Case-cohort study of plasma phospholipid fatty acid profiles, cognitive function, and risk of dementia: a secondary analysis in the Ginkgo Evaluation of Memory Study
ConclusionsSpecific elements of diet may be associated with late-life dementia, a hypothesis that requires formal testing in randomized controlled trials and that represents a possible preventive intervention. (Source: American Journal of Clinical Nutrition)
Source: American Journal of Clinical Nutrition - April 21, 2021 Category: Nutrition Source Type: research

The utility of predicted values in place of directly measured body composition
See corresponding article onpage 661. (Source: American Journal of Clinical Nutrition)
Source: American Journal of Clinical Nutrition - April 20, 2021 Category: Nutrition Source Type: research

Improved diet quality is associated with decreased concentrations of inflammatory markers in adults with uncontrolled asthma
ConclusionsOur data in adult patients with poorly controlled asthma suggest that dietary changes, like the introduction of DASH, may have beneficial effects on reducing inflammatory status. This trial was registered athttp://www.clinicaltrials.gov as NCT01725945. (Source: American Journal of Clinical Nutrition)
Source: American Journal of Clinical Nutrition - April 19, 2021 Category: Nutrition Source Type: research

Dietary quality and bisphenols: trends in bisphenol A, F, and S exposure in relation to the Healthy Eating Index using representative data from the NHANES 2007 –2016
ConclusionsHealthier dietary quality and several HEI subgroups were related to lower urinary BPA concentrations; no significant (P ≤ 0.0005) findings were observed for BPF and BPS. The association between bisphenol substitutes and dietary quality should continue to be monitored as bisphenol substitutes continue to increase in the food system. (Source: American Journal of Clinical Nutrition)
Source: American Journal of Clinical Nutrition - April 19, 2021 Category: Nutrition Source Type: research

Diets benefiting health and climate relate to longevity in northern Sweden
ConclusionsDiets beneficial for both health and climate are feasible and associated with lower mortality risk in women. Further studies are needed to understand how men may transition into diets that are more sustainable from a combined health and climate perspective. (Source: American Journal of Clinical Nutrition)
Source: American Journal of Clinical Nutrition - April 19, 2021 Category: Nutrition Source Type: research

A combination of single nucleotide polymorphisms is associated with the interindividual variability in the blood lipid response to dietary fatty acid consumption in a randomized clinical trial
ConclusionsWe report combinations of SNPs associated with a significant part of the variability in LDL cholesterol and TG concentrations following dietary interventions differing in their fatty acid profiles. (Source: American Journal of Clinical Nutrition)
Source: American Journal of Clinical Nutrition - April 19, 2021 Category: Nutrition Source Type: research

Pathways to “5-a-day”: modeling the health impacts and environmental footprints of meeting the target for fruit and vegetable intake in the United Kingdom
ConclusionsBenefits to both population and environmental health could be expected from consumption pathways that meet the United Kingdom's 5-a-day target for fruit and vegetables. Our analysis identifies cross-sectoral trade-offs and opportunities for national policy to promote fruit and vegetable consumption in the United Kingdom. (Source: American Journal of Clinical Nutrition)
Source: American Journal of Clinical Nutrition - April 19, 2021 Category: Nutrition Source Type: research

Diet quality, gut microbiota, and microRNAs associated with mild cognitive impairment in middle-aged and elderly Chinese population
ConclusionsA better diet quality is associated with a lower risk of MCI, which may be mediated by the microbiota composition and miRNA expression. These findings suggest that diet, the gut microbiota, and miRNAs may serve as  a combinatorial biomarker to identify MCI patients and provide new insight for the diagnosis and prevention of MCI. This study was registered at the Chinese Clinical Trial Registry as ChiCTROOC-17011882. (Source: American Journal of Clinical Nutrition)
Source: American Journal of Clinical Nutrition - April 19, 2021 Category: Nutrition Source Type: research

Effects of dietary polyphenol supplementation on iron status and erythropoiesis: a systematic review and meta-analysis of randomized controlled trials
ConclusionHealthy individuals and patients with metabolic diseases may benefit from the positive impact of polyphenols on erythropoiesis. Patients with β-thalassemia may benefit from the effect of polyphenols on reducing SI. This trial was registered at PROSPERO (International prospective register of systematic reviews) as CRD42020161983. (Source: American Journal of Clinical Nutrition)
Source: American Journal of Clinical Nutrition - April 19, 2021 Category: Nutrition Source Type: research

Building better guidelines for healthy and sustainable diets
See corresponding perspective onpage 405 and article onpage 713. (Source: American Journal of Clinical Nutrition)
Source: American Journal of Clinical Nutrition - April 19, 2021 Category: Nutrition Source Type: research

Proposed reductions in limits on added sugar and alcohol for the new dietary guidelines: our perspective
nutritionalcoholsugarguidelinesdiet (Source: American Journal of Clinical Nutrition)
Source: American Journal of Clinical Nutrition - April 19, 2021 Category: Nutrition Source Type: research

Association of loss of Supplemental Nutrition Assistance Program benefits with food insecurity and dietary intake of adults and children
ConclusionsThis study suggests that loss of benefits may increase household food insecurity. Although child/adolescent intakes of certain HEI-2015 adequacy components were lower among former SNAP participants, overall diet quality score did not differ. Findings collectively imply the need for policies that protect households from the adverse effects of benefits loss. (Source: American Journal of Clinical Nutrition)
Source: American Journal of Clinical Nutrition - April 19, 2021 Category: Nutrition Source Type: research

Gestational weight gain in 4 low- and middle-income countries and associations with birth outcomes: a secondary analysis of the Women First Trial
ConclusionsThese results underscore the importance of adequate maternal nutrition both before and during pregnancy as a potentially modifiable factor to improve fetal growth. (Source: American Journal of Clinical Nutrition)
Source: American Journal of Clinical Nutrition - April 19, 2021 Category: Nutrition Source Type: research

Polymorphisms in SLC44A1 are associated with cognitive improvement in children diagnosed with fetal alcohol spectrum disorder: an exploratory study of oral choline supplementation
ConclusionsTheseSLC44A1 variants were previously associated with greater vulnerability to choline deficiency. Our data potentially support the use of choline supplements to improve cognitive function in individuals diagnosed with FASD who carry these effect alleles. Although these findings require replication in both retrospective and prospective confirmatory trials, they emphasize the need to incorporate similar genetic analyses of choline-related polymorphisms in other FASD-choline trials, and to test for similar associations within the general FASD population. This trial was registered atwww.clinicaltrials.gov as NCT011...
Source: American Journal of Clinical Nutrition - April 19, 2021 Category: Nutrition Source Type: research

Nutritional rickets: calcium or vitamin D deficiency?
See corresponding article onpage 231. (Source: American Journal of Clinical Nutrition)
Source: American Journal of Clinical Nutrition - April 19, 2021 Category: Nutrition Source Type: research