state of disease. Survival of patients with untreated SCLC brain metastases is generally (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - December 1, 2021 Category: Cancer & Oncology Tags: Review Article Source Type: research
Reirradiation in Conservative Salvage of Recurrent Soft-tissue Sarcoma: An Analysis of Treatment Efficacy and Toxicities
Conclusions:
Achieving local control of recurrent soft-tissue sarcoma is challenging. Treatment with reoperation and reirradiation can lead to debilitating complications affecting function and quality of life. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - December 1, 2021 Category: Cancer & Oncology Tags: Original Articles: Soft Tissue Source Type: research
Preoperative Radiation Performed at a Nonsarcoma Center May Lead to Increased Wound Complications Following Resection in Patients With Soft Tissue Sarcomas
Conclusions:
Preoperative RT performed at an academic cancer center led to lower rates of postoperative wound complication. This may support the recommendation that preoperative RT and resection of STS be performed at an experienced sarcoma center. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - December 1, 2021 Category: Cancer & Oncology Tags: Original Articles: Soft Tissue Source Type: research
Phase II Study of the Modified Weekly Nab-paclitaxel Regimen in Previously Treated Patients With Advanced Non–Small Cell Lung Cancer
Conclusions:
Nab-paclitaxel monotherapy with a dose and schedule suitable for outpatients showed high ORR, long median PFS, and acceptable toxicity for patients with previously treated NSCLC. This dosage method may be useful for selected patients. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - December 1, 2021 Category: Cancer & Oncology Tags: Original Articles: Thoracic Source Type: research
Do Patients With Multiple Myeloma Enrolled in Clinical Trials Live Longer?
Objectives:
Enrollment in clinical trials is thought to improve survival outcomes through the trial effect. In this retrospective observational cohort study, we aimed to discern differences in survival outcomes by clinical trial enrollment and race-ethnicity.
Materials and Methods:
Of 1285 patients receiving care for multiple myeloma at an National Cancer Institute designated cancer center from 2012 to 2018, 1065 (83%) were nontrial and 220 (17%) were trial participants. Time to event analyses were used to adjust for baseline characteristics and account for clinical trial enrollment as a time-varying covariate. ...
Source: American Journal of Clinical Oncology - December 1, 2021 Category: Cancer & Oncology Tags: Original Articles: Hematopoetic Source Type: research
Socioeconomic Determinants of the Use of Molecular Testing in Stage IV Colorectal Cancer
Objectives:
Treatment with epidermal growth factor receptor monoclonal antibodies extends life for patients with advanced colorectal cancers (CRCs) whose tumors exhibit wild-type KRAS, but KRAS testing may be underused. We studied the role of socioeconomic factors in the application of KRAS testing.
Materials and Methods:
We identified subjects with stage IV colorectal adenocarcinoma diagnosed 2010-2015 in the Surveillance, Epidemiology, and End Results (SEER) database. We used multivariable logistic regression models to evaluate associations between clinical/demographic factors and the rate of KRAS testing. We ...
Source: American Journal of Clinical Oncology - December 1, 2021 Category: Cancer & Oncology Tags: Original Articles: Gastrointestinal Source Type: research
Phase I/II Dose-Escalation Trial of 3-Fraction Stereotactic Radiosurgery for Resection Cavities From Large Brain Metastases: Health-related Quality of Life Outcomes
Objectives:
We investigated differences in quality of life (QoL) in patients enrolled on a phase I/II dose-escalation study of 3-fraction resection cavity stereotactic radiosurgery (SRS) for large brain metastases.
Methods:
Eligible patients had 1 to 4 brain metastases, one of which was a resection cavity 4.2 to 33.5 cm3. European Organization for Research and Treatment of Cancer (EORTC) quality of life questionnaires core-30 (QLQ-30) and brain cancer specific module (QLQ-BN20) were obtained before SRS and at each follow-up. Nine scales were analyzed (global health status; physical, social, and emotional funct...
Source: American Journal of Clinical Oncology - October 28, 2021 Category: Cancer & Oncology Tags: Original Articles: Central Nervous System Source Type: research
